Ramina, Process Analyzer | Thermo Fisher Scientific

With the Ramina Process Analyzer, biopharma manufacturers and process development can conduct real-time and nondestructive in-line process analysis without the need for sample preparation. Using Raman spectroscopy technology the process Raman analyzer makes precise and accurate measurements simple to execute and understand with its one-button hardware and easy-to-use software.

Designed for out-of-the-box use, enabling you to take highly accurate Raman measurements in less than 15 minutes. Pack this process analyzer in a protective case and take it to the point of need, as its factory calibration ensures precise and continuous monitoring on the go. The analyzer can be easily integrated into your existing process monitoring and eliminates the need for costly technical expertise.

Now available: cGMP & 21 CFR Part 11 compliance features for regulated environments

Therapeutic modalities that benefit from process monitoring:
- Protein Therapy: Small molecule - metabolite monitoring

The Ramina Process Analyzer offers:

Analysis without sample preparation, delivering Raman spectral results in real time
Easy setup and deployment by non–Raman spectroscopists

Nondestructive workflows to protect precious samples
Noninvasive handling to minimize contamination of samples

Small footprint for convenient deployment
Factory calibration for hardware stability and portability

Real-time results for a fast-paced industry

The Ramina Process Analyzer enables real-time, accurate spectral results for in-line bioprocess monitoring. The Ramina Process Analyzer streamlines workflows and empowers users to utilize Process Raman Spectroscopy as a Process Analytical Technology (PAT) tool to promote increased robustness of manufacturing operations through real-time data acquisition.

Process Raman Spectroscopy for industrial fermentation

Industrial fermentation is a growing industry creating innovative solutions to the planet’s greatest environmental challenges including reducing greenhouse gas emissions and solving the world's food shortages. The Ramina Process Analyzer offers real-time analysis with process control for industrial fermentation applications including cultivated meat production, complex composition characterization, and carbon capture processes.

Quality measurement at every point-of-production

The Ramina Process Analyzer speeds up analysis, offers flexibility by measuring liquids and gases, and supplies data correlated to the American Society for Testing and Materials (ASTM), Gas Producers of America (GPA), and American Gas Association (AGA) standards. The Ramina Process Analyzer has been successfully deployed in midstream and downstream applications, such as monitoring the quality and composition of refined fuels, identifying contaminants in biofuels, and analyzing natural gas streams.

Maximize the power of Raman with Lykos PAT Software

Thermo Scientific Lykos PAT Software is a remote control and monitoring software designed to simplify the complexities of chemometrics. Lykos PAT Software facilitates data acquisition and analysis by displaying, storing, and exporting bioprocess monitoring data in real-time, enabling remote control and monitoring of the Ramina analyzer and providing an intuitive workflow to streamline processes for nonRaman spectroscopists and Raman experts alike.

Integrated single-use bioreactor ballprobe

Single-use ballprobe offering that is easy to use, available in pre-sterilized and unsterilized with sample interface that enables short batch preparation time and high confidence in sterility

For specific applications, the Single-use Bioreactor Ballprobe can be customized to meet your needs. FiberheadSU is required to use Single-use Ballprobes, the existing standard Fiberheads can be converted to the FiberheadSU model.

Biopharma

Integrated single-use bioreactor ballprobe

Single-use ballprobe offering that is easy to use, available in pre-sterilized and unsterilized with sample interface that enables short batch preparation time and high confidence in sterility

Featured resources

Ramina Process Analyzer System and HyPerforma Dynadrive SUB

Your guide to biopharmaceutical process monitoring with Raman spectroscopy

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PAT - Process monitoring from raw materials to finished products

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Webinar: Lower Bioprocessing Costs and Time with Raman Spectroscopy

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Search Process Raman Spectroscopy Resources

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Type	Title	Industry
Application Note	Accelerating the analysis of refined fuel properties using a novel solid state Raman analyzer	Oil & gas
Application Note	In-line, on-line, at-line, or off-line	General
Application Note	Ramina Process Analyzer - Chemometric model transferability across instruments	Biopharma
Application Note	Ramina process analyzer application note	General
Application Note	Ramina Process Analyzer System and HyPerforma Dynadrive SUB	Biopharma
Application Note	Real time metabolite monitoring using the Ramina Process Analyzer System Real time metabolite monitoring using the Ramina Process Analyzer System	Biopharma
Article	Using process Raman spectroscopy in cultivated meat production	Industrial fermentation
Brochure	PAT - Process monitoring from raw materials to finished products in biopharmaceutical industry	Biopharma
Brochure	Process Raman spectroscopy for downstream applications in oil and gas industries	Oil & gas
Brochure	Ramina Process Analyzer	General
Case Study	Enabling NGL field analysis for certification and Quality Assurance (QA) with process Raman spectroscopy	Oil & gas
Case Study	Measuring polymer material properties with Raman spectroscopy	Polymers
Case Study	Measuring the transformation of materials for lithium-ion battery recycling with Raman spectroscopy	Battery recycling
Case Study	Process Raman spectroscopy for carbon capture applications	Carbon capture
Case Study	Process Raman spectroscopy for energy. An affordable, data-rich complement to existing analytical tools	Oil & gas
Catalog	Ramina probes for a range of applications	General
Datasheet	Single-Use Bioreactor BallProbe with TouchRaman immersion technology	General
Flyer	Five things you didn’t know about the Ramina Process Analyzer	General
Flyer	Ramina redesigns Raman	General
On-Demand Webinar	Process Raman Spectroscopy Beyond Small Molecule Applications	Biopharma
Poster	Discover the possibilities with our chemometrics assistance	General
Services	Ramina service offerings	General

On-demand webinars for biotech process monitoring

Breakthrough technologies and applications that are making pharmaceutical and biopharmaceutical processes more efficient.

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Service & support

Chemometrics & consulting

When you need assistance designing best practices for data collection and building models, our dedicated chemometrician will consult with you to understand your specific needs. We are available to assist with and guide you in developing tailored, powerful chemometric models and provide model reports to ensure your success with Ramina.

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Count on industry-leading service and support

We are here to continue to support you after your initial product purchase. Our service plans are designed with the valuable services important to you: technical support, software updates, training, and coverage of labor and parts for depot repair.

Premium

The Premium service plan offers exclusive support advantages and includes on-site qualification services and training. With the Premium plan, you will be confident your system is running at peak performance.

Essential

The Essential service plan offers a unique hardware/software support blend to maintain the efficiency and productivity of your system.

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Leading compliance and industry professionals

Our system qualification services mean you can be confident that your system is installed, operating, and performing according to the manufacturer’s specifications. A team of certified service engineers will conduct comprehensive tests to verify performance and provide reliable, system documentation to support regulatory requirements.

Depot repair services

Equipment uptime is critical to your productivity. With our depot repair services, you can trust your system is cared for by a qualified service team who shares your goal of minimizing downtime. All parts are manufacturer-approved parts guaranteed to perform to design specifications.