Sulfo-KMUS (N-κ-maleimidoundecanoyl-oxysulfosuccinimide ester)

Thermo Scientific Pierce Sulfo-KMUS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long spacer arm (16.3 angstroms).

Features of Sulfo-KMUS:

• Reactive groups: sulfo-NHS ester and maleimide
• Reactive toward: amino and sulfhydryl groups
• Long aliphatic spacer arm compared to Sulfo-GMBS
• Sulfo-NHS ester reacts with primary amines at pH 7-9, forming a stable amide bond
• Maleimide reacts with -SH groups at pH 6.5-7.5, forming a stable thioether bond
• Non-cleavable
• Water-soluble

Product References:
Crosslinker Application Guide -- search for recent literature references for this product