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SMPT (4-succinimidyloxycarbonyl-alpha-methyl-α(2-pyridyldithio)toluene)
Thermo Scientific Pierce SMPT is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form strongRead more
Catalog number 21558
Price (USD)
358.00
Each
Price (USD)
358.00
Each
Thermo Scientific Pierce SMPT is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form strong (hindered) yet cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
Features of SMPT:
• Reactive groups: NHS ester and pyridyldithiol
• Reactive towards: amino and sulfhydryl groups
• Cleavable with disulfide reducing agents
• Water-insoluble (dissolve first in DMF or DMSO)
• Contains a hindered disulfide bond; has formed immunotoxins with improved stability
• In vitro, an SMPT conjugate was as effective as conjugates formed with SPDP and 2-IT
• Compare to other varieties of SPDP-type reagents, including pegylated forms
Product References:
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
SPDP (succinimidyl 3-(2-pyridyldithio)propionate)
Features of SMPT:
• Reactive groups: NHS ester and pyridyldithiol
• Reactive towards: amino and sulfhydryl groups
• Cleavable with disulfide reducing agents
• Water-insoluble (dissolve first in DMF or DMSO)
• Contains a hindered disulfide bond; has formed immunotoxins with improved stability
• In vitro, an SMPT conjugate was as effective as conjugates formed with SPDP and 2-IT
• Compare to other varieties of SPDP-type reagents, including pegylated forms
Product References:
Crosslinker Application Guide -- search for recent literature references for this product
Related Products
SPDP (succinimidyl 3-(2-pyridyldithio)propionate)
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Chemical ReactivityAmine-Sulfhydryl
CleavableBy Thiols
DescriptionSMPT
Molecular Weight (g/mol)388.46
PEGylatedNo
Spacer Arm Length11.2 Å
Cell PermeabilityYes
Shipping ConditionAmbient
Product LinePierce™
Labeling MethodChemical Labeling
Crosslinker TypeHeterobifunctional
Reactive MoietyNHS Ester, Pyridyldisulfide
SpacerMedium (10 to 30 Å)
FormPowder
Quantity50 mg
SolubilityDMF, DMSO
FormatStandard
Water SolubleNo
Product TypeCrosslinker
Unit SizeEach
Contents & Storage
Upon receipt store desiccated at 4°C.