GeneBLAzer™ M4-Gqo5-NFAT-bla CHO-K1 Cells

GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells contain the human Acetylcholine (muscarinic) subtype 4 receptor (M4) stably integrated into the GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cell line. GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cells (Cat. No. K1536) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Chimeric G protein, Gqo5.

The GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC₅₀ concentrations of Cabachol. In addition, GeneBLAzer™ M4 Gqo5-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The clinical implications of the M4 receptor are unknown, however studies with knockout mice suggest that M4 may have implications in dopaminergic function, karatinocyte migration and wound healing, anxiolysis, and analgesia. In addition, M4 may be important in memory circuits and have implications in Alzheimer's Disease. Additional information on the muscarinic receptors can be found in literature.

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