TSQ Altis™ Triple Quadrupole Mass Spectrometer

Thermo Scientific TSQ Altis MS offers the ultimate in sensitivity, robustness and exemplary ease-of-use for users of all expertise levels.

Catalog Number	Description
TSQ02-10002	TSQ Altis triple-stage quadrupole mass spectrometer

Catalog number TSQ02-10002

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Description:

TSQ Altis triple-stage quadrupole mass spectrometer

Address the most stringent analytical challenges for targeted quantitation workflows with the Thermo Scientific™ TSQ Altis™ Triple Quadrupole Mass Spectrometer. With its improved Active Ion Management (AIM™) technology, segmented quadrupoles, novel electron multipliers, and enhanced ion transmission tubes, the TSQ Altis MS helps you achieve unprecedented experimental sensitivity for all molecular species in complex matrices without sacrificing robustness.

Sensitivity with Robustness: No Compromise

The TSQ Altis Triple Quadrupole Mass Spectrometer, together with its industry-leading quantitation software, UHPLC system, and superior sample preparation kits, helps researchers address critical analytical challenges using robust, reliable, and sensitive targeted quantitation. The main benefits of the TSQ Altis MS include:

Ultimate sensitivity for all molecular types in matrices ranging from simple to complex.
Outstanding instrument robustness enables increased confidence in generated data with no loss of instrument uptime.
Ultrafast selected reaction monitoring (SRM) increases the amount of molecular quantifications in less time.
Close integration with application-specific software results in increased productivity across all application markets.
Simplicity and ease-of-use allow users of all expertise levels to acquire high quality results with increased confidence.

Specifications

TypeTriple Quadrupole LC-MS

Mass Range5 to 2000 m/z

DescriptionTSQ Altis triple-stage quadrupole mass spectrometer

For Use With (Application)Pharmaceutical, Environmental, Food Safety, Clinical Research, and Forensic Toxicology

Unit SizeEach

Frequently asked questions (FAQs)

How do I clean/store my Triple Quadrupole mass spectrometry instruments after analysis?

For short periods (less than 24 hr) the system can just be put into standby. However, it is good practice to flush the system with 50:50 solvent/water (where the solvent is either methanol or acetonitrile) to remove buffers or additives and stop microbial growth.

For longer periods, flush the LC system with 50:50 solvent/water. Then flush with 100% solvent. Put the system into standby.

Find additional tips, troubleshooting help, and resources within our Mass Spectrometry Support Center.

How do I perform mass calibration on Triple Quadrupole mass spectrometry instruments and how often should I do it?

The mass calibration should ideally be performed every 3 months and definitely performed at least every 6 months. Refer to the Instrument Manual (https://tools.thermofisher.com/content/sfs/manuals/TSQ-Series-Hardware.pdf) for detailed instructions on how to perform mass calibration.

Find additional tips, troubleshooting help, and resources within our Mass Spectrometry Support Center.

How should I clean the Ion Transfer Tube on Triple Quadrupole mass spectrometry instruments?

The Ion Transfer Tube should be removed and sonicated in a 50:50 solution of methanol/water that contains 20% formic acid for 30 min. Rinse thoroughly with water. Then sonicate in methanol for 15 min. Dry with nitrogen gas.

The same procedure can be applied to the Ion Sweep Cone.

Refer to the Instrument Manual (https://tools.thermofisher.com/content/sfs/manuals/TSQ-Series-Hardware.pdf) for more detailed instructions.

Find additional tips, troubleshooting help, and resources within our Mass Spectrometry Support Center.

How should I adjust my ion source position on Triple Quadrupole mass spectrometry instruments?

Perform loop injections of your analyte using isocractic elution through a short column at the flow rate and approximate mobile phase composition. Use a concentration where the signal to noise is approximately 10:1. Record the raw data file and integrate the peaks, comparing peak areas at different source positions (i.e., left and right, up and down, fore and aft). Ensure that the background noise is not increasing more than the peak area.

Note: The needle position on the Thermo Fisher Scientific TSQ Altis MS, TSQ Quantis MS, and TSQ Fortis MS instruments is set and should not be adjusted.

Find additional tips, troubleshooting help, and resources within our Mass Spectrometry Support Center.

Do I need to warm/equilibrate Triple Quadrupole mass spectrometry instruments prior to starting a session of analysis?

It is advisable to turn both the LC system and the MS system on for at least 30 min prior to analysis. This time can usually be spent testing one or more solvents or matrix blanks.

Find additional tips, troubleshooting help, and resources within our Mass Spectrometry Support Center.

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