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          • › Hs00180269_m1
          See other BAX GE Assays ›
          Gene Symbol:
          BAX
          Gene Name:
          BCL2 associated X, apoptosis regulator
          Gene Aliases:
          BCL2L4
          Chromosome Location:
          Chr.19: 48954825 - 48961798 on Build GRCh38
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          Assay ID Hs00180269_m1
          Best Coverage
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          Availability Inventoried
          Catalog # 4331182
          Price
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          • Genomic Map
          • Assay Details
          • More Information
          • Citations (15)

          Genomic Map

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          Assay Details

          Gene Symbol: BAX
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_001291428.1 NP_001278357.1 4 - 5 439 62
          NM_001291429.1 NP_001278358.1 3 - 4 387 62
          NM_001291430.1 NP_001278359.1 2 - 3 240 62
          NM_001291431.1 NP_001278360.1 2 - 3 240 62
          NM_004324.3 NP_004315.1 4 - 5 439 62
          NM_138761.3 NP_620116.1 4 - 5 439 62
          NM_138763.3 NP_620118.1 3 - 4 292 62
          NM_138764.4 NP_620119.2 4 - 5 439 62
          XM_017027077.1 XP_016882566.1 4 - 5 448 62
          GenBank mRNA AF247393.1 - 4 - 5 370 62
          AF250190.1 - 2 - 3 171 62
          AJ417988.1 - 3 - 4 349 62
          AJ586909.1 - 2 - 3 158 62
          AJ586910.1 - 3 - 4 305 62
          AK291076.1 - 4 - 5 419 62
          BC014175.2 - 4 - 5 422 4578562 62
          BM706954.1 - 2 - 3 252 62
          CN281003.1 - 4 - 5 392 62
          HQ889830.1 - 2 - 3 171 62
          JX524562.1 - 3 - 4 319 62
          KF830846.1 - 3 - 4 319 62
          KF830847.1 - 3 - 4 319 62
          KF830848.1 - 3 - 4 319 62
          L22473.1 - 4 - 5 370 62
          L22474.1 - 4 - 5 370 62
          U19599.1 - 3 - 4 223 62

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          More Information


          Set Membership:

          Amplicon length less than or equal to 70 Apoptosis Immune Tolerance Network Mammalian Gene Collection Recommended Assay Homo sapiens Human Pathogenesis of ALS Human Immune Response Human c-Myc and Apoptosis Human NGF Pathway Human Apoptotic Pathways triggered by HIV1 Human p53 Signaling Human Developmental Phases of Colorectal Cancer HUMAN COLORECTAL CANCER METASTASIS HUMAN MOLECULAR MECHANISMS OF CANCER HUMAN APOPTOSIS THROUGH DEATH RECEPTORS HUMAN P53 MEDIATED APOPTOSIS HUMAN IL-6 PATHWAY HUMAN CELLULAR APOPTOSIS PATHWAY Inventoried Human_c-Myc_and_Apoptosis Human_Immune Human_Developmental_Phases_of_Colorectal_Cancer Human_Pathogenesis_of_ALS Human_NGF_Pathway Human_p53_Signaling Human_Apoptotic_Pathways_Triggered_by_HIV1 Human_IL-6_Pathway Human_Apoptosis_through_Death_Receptors Human_Molecular_Mechanisms_of_Cancer Human_p53_Mediated_Apoptosis Human_Cellular_Apoptosis_Pathway Human_Colorectal_Cancer_Metastasis Probe spans exons

          Gene Ontology Categories:

          Function(s) Process(es)

          ovarian follicle development
          neuron migration
          T cell homeostatic proliferation
          B cell homeostasis
          B cell apoptotic process
          kidney development
          release of cytochrome c from mitochondria
          protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
          blood vessel remodeling
          myeloid cell homeostasis
          B cell negative selection
          B cell homeostatic proliferation
          positive regulation of B cell apoptotic process
          glycosphingolipid metabolic process
          regulation of nitrogen utilization
          apoptotic process
          activation of cysteine-type endopeptidase activity involved in apoptotic process
          DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
          activation of signaling protein activity involved in unfolded protein response
          inner mitochondrial membrane organization
          outer mitochondrial membrane organization
          germ cell development
          aging
          mitochondrial fusion
          extrinsic apoptotic signaling pathway via death domain receptors
          intrinsic apoptotic signaling pathway in response to DNA damage
          activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
          apoptotic mitochondrial changes
          fertilization
          response to toxic substance
          response to salt stress
          establishment or maintenance of transmembrane electrochemical gradient
          response to gamma radiation
          viral process
          hypothalamus development
          cerebral cortex development
          negative regulation of protein binding
          positive regulation of protein oligomerization
          endoplasmic reticulum calcium ion homeostasis
          negative regulation of endoplasmic reticulum calcium ion concentration
          release of matrix enzymes from mitochondria
          negative regulation of peptidyl-serine phosphorylation
          regulation of mammary gland epithelial cell proliferation
          glial cell apoptotic process
          cellular response to UV
          ectopic germ cell programmed cell death
          response to cocaine
          odontogenesis of dentin-containing tooth
          response to drug
          regulation of apoptotic process
          positive regulation of apoptotic process
          regulation of protein homodimerization activity
          regulation of protein heterodimerization activity
          negative regulation of neuron apoptotic process
          positive regulation of neuron apoptotic process
          mitochondrial fragmentation involved in apoptotic process
          development of secondary sexual characteristics
          cellular respiration
          retinal cell programmed cell death
          response to copper ion
          positive regulation of developmental pigmentation
          negative regulation of fibroblast proliferation
          spermatid differentiation
          post-embryonic camera-type eye morphogenesis
          response to axon injury
          homeostasis of number of cells within a tissue
          protein oligomerization
          protein homooligomerization
          positive regulation of release of sequestered calcium ion into cytosol
          neuron apoptotic process
          response to corticosterone
          regulation of mitochondrial membrane potential
          Sertoli cell proliferation
          retina development in camera-type eye
          positive regulation of apoptotic process involved in mammary gland involution
          vagina development
          intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
          thymocyte apoptotic process
          mitochondrion morphogenesis
          intrinsic apoptotic signaling pathway by p53 class mediator
          positive regulation of release of cytochrome c from mitochondria
          apoptotic signaling pathway
          extrinsic apoptotic signaling pathway
          extrinsic apoptotic signaling pathway in absence of ligand
          intrinsic apoptotic signaling pathway
          activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
          positive regulation of endoplasmic reticulum unfolded protein response
          positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
          apoptotic process involved in patterning of blood vessels
          apoptotic process involved in embryonic digit morphogenesis
          regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
          positive regulation of apoptotic DNA fragmentation
          positive regulation of IRE1-mediated unfolded protein response
          B cell receptor apoptotic signaling pathway
          negative regulation of apoptotic signaling pathway
          positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
          positive regulation of intrinsic apoptotic signaling pathway
          protein binding
          lipid binding
          channel activity
          heat shock protein binding
          protein complex binding
          identical protein binding
          protein homodimerization activity
          protein heterodimerization activity
          chaperone binding
          BH3 domain binding

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          Citations (15)

          The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.
          Authors
          Scholz H, Lund T, Dahle MK, Collins JL, Korsgren O, Wang JE, Foss A
          Journal
          Diabetologia - Page No 1352 (Wed Jul 01 00:00:00 EDT 2009)
          Volume (Year)
          52 (2009)
          Product Usage
          -
          MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival.
          Authors
          Forte E, Luftig MA
          Journal
          J Virol - Page No 2491 (Sun Mar 01 00:00:00 EST 2009)
          Volume (Year)
          83 (2009)
          Product Usage
          -
          Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2.
          Authors
          Ferrante E, Pellegrini C, Bondioni S, Peverelli E, Locatelli M, Gelmini P, Luciani P, Peri A, Mantovani G, Bosari S, Beck-Peccoz P, Spada A, Lania A
          Journal
          Endocr Relat Cancer - Page No 955 (Fri Sep 01 00:00:00 EDT 2006)
          Volume (Year)
          13 (2006)
          Product Usage
          -
          Cell cycle arrest and proapoptotic effects of the anticancer cyclodepsipeptide serratamolide (AT514) are independent of p53 status in breast cancer cells.
          Authors
          Soto-Cerrato V, Montaner B, Martinell M, Vilaseca M, Giralt E, Perez-Tomas R
          Journal
          Biochem Pharmacol - Page No 32 (Mon Dec 19 00:00:00 EST 2005)
          Volume (Year)
          71 (2005)
          Product Usage
          -
          Local erythropoietin and endothelial progenitor cells improve regional cardiac function in acute myocardial infarction.
          Authors
          Stein A, Knodler M, Makowski M, Kuhnel S, Nekolla S, Keithahn A, Weidl E, Groha P, Schurmann M, Saraste A, Botnar R, Oostendorp RA, Ott I
          Journal
          Bmc Cardiovasc Disord - Page No 43 (Fri Jan 01 00:00:00 EST 2010)
          Volume (Year)
          10 (2010)
          Product Usage
          -
          Quantitative evaluation of the apoptosis regulating genes Survivin, Bcl-2 and Bax in inflammatory and malignant pleural lesions.
          Authors
          Falleni M, Pellegrini C, Marchetti A, Roncalli M, Nosotti M, Palleschi A, Santambrogio L, Coggi G, Bosari S
          Journal
          Lung Cancer - Page No 211 (Sun May 01 00:00:00 EDT 2005)
          Volume (Year)
          48 (2005)
          Product Usage
          -
          The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin.
          Authors
          Song J, Jie C, Polk P, Shridhar R, Clair T, Zhang J, Yin L, Keppler D
          Journal
          Biochem Biophys Res Commun - Page No 175 (Fri Feb 03 00:00:00 EST 2006)
          Volume (Year)
          340 (2006)
          Product Usage
          -
          High radiosensitivity of germ cells in human male fetus.
          Authors
          Lambrot R, Coffigny H, Pairault C, Lecureuil C, Frydman R, Habert R, Rouiller-Fabre V
          Journal
          J Clin Endocrinol Metab - Page No 2632 (Sun Jul 01 00:00:00 EDT 2007)
          Volume (Year)
          92 (2007)
          Product Usage
          -
          DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (TP53, p21CDKN1A, BCL2 and BAX) with respect to occupational exposure to styrene.
          Authors
          Hanova M, Vodickova L, Vaclavikova R, Smerhovsky Z, Stetina R, Hlavac P, Naccarati A, Slyskova J, Polakova V, Soucek P, Kumar R, Hemminki K, Vodicka P
          Journal
          Carcinogenesis - Page No (Thu Oct 21 00:00:00 EDT 2010)
          Volume (Year)
           (2010)
          Product Usage
          -
          Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes.
          Authors
          Grcevic D, Kusec R, Kovacic N, Lukic A, Lukic IK, Ivcevic S, Nemet D, Seiwerth RS, Ostojic SK, Croucher PI, Marusic A
          Journal
          Leuk Res - Page No 742 (Tue Jun 01 00:00:00 EDT 2010)
          Volume (Year)
          34 (2010)
          Product Usage
          -
          c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs.
          Authors
          Abaza MS, Al-Saffar A, Al-Sawan S, Al-Attiyah R
          Journal
          Tumour Biol - Page No 287 (Tue Jan 01 00:00:00 EST 2008)
          Volume (Year)
          29 (2008)
          Product Usage
          -
          IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis.
          Authors
          Ning Y, Riggins RB, Mulla JE, Chung H, Zwart A, Clarke R
          Journal
          Mol Cancer Ther - Page No 1274 (Sat May 01 00:00:00 EDT 2010)
          Volume (Year)
          9 (2010)
          Product Usage
          -
          Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation.
          Authors
          Cho SW, Hartle L, Son SM, Yang F, Goldberg M, Xu Q, Langer R, Anderson DG
          Journal
          Biochem Biophys Res Commun - Page No 158 (Fri Nov 07 00:00:00 EST 2008)
          Volume (Year)
          376 (2008)
          Product Usage
          -
          Modeled gravitational unloading triggers differentiation and apoptosis in preosteoclastic cells.
          Authors
          Monici M, Fusi F, Paglierani M, Marziliano N, Cogoli A, Pratesi R, Bernabei PA
          Journal
          J Cell Biochem - Page No 65 (Mon May 01 00:00:00 EDT 2006)
          Volume (Year)
          98 (2006)
          Product Usage
          -
          Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells.
          Authors
          Ni Ainle F, O'Donnell JS, Johnson JA, Brown L, Gleeson EM, Smith OP, Preston RJ
          Journal
          J Biol Chem - Page No (Tue Nov 02 00:00:00 EDT 2010)
          Volume (Year)
           (2010)
          Product Usage
          -

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