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          • Home
          • › Search Tool
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          • › Mm00437304_m1
          See other VEGFA GE Assays ›
          Gene Symbol:
          Vegfa
          Gene Name:
          vascular endothelial growth factor A
          Gene Aliases:
          Vegf, Vpf
          Chromosome Location:
          Chr.17: 46016993 - 46032377 on Build GRCm38
          Species:
          Mouse
          Species Specific ID (Flybase ID):
          -
          Assay ID Mm00437304_m1
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • Assay Details
          • More Information
          • Citations (27)

          Genomic Map

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          Assay Details

          Gene Symbol: Vegfa
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_001025250.3 NP_001020421.2 1 - 2 1087 77
          NM_001025257.3 NP_001020428.2 1 - 2 1087 77
          NM_001287056.1 NP_001273985.1 1 - 2 1087 77
          NM_001287057.1 NP_001273986.1 1 - 2 1087 77
          NM_001287058.1 NP_001273987.1 1 - 2 1087 77
          NM_009505.4 NP_033531.3 1 - 2 1087 77
          GenBank mRNA AY263146.1 - 1 - 2 66 77
          AY707864.1 - 2 - 3 284 77
          AY750956.1 - 2 - 3 245 77
          AY750957.1 - 2 - 3 208 77
          BC061468.1 - 1 - 2 460 6816435 77
          CA321456.1 - 1 - 2 460 77
          EF028705.1 - 2 - 3 280 77
          M95200.1 - 1 - 2 152 77
          S37052.1 - 1 - 2 78 77
          S38083.1 - 1 - 2 78 77
          S38100.1 - 1 - 2 78 77
          U50279.1 - 1 - 2 66 77

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          More Information


          Updated Mapping Information

          This assay targets the same location as MTA transcript cluster(s) TC1700002162.mm.1

          Set Membership:

          Ambion siRNA available Amplicon length between 71 and 85 Mammalian Gene Collection Mus musculus Mouse Immune Response 1700 Inventoried Mouse_Immune_Response Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene Vegfa

          Panther Classification:

          Molecular Function -

          growth factor

          Gene Ontology Categories:

          Function(s) Process(es)

          negative regulation of transcription from RNA polymerase II promoter
          angiogenesis
          ovarian follicle development
          blood vessel development
          patterning of blood vessels
          response to hypoxia
          in utero embryonic development
          kidney development
          positive regulation of protein phosphorylation
          positive regulation of endothelial cell proliferation
          vasculature development
          lymphangiogenesis
          blood vessel remodeling
          sprouting angiogenesis
          cell migration involved in sprouting angiogenesis
          positive regulation of neuroblast proliferation
          positive regulation of mesenchymal cell proliferation
          positive regulation of receptor internalization
          basophil chemotaxis
          heart morphogenesis
          outflow tract morphogenesis
          coronary vein morphogenesis
          regulation of transcription from RNA polymerase II promoter
          multicellular organism development
          nervous system development
          mesoderm development
          lactation
          cell proliferation
          positive regulation of cell proliferation
          regulation of cell shape
          positive regulation of signal transduction
          positive regulation of endothelial cell migration
          positive regulation of gene expression
          cell migration
          negative regulation of cell-cell adhesion
          cell differentiation
          monocyte differentiation
          macrophage differentiation
          lung development
          positive regulation of cell migration
          regulation of cGMP metabolic process
          epithelial cell differentiation
          positive regulation of vascular endothelial growth factor receptor signaling pathway
          post-embryonic camera-type eye development
          positive regulation of protein complex assembly
          positive regulation of protein autophosphorylation
          activation of protein kinase activity
          positive regulation of CREB transcription factor activity
          positive regulation of peptidyl-serine phosphorylation
          tube formation
          endothelial cell chemotaxis
          cellular response to vascular endothelial growth factor stimulus
          lymph vessel morphogenesis
          positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
          vascular endothelial growth factor signaling pathway
          positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
          VEGF-activated neuropilin signaling pathway
          growth
          T-helper 1 type immune response
          eye photoreceptor cell development
          negative regulation of apoptotic process
          negative regulation of programmed cell death
          positive regulation of vascular permeability
          surfactant homeostasis
          negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
          positive regulation of MAP kinase activity
          negative regulation of neuron apoptotic process
          positive regulation of blood vessel endothelial cell migration
          endothelial cell migration
          regulation of endothelial cell differentiation
          positive regulation of angiogenesis
          negative regulation of bone resorption
          positive regulation of cell adhesion
          positive regulation of transcription from RNA polymerase II promoter
          vascular endothelial growth factor receptor signaling pathway
          mRNA stabilization
          lung alveolus development
          cell maturation
          blood vessel morphogenesis
          camera-type eye morphogenesis
          positive regulation of smooth muscle cell proliferation
          neuron development
          cardiac muscle fiber development
          branching morphogenesis of an epithelial tube
          positive regulation of axon extension involved in axon guidance
          artery morphogenesis
          positive regulation of epithelial cell proliferation
          positive regulation of peptidyl-tyrosine phosphorylation
          positive chemotaxis
          positive regulation of positive chemotaxis
          induction of positive chemotaxis
          positive regulation of cellular component movement
          positive regulation of cell division
          positive regulation of focal adhesion assembly
          positive regulation of protein kinase B signaling
          primitive erythrocyte differentiation
          cell chemotaxis
          lung vasculature development
          mammary gland alveolus development
          positive regulation of mast cell chemotaxis
          cardiac vascular smooth muscle cell development
          angiogenesis involved in coronary vascular morphogenesis
          coronary artery morphogenesis
          positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
          positive regulation of ERK1 and ERK2 cascade
          cellular response to hypoxia
          dopaminergic neuron differentiation
          commissural neuron axon guidance
          positive regulation of protein kinase C signaling
          positive regulation of cell migration involved in sprouting angiogenesis
          positive regulation of branching involved in ureteric bud morphogenesis
          regulation of retinal ganglion cell axon guidance
          positive regulation of peptidyl-tyrosine autophosphorylation
          positive regulation of p38MAPK cascade
          negative regulation of neuron death
          positive regulation of lymphangiogenesis
          regulation of hematopoietic progenitor cell differentiation
          positive regulation of histone deacetylase activity
          positive regulation of retinal ganglion cell axon guidance
          positive regulation of protein localization to early endosome
          positive regulation of protein kinase D signaling
          positive regulation of receptor activity
          negative regulation of extrinsic apoptotic signaling pathway
          fibronectin binding
          receptor binding
          cytokine activity
          platelet-derived growth factor receptor binding
          vascular endothelial growth factor receptor binding
          protein binding
          growth factor activity
          heparin binding
          neuropilin binding
          chemoattractant activity
          identical protein binding
          protein homodimerization activity
          vascular endothelial growth factor receptor 1 binding
          vascular endothelial growth factor receptor 2 binding
          protein heterodimerization activity
          receptor agonist activity
          extracellular matrix binding

          MicroArray Probes:

          Affymetrix ABI

          Array Name Probe IDs Targets Target Type
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 NM_001025250.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 NM_001025250.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 NM_001025257.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 NM_001025257.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 NM_001287056.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 NM_001287057.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 NM_001287058.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 NM_009505.4.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 NM_009505.4 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020305.mm.1 TC1700002162.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 NM_001025250.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 NM_001025250.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 NM_001025257.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 NM_001025257.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 NM_001287056.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 NM_001287057.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 NM_001287058.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 NM_009505.4.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 NM_009505.4 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020306.mm.1 TC1700002162.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 NM_001025250.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 NM_001025250.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 NM_001025257.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 NM_001025257.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 NM_001287056.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 NM_001287057.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 NM_001287058.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 NM_009505.4.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 NM_009505.4 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020307.mm.1 TC1700002162.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 NM_001025250.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 NM_001025250.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 NM_001025257.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 NM_001025257.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 NM_001287056.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 NM_001287057.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 NM_001287058.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 NM_009505.4.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 NM_009505.4 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020309.mm.1 TC1700002162.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 NM_001025250.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 NM_001025250.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 NM_001025257.3.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 NM_001025257.3 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 NM_001287056.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 NM_001287057.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 NM_001287058.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 NM_009505.4.1 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 NM_009505.4 Refseq
          Affymetrix Mouse Clariom S Array PSR1700020308.mm.1 TC1700002162.mm.1 MTA TC
          Array Name Probe IDs Targets Target Type
          ABI Mouse Genome Survey Microarray 620740 - -

          Back To Top
           

          Citations (27)

          Parathyroid hormone-related protein promotes epithelial-mesenchymal transition.
          Authors
          Ardura JA, Rayego-Mateos S, Ramila D, Ruiz-Ortega M, Esbrit P
          Journal
          J Am Soc Nephrol - Page No 237 (Mon Feb 01 00:00:00 EST 2010)
          Volume (Year)
          21 (2010)
          Product Usage
          -
          Mechanisms of sex differences in TNFR2-mediated cardioprotection.
          Authors
          Wang M, Crisostomo PR, Markel TA, Wang Y, Meldrum DR
          Journal
          Circulation - Page No S38 (Tue Sep 30 00:00:00 EDT 2008)
          Volume (Year)
          118 (2008)
          Product Usage
          -
          Oral iron chelator deferiprone protects against iron overload induced retinal degeneration.
          Authors
          Hadziahmetovic M, Song Y, Wolkow N, Iacovelli J, Grieco S, Lee J, Lyubarsky A, Pratico D, Connelly J, Spino M, Harris ZL, Dunaief J
          Journal
          Invest Ophthalmol Vis Sci - Page No (Thu Nov 04 00:00:00 EDT 2010)
          Volume (Year)
           (2010)
          Product Usage
          -
          Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
          Authors
          Park E, Zhu F, Liu B, Xia X, Shen J, Bustos T, Fischer SM, Hu Y
          Journal
          Cancer Res - Page No 9158 (Mon Oct 01 00:00:00 EDT 2007)
          Volume (Year)
          67 (2007)
          Product Usage
          -
          Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2.
          Authors
          Le XF, Mao W, Lu C, Thornton A, Heymach JV, Sood AK, Bast RC Jr
          Journal
          Cell Cycle - Page No 3747 (Mon Dec 01 00:00:00 EST 2008)
          Volume (Year)
          7 (2008)
          Product Usage
          -
          Early organ-specific endothelial activation during hemorrhagic shock and resuscitation.
          Authors
          van Meurs M, Wulfert FM, Knol AJ, De Haes A, Houwertjes M, Aarts LP, Molema G
          Journal
          Shock - Page No 291 (Fri Feb 01 00:00:00 EST 2008)
          Volume (Year)
          29 (2008)
          Product Usage
          -
          Soleus, plantaris and gastrocnemius VEGF mRNA responses to hypoxia and exercise are preserved in aged compared with young female C57BL/6 mice.
          Authors
          Gavin TP, Westerkamp LM, Zwetsloot KA
          Journal
          Acta Physiol (Oxf) - Page No 113 (Sun Oct 01 00:00:00 EDT 2006)
          Volume (Year)
          188 (2006)
          Product Usage
          -
          VEGFR-3/Flt-4 mediates proliferation and chemotaxis in glial precursor cells.
          Authors
          Kranich S, Hattermann K, Specht A, Lucius R, Mentlein R
          Journal
          Neurochem Int - Page No 747 (Tue Dec 01 00:00:00 EST 2009)
          Volume (Year)
          55 (2009)
          Product Usage
          -
          Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice.
          Authors
          Kubota Y, Hirashima M, Kishi K, Stewart CL, Suda T
          Journal
          J Clin Invest - Page No 2393 (Tue Jul 01 00:00:00 EDT 2008)
          Volume (Year)
          118 (2008)
          Product Usage
          -
          Fibroblast growth factor expression during skeletal fracture healing in mice.
          Authors
          Schmid GJ, Kobayashi C, Sandell LJ, Ornitz DM
          Journal
          Dev Dyn - Page No 766 (Sun Mar 01 00:00:00 EST 2009)
          Volume (Year)
          238 (2009)
          Product Usage
          -
          Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney.
          Authors
          Ardura JA, Berruguete R, Ramila D, Alvarez-Arroyo MV, Esbrit P
          Journal
          Am J Physiol Renal Physiol - Page No F415 (Fri Aug 01 00:00:00 EDT 2008)
          Volume (Year)
          295 (2008)
          Product Usage
          -
          Topical delivery of silver nanoparticles promotes wound healing.
          Authors
          Tian J, Wong KK, Ho CM, Lok CN, Yu WY, Che CM, Chiu JF, Tam PK
          Journal
          Chemmedchem - Page No 129 (Mon Jan 01 00:00:00 EST 2007)
          Volume (Year)
          2 (2007)
          Product Usage
          -
          Regulation of angiopoietin expression by bacterial lipopolysaccharide.
          Authors
          Mofarrahi M, Nouh T, Qureshi S, Guillot L, Mayaki D, Hussain SN
          Journal
          Am J Physiol Lung Cell Mol Physiol - Page No L955 (Thu May 01 00:00:00 EDT 2008)
          Volume (Year)
          294 (2008)
          Product Usage
          -
          Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin.
          Authors
          Vihanto MM, Plock J, Erni D, Frey BM, Frey FJ, Huynh-Do U
          Journal
          Faseb J - Page No 1689 (Sat Oct 01 00:00:00 EDT 2005)
          Volume (Year)
          19 (2005)
          Product Usage
          -
          Anti-tumor effects of anti-VEGF siRNA encapsulated with PLGA microspheres in mice.
          Authors
          Murata N, Takashima Y, Toyoshima K, Yamamoto M, Okada H
          Journal
          J Control Release - Page No 246 (Thu Mar 20 00:00:00 EDT 2008)
          Volume (Year)
          126 (2008)
          Product Usage
          -
          von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina.
          Authors
          Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H
          Journal
          Development - Page No 1563 (Sat May 01 00:00:00 EDT 2010)
          Volume (Year)
          137 (2010)
          Product Usage
          -
          Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue.
          Authors
          Yin J, Gao Z, He Q, Zhou D, Guo Z, Ye J
          Journal
          Am J Physiol Endocrinol Metab - Page No E333 (Sun Feb 01 00:00:00 EST 2009)
          Volume (Year)
          296 (2009)
          Product Usage
          -
          IFATS collection: Fibroblast growth factor-2-induced hepatocyte growth factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal kinase-dependent mechanism.
          Authors
          Suga H, Eto H, Shigeura T, Inoue K, Aoi N, Kato H, Nishimura S, Manabe I, Gonda K, Yoshimura K
          Journal
          Stem Cells - Page No 238 (Thu Jan 01 00:00:00 EST 2009)
          Volume (Year)
          27 (2009)
          Product Usage
          -
          CD147 impacts angiogenesis and metastasis formation.
          Authors
          Voigt H, Vetter-Kauczok CS, Schrama D, Hofmann UB, Becker JC, Houben R
          Journal
          Cancer Invest - Page No 329 (Sun Mar 01 00:00:00 EST 2009)
          Volume (Year)
          27 (2009)
          Product Usage
          -
          Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity.
          Authors
          Pang C, Gao Z, Yin J, Zhang J, Jia W, Ye J
          Journal
          Am J Physiol Endocrinol Metab - Page No E313 (Fri Aug 01 00:00:00 EDT 2008)
          Volume (Year)
          295 (2008)
          Product Usage
          -
          Critical role for osteopontin in diabetic nephropathy.
          Authors
          Nicholas SB, Liu J, Kim J, Ren Y, Collins AR, Nguyen L, Hsueh WA
          Journal
          Kidney Int - Page No 588 (Thu Apr 01 00:00:00 EDT 2010)
          Volume (Year)
          77 (2010)
          Product Usage
          -
          Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting.
          Authors
          Pietras K, Pahler J, Bergers G, Hanahan D
          Journal
          Plos Med - Page No e19 (Tue Jan 29 00:00:00 EST 2008)
          Volume (Year)
          5 (2008)
          Product Usage
          -
          Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes.
          Authors
          Bitto A, Minutoli L, Altavilla D, Polito F, Fiumara T, Marini H, Galeano M, Calo M, Lo Cascio P, Bonaiuto M, Migliorato A, Caputi AP, Squadrito F
          Journal
          Pharmacol Res - Page No 159 (Fri Feb 01 00:00:00 EST 2008)
          Volume (Year)
          57 (2008)
          Product Usage
          -
          Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy.
          Authors
          Turunen MP, Lehtola T, Heinonen SE, Assefa GS, Korpisalo P, Girnary R, Glass CK, Vaisanen S, Yla-Herttuala S
          Journal
          Circ Res - Page No 604 (Fri Sep 11 00:00:00 EDT 2009)
          Volume (Year)
          105 (2009)
          Product Usage
          -
          Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice.
          Authors
          Granger A, Abdullah I, Huebner F, Stout A, Wang T, Huebner T, Epstein JA, Gruber PJ
          Journal
          Faseb J - Page No 3549 (Wed Oct 01 00:00:00 EDT 2008)
          Volume (Year)
          22 (2008)
          Product Usage
          -
          Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis.
          Authors
          Wang IC, Meliton L, Ren X, Zhang Y, Balli D, Snyder J, Whitsett JA, Kalinichenko VV, Kalin TV
          Journal
          Plos One - Page No e6609 (Thu Jan 01 00:00:00 EST 2009)
          Volume (Year)
          4 (2009)
          Product Usage
          -
          Sema3a maintains normal heart rhythm through sympathetic innervation patterning.
          Authors
          Ieda M, Kanazawa H, Kimura K, Hattori F, Ieda Y, Taniguchi M, Lee JK, Matsumura K, Tomita Y, Miyoshi S, Shimoda K, Makino S, Sano M, Kodama I, Ogawa S, Fukuda K
          Journal
          Nat Med - Page No 604 (Tue May 01 00:00:00 EDT 2007)
          Volume (Year)
          13 (2007)
          Product Usage
          -

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