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          • Home
          • › Search Tool
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          • › Mm00441724_m1
          See other TGFB1 GE Assays ›
          Gene Symbol:
          Tgfb1
          Gene Name:
          transforming growth factor, beta 1
          Gene Aliases:
          TGF-beta1, TGFbeta1, Tgfb, Tgfb-1
          Chromosome Location:
          Chr.7: 25687002 - 25704996 on Build GRCm38
          Species:
          Mouse
          Species Specific ID (Flybase ID):
          -
          Assay ID Mm00441724_m1
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • Assay Details
          • More Information
          • Citations (19)

          Genomic Map

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          Assay Details

          Gene Symbol: Tgfb1
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_011577.1 NP_035707.1 1 - 2 1220 99
          GenBank mRNA AJ009862.1 - 1 - 2 1220 99
          AK144163.1 - 1 - 2 1222 99
          BC013738.1 - 1 - 2 667 3586216 99
          M13177.1 - 1 - 2 705 99

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          More Information


          Updated Mapping Information

          This assay targets the same location as MTA transcript cluster(s) TC0700000424.mm.1

          Set Membership:

          Ambion siRNA available Amplicon length between 86 and 100 Mammalian Gene Collection Mus musculus Mouse Chemokine Panel Mouse Tumor Metastasis Panel Mouse Immune Response Inventoried Mouse_Immune_Response Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene Tgfb1

          Panther Classification:

          Molecular Function -

          growth factor

          Gene Ontology Categories:

          Function(s) Process(es)

          protein import into nucleus, translocation
          negative regulation of transcription from RNA polymerase II promoter
          MAPK cascade
          skeletal system development
          morphogenesis of a branching structure
          cell activation
          epithelial to mesenchymal transition
          negative regulation of protein phosphorylation
          positive regulation of protein phosphorylation
          regulation of sodium ion transport
          chondrocyte differentiation
          hematopoietic progenitor cell differentiation
          CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
          tolerance induction to self antigen
          protein phosphorylation
          protein export from nucleus
          ATP biosynthetic process
          phosphate-containing compound metabolic process
          cellular calcium ion homeostasis
          defense response
          inflammatory response
          cell cycle arrest
          mitotic cell cycle checkpoint
          epidermal growth factor receptor signaling pathway
          transforming growth factor beta receptor signaling pathway
          common-partner SMAD protein phosphorylation
          SMAD protein complex assembly
          SMAD protein import into nucleus
          Notch signaling pathway
          negative regulation of neuroblast proliferation
          endoderm development
          skeletal muscle tissue development
          negative regulation of DNA replication
          cell proliferation
          positive regulation of cell proliferation
          negative regulation of cell proliferation
          germ cell migration
          defense response to fungus, incompatible interaction
          organ morphogenesis
          response to organic substance
          regulation of gene expression
          positive regulation of gene expression
          negative regulation of gene expression
          positive regulation of epithelial to mesenchymal transition
          positive regulation of fibroblast migration
          positive regulation of peptidyl-threonine phosphorylation
          positive regulation of pathway-restricted SMAD protein phosphorylation
          negative regulation of macrophage cytokine production
          cell growth
          regulation of striated muscle tissue development
          regulation of transforming growth factor beta receptor signaling pathway
          evasion or tolerance of host defenses by virus
          negative regulation of cell-cell adhesion
          hyaluronan catabolic process
          T cell differentiation
          negative regulation of ossification
          negative regulation of cell growth
          positive regulation of cell migration
          mammary gland development
          positive regulation of histone deacetylation
          organ regeneration
          positive regulation of protein complex assembly
          positive regulation of exit from mitosis
          lipopolysaccharide-mediated signaling pathway
          positive regulation of cellular protein metabolic process
          response to estradiol
          response to progesterone
          regulation of interleukin-23 production
          negative regulation of interleukin-17 production
          positive regulation of interleukin-17 production
          receptor catabolic process
          regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
          positive regulation of superoxide anion generation
          mononuclear cell proliferation
          positive regulation of collagen biosynthetic process
          positive regulation of peptidyl-serine phosphorylation
          positive regulation of histone acetylation
          positive regulation of protein dephosphorylation
          growth
          wound healing
          T cell activation
          regulation of cell proliferation
          negative regulation of T cell proliferation
          regulation of protein import into nucleus
          positive regulation of protein import into nucleus
          positive regulation of odontogenesis
          myelination
          regulation of apoptotic process
          myeloid dendritic cell differentiation
          T cell homeostasis
          positive regulation of apoptotic process
          positive regulation of MAP kinase activity
          regulation of MAPK cascade
          protein kinase B signaling
          positive regulation of blood vessel endothelial cell migration
          negative regulation of blood vessel endothelial cell migration
          positive regulation of phosphatidylinositol 3-kinase activity
          regulatory T cell differentiation
          cell-cell junction organization
          negative regulation of fat cell differentiation
          negative regulation of myoblast differentiation
          negative regulation of cell cycle
          negative regulation of transcription, DNA-templated
          positive regulation of transcription, DNA-templated
          negative regulation of mitotic cell cycle
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of fibroblast proliferation
          positive regulation of isotype switching to IgA isotypes
          cell development
          lymph node development
          negative regulation of skeletal muscle tissue development
          positive regulation of epithelial cell proliferation
          negative regulation of epithelial cell proliferation
          positive regulation of protein secretion
          negative regulation of phagocytosis
          negative regulation of immune response
          negative regulation of T cell activation
          positive regulation of chemotaxis
          positive regulation of NF-kappaB transcription factor activity
          regulation of binding
          regulation of DNA binding
          positive regulation of smooth muscle cell differentiation
          negative regulation of release of sequestered calcium ion into cytosol
          positive regulation of cell division
          positive regulation of protein kinase B signaling
          pathway-restricted SMAD protein phosphorylation
          positive regulation of SMAD protein import into nucleus
          SMAD protein signal transduction
          mammary gland branching involved in thelarche
          branch elongation involved in mammary gland duct branching
          regulation of branching involved in mammary gland duct morphogenesis
          negative regulation of gene silencing by miRNA
          regulation of cartilage development
          lens fiber cell differentiation
          response to cholesterol
          positive regulation of cell cycle arrest
          cellular response to growth factor stimulus
          cellular response to organic cyclic compound
          cellular response to dexamethasone stimulus
          cellular response to transforming growth factor beta stimulus
          T-helper 17 cell lineage commitment
          extracellular matrix assembly
          positive regulation of branching involved in ureteric bud morphogenesis
          extrinsic apoptotic signaling pathway
          negative regulation of hyaluronan biosynthetic process
          positive regulation of protein localization to nucleus
          positive regulation of NAD+ ADP-ribosyltransferase activity
          regulation of actin cytoskeleton reorganization
          positive regulation of transcription regulatory region DNA binding
          glycoprotein binding
          antigen binding
          type II transforming growth factor beta receptor binding
          cytokine activity
          transforming growth factor beta receptor binding
          protein binding
          growth factor activity
          enzyme binding
          type I transforming growth factor beta receptor binding
          type III transforming growth factor beta receptor binding
          protein homodimerization activity
          protein heterodimerization activity
          protein N-terminus binding

          MicroArray Probes:

          Affymetrix

          Array Name Probe IDs Targets Target Type
          Affymetrix Mouse Clariom S Array PSR0700003311.mm.1 TC0700000424.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR0700003311.mm.1 NM_011577.2 Refseq
          Affymetrix Mouse Clariom S Array PSR0700003309.mm.1 TC0700000424.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR0700003309.mm.1 NM_011577.2 Refseq
          Affymetrix Mouse Clariom S Array PSR0700003312.mm.1 TC0700000424.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR0700003312.mm.1 NM_011577.2 Refseq
          Affymetrix Mouse Clariom S Array PSR0700003308.mm.1 TC0700000424.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR0700003308.mm.1 NM_011577.2 Refseq

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          Citations (19)

          Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.
          Authors
          Hillebrandt S, Wasmuth HE, Weiskirchen R, Hellerbrand C, Keppeler H, Werth A, Schirin-Sokhan R, Wilkens G, Geier A, Lorenzen J, Kohl J, Gressner AM, Matern S, Lammert F
          Journal
          Nat Genet - Page No 835 (Mon Aug 01 00:00:00 EDT 2005)
          Volume (Year)
          37 (2005)
          Product Usage
          -
          Blockade of IP-10/CXCR3 promotes progressive renal fibrosis.
          Authors
          Nakaya I, Wada T, Furuichi K, Sakai N, Kitagawa K, Yokoyama H, Ishida Y, Kondo T, Sugaya T, Kawachi H, Shimizu F, Narumi S, Haino M, Gerard C, Matsushima K, Kaneko S
          Journal
          Nephron Exp Nephrol - Page No e12 (Mon Jan 01 00:00:00 EST 2007)
          Volume (Year)
          107 (2007)
          Product Usage
          -
          Substance P modulates colitis-associated fibrosis.
          Authors
          Koon HW, Shih D, Karagiannides I, Zhao D, Fazelbhoy Z, Hing T, Xu H, Lu B, Gerard N, Pothoulakis C
          Journal
          Am J Pathol - Page No 2300 (Mon Nov 01 00:00:00 EDT 2010)
          Volume (Year)
          177 (2010)
          Product Usage
          -
          Role for staphylococci in misguided thrombus resolution of chronic thromboembolic pulmonary hypertension.
          Authors
          Bonderman D, Jakowitsch J, Redwan B, Bergmeister H, Renner MK, Panzenbock H, Adlbrecht C, Georgopoulos A, Klepetko W, Kneussl M, Lang IM
          Journal
          Arterioscler Thromb Vasc Biol - Page No 678 (Tue Apr 01 00:00:00 EDT 2008)
          Volume (Year)
          28 (2008)
          Product Usage
          -
          Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators.
          Authors
          Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T
          Journal
          Int J Parasitol - Page No 457 (Sun Mar 01 00:00:00 EST 2009)
          Volume (Year)
          39 (2009)
          Product Usage
          -
          Inverse dose-rate-effects on the expressions of extra-cellular matrix-related genes in low-dose-rate gamma-ray irradiated murine cells.
          Authors
          Sugihara T, Murano H, Tanaka K, Oghiso Y
          Journal
          J Radiat Res (Tokyo) - Page No 231 (Thu May 01 00:00:00 EDT 2008)
          Volume (Year)
          49 (2008)
          Product Usage
          -
          Fluid Shear Stress Induces Renal Epithelial Gene Expression through Polycystin-2-Dependent Trafficking of Extracellular Regulated Kinase.
          Authors
          Flores D, Battini L, Gusella GL, Rohatgi R
          Journal
          Nephron Physiol - Page No p27 (Tue Nov 23 00:00:00 EST 2010)
          Volume (Year)
          117 (2010)
          Product Usage
          -
          Angiotensin mediates renal fibrosis in the nephropathy of glycogen storage disease type Ia.
          Authors
          Yiu WH, Pan CJ, Ruef RA, Peng WT, Starost MF, Mansfield BC, Chou JY
          Journal
          Kidney Int - Page No 716 (Sat Mar 01 00:00:00 EST 2008)
          Volume (Year)
          73 (2008)
          Product Usage
          -
          Absence of IL-23p19 in donor allogeneic cells reduces mortality from acute GVHD.
          Authors
          Thompson JS, Chu Y, Glass JF, Brown SA
          Journal
          Bone Marrow Transplant - Page No 712 (Thu Apr 01 00:00:00 EDT 2010)
          Volume (Year)
          45 (2010)
          Product Usage
          -
          Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium.
          Authors
          Asgeirsdottir SA, Kamps JA, Bakker HI, Zwiers PJ, Heeringa P, van der Weide K, van Goor H, Petersen AH, Morselt H, Moorlag HE, Steenbergen E, Kallenberg CG, Molema G
          Journal
          Mol Pharmacol - Page No 121 (Sun Jul 01 00:00:00 EDT 2007)
          Volume (Year)
          72 (2007)
          Product Usage
          -
          Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.
          Authors
          Raslan F, Schwarz T, Meuth SG, Austinat M, Bader M, Renne T, Roosen K, Stoll G, Siren AL, Kleinschnitz C
          Journal
          J Cereb Blood Flow Metab - Page No 1477 (Sun Aug 01 00:00:00 EDT 2010)
          Volume (Year)
          30 (2010)
          Product Usage
          -
          Topical delivery of silver nanoparticles promotes wound healing.
          Authors
          Tian J, Wong KK, Ho CM, Lok CN, Yu WY, Che CM, Chiu JF, Tam PK
          Journal
          Chemmedchem - Page No 129 (Mon Jan 01 00:00:00 EST 2007)
          Volume (Year)
          2 (2007)
          Product Usage
          -
          Immunomodulation of TGF-beta 1 in mdx mouse inhibits connective tissue proliferation in diaphragm but increases inflammatory response: implications for antifibrotic therapy.
          Authors
          Andreetta F, Bernasconi P, Baggi F, Ferro P, Oliva L, Arnoldi E, Cornelio F, Mantegazza R, Confalonieri P
          Journal
          J Neuroimmunol - Page No 77 (Thu Jun 01 00:00:00 EDT 2006)
          Volume (Year)
          175 (2006)
          Product Usage
          -
          Myeloid differentiation factor-88 contributes to TLR9-mediated modulation of acute coxsackievirus B3-induced myocarditis in vivo.
          Authors
          Riad A, Westermann D, Escher F, Becher PM, Savvatis K, Lettau O, Heimesaat MM, Bereswill S, Volk HD, Schultheiss HP, Tschope C
          Journal
          Am J Physiol Heart Circ Physiol - Page No H2024 (Tue Jun 01 00:00:00 EDT 2010)
          Volume (Year)
          298 (2010)
          Product Usage
          -
          Inflammatory biomarker, neopterin, enlarges splenic mast-cell-progenitor pool: prominent impairment of responses in age-related stromal cell-impairment mouse SCI/SAM.
          Authors
          Fukumoto T, Tsuboi I, Harada T, Hiramoto M, Minami A, Koshinaga M, Hirabayashi Y, Kanno J, Inoue T, Aizawa S
          Journal
          Int Immunopharmacol - Page No 1847 (Tue Dec 05 00:00:00 EST 2006)
          Volume (Year)
          6 (2006)
          Product Usage
          -
          Characterization of time-related changes after experimental bile duct ligation.
          Authors
          Georgiev P, Jochum W, Heinrich S, Jang JH, Nocito A, Dahm F, Clavien PA
          Journal
          Br J Surg - Page No 646 (Thu May 01 00:00:00 EDT 2008)
          Volume (Year)
          95 (2008)
          Product Usage
          -
          Delayed osteoprogenitor differentiation in cleft-palate models.
          Authors
          Pungchanchaikul P, Bloch-Zupan A, Ferretti P
          Journal
          Cells Tissues Organs - Page No 283 (Fri Jan 01 00:00:00 EST 2010)
          Volume (Year)
          192 (2010)
          Product Usage
          -
          Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model.
          Authors
          Shindo N, Fujisawa T, Sugimoto K, Nojima K, Oze-Fukai A, Yoshikawa Y, Wang X, Yasuda O, Ikegami H, Rakugi H
          Journal
          J Hepatol - Page No 903 (Tue Jun 01 00:00:00 EDT 2010)
          Volume (Year)
          52 (2010)
          Product Usage
          -
          Omacor, n-3 polyunsaturated fatty acid, attenuated albuminuria and renal dysfunction with decrease of SREBP-1 expression and triglyceride amount in the kidney of type II diabetic animals.
          Authors
          Chin HJ, Fu YY, Ahn JM, Na KY, Kim YS, Kim S, Chae DW
          Journal
          Nephrol Dial Transplant - Page No 1450 (Sat May 01 00:00:00 EDT 2010)
          Volume (Year)
          25 (2010)
          Product Usage
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