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          • › Mm00445273_m1
          See other TLR4 GE Assays ›
          Gene Symbol:
          Tlr4
          Gene Name:
          toll-like receptor 4
          Gene Aliases:
          Lps, Ly87, Ran/M1, Rasl2-8
          Chromosome Location:
          Chr.4: 66827811 - 66842797 on Build GRCm38
          Species:
          Mouse
          Species Specific ID (Flybase ID):
          -
          Assay ID Mm00445273_m1
          Best Coverage
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
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          • Genomic Map
          • Assay Details
          • More Information

          Genomic Map

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          Assay Details

          Gene Symbol: Tlr4
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_021297.2 NP_067272.1 1 - 2 112 87
          GenBank mRNA AF095353.1 - 1 - 2 298 87
          AF110133.1 - 1 - 2 112 87
          AF185285.1 - 1 - 2 91 87
          AK014533.1 - 313 87
          AK030348.1 - 1 - 2 312 87
          AK154297.1 - 1 - 2 205 87
          AK170566.1 - 1 - 2 163 87
          BC029856.1 - 1 - 2 324 3493732 87
          JX878358.1 - 1 - 2 106 87
          JX878359.1 - 1 - 2 106 87

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          More Information


          Updated Mapping Information

          This assay targets the same location as MTA transcript cluster(s) TC0400000743.mm.1

          Set Membership:

          Ambion siRNA available Amplicon length between 86 and 100 Mammalian Gene Collection Recommended Assay Mus musculus 1700 Inventoried Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene Tlr4

          Gene Ontology Categories:

          Function(s) Process(es)

          activation of MAPK activity
          microglial cell activation
          activation of innate immune response
          toll-like receptor signaling pathway
          B cell proliferation involved in immune response
          immune system process
          nitric oxide production involved in inflammatory response
          regulation of dendritic cell cytokine production
          MyD88-dependent toll-like receptor signaling pathway
          innate immune response-activating signal transduction
          leukotriene metabolic process
          inflammatory response
          response to oxidative stress
          signal transduction
          activation of NF-kappaB-inducing kinase activity
          I-kappaB phosphorylation
          response to bacterium
          positive regulation of platelet activation
          positive regulation of B cell proliferation
          lipopolysaccharide-mediated signaling pathway
          response to lipopolysaccharide
          detection of lipopolysaccharide
          interferon-gamma production
          negative regulation of interferon-gamma production
          negative regulation of interleukin-17 production
          negative regulation of interleukin-23 production
          negative regulation of interleukin-6 production
          negative regulation of tumor necrosis factor production
          positive regulation of chemokine production
          positive regulation of interferon-alpha production
          positive regulation of interferon-beta production
          positive regulation of interferon-gamma production
          positive regulation of interleukin-1 production
          positive regulation of interleukin-10 production
          positive regulation of interleukin-12 production
          positive regulation of interleukin-6 production
          positive regulation of interleukin-8 production
          positive regulation of tumor necrosis factor production
          positive regulation of stress-activated MAPK cascade
          toll-like receptor 4 signaling pathway
          macrophage activation
          positive regulation of NF-kappaB import into nucleus
          positive regulation of tumor necrosis factor biosynthetic process
          positive regulation of apoptotic process
          positive regulation of I-kappaB kinase/NF-kappaB signaling
          positive regulation of DNA binding
          positive regulation of interleukin-12 biosynthetic process
          innate immune response
          positive regulation of MHC class II biosynthetic process
          positive regulation of interferon-beta biosynthetic process
          positive regulation of interleukin-1 biosynthetic process
          positive regulation of interleukin-13 biosynthetic process
          positive regulation of interleukin-6 biosynthetic process
          positive regulation of interleukin-8 biosynthetic process
          positive regulation of nitric oxide biosynthetic process
          response to ethanol
          mast cell activation
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of JNK cascade
          positive regulation of lymphocyte proliferation
          regulation of cytokine secretion
          regulation of inflammatory response
          positive regulation of inflammatory response
          positive regulation of peptidyl-tyrosine phosphorylation
          defense response to Gram-negative bacterium
          positive regulation of sequence-specific DNA binding transcription factor activity
          positive regulation of NF-kappaB transcription factor activity
          positive regulation of nitric-oxide synthase biosynthetic process
          regulation of sensory perception of pain
          intestinal epithelial structure maintenance
          positive regulation of macrophage cytokine production
          negative regulation of ERK1 and ERK2 cascade
          positive regulation of ERK1 and ERK2 cascade
          positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
          positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
          response to fatty acid
          cellular response to lipopolysaccharide
          cellular response to lipoteichoic acid
          lipopolysaccharide binding
          lipopolysaccharide receptor activity
          receptor activity
          transmembrane signaling receptor activity
          protein binding
          phosphatidylinositol 3-kinase binding

          MicroArray Probes:

          Affymetrix ABI

          Array Name Probe IDs Targets Target Type
          Affymetrix Mouse Clariom S Array PSR0400005316.mm.1 NM_021297.3 Refseq
          Affymetrix Mouse Clariom S Array PSR0400005316.mm.1 TC0400000743.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR0400005318.mm.1 NM_021297.3 Refseq
          Affymetrix Mouse Clariom S Array PSR0400005318.mm.1 TC0400000743.mm.1 MTA TC
          Affymetrix Mouse Clariom S Array PSR0400005315.mm.1 TC0400000743.mm.1 MTA TC
          Array Name Probe IDs Targets Target Type
          ABI Mouse Genome Survey Microarray 557908 - -

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