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          System Message

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          See other TLR4 SIRNA Assays ›
          Gene Symbol:
          TLR4
          Gene Name:
          toll like receptor 4
          Gene Aliases:
          ARMD10, CD284, TLR-4, TOLL
          Chromosome Location:
          Chr.9: 117704175 - 117717491 on Build GRCh38
          UniGene ID:
          Hs.174312
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          siRNA ID 110006

          Purification
          Size
          Availability Inventoried
          Catalog # AM16708
          Price
          Your Price
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          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: TLR4
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_003266.3 NP_003257.1 4 2622
          NM_138554.4 NP_612564.1 3 2502
          NM_138557.2 NP_612567.1 2 2335
          GenBank mRNA AB445638.1 - 3 2204
          AK226155.1 - 4 2377
          AK290053.1 - 4 2605
          AK293068.1 - 3 2333
          AK303730.1 - 2 2166
          BC025294.1 - 2 2121
          BC117422.1 - 3 2224 40125973
          BC143841.1 - 4 2344
          U69193.1 - 1 205
          U88880.1 - 4 2368
          U93091.1 - 3 2307

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          More Information


          Gene Ontology Categories:

          Function(s) Process(es)

          activation of MAPK activity
          toll-like receptor signaling pathway
          B cell proliferation involved in immune response
          nitric oxide production involved in inflammatory response
          regulation of dendritic cell cytokine production
          MyD88-dependent toll-like receptor signaling pathway
          MyD88-independent toll-like receptor signaling pathway
          inflammatory response
          immune response
          I-kappaB kinase/NF-kappaB signaling
          I-kappaB phosphorylation
          positive regulation of platelet activation
          positive regulation of gene expression
          astrocyte development
          detection of fungus
          positive regulation of B cell proliferation
          lipopolysaccharide-mediated signaling pathway
          response to lipopolysaccharide
          detection of lipopolysaccharide
          interferon-gamma production
          negative regulation of interferon-gamma production
          negative regulation of interleukin-17 production
          negative regulation of interleukin-23 production
          negative regulation of interleukin-6 production
          negative regulation of tumor necrosis factor production
          positive regulation of chemokine production
          positive regulation of interferon-alpha production
          positive regulation of interferon-beta production
          positive regulation of interferon-gamma production
          positive regulation of interleukin-1 production
          positive regulation of interleukin-10 production
          positive regulation of interleukin-12 production
          positive regulation of interleukin-6 production
          positive regulation of interleukin-8 production
          positive regulation of tumor necrosis factor production
          negative regulation of MyD88-independent toll-like receptor signaling pathway
          toll-like receptor 4 signaling pathway
          TRIF-dependent toll-like receptor signaling pathway
          T-helper 1 type immune response
          macrophage activation
          positive regulation of NF-kappaB import into nucleus
          positive regulation of tumor necrosis factor biosynthetic process
          defense response to bacterium
          positive regulation of interleukin-12 biosynthetic process
          innate immune response
          positive regulation of MHC class II biosynthetic process
          positive regulation of interferon-beta biosynthetic process
          positive regulation of interleukin-8 biosynthetic process
          positive regulation of nitric oxide biosynthetic process
          negative regulation of osteoclast differentiation
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of JNK cascade
          interleukin-1 beta secretion
          regulation of cytokine secretion
          positive regulation of inflammatory response
          defense response to Gram-negative bacterium
          positive regulation of NF-kappaB transcription factor activity
          positive regulation of nitric-oxide synthase biosynthetic process
          intestinal epithelial structure maintenance
          positive regulation of macrophage cytokine production
          necroptotic process
          negative regulation of ERK1 and ERK2 cascade
          positive regulation of ERK1 and ERK2 cascade
          positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
          positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
          cellular response to lipopolysaccharide
          cellular response to lipoteichoic acid
          cellular response to mechanical stimulus
          apoptotic signaling pathway
          positive regulation of NLRP3 inflammasome complex assembly
          lipopolysaccharide binding
          lipopolysaccharide receptor activity
          receptor activity
          transmembrane signaling receptor activity
          protein binding

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