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          System Message

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          LOADING ...
          See other TNF SIRNA Assays ›
          Gene Symbol:
          TNF
          Gene Name:
          tumor necrosis factor
          Gene Aliases:
          DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F
          Chromosome Location:
          Chr.6: 31575567 - 31578336 on Build GRCh38
          UniGene ID:
          Hs.241570
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          siRNA ID HSS110856
          Size 20 nmol
          Availability Made To Order
          Catalog # 1299001
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: TNF
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_000594.3 NP_000585.2 4 830
          GenBank mRNA AB451492.1 - 2 427
          AF043342.1 - 2 427
          AK314960.1 - 4 829
          BC028148.1 - 4 812 5217636
          FJ795028.1 - 4 654
          HQ201306.2 - 4 655
          M10988.1 - 4 740
          X01394.1 - 4 807

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          More Information


          Gene Ontology Categories:

          Function(s) Process(es)

          protein import into nucleus, translocation
          negative regulation of transcription from RNA polymerase II promoter
          MAPK cascade
          activation of MAPKKK activity
          activation of MAPK activity
          positive regulation of cytokine production
          positive regulation of protein phosphorylation
          chronic inflammatory response to antigenic stimulus
          negative regulation of cytokine secretion involved in immune response
          positive regulation of chronic inflammatory response to antigenic stimulus
          positive regulation of humoral immune response mediated by circulating immunoglobulin
          glucose metabolic process
          activation of cysteine-type endopeptidase activity involved in apoptotic process
          inflammatory response
          humoral immune response
          I-kappaB kinase/NF-kappaB signaling
          JNK cascade
          extrinsic apoptotic signaling pathway via death domain receptors
          intrinsic apoptotic signaling pathway in response to DNA damage
          response to virus
          response to salt stress
          positive regulation of gene expression
          negative regulation of gene expression
          negative regulation of alkaline phosphatase activity
          regulation of tumor necrosis factor-mediated signaling pathway
          negative regulation of lipid storage
          extracellular matrix organization
          osteoclast differentiation
          sequestering of triglyceride
          cortical actin cytoskeleton organization
          positive regulation of protein complex assembly
          positive regulation of fever generation
          lipopolysaccharide-mediated signaling pathway
          negative regulation of interleukin-6 production
          positive regulation of chemokine production
          positive regulation of interferon-gamma production
          positive regulation of interleukin-6 production
          positive regulation of interleukin-8 production
          receptor biosynthetic process
          positive regulation of peptidyl-serine phosphorylation
          tumor necrosis factor-mediated signaling pathway
          positive regulation of heterotypic cell-cell adhesion
          negative regulation of myosin-light-chain-phosphatase activity
          positive regulation of NF-kappaB import into nucleus
          positive regulation of apoptotic process
          positive regulation of programmed cell death
          regulation of I-kappaB kinase/NF-kappaB signaling
          positive regulation of I-kappaB kinase/NF-kappaB signaling
          negative regulation of protein complex disassembly
          positive regulation of protein complex disassembly
          positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
          positive regulation of MAP kinase activity
          protein kinase B signaling
          positive regulation of JUN kinase activity
          negative regulation of growth of symbiont in host
          negative regulation of viral genome replication
          positive regulation of chemokine biosynthetic process
          positive regulation of interleukin-8 biosynthetic process
          positive regulation of nitric oxide biosynthetic process
          negative regulation of fat cell differentiation
          negative regulation of myoblast differentiation
          negative regulation of osteoblast differentiation
          positive regulation of osteoclast differentiation
          positive regulation of cell adhesion
          positive regulation of protein kinase activity
          negative regulation of transcription, DNA-templated
          positive regulation of transcription, DNA-templated
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of translational initiation by iron
          negative regulation of glucose import
          embryonic digestive tract development
          positive regulation of smooth muscle cell proliferation
          positive regulation of cytokine secretion
          positive regulation of phagocytosis
          regulation of insulin secretion
          defense response to Gram-positive bacterium
          leukocyte tethering or rolling
          negative regulation of lipid catabolic process
          regulation of immunoglobulin secretion
          positive regulation of membrane protein ectodomain proteolysis
          positive regulation of sequence-specific DNA binding transcription factor activity
          positive regulation of NF-kappaB transcription factor activity
          positive regulation of protein transport
          response to glucocorticoid
          positive regulation of NFAT protein import into nucleus
          positive regulation of hair follicle development
          positive regulation of protein kinase B signaling
          positive regulation of vitamin D biosynthetic process
          positive regulation of calcidiol 1-monooxygenase activity
          epithelial cell proliferation involved in salivary gland morphogenesis
          regulation of branching involved in salivary gland morphogenesis
          negative regulation of branching involved in lung morphogenesis
          positive regulation of ERK1 and ERK2 cascade
          cellular response to amino acid stimulus
          cellular response to nicotine
          cellular response to organic cyclic compound
          death-inducing signaling complex assembly
          positive regulation of mononuclear cell migration
          positive regulation of podosome assembly
          establishment of protein localization to plasma membrane
          extrinsic apoptotic signaling pathway
          necroptotic signaling pathway
          positive regulation of NIK/NF-kappaB signaling
          positive regulation of superoxide dismutase activity
          regulation of establishment of endothelial barrier
          negative regulation of bicellular tight junction assembly
          positive regulation of leukocyte adhesion to vascular endothelial cell
          positive regulation of leukocyte adhesion to arterial endothelial cell
          positive regulation of protein localization to cell surface
          positive regulation of ceramide biosynthetic process
          positive regulation of blood microparticle formation
          positive regulation of chemokine (C-X-C motif) ligand 2 production
          negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
          protease binding
          cytokine activity
          tumor necrosis factor receptor binding
          protein binding
          identical protein binding
          transcription regulatory region DNA binding

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