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          System Message

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          LOADING ...
          See other TNF SIRNA Assays ›
          Gene Symbol:
          Tnf
          Gene Name:
          tumor necrosis factor
          Gene Aliases:
          DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa, Tnfsf1a
          Chromosome Location:
          Chr.17: 35199367 - 35202007 on Build GRCm38
          UniGene ID:
          Mm.1293
          Species:
          Mouse
          Species Specific ID (Flybase ID):
          -
          siRNA ID s75250

          Purification
          Size
          Availability Made To Order
          Catalog # 4390771
          Price
          Your Price
          Online offer:
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          • Genomic Map
          • siRNA Details
          • More Information

          Genomic Map

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          siRNA Details

          Gene Symbol: Tnf
          Interrogated Sequence Translated Protein Targeted Exon(s) siRNA Location IMAGE Clone ID
          RefSeq NM_001278601.1 NP_001265530.1 3 769
          NM_013693.3 NP_038721.1 4 817
          GenBank mRNA AK153319.1 - 4 817
          AK153800.1 - 4 817
          AK154223.1 - 3 768
          AK155964.1 - 4 815
          BC117057.1 - 4 715 40126376
          BC137720.1 - 4 716 8860739
          M11731.1 - 4 793
          M13049.1 - 4 813
          X02611.1 - 4 806

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          More Information


          Gene Ontology Categories:

          Function(s) Process(es)

          protein import into nucleus, translocation
          negative regulation of transcription from RNA polymerase II promoter
          MAPK cascade
          activation of MAPKKK activity
          activation of MAPK activity
          cell activation
          positive regulation of cytokine production
          regulation of protein phosphorylation
          positive regulation of protein phosphorylation
          negative regulation of L-glutamate transport
          chronic inflammatory response to antigenic stimulus
          negative regulation of cytokine secretion involved in immune response
          positive regulation of chronic inflammatory response to antigenic stimulus
          positive regulation of humoral immune response mediated by circulating immunoglobulin
          glucose metabolic process
          apoptotic process
          activation of cysteine-type endopeptidase activity involved in apoptotic process
          obsolete transformed cell apoptotic process
          defense response
          inflammatory response
          immune response
          humoral immune response
          signal transduction
          JNK cascade
          multicellular organism development
          cell proliferation
          positive regulation of cell proliferation
          negative regulation of cell proliferation
          extrinsic apoptotic signaling pathway via death domain receptors
          intrinsic apoptotic signaling pathway in response to DNA damage
          response to virus
          organ morphogenesis
          positive regulation of gene expression
          negative regulation of gene expression
          negative regulation of alkaline phosphatase activity
          calcium-mediated signaling
          extracellular matrix organization
          osteoclast differentiation
          sequestering of triglyceride
          positive regulation of protein complex assembly
          positive regulation of fever generation
          lipopolysaccharide-mediated signaling pathway
          negative regulation of interleukin-6 production
          positive regulation of chemokine production
          positive regulation of interferon-gamma production
          positive regulation of interleukin-18 production
          positive regulation of interleukin-6 production
          receptor biosynthetic process
          positive regulation of peptidyl-serine phosphorylation
          tumor necrosis factor-mediated signaling pathway
          positive regulation of heterotypic cell-cell adhesion
          regulation of cell proliferation
          positive regulation of NF-kappaB import into nucleus
          defense response to bacterium
          positive regulation of apoptotic process
          positive regulation of programmed cell death
          regulation of I-kappaB kinase/NF-kappaB signaling
          positive regulation of I-kappaB kinase/NF-kappaB signaling
          negative regulation of protein complex disassembly
          positive regulation of protein complex disassembly
          positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
          positive regulation of MAP kinase activity
          protein kinase B signaling
          positive regulation of JUN kinase activity
          positive regulation of neuron apoptotic process
          negative regulation of growth of symbiont in host
          negative regulation of viral genome replication
          positive regulation of chemokine biosynthetic process
          cellular extravasation
          positive regulation of interleukin-8 biosynthetic process
          positive regulation of nitric oxide biosynthetic process
          negative regulation of myoblast differentiation
          negative regulation of osteoblast differentiation
          regulation of osteoclast differentiation
          positive regulation of osteoclast differentiation
          positive regulation of action potential
          positive regulation of cell adhesion
          positive regulation of mitotic nuclear division
          positive regulation of protein kinase activity
          negative regulation of transcription, DNA-templated
          positive regulation of transcription, DNA-templated
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of translational initiation by iron
          negative regulation of glucose import
          positive regulation of JNK cascade
          positive regulation of smooth muscle cell proliferation
          regulation of protein secretion
          positive regulation of cytokine secretion
          positive regulation of inflammatory response
          positive regulation of phagocytosis
          regulation of insulin secretion
          positive regulation of synaptic transmission
          defense response to Gram-positive bacterium
          leukocyte migration
          leukocyte tethering or rolling
          detection of mechanical stimulus involved in sensory perception of pain
          negative regulation of lipid catabolic process
          regulation of immunoglobulin secretion
          positive regulation of membrane protein ectodomain proteolysis
          positive regulation of sequence-specific DNA binding transcription factor activity
          positive regulation of NF-kappaB transcription factor activity
          positive regulation of protein transport
          response to glucocorticoid
          positive regulation of NFAT protein import into nucleus
          positive regulation of hair follicle development
          positive regulation of protein kinase B signaling
          positive regulation of vitamin D biosynthetic process
          positive regulation of calcidiol 1-monooxygenase activity
          epithelial cell proliferation involved in salivary gland morphogenesis
          regulation of branching involved in salivary gland morphogenesis
          negative regulation of branching involved in lung morphogenesis
          cellular response to lipopolysaccharide
          cellular response to amino acid stimulus
          cellular response to nicotine
          cellular response to organic cyclic compound
          positive regulation of podosome assembly
          apoptotic signaling pathway
          extrinsic apoptotic signaling pathway
          necroptotic signaling pathway
          positive regulation of protein localization to cell surface
          positive regulation of chemokine (C-X-C motif) ligand 2 production
          regulation of reactive oxygen species metabolic process
          negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
          protease binding
          cytokine activity
          tumor necrosis factor receptor binding
          protein binding
          identical protein binding
          transcription regulatory region DNA binding

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