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Highest antigen sequence indentity to the following orthologs: Mouse (66%), Rat (66%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-139833. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: acid sensing (proton gated) ion channel family member 4; acid sensing ion channel family member 4; acid-sensing (proton-gated) ion channel family member 4; Acid-sensing ion channel 4; Amiloride-sensitive cation channel 4; Amiloride-sensitive cation channel 4, pituitary; amiloride-sensitive cation channel family member 4, pituitary; ASIC4; brain sodium channel 4; MGC17248; MGC24860
Gene Aliases: ACCN4; ASIC4; BNAC4
UniProt ID: (Human) Q96FT7
Entrez Gene ID: (Human) 55515
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