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Invitrogen
Human CCDC106 (aa 195-279) Control Fragment Recombinant Protein
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Product Details
RP-99161
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
KLKSMSRAFEHHRVDRNTVALTTPIAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFLALDDETLKKVQALKKSKLLLPITYRFK
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-60281. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coiled-coil domain-containing protein 106; protein predicted by clone 23882
Gene Aliases: CCDC106; HSU79303; ZNF581
UniProt ID: (Human) Q9BWC9
Entrez Gene ID: (Human) 29903
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