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Invitrogen
Human CCDC115 (aa 96-177) Control Fragment Recombinant Protein
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Product Details
RP-96090
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
PREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (83%), Rat (83%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56987. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The CCDC115 gene encodes a protein known as coiled-coil domain-containing protein 115, which is involved in cellular processes related to membrane trafficking and Golgi apparatus function. CCDC115 is integral to maintaining Golgi homeostasis and is implicated in the functioning of the vacuolar H+-ATPase (V-ATPase) proton pump, critical for acidifying intracellular compartments. Mutations in CCDC115 have been associated with a genetic condition known as congenital disorder of glycosylation type IIo (CDG-IIo), which leads to defects in protein glycosylation. This disorder results in a spectrum of symptoms, including developmental delays, neurological impairments, and multi-systemic dysfunction due to improper glycosylation of proteins, impacting their stability and function. Research indicates that CCDC115's activity in ion transport and vacuolar acidification is essential for Golgi apparatus function and overall cellular homeostasis. Investigations into CCDC115 are crucial for understanding its role in glycosylation-related disorders and for developing potential therapeutic strategies to manage these conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coiled-coil domain-containing protein 115; Vacuolar ATPase assembly protein VMA22
Gene Aliases: CCDC115; ccp1; CDG2O; VMA22
UniProt ID: (Human) Q96NT0
Entrez Gene ID: (Human) 84317
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