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Invitrogen
Human CCDC91 (aa 1-89) Control Fragment Recombinant Protein
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Product Details
RP-97723
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQ
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (70%), Rat (70%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58280. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
CCDC91 (Coiled-Coil Domain-Containing 91) is a gene located on chromosome 12q24.31 that encodes a protein involved in vesicle-mediated transport and Golgi function. The CCDC91 protein contains coiled-coil domains, which facilitate protein-protein interactions necessary for its role in the secretory pathway. Specifically, CCDC91 is a component of the Golgi-associated retrograde protein (GARP) complex, which is essential for the recycling of transport vesicles from endosomes to the trans-Golgi network (TGN). Research has revealed that CCDC91 is crucial for maintaining Golgi structure and function and is involved in the sorting and trafficking of proteins and lipids within the cell. The protein's interactions with other components of the vesicular transport machinery enable the efficient movement of cargo between organelles, which is critical for various cellular processes, including secretion, endocytosis, and lysosomal degradation. Mutations or dysregulation of CCDC91 can disrupt these processes, potentially leading to diseases associated with vesicle trafficking defects, such as certain neurodegenerative disorders and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coiled-coil domain-containing protein 91; GGA binding partner; GGA-binding partner; p56 accessory protein
Gene Aliases: CCDC91; GGABP; HSD8; p56
UniProt ID: (Human) Q7Z6B0
Entrez Gene ID: (Human) 55297
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