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Invitrogen
Human DNMBP (aa 60-158) Control Fragment Recombinant Protein
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Product Details
RP-97024
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
TIPSLKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSA
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (84%), Rat (84%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58150. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The Dynamin Binding Protein (DNMBP) gene is located on chromosome 10 and has been implicated in Alzheimer's disease due to its role in regulating the actin cytoskeleton and synaptic vesicle pools, which are critical for proper neuronal function and memory performance. DNMBP mRNA expression levels are shown to be lower in Alzheimer's brains, suggesting its potential role in cognitive decline. Genetic studies have linked DNMBP to late-onset Alzheimer's disease (AD) through its single nucleotide polymorphisms (SNPs) such as rs11190305 and rs3740058, although the results show variability across different ethnic populations regarding its association with AD risk. Additionally, research on aged rats demonstrated a correlation between DNMBP expression and long-term memory performance, indicating its significance in maintaining cognitive functions during aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dynamin-binding protein; Scaffold protein Tuba
Gene Aliases: ARHGEF36; DNMBP; KIAA1010; TUBA
UniProt ID: (Human) Q6XZF7
Entrez Gene ID: (Human) 23268
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