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Invitrogen
Human DST (aa 2614-2703) Control Fragment Recombinant Protein
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Product Details
RP-94902
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
KPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHE
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (33%), Rat (33%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56396. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
As basal cells of stratified squamous epithelia begin to migrate in response to wound healing, they lose their cell-substrate adhesion junctions, the hemidesmosomes. The hemidesmosome is an adhesion structure of the epidermal-dermal junction in keratinocytes. When keratinocytes migrate laterally or upward to differentiate they must control the formation and disintegration of the hemidesmosomes. The bullous pemphigoid antigen BPAG1 is a hemidesmosomal protein of the cutaneous basement membrane zone. The primary sequence deduced from full-length human cDNAs predicts that this molecule consists of a central rod region and flanking globular domains. A neuronal isoform, BPAG1n3 is the result of differential splicing of BPAG1. BPAG1n3 is distinguished by its initial 32 amino acid residues and by the absence of the amino-terminal half of the actin-binding domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; BPA; Bullous pemphigoid antigen 1; Dystonia musculorum protein; Dystonin; Hemidesmosomal plaque protein; trabeculin-beta
Gene Aliases: BP230; BP240; BPA; BPAG1; CATX-15; CATX15; D6S1101; DMH; DST; DT; EBSB2; HSAN6; KIAA0728; MACF2
UniProt ID: (Human) Q03001
Entrez Gene ID: (Human) 667
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