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Invitrogen
Human DUSP18 Control Fragment Recombinant Protein
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Product Details
RP-106334
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
APSCAFPVQFRQPSVSGLSQITKSLYISNGVAATN
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (74%), Rat (74%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-65657. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
DUSP18 (E.C 3.1.3.16), a novel DSP, is a member of highly conserved protein-tyrosine phosphatase super family. Members of this family cooperate with protein kinases and play a vital role in cell cycle regulation and mitogenic signal transduction. DUSP18 is a low molecular weight protein consisting of conserved N-terminal DSP domain but lacks CH2 domain. Studies reveal that DUSP18 is a unique DSP that interacts and dephosphorylates SAPK/JNK. Reports suggest it inhibits SAPK/JNK invivo and might serve an important role in the regulation of SAPK/JNK pathway. Northern Blot analysis detected a ubiquitous expression of DUSP18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bK963H5.1; Dual specificity protein phosphatase 18; LMW-DSP20; Low molecular weight dual specificity phosphatase 20
Gene Aliases: DSP18; DUSP18; DUSP20; LMWDSP20
UniProt ID: (Human) Q8NEJ0
Entrez Gene ID: (Human) 150290
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