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Invitrogen
Human FAM84A (aa 21-103) Control Fragment Recombinant Protein
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Product Details
RP-98523
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
PSGIEKDELRVGVAYFFSDDEEDLDERGQPDKFGVKAPPGCTPCPESPSRHHHHLLHQLVLNETQFSAFRGQECIFSKVSGGP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (95%), Rat (95%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-61571. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The FAM84A gene, also known as Family With Sequence Similarity 84 Member A, is located on chromosome 1q21.3. This gene encodes a protein that has been implicated in the development and progression of various cancers. In particular, FAM84A has been identified as a key player in the epithelial-mesenchymal transition (EMT) and Wnt/beta-catenin signaling pathways, which are crucial for tumor development and metastasis. Studies have shown that the downregulation of FAM84A can inhibit thyroid cancer progression while being negatively regulated by the tumor suppressor miR-874-3p. Additionally, FAM84A has been noted to be over-expressed in phenobarbital-promoted mouse liver tumors, indicating its potential role in chemical carcinogenesis. The gene's expression is regulated by nuclear receptor CAR, highlighting its involvement in liver cancer pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: family with sequence similarity 84, member A; LRAT domain-containing 1; Neurologic sensory protein 1; neurological/sensory 1; NSE1; Protein FAM84A; Protein LRATD1
Gene Aliases: FAM84A; LRATD1; NSE1; PP11517
UniProt ID: (Human) Q96KN4
Entrez Gene ID: (Human) 151354
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