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Invitrogen
Human FEM1A (aa 231-300) Control Fragment Recombinant Protein
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Product Details
RP-107265
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
VEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (57%), Rat (57%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66607. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
FEM1A (FEM-1 homolog a), also known as EPRAP (Prostaglandin E receptor 4-associated protein), is a 669 amino acid cytoplasmic protein that belongs to the FEM-1 family. FEM1A is present in atheromata and in macrophages derived from peripheral blood monocytes. FEM1A may be a component of an E3 ubiquitin-protein ligase complex and functions as a substrate recognition subunit. It is suggested that FEM1A participates in anti-inflammatory signaling of macrophages via its interaction with EP4. FEM1A is down-regulated in Rhabdomyosarcoma, the most common soft tissue neoplasm of children. FEM1A is considered a candidate gene for polycystic ovary syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp762M136; FEM1-alpha; FEM1a; Prostaglandin E receptor 4-associated protein; Protein fem-1 homolog A
Gene Aliases: EPRAP; FEM1A
UniProt ID: (Human) Q9BSK4
Entrez Gene ID: (Human) 55527
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