Product References
Tuberculosis in otherwise healthy adults with inherited TNF deficiency.
Nature
Arias AA,Neehus AL,Ogishi M,Meynier V,Krebs A,Lazarov T,Lee AM,Arango-Franco CA,Yang R,Orrego J,Corcini Berndt M,Rojas J,Li H,Rinchai D,Erazo-Borrás L,Han JE,Pillay B,Ponsin K,Chaldebas M,Philippot Q,Bohlen J,Rosain J,Le Voyer T,Janotte T,Amarajeeva K,Soudée C,Brollo M,Wiegmann K,Marquant Q,Seeleuthner Y,Lee D,Lainé C,Kloos D,Bailey R,Bastard P,Keating N,Rapaport F,Khan T,Moncada-Vélez M,Carmona MC,Obando C,Alvarez J,Cataño JC,Martínez-Rosado LL,Sanchez JP,Tejada-Giraldo M,L'Honneur AS,Agudelo ML,Perez-Zapata LJ,Arboleda DM,Alzate JF,Cabarcas F,Zuluaga A,Pelham SJ,Ensser A,Schmidt M,Velásquez-Lopera MM,Jouanguy E,Puel A,Krönke M,Ghirardello S,Borghesi A,Pahari S,Boisson B,Pittaluga S,Ma CS,Emile JF,Notarangelo LD,Tangye SG,Marr N,Lachmann N,Salvator H,Schlesinger LS,Zhang P,Glickman MS,Nathan CF,Geissmann F,Abel L,Franco JL,Bustamante J,Casanova JL,Boisson-Dupuis S
100-18B was used in Cell Culture to report two adults with recurrent pulmonary tuberculosis who are homozygous for a private loss-of-function TNF variant.
Sun Sep 01 00:00:00 UTC 2024
Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases.
Nature communications
Chen C,Shu Y,Yan C,Li H,Huang Z,Shen S,Liu C,Jiang Y,Huang S,Wang Z,Mei F,Qin F,Liu X,Qiu W
100-18B was used in Cell Culture to reveal elevated astrocytic clusterin levels in both active lesions of patient tissues and female murine Multiple sclerosis models.
Fri Sep 06 00:00:00 UTC 2024
Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
Cellular oncology (Dordrecht, Netherlands)
McAloney CA,Makkawi R,Budhathoki Y,Cannon MV,Franz EM,Gross AC,Cam M,Vetter TA,Duhen R,Davies AE,Roberts RD
100-18B was used in In vitro experiments to develop therapeutic strategies that prevent and treat metastasis by identifying mechanisms that facilitate survival of disseminated tumour cells.
Thu Feb 01 00:00:00 UTC 2024
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.
Nature immunology
Linnerbauer M,Lößlein L,Vandrey O,Peter A,Han Y,Tsaktanis T,Wogram E,Needhamsen M,Kular L,Nagel L,Zissler J,Andert M,Meszaros L,Hanspach J,Zuber F,Naumann UJ,Diebold M,Wheeler MA,Beyer T,Nirschl L,Cirac A,Laun FB,Günther C,Winkler J,Bäuerle T,Jagodic M,Hemmer B,Prinz M,Quintana FJ,Rothhammer V
100-18B was used in Cell Culture to identify astrocyte-derived HB-EGF and its epigenetic regulation as a modulator of autoimmune CNS inflammation and potential therapeutic target in MS.
Fri Mar 01 00:00:00 UTC 2024
Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression.
Life science alliance
Xavier V,Martinelli S,Corbyn R,Pennie R,Rakovic K,Powley IR,Officer-Jones L,Ruscica V,Galloway A,Carlin LM,Cowling VH,Le Quesne J,Martinou JC,MacVicar T
100-18B was used in Cell Culture to establish a new link between cell proliferation and mitochondrial nucleic acid homeostasis.
Fri Nov 01 00:00:00 UTC 2024
Upregulation of Transferrin Receptor 1 (TfR1) but Not Glucose Transporter 1 (GLUT1) or CD98hc at the Blood-Brain Barrier in Response to Valproic Acid.
Cells
Helgudóttir SS,Johnsen KB,Routhe LG,Rasmussen CLM,Thomsen MS,Moos T
100-18B was used in Cell Culture to challenge the expression of TfR1, GLUT1, and CD98hc in brain capillaries using the histone deacetylase inhibitor valproic acid.
Thu Jul 11 00:00:00 UTC 2024
Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice.
GeroScience
Nolt GL,Keeble AR,Wen Y,Strong AC,Thomas NT,Valentino TR,Brightwell CR,Murach KA,Patrizia S,Weinstabl H,Gollner A,McCarthy JJ,Fry CS,Franti M,Filareto A,Peterson CA,Dungan CM
100-18B was used in Cell Culture to show that the novel pharmaceutical agent BI01 is an effective senolytic agent that may also augment muscle metabolism to enhance muscle regeneration and hypertrophy in old mice.
Mon Apr 01 00:00:00 UTC 2024
Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy.
Cancer cell
Wienke J,Visser LL,Kholosy WM,Keller KM,Barisa M,Poon E,Munnings-Tomes S,Himsworth C,Calton E,Rodriguez A,Bernardi R,van den Ham F,van Hooff SR,Matser YAH,Tas ML,Langenberg KPS,Lijnzaad P,Borst AL,Zappa E,Bergsma FJ,Strijker JGM,Verhoeven BM,Mei S,Kramdi A,Restuadi R,Sanchez-Bernabeu A,Cornel AM,Holstege FCP,Gray JC,Tytgat GAM,Scheijde-Vermeulen MA,Wijnen MHWA,Dierselhuis MP,Straathof K,Behjati S,Wu W,Heck AJR,Koster J,Nierkens S,Janoueix-Lerosey I,de Krijger RR,Baryawno N,Chesler L,Anderson J,Caron HN,Margaritis T,van Noesel MM,Molenaar JJ
100-18B was used in In vitro experiments to dissect the immunoregulatory interactions in neuroblastoma by single-cell RNA-sequencing of 24 tumors (10 pre- and 14 post-chemotherapy, including 5 pairs) to identify strategies for optimizing immunotherapy efficacy.
Mon Feb 12 00:00:00 UTC 2024
Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance.
Autophagy
Zhang X,Lao M,Yang H,Sun K,Dong Y,He L,Jiang X,Wu H,Jiang Y,Li M,Ying H,Liu X,Xu J,Chen Y,Zhang H,Zhou R,Gao J,Bai X,Liang T
100-18B was used in Cell Culture to reveal that the inhibition of CAF autophagy suppresses in vivo tumor development in immune-deficient xenografts.
Sat Jun 01 00:00:00 UTC 2024
Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2.
iScience
Flamier A,Bisht P,Richards A,Tomasello DL,Jaenisch R
100-18B was used in In vitro experiments to indicate that sensory neurons can be infected by the original WA1/2020 strain of SARS-CoV-2 as well as the delta and omicron variants, yet infectability differs between the original strain and the variants.
Fri Sep 15 00:00:00 UTC 2023
Transcription Factor-Mediated Differentiation of Motor Neurons from Human Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Wu J,Tang Y
100-18B was used in Cell Culture to describe a method of generating functional MNs via lentiviral delivery of transcription factors, based on the preservable NPC platform derived from hPSCs.
Thu Dec 15 00:00:00 UTC 2022
RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy.
eLife
Necarsulmer JC,Simon JM,Evangelista BA,Chen Y,Tian X,Nafees S,Marquez AB,Jiang H,Wang P,Ajit D,Nikolova VD,Harper KM,Ezzell JA,Lin FC,Beltran AS,Moy SS,Cohen TJ
100-18B was used in In vitro experiments to develop endogenous models of sporadic TDP-43 proteinopathy based on the principle that disease-associated TDP-43 acetylation at lysine 145 (K145) alters TDP-43 conformation, impairs RNA-binding capacity, and induces downstream mis-regulation of target genes.
Wed Oct 11 00:00:00 UTC 2023
Differentiation of Human Induced Pluripotent Stem Cells (iPSCs)-derived Mesenchymal Progenitors into Chondrocytes.
Bio-protocol
Khan NM,Diaz-Hernandez ME,Drissi H
100-18B was used in Cell Culture to describe the detailed procedure for successful derivation of mesenchymal progenitor population from human iPSCs, which are then differentiated into chondrocytes using high-density culture conditions by stimulating with bone morphogenetic protein-2 (BMP-2) or transforming growth factor beta-3 (TGFβ-3).
Sun Nov 05 00:00:00 UTC 2023
Click chemistry functionalization of self-assembling peptide hydrogels.
Journal of biomedical materials research. Part A
Sharick JT,Atieh AJ,Gooch KJ,Leight JL
100-18B was used in Cell Culture to demonstrate that Click self-assembling peptides retain the ability to self-assemble into fibers.
Wed Mar 01 00:00:00 UTC 2023
Cytotoxic immune cells do not affect TDP-43 and p62 sarcoplasmic aggregation but influence TDP-43 localisation.
Scientific reports
McCord B,Day RM
100-18B was used in Cell Culture to investigate if exposure to cytotoxic inflammatory cells caused TDP-43 and p62 aggregation or TDP-43 mislocalisation in cultured myotubes.
Sat Sep 23 00:00:00 UTC 2023
Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity.
Biomaterials science
Dutta D,Pirolli NH,Levy D,Tsao J,Seecharan N,Wang Z,Xu X,Jia X,Jay SM
100-18B was used in In vitro experiments to assess whether oligodendrocyte precursor cells and immature oligodendrocytes, which are further differentiated than neural progenitor/stem cells (NPSCs) and which both give rise to mature myelinating oligodendrocytes, could yield extracellular vesicles with neurotherapeutic properties comparable or superior to those from NPSCs.
Tue Aug 08 00:00:00 UTC 2023
Chenodeoxycholic acid rescues axonal degeneration in induced pluripotent stem cell-derived neurons from spastic paraplegia type 5 and cerebrotendinous xanthomatosis patients.
Orphanet journal of rare diseases
Mou Y,Nandi G,Mukte S,Chai E,Chen Z,Nielsen JE,Nielsen TT,Criscuolo C,Blackstone C,Fraidakis MJ,Li XJ
100-18B was used in In vitro experiments to demonstrate disease-specific lipid disturbances and axonopathy mechanisms in human pluripotent stem cell-based neuronal models of cerebrotendinous xanthomatosis (CTX) and spastic paraplegia type 5 (SPG5) and identify chenodeoxycholic acid (CDCA), an established treatment of CTX, as a potential pharmacotherapy for SPG5.
Thu Apr 06 00:00:00 UTC 2023
A 3D Ex Vivo Tumor-Immune Coculture System Mimicking In Vivo Tumor Environmental Stress on CD8+ T Cells Exhaustion.
Advanced biology
Meng Z,Niu X,Xia L,Chen Y,Wang Z,Wang H,Ji P,Cui W,Wang Y,Lu S
100-18B was used in Cell Culture to establish that the 3D-HyGTIC system is not only inclined to mimic the early differentiation trajectories of tumor-infiltrating CD8+ T cells but also may facilitate an evaluation of the efficacy of IC blockades and guide the designing of combination immunotherapy.
Sat Jul 01 00:00:00 UTC 2023
An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming.
Science advances
Weng M,Hu H,Graus MS,Tan DS,Gao Y,Ren S,Ho DHH,Langer J,Holzner M,Huang Y,Ling GS,Lai CSW,Francois M,Jauch R
100-18B was used in Cell Culture to report iNSC reprogramming from embryonic and aged mouse fibroblasts as well as from human blood using an engineered Sox17 (eSox17FNV).
Fri Aug 25 00:00:00 UTC 2023
Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells.
Science advances
Petrelli F,Scandella V,Montessuit S,Zamboni N,Martinou JC,Knobloch M
100-18B was used in Cell Culture to highlight the importance of metabolism for NSPC regulation and identify an important pathway through which mitochondrial pyruvate import controls NSPC quiescence and activation.
Wed Mar 01 00:00:00 UTC 2023
Derivation and Primordial Germ Cell Induction of Intermediate Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Yu L,Ballard E,Pinzon Arteaga CA,Wu J
100-18B was used in Cell Culture to describe the method for derivation and maintenance of mouse and human FTW-PSCs, as well as PGC-LC induction from FTW-PSCs.
Fri Jul 21 00:00:00 UTC 2023
Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice.
Glia
Yamanaka K,Nakamura K,Shibahara T,Takashima M,Takaki H,Hidaka M,Komori M,Yoshikawa Y,Wakisaka Y,Ago T,Kitazono T
100-18B was used in Cell Culture to examine the effect of Nox4 deletion on demyelination-remyelination, the most common pathological change in the brain.
Wed Mar 01 00:00:00 UTC 2023
Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination.
STAR protocols
von der Bey M,De Cicco S,Zach S,Hengerer B,Ercan-Herbst E
100-18B was used in In vitro experiments to describe steps to differentiate hiPSCs into cortical neurons and oligodendrocyte lineage cells on 3D nanofibers.
Fri Mar 17 00:00:00 UTC 2023
Engineering Adenoviral Vectors with Improved GBM Selectivity.
Viruses
Bates EA,Lovatt C,Plein AR,Davies JA,Siebzehnrubl FA,Parker AL
100-18B was used in Cell Culture to demonstrate tight Glioblastoma (GBM)-specific transgene expression using these constructs, indicating that the combination of pseudotyping and tumour-specific promoter approaches may enable the development of efficacious therapies better suited to GBM.
Fri Apr 28 00:00:00 UTC 2023
Precise modulation of transcription factor levels identifies features underlying dosage sensitivity.
Nature genetics
Naqvi S,Kim S,Hoskens H,Matthews HS,Spritz RA,Klein OD,Hallgrímsson B,Swigut T,Claes P,Pritchard JK,Wysocka J
100-18B was used in In vitro experiments to propose that such REs and genes underlie the sensitivity of specific phenotypes to TF dosage, while buffering of other genes leads to robust, nonlinear dosage-to-phenotype relationships.
Mon May 01 00:00:00 UTC 2023
Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity.
Nature communications
Pagliaro A,Finger R,Zoutendijk I,Bunschuh S,Clevers H,Hendriks D,Artegiani B
100-18B was used in Cell Culture to find that a prolonged, decreasing gradient of TGF-β signaling is a determining factor in expanded neuroepithelium organoid formation and allows for an extended phase of neuroepithelium expansion.
Tue Nov 28 00:00:00 UTC 2023
Identification of Dysregulated microRNAs in Glioblastoma Stem-like Cells.
Brain sciences
Evers L,Schäfer A,Pini R,Zhao K,Stei S,Nimsky C,Bartsch JW
100-18B was used in Cell Culture to explore changes in the miRNA expression profiles in patient-derived glioblastoma stem-like cells altered on differentiation into glial fibre acid protein (GFAP)-expressing, astrocytic tumour cells using a polymerase chain reaction (PCR) array.
Sat Feb 18 00:00:00 UTC 2023
C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.
iScience
Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y
100-18B was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.
Fri Oct 20 00:00:00 UTC 2023
Modeling drug-induced liver injury and screening for anti-hepatofibrotic compounds using human PSC-derived organoids.
Cell regeneration (London, England)
Wu X,Jiang D,Yang Y,Li S,Ding Q
100-18B was used in Tissue/organ culture to demonstrate the potential applications of human liver organoids in drug safety testing and anti-fibrotic drug screening.
Fri Mar 03 00:00:00 UTC 2023
Mapping oto-pharyngeal development in a human inner ear organoid model.
Development (Cambridge, England)
Steinhart MR,van der Valk WH,Osorio D,Serdy SA,Zhang J,Nist-Lund C,Kim J,Moncada-Reid C,Sun L,Lee J,Koehler KR
100-18B was used in Cell Culture to establish the Inner Ear Organoid Developmental Atlas (IODA), offering deeper insights into human biology and improving inner ear tissue differentiation.
Sun Oct 01 00:00:00 UTC 2023
Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling.
Stem cell research & therapy
Kim HJ,Kim G,Chi KY,Kim H,Jang YJ,Jo S,Lee J,Lee Y,Woo DH,Han C,Kim SK,Park HJ,Kim JH
100-18B was used in Cell Culture to demonstrate that mLOs can reproduce parenchymal and non-parenchymal cell interactions and suggest that their application can advance the precise modeling of liver diseases in vitro.
Fri Feb 03 00:00:00 UTC 2023
SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice.
Frontiers in cellular neuroscience
Fazal SV,Mutschler C,Chen CZ,Turmaine M,Chen CY,Hsueh YP,Ibañez-Grau A,Loreto A,Casillas-Bajo A,Cabedo H,Franklin RJM,Barker RA,Monk KR,Steventon BJ,Coleman MP,Gomez-Sanchez JA,Arthur-Farraj P
100-18B was used in Cell Culture to show that SARM1 is not required for initiation of myelination and myelin sheath maintenance is unaffected in the adult mouse nervous system.
Tue Sep 17 00:00:00 UTC 2024
The quality and quantity media-cultured mononuclear cell transplantation is safe and effective in ischemic hindlimb mouse model.
JVS-vascular science
Chinchalongporn W,Chruewkamlow N,Sermsathanasawadi N,Vorateera K,Jintaworn S,Wongwanit C,Ruangsetakit C
100-18B was used in Cell Culture to investigate in vitro proangiogenic and anti-inflammatory phenotypes and functions and the in vivo efficacy and safety of quality and quantity (QQ) media-cultured mononuclear cells (MNCs) compared with standard cultured MNCs from the peripheral blood of patients with chronic limb-threatening ischemia (CLTI) with atheosclerotic risk factors.
Tue Nov 14 00:00:00 UTC 2023
Imaging glymphatic response to glioblastoma.
Cancer imaging : the official publication of the International Cancer Imaging Society
Kaur J,Ding G,Zhang L,Lu Y,Luo H,Li L,Boyd E,Li Q,Wei M,Zhang Z,Chopp M,Jiang Q
100-18B was used in Cell Culture to demonstrate the presence of Glioblastoma multiforme-impaired glymphatic response in the rat brain and impaired perineural pathway along the optic nerves.
Mon Oct 30 00:00:00 UTC 2023
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
Nature neuroscience
Nelson MR,Liu P,Agrawal A,Yip O,Blumenfeld J,Traglia M,Kim MJ,Koutsodendris N,Rao A,Grone B,Hao Y,Yoon SY,Xu Q,De Leon S,Choenyi T,Thomas R,Lopera F,Quiroz YT,Arboleda-Velasquez JF,Reiman EM,Mahley RW,Huang Y
100-18B was used in In vitro experiments to find that the homozygous R136S mutation rescued APOE4-driven Tau pathology, neurodegeneration and neuroinflammation.
Fri Dec 01 00:00:00 UTC 2023
Myelination- and migration-associated genes are downregulated after phagocytosis in cultured oligodendrocyte precursor cells.
Journal of neurochemistry
Hamanaka G,Hernández IC,Takase H,Ishikawa H,Benboujja F,Kimura S,Fukuda N,Guo S,Lok J,Lo EH,Arai K
100-18B was used in Cell Culture to show that cultured OPCs phagocytosed myelin-debris-rich lysates prepared from rat corpus callosum, without progressing to cell death.
Wed Nov 01 00:00:00 UTC 2023
A simplified and defined serum-free medium for cultivating fat across species.
iScience
Mitić R,Cantoni F,Börlin CS,Post MJ,Jackisch L
100-18B was used in Cell Culture to propose a simplified one-step adipogenic protocol which, given the replacement of rosiglitazone by a food-compatible PPARγ agonist, is suitable for making cultivated fat.
Fri Jan 20 00:00:00 UTC 2023
Rational Design and Acoustic Assembly of Human Cerebral Cortex-Like Microtissues from hiPSC-Derived Neural Progenitors and Neurons.
Advanced materials (Deerfield Beach, Fla.)
Wang J,Qiao H,Wang Z,Zhao W,Chen T,Li B,Zhu L,Chen S,Gu L,Wu Y,Zhang Z,Bi L,Chen P
100-18B was used in Cell Culture to demonstrate the rational design of brain-like cortical tissue models sourced from humans through a process involving reverse engineering and bionic design.
Tue Aug 01 00:00:00 UTC 2023
Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation.
Journal of biomedical science
Baringer SL,Palsa K,Spiegelman VS,Simpson IA,Connor JR
100-18B was used in Cell Culture to provide a molecular mechanism for apo- and holo-Tf regulation of iron release from endothelial cells.
Tue Jun 06 00:00:00 UTC 2023
Derivation of Human Extraembryonic Mesoderm-like Cells from Primitive Endoderm.
International journal of molecular sciences
Farkas K,Ferretti E
100-18B was used in In vitro experiments to find that the ExM-like cells clustered with the LUM/ANXA1-rich cell populations of the gastrulating embryo, indicating similarity between in vitro and ex utero cell populations.
Wed Jul 12 00:00:00 UTC 2023
ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma.
Journal of experimental & clinical cancer research : CR
Xu T,Zhu C,Chen J,Song F,Ren X,Wang S,Yi X,Zhang Y,Zhang W,Hu Q,Qin H,Liu Y,Zhang S,Tan Z,Pan Z,Huang P,Ge M
100-18B was used in Cell Culture to unveiled a novel role of ISG15 in the modulation of Anaplastic thyroid carcinoma cancer stem-like cells.
Thu Jul 27 00:00:00 UTC 2023
Enhanced angiogenic properties of umbilical cord blood primed by OP9 stromal cells ameliorates neurological deficits in cerebral infarction mouse model.
Scientific reports
Yoshida Y,Takeda Y,Yamahara K,Yamamoto H,Takagi T,Kuramoto Y,Nakano-Doi A,Nakagomi T,Soma T,Matsuyama T,Doe N,Yoshimura S
100-18B was used in Cell Culture to develop a strong, fast, and feasible method to augment the M2, tissue-protecting, pro-angiogenic features of UCB using OP9.
Fri Jan 06 00:00:00 UTC 2023
Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma.
Life science alliance
Panizza E,Regalado BD,Wang F,Nakano I,Vacanti NM,Cerione RA,Antonyak MA
100-18B was used in Cell Culture to show that the proteome-level regulation occurring upon radiation treatment of several patient-derived GSC lines predicts their resistance status, whereas glioma transcriptional subtypes do not.
Thu Jun 01 00:00:00 UTC 2023
Prenatal low-dose methylmercury exposure causes premature neuronal differentiation and autism-like behaviors in a rodent model.
iScience
Loan A,Leung JW,Cook DP,Ko C,Vanderhyden BC,Wang J,Chan HM
100-18B was used in Cell Culture to ask whether a non-genetic factor, prenatal exposure to the environmental pollutant methylmercury (MeHg), is a contributing factor in autism spectrum disorder onset.
Fri Mar 17 00:00:00 UTC 2023
Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells.
Frontiers in cell and developmental biology
Zhou M,Zhang M,Guo T,Zhao L,Guo X,Yin Z,Cheng L,Liu H,Zhao L,Li X,Li R
100-18B was used in Cell Culture to reprogram porcine fetal fibroblasts using porcine, bovine and murine transcription factors.
Tue May 09 00:00:00 UTC 2023
Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells.
Frontiers in cell and developmental biology
Zhou M,Zhang M,Guo T,Zhao L,Guo X,Yin Z,Cheng L,Liu H,Zhao L,Li X,Li R
100-18B was used in Cell Culture to reprogram porcine fetal fibroblasts using porcine, bovine and murine transcription factors.
Tue May 09 00:00:00 UTC 2023
Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells.
Frontiers in cell and developmental biology
Zhou M,Zhang M,Guo T,Zhao L,Guo X,Yin Z,Cheng L,Liu H,Zhao L,Li X,Li R
100-18B was used in Cell Culture to reprogram porcine fetal fibroblasts using porcine, bovine and murine transcription factors.
Tue May 09 00:00:00 UTC 2023
SOX18-enforced expression diverts hemogenic endothelium-derived progenitors from T towards NK lymphoid pathways.
iScience
Jung HS,Suknuntha K,Kim YH,Liu P,Dettle ST,Sedzro DM,Smith PR,Thomson JA,Ong IM,Slukvin II
100-18B was used in Cell Culture to reveal that SOX18 forced expression at the mesodermal stage, in contrast to its homolog SOX17, has minimal effects on arterial specification of hemogenic endothelium, expression of HOXA genes and lymphoid differentiation.
Fri May 19 00:00:00 UTC 2023
The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells.
iScience
Gonzalez L,Domingo-Muelas A,Duart-Abadia P,Nuñez M,Mikolcevic P,Llonch E,Cubillos-Rojas M,Cánovas B,Forrow SMA,Morante-Redolat JM,Fariñas I,Nebreda AR
100-18B was used in Cell Culture to indicate that RingoA plays an important role in setting the threshold of cyclin-dependent kinase activity required for adult neural stem cells to exit quiescence and may represent a dormancy regulator in adult mammalian tissues.
Fri Mar 17 00:00:00 UTC 2023
TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis.
Heliyon
Huang X,Liu B,Liang Y,Mai C,Shen Y,Huang X,Chen J,Liang X,Hu B,Li W,Li X,Zhang Y
100-18B was used in Cell Culture to reveal that TNF receptor-associated factor 3 interacting protein 2 (TRAF3IP2) accelerated mesenchymal stem cells (MSC) senescence via downregulation of nicotinamide phosphoribosyl transferase (NAMPT)-mediated nicotinamide adenine dinucleotide (NAD) biosynthesis by mediation of the activated protein kinase (AMPK) pathway, highlighting a novel means to rejuvenate senescent MSCs.
Fri Sep 01 00:00:00 UTC 2023
Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging.
Nature aging
Yeo RW,Zhou OY,Zhong BL,Sun ED,Navarro Negredo P,Nair S,Sharmin M,Ruetz TJ,Wilson M,Kundaje A,Dunn AR,Brunet A
100-18B was used in Cell Culture to characterize genome-wide chromatin accessibility of neurogenic niche cells in vivo during aging.
Sat Jul 01 00:00:00 UTC 2023
Generating human blastoids modeling blastocyst-stage embryos and implantation.
Nature protocols
Heidari Khoei H,Javali A,Kagawa H,Sommer TM,Sestini G,David L,Slovakova J,Novatchkova M,Scholte Op Reimer Y,Rivron N
100-18B was used in Cell Culture to describe how we formed human blastoids that (1) efficiently achieve the morphology of the blastocyst and (2) form lineages according to the pace and sequence of blastocyst development, (3) ultimately forming cells that transcriptionally reflect the blastocyst (preimplantation stage).
Mon May 01 00:00:00 UTC 2023
Accelerated differentiation of human induced pluripotent stem cells into regionally specific dorsal and ventral spinal neural progenitor cells for application in spinal cord therapeutics.
Frontiers in neuroscience
Huntemer-Silveira A,Malone D,Frie A,Walsh P,Parr AM
100-18B was used in In vitro experiments to describe here the production of a diverse population of both ventral spinal and dorsal horn progenitor cells.
Sat Feb 10 00:00:00 UTC 2024
Targeting intratumor heterogeneity suppresses colorectal cancer chemoresistance and metastasis.
EMBO reports
Chao S,Zhang F,Yan H,Wang L,Zhang L,Wang Z,Xue R,Wang L,Wu Z,Jiang B,Shi G,Xue Y,Du J,Bu P
100-18B was used in Cell Culture to demonstrate that asymmetric division of CCSCs contributes to the early establishment of ITH.
Thu Aug 03 00:00:00 UTC 2023
Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study.
International endodontic journal
Guo R,Gu T,Xiao Y,Xiao T,Liu Q,Li Z,Yu J
100-18B was used in In vitro experiments to determine the role of miR-27b-5p in regulating osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth (SHEDs) and further examined the regulatory mechanism of bone morphogenetic protein receptor type-1A (BMPR1A).
Sun Oct 01 00:00:00 UTC 2023
Analyzing mitochondrial respiration of human induced pluripotent stem cell-derived myeloid progenitors using Seahorse technology.
STAR protocols
Fan Y,Mizoguchi Y,Tatematsu M,Linder MI,Frenz S,Choi J,Klein C
100-18B was used in In vitro experiments to describe a protocol to analyze and to quantify key parameters of mitochondrial respiration of iPSC-derived myeloid progenitors by the Seahorse XFe96 Analyzer.
Fri Mar 17 00:00:00 UTC 2023
Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells.
Cell reports methods
Iwatsuki K,Oikawa M,Kobayashi H,Penfold CA,Sanbo M,Yamamoto T,Hochi S,Kurimoto K,Hirabayashi M,Kobayashi T
100-18B was used in In vitro experiments to demonstrate that rat EpiSCs retain competency to produce authentic primordial germ cell-like cells that undergo functional gametogenesis leading to the birth of viable offspring.
Mon Aug 28 00:00:00 UTC 2023
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
100-18B was used in Cell Culture to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 UTC 2023
Acute liver steatosis translationally controls the epigenetic regulator MIER1 to promote liver regeneration in a study with male mice.
Nature communications
Chen Y,Chen L,Wu X,Zhao Y,Wang Y,Jiang D,Liu X,Zhou T,Li S,Wei Y,Liu Y,Hu C,Zhou B,Qin J,Ying H,Ding Q
100-18B was used in In vitro experiments to identify an epigenetic mechanism by which the early phase lipid redistribution from adipose tissue to liver during regeneration impacts hepatocyte proliferation, and suggest a potential strategy to boost liver regeneration.
Sat Mar 18 00:00:00 UTC 2023
The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor.
Frontiers in molecular neuroscience
Knorr DY,Rodriguez Polo I,Pies HS,Schwedhelm-Domeyer N,Pauls S,Behr R,Heinrich R
100-18B was used in Cell Culture to show that the human CRLF3 mediates neuroprotection upon activation with the natural Epo splice variant EV-3.
Sun May 14 00:00:00 UTC 2023
The constitutively active pSMAD2/3 relatively improves the proliferation of chicken primordial germ cells.
Molecular reproduction and development
Zare M,Mirhoseini SZ,Ghovvati S,Yakhkeshi S,Hesaraki M,Barati M,Sayyahpour FA,Baharvand H,Hassani SN
100-18B was used in Cell Culture to show that TGF-β signaling agonists (IDE1 and Activin-A) improved PGC proliferation to some extent while treatment with SB431542, the antagonist of TGF-β, disrupted PGCs' proliferation.
Thu Jun 01 00:00:00 UTC 2023
Integrative characterisation of secreted factors involved in intercellular communication between prostate epithelial or cancer cells and fibroblasts.
Molecular oncology
Wu Y,Clark KC,Niranjan B,Chüeh AC,Horvath LG,Taylor RA,Daly RJ
100-18B was used in Cell Culture to define secretome changes upon co-culture of prostate epithelial or cancer cells with fibroblasts that mimic bi-directional communication in tumours.
Wed Mar 01 00:00:00 UTC 2023
Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness.
Signal transduction and targeted therapy
He B,Gao R,Lv S,Chen A,Huang J,Wang L,Feng Y,Feng J,Liu B,Lei J,Deng B,He B,Cui B,Peng F,Yan M,Wang Z,Lam EW,Jin B,Shao Z,Li Y,Jiao J,Wang X,Liu Q
100-18B was used in Cell Culture to elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program, suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals.
Wed Jul 19 00:00:00 UTC 2023
Structural elements promote architectural stripe formation and facilitate ultra-long-range gene regulation at a human disease locus.
Molecular cell
Chen LF,Long HK,Park M,Swigut T,Boettiger AN,Wysocka J
100-18B was used in In vitro experiments to provide mechanistic insights into architectural stripe formation and gene regulation over ultra-long genomic ranges.
Thu May 04 00:00:00 UTC 2023
Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.
Methods in molecular biology (Clifton, N.J.)
Chen SW,Wong YH
100-18B was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.
Mon Jun 12 00:00:00 UTC 2023
Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging.
Cell reports methods
LaLone V,Aizenshtadt A,Goertz J,Skottvoll FS,Mota MB,You J,Zhao X,Berg HE,Stokowiec J,Yu M,Schwendeman A,Scholz H,Wilson SR,Krauss S,Stevens MM
100-18B was used in In vitro experiments to develop an integrated bioanalytical methodology, qRamanomics, to qualify Raman spectral imaging as a tissue phantom calibrated tool for quantitative spatial chemotyping of major classes of biomolecules.
Mon Apr 24 00:00:00 UTC 2023
Methanol fixation is the method of choice for droplet-based single-cell transcriptomics of neural cells.
Communications biology
Gutiérrez-Franco A,Ake F,Hassan MN,Cayuela NC,Mularoni L,Plass M
100-18B was used in Cell Culture to perform a systematic comparison of preservation methods for droplet-based single-cell RNA-seq on neural and glial cells derived from induced pluripotent stem cells.
Mon May 15 00:00:00 UTC 2023
Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in the dystrophic muscle in Duchenne muscular dystrophy.
Life science alliance
Vu Hong A,Bourg N,Sanatine P,Poupiot J,Charton K,Gicquel E,Massourides E,Spinazzi M,Richard I,Israeli D
100-18B was used in Sample Preparation (FC/FACS) to provide insight into the mechanism of mitochondrial dysfunction in muscular dystrophy.
Sun Jan 01 00:00:00 UTC 2023
Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18.
Archiv der Pharmazie
Patberg M,Oniani T,Disse P,Peischard S,Vinnenberg L,Zobeiri M,Romanelli MN,Epping L,Wiendl H,Meuth SG,Hundehege P,Seebohm G,Budde T,Junker A
100-18B was used in Cell Culture to report the optimized synthetic route for the preparation of EC18 and its evaluation in three different pharmacological models, allowing us to assess its activity on cardiac function, thalamocortical neurons, and immune cells.
Thu Jun 01 00:00:00 UTC 2023
Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition.
Neuronal signaling
Rowland HA,Moxon SR,Corbett NJ,Hanson K,Fisher K,Kellett KAB,Hooper NM
100-18B was used in Cell Culture to assessed the contribution of the two key Aβ-degrading zinc metalloproteases, insulin-degrading enzyme (IDE) and neprilysin (NEP), to Aβ degradation in human induced pluripotent stem cell (iPSC)-derived cortical neurons.
Fri Dec 01 00:00:00 UTC 2023
Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets.
Molecular & cellular proteomics : MCP
Tshilenge KT,Aguirre CG,Bons J,Gerencser AA,Basisty N,Song S,Rose J,Lopez-Ramirez A,Naphade S,Loureiro A,Battistoni E,Milani M,Wehrfritz C,Holtz A,Hetz C,Mooney SD,Schilling B,Ellerby LM
100-18B was used in Cell Culture to define the proteome of human Huntington's disease patient-derived medium-spiny projection neurons.
Mon May 01 00:00:00 UTC 2023
Enhancing Transcriptional Reprogramming of Mesenchymal Glioblastoma with Grainyhead-like 2 and HDAC Inhibitors Leads to Apoptosis and Cell-Cycle Dysregulation.
Genes
Kotian S,Carnes RM,Stern JL
100-18B was used in Cell Culture to enhance the transcriptional reprogramming and apoptotic effects of HDAC inhibitors in Glioblastoma by introducing an epithelial transcription factor, Grainyhead-like 2 (GRHL2), to specifically counter the mesenchymal state.
Tue Sep 12 00:00:00 UTC 2023
3D human induced pluripotent stem cell-derived bioengineered skeletal muscles for tissue, disease and therapy modeling.
Nature protocols
Pinton L,Khedr M,Lionello VM,Sarcar S,Maffioletti SM,Dastidar S,Negroni E,Choi S,Khokhar N,Bigot A,Counsell JR,Bernardo AS,Zammit PS,Tedesco FS
100-18B was used in Cell Culture to provide examples of applications of this advanced platform for testing gene and cell therapies in vitro, as well as for in vivo studies, providing proof of principle of its potential as a tool to develop next-generation neuromuscular or musculoskeletal therapies.
Sat Apr 01 00:00:00 UTC 2023
Functional characterization of Alzheimer's disease genetic variants in microglia.
Nature genetics
Yang X,Wen J,Yang H,Jones IR,Zhu X,Liu W,Li B,Clelland CD,Luo W,Wong MY,Ren X,Cui X,Song M,Liu H,Chen C,Eng N,Ravichandran M,Sun Y,Lee D,Van Buren E,Jiang MZ,Chan CSY,Ye CJ,Perera RM,Gan L,Li Y,Shen Y
100-18B was used in In vitro experiments to show that AD variants exhibit allelic imbalance on target gene expression.
Sun Oct 01 00:00:00 UTC 2023
HSV-1 LAT Promoter Deletion Viruses Exhibit Strain-Specific and LAT-Dependent Epigenetic Regulation of Latent Viral Genomes in Human Neurons.
Journal of virology
Grams TR,Edwards TG,Bloom DC
100-18B was used in Cell Culture to highlight the need to account for strain-specific differences when characterizing the LAT's function and the dynamics of reactivation.
Tue Feb 28 00:00:00 UTC 2023
A 3D cell culture system for bioengineering human neuromuscular junctions to model ALS.
Frontiers in cell and developmental biology
Massih B,Veh A,Schenke M,Mungwa S,Seeger B,Selvaraj BT,Chandran S,Reinhardt P,Sterneckert J,Hermann A,Sendtner M,Lüningschrör P
100-18B was used in Cell Culture to present a human neuromuscular co-culture system consisting of induced pluripotent stem cell-derived motoneurons and 3D skeletal muscle tissue derived from myoblasts.
Wed Mar 13 00:00:00 UTC 2024
Generation and characterization of stable pig pregastrulation epiblast stem cell lines.
Cell research
Zhi M,Zhang J,Tang Q,Yu D,Gao S,Gao D,Liu P,Guo J,Hai T,Gao J,Cao S,Zhao Z,Li C,Weng X,He M,Chen T,Wang Y,Long K,Jiao D,Li G,Zhang J,Liu Y,Lin Y,Pang D,Zhu Q,Chen N,Huang J,Chen X,Yao Y,Yang J,Xie Z,Huang X,Liu M,Zhang R,Li Q,Miao Y,Tian J,Huang X,Ouyang H,Liu B,Xie W,Zhou Q,Wei H,Liu Z,Zheng C,Li M,Han J
Fri Apr 01 00:00:00 UTC 2022
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.
Cell research
Gu Y,Cao J,Zhang X,Gao H,Wang Y,Wang J,He J,Jiang X,Zhang J,Shen G,Yang J,Zheng X,Hu G,Zhu Y,Du S,Zhu Y,Zhang R,Xu J,Lan F,Qu D,Xu G,Zhao Y,Gao D,Xie Y,Luo M,Lu Z
Sat Jan 01 00:00:00 UTC 2022
Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer.
Cancer discovery
Yi E,Gujar AD,Guthrie M,Kim H,Zhao D,Johnson KC,Amin SB,Costa ML,Yu Q,Das S,Jillette N,Clow PA,Cheng AW,Verhaak RGW
100-18B was used in Cell Culture to uncover fundamental ecDNA properties by tracking ecDNAs in live cells, highlighting uneven and random segregation and ecDNA hubs that drive cargo gene transcription.
Tue Feb 01 00:00:00 UTC 2022
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.
The Journal of experimental medicine
Khalil BD,Sanchez R,Rahman T,Rodriguez-Tirado C,Moritsch S,Martinez AR,Miles B,Farias E,Mezei M,Nobre AR,Singh D,Kale N,Sproll KC,Sosa MS,Aguirre-Ghiso JA
Mon Jan 03 00:00:00 UTC 2022
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy.
The Journal of experimental medicine
Khalil BD,Sanchez R,Rahman T,Rodriguez-Tirado C,Moritsch S,Martinez AR,Miles B,Farias E,Mezei M,Nobre AR,Singh D,Kale N,Sproll KC,Sosa MS,Aguirre-Ghiso JA
Mon Jan 03 00:00:00 UTC 2022
Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.
Hepatology (Baltimore, Md.)
Amarachintha SP,Mourya R,Ayabe H,Yang L,Luo Z,Li X,Thanekar U,Shivakumar P,Bezerra JA
Sat Jan 01 00:00:00 UTC 2022
Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors.
Nature protocols
Ackermann M,Rafiei Hashtchin A,Manstein F,Carvalho Oliveira M,Kempf H,Zweigerdt R,Lachmann N
Tue Feb 01 00:00:00 UTC 2022
Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance.
Proceedings of the National Academy of Sciences of the United States of America
Page SC,Sripathy SR,Farinelli F,Ye Z,Wang Y,Hiler DJ,Pattie EA,Nguyen CV,Tippani M,Moses RL,Chen HY,Tran MN,Eagles NJ,Stolz JM,Catallini JL,Soudry OR,Dickinson D,Berman KF,Apud JA,Weinberger DR,Martinowich K,Jaffe AE,Straub RE,Maher BJ
Tue Jan 18 00:00:00 UTC 2022
Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions.
Cell systems
Sáez M,Blassberg R,Camacho-Aguilar E,Siggia ED,Rand DA,Briscoe J
100-18B was used in Cell Culture to investigate the effectiveness of the Waddington landscape on developing tissues.
Wed Jan 19 00:00:00 UTC 2022
Spinal dI4 Interneuron Differentiation From Human Pluripotent Stem Cells.
Frontiers in molecular neuroscience
Xu J,Huang LJ,Fang Z,Luo HM,Chen YQ,Li YJ,Gong CZ,Chen H
100-18B was used in Cell Culture to investigate spinal interneuron targeting in spinal cord injury treatment.
Fri Apr 29 00:00:00 UTC 2022
Fibroadipogenic Progenitors Regulate the Basal Proliferation of Satellite Cells and Homeostasis of Pharyngeal Muscles via HGF Secretion.
Frontiers in cell and developmental biology
Kim E,Wu F,Lim D,Zeuthen C,Zhang Y,Allen J,Muraine L,Trollet C,Vest KE,Choo HJ
100-18B was used in Sample Preparation (FC/FACS) to study gives new insights to explain the distinctive SC activity of pharyngeal muscles.
Sat Nov 04 00:00:00 UTC 2023
β-elemene suppresses tumor metabolism and stem cell-like properties of non-small cell lung cancer cells by regulating PI3K/AKT/mTOR signaling.
American journal of cancer research
Cheng G,Li L,Li Q,Lian S,Chu H,Ding Y,Li C,Leng Y
100-18B was used in Cell Culture to show that β-elemene is an effective anticancer adjuvant agent with potential clinical applications.
Sat Jul 16 00:00:00 UTC 2022
The Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness.
Frontiers in oncology
Schäfer A,Evers L,Meier L,Schlomann U,Bopp MHA,Dreizner GL,Lassmann O,Ben Bacha A,Benescu AC,Pojskic M,Preußer C,von Strandmann EP,Carl B,Nimsky C,Bartsch JW
100-18B was used in In vitro experiments to study whether microRNA (miRNA) expression levels could be regulators of MMP9 expression in glioblastoma (GBM) cells expressing ADAM8.
Tue Apr 05 00:00:00 UTC 2022
Enhanced hippocampal neurogenesis mediated by PGC-1α-activated OXPHOS after neonatal low-dose Propofol exposure.
Frontiers in aging neuroscience
Chen K,Lu D,Yang X,Zhou R,Lan L,Wu Y,Wang C,Xu X,Jiang MH,Wei M,Feng X
100-18B was used in Cell Culture to investigate effects of Propofol anaesthetic on developing brains, modeled in mice.
Tue Aug 16 00:00:00 UTC 2022
Tumor Necrosis Factor-α (TNFα) Stimulate Triple-Negative Breast Cancer Stem Cells to Promote Intratumoral Invasion and Neovasculogenesis in the Liver of a Xenograft Model.
Biology
Narasimhan H,Ferraro F,Bleilevens A,Weiskirchen R,Stickeler E,Maurer J
100-18B was used in Cell Culture to investigate mechanisms of cancer stem cells and their role in cancer progression.
Sun Oct 09 00:00:00 UTC 2022
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Fluids and barriers of the CNS
Williams LM,Fujimoto T,Weaver RR,Logsdon AF,Evitts KM,Young JE,Banks WA,Erickson MA
100-18B was used in Cell Culture to study responses to disease-relevant stimuli in proliferating vs. more quiescent endothelial cell states.
Sat Feb 05 00:00:00 UTC 2022
Nuclear receptor ligand screening in an iPSC-derived in vitro blood-brain barrier model identifies new contributors to leptin transport.
Fluids and barriers of the CNS
Shi Y,Kim H,Hamann CA,Rhea EM,Brunger JM,Lippmann ES
100-18B was used in Cell Culture to study the use of a human induced pluripotent stem cell (iPSC)-derived blood-brain barrier (BBB) model to explore mechanisms that influence leptin transport.
Wed Sep 21 00:00:00 UTC 2022
Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5.
Nature cancer
Sun Y,Yan K,Wang Y,Xu C,Wang D,Zhou W,Guo S,Han Y,Tang L,Shao Y,Shan S,Zhang QC,Tang Y,Zhang L,Xi Q
100-18B was used in Cell Culture to show how BMP signaling impacts diffuse intrinsic pontine glioma (DIPG) and identifies the potent antitumor efficacy of Dacinostat for DIPG.
Thu Sep 01 00:00:00 UTC 2022
Improving the Safety of Mesenchymal Stem Cell-Based Ex Vivo Therapy Using Herpes Simplex Virus Thymidine Kinase.
Molecules and cells
Bashyal N,Lee TY,Chang DY,Jung JH,Kim MG,Acharya R,Kim SS,Oh IH,Suh-Kim H
100-18B was used in Cell Culture to propose genetic modification with HSV-TK(A168H) makes allogeneic MSC-based ex vivo therapy safer by eliminating transplanted cells during SAEs such as uncontrolled cell proliferation.
Sun Jul 31 00:00:00 UTC 2022
Transfer of photothermal nanoparticles using stem cell derived small extracellular vesicles for in vivo treatment of primary and multinodular tumours.
Journal of extracellular vesicles
Sancho-Albero M,Encinas-Giménez M,Sebastián V,Pérez E,Luján L,Santamaría J,Martin-Duque P
Tue Mar 01 00:00:00 UTC 2022
Divergence between Neuronal and Oligodendroglial Cell Fate, in Postnatal Brain Neural Stem Cells, Leads to Divergent Properties in Polymorphic In Vitro Assays.
Cells
Anesti M,Magkafa S,Prantikou E,Kazanis I
100-18B was used in Cell Culture to create polymorphic neural stem cell cultures and allow cells to progress towards the neuronal and the oligodendroglial lineage.
Wed May 25 00:00:00 UTC 2022
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens.
Cell stem cell
Karvas RM,Khan SA,Verma S,Yin Y,Kulkarni D,Dong C,Park KM,Chew B,Sane E,Fischer LA,Kumar D,Ma L,Boon ACM,Dietmann S,Mysorekar IU,Theunissen TW
100-18B was used in Cell Culture to demonstrate that SC-TOs exhibit selective vulnerability to emerging pathogens (SARS-CoV-2 and Zika virus), which correlates with expression levels of their respective entry factors.
Thu May 05 00:00:00 UTC 2022
Serum-Free Production of Three-Dimensional Hepatospheres from Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Rashidi H,Hay DC
100-18B was used in Cell Culture to describe a methodology to generate 3D hepatospheres from human pluripotent stem cells using defined and commercially available reagents.
Thu Jun 23 00:00:00 UTC 2022
Cooperative ETS Transcription Factors Enforce Adult Endothelial Cell Fate and Cardiovascular Homeostasis.
Nature cardiovascular research
Gomez-Salinero JM,Itkin T,Houghton S,Badwe C,Lin Y,Kalna V,Dufton N,Peghaire CR,Yokoyama M,Wingo M,Lu TM,Li G,Xiang JZ,Hsu YS,Redmond D,Schreiner R,Birdsey GM,Randi AM,Rafii S
100-18B was used in Cell Culture to show that maintenance of endothelial cell fate and function are linked and active processes, which depend on the constitutive cooperativity of only two ETS-transcription factors ERG and Fli1.
Sat Oct 01 00:00:00 UTC 2022
Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium.
Cell & bioscience
Yuan Y,Chen H,Ou S,Cai B,Zhang R,Qin Y,Pan M,Cao S,Pei D,Hou FF
100-18B was used in In vitro experiments to evaluate the use of reprogramming mitochondria-rich hUCs to generate mitochondria-rich kidney organoids.
Sat Oct 15 00:00:00 UTC 2022
Induced pluripotent stem cell-derived cells model brain microvascular endothelial cell glucose metabolism.
Fluids and barriers of the CNS
Weber CM,Moiz B,Zic SM,Alpízar Vargas V,Li A,Clyne AM
100-18B was used in Cell Culture to suggest that hiBMEC can be used to model cerebral vascular glucose metabolism, which expands their use beyond barrier models.
Fri Dec 09 00:00:00 UTC 2022
Breaking constraint of mammalian axial formulae.
Nature communications
Hauswirth GM,Garside VC,Wong LSF,Bildsoe H,Manent J,Chang YC,Nefzger CM,Firas J,Chen J,Rossello FJ,Polo JM,McGlinn E
Tue Jan 11 00:00:00 UTC 2022
Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Scientific reports
Zywitza V,Rusha E,Shaposhnikov D,Ruiz-Orera J,Telugu N,Rishko V,Hayashi M,Michel G,Wittler L,Stejskal J,Holtze S,Göritz F,Hermes R,Wang J,Izsvák Z,Colleoni S,Lazzari G,Galli C,Hildebrandt TB,Hayashi K,Diecke S,Drukker M
100-18B was used in Cell Culture to study rescuing the northern white rhinoceros (NWR) functionally extinct species using induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Tue Mar 08 00:00:00 UTC 2022
Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
Scientific reports
Zywitza V,Rusha E,Shaposhnikov D,Ruiz-Orera J,Telugu N,Rishko V,Hayashi M,Michel G,Wittler L,Stejskal J,Holtze S,Göritz F,Hermes R,Wang J,Izsvák Z,Colleoni S,Lazzari G,Galli C,Hildebrandt TB,Hayashi K,Diecke S,Drukker M
100-18B was used in Cell Culture to study rescuing the northern white rhinoceros (NWR) functionally extinct species using induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Tue Mar 08 00:00:00 UTC 2022
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease.
NPJ Regenerative medicine
Yun W,Choi KA,Hwang I,Zheng J,Park M,Hong W,Jang AY,Kim JH,Choi W,Kim DS,Kim IY,Kim YJ,Liu Y,Yoon BS,Park G,Song G,Hong S,You S
Thu Jan 13 00:00:00 UTC 2022
Transcriptomic analysis of a 3D blood-brain barrier model exposed to disturbed fluid flow.
Fluids and barriers of the CNS
Bouhrira N,DeOre BJ,Tran KA,Galie PA
100-18B was used in Cell Culture to study the importance of flow regimes exhibiting spatial and temporal heterogeneous shear stress profiles on cell-matrix interaction in endothelial cells lining the blood-brain barrier, and identify lumican as a contributor to the formation and maintenance of an intact barrier.
Thu Nov 24 00:00:00 UTC 2022
Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma.
Nature communications
Aubin RG,Troisi EC,Montelongo J,Alghalith AN,Nasrallah MP,Santi M,Camara PG
100-18B was used in Cell Culture to investigate gene expression of ependymoma tumorigenic mechanisms to discover potential treatments.
Fri Jul 08 00:00:00 UTC 2022
Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice.
Nature communications
Zhou T,Li Y,Li X,Zeng F,Rao Y,He Y,Wang Y,Liu M,Li D,Xu Z,Zhou X,Du S,Niu F,Peng J,Mei X,Ji SJ,Shu Y,Lu W,Guo F,Wu T,Yuan TF,Mao Y,Peng B
100-18B was used in Cell Culture to elucidate that removal of micropglial debris is astrocyte-depnedant, involving C4b opsonization followed by RUBICON-dependent LC3-associated phagocytosis (LAP) of engulfed fragments in a form of noncanonical autophagy.
Mon Oct 24 00:00:00 UTC 2022
Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2.
Stem cells international
Wu L,Ye S,Yao Y,Zhang C,Liu W
100-18B was used in Cell Culture to provide a new understanding of oral squamous cell carcinoma-cancer stem cell molecular mechanisms and suggest a potential therapeutic strategy for oral squamous cell carcinoma through targeting cancer stem cell-small extracellular vesicles and M2-tumor-associated macrophages.
Sat Dec 10 00:00:00 UTC 2022
Ferroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke.
Cell death & disease
Shen D,Wu W,Liu J,Lan T,Xiao Z,Gai K,Hu L,Luo Z,Wei C,Wang X,Lu Y,Wang Y,Zhang C,Wang P,Zuo Z,Yang F,Li Q
100-18B was used in Cell Culture to demonstrate that ferroptosis is an essential form of OPC cell death in hemorrhagic stroke, and rescuing ferroptotic OPCs could serve as a therapeutic target for stroke and related diseases.
Wed Mar 23 00:00:00 UTC 2022
A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice.
Communications biology
Hattori EY,Masuda T,Mineharu Y,Mikami M,Terada Y,Matsui Y,Kubota H,Matsuo H,Hirata M,Kataoka TR,Nakahata T,Ikeda S,Miyamoto S,Sugiyama H,Arakawa Y,Kamikubo Y
100-18B was used in Cell Culture to study how RUNX1 downregulates p21 by enhancing expressions of BIRC5 and PIF1, conferring anti-apoptotic properties on glioblastoma.
Fri Sep 09 00:00:00 UTC 2022
A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer.
Cell reports methods
Shimada H,Sato Y,Sasaki T,Shimozawa A,Imaizumi K,Shindo T,Miyao S,Kiyama K,Kondo T,Shibata S,Ishii S,Kuromitsu J,Aoyagi H,Ito D,Okano H
100-18B was used in Cell Culture to show that this model can be used as a platform for investigating pathogenetic mechanisms and evaluation of target molecules for drug discovery for tauopathy.
Mon Sep 19 00:00:00 UTC 2022
Scalable Generation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Methods in molecular biology (Clifton, N.J.)
Hamad S,Derichsweiler D,Hescheler J,Pfannkuche K
100-18B was used in Cell Culture to describe a refined protocol for scalable generation of hiPSC-CMs that manipulates porcupine and tankyrase sub-pathways of Wnt signaling for tight inhibition of non-canonical Wnt signaling.
Thu Jun 23 00:00:00 UTC 2022
Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.
Nature aging
Wang X,Shelton SD,Bordieanu B,Frank AR,Yi Y,Venigalla SSK,Gu Z,Lenser NP,Glogauer M,Chandel NS,Zhao H,Zhao Z,McFadden DG,Mishra P
100-18B was used in Cell Culture to propose a model in which ETC-dysfunctional MuSCs are removed from the stem cell compartment by fusing with differentiated tissue.
Tue Jul 18 00:00:00 UTC 2023
The guanine nucleotide exchange factor Vav3 intervenes in the migration pathway of oligodendrocyte precursor cells on tenascin-C.
Frontiers in cell and developmental biology
Schäfer I,Bauch J,Wegrzyn D,Roll L,van Leeuwen S,Jarocki A,Faissner A
100-18B was used in Cell Culture to provide novel insights into the control of Oligodendrocyte precursor cell migration, which could be useful for further understanding of the complex differentiation and myelination process.
Thu Dec 22 00:00:00 UTC 2022
Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1.
Cell reports
Han Y,Villarreal-Ponce A,Gutierrez G,Nguyen Q,Sun P,Wu T,Sui B,Berx G,Brabletz T,Kessenbrock K,Zeng YA,Watanabe K,Dai X
100-18B was used in Cell Culture to show that Zeb1 is a transcriptional regulator that maintains both basal cell fate and stem cell quiescence, and it functions in part through suppressing Wnt signaling.
Tue Jan 11 00:00:00 UTC 2022
Geometric Control of Cell Behavior by Biomolecule Nanodistribution.
ACS biomaterials science & engineering
Pospíšil J,Hrabovský M,Bohačiaková D,Hovádková Z,Jurásek M,Mlčoušková J,Paruch K,Nevolová Š,Damborsky J,Hampl A,Jaros J
100-18B was used in Cell Culture to use electron-beam lithography (EBL) for cell-interaction studies by coating cell-culture-relevant material with electron-conductive indium tin oxide, which formed nanopatterns of complex nanohexagonal structures over a large area.
Mon Nov 14 00:00:00 UTC 2022
Generation of Cardiomyocytes and Endothelial Cells from Human iPSCs by Chemical Modulation of Wnt Signaling.
Methods in molecular biology (Clifton, N.J.)
Joachim A,Ye S,Zhao MT
100-18B was used in Cell Culture to provide protocols to generate iPSC-CMs and iPSC-ECs using small molecule-mediated monolayer differentiation.
Wed Jul 06 00:00:00 UTC 2022
Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress.
Cell death & disease
Al Haq AT,Tseng HY,Chen LM,Wang CC,Hsu HL
Tue Jan 11 00:00:00 UTC 2022
MiR-183-5p-PNPT1 Axis Enhances Cisplatin-induced Apoptosis in Bladder Cancer Cells.
Current medical science
Hu QG,Yang Z,Chen JW,Kazobinka G,Tian L,Li WC
100-18B was used in Cell Culture to provide new insight into the mechanisms underlying intrinsic apoptosis in BC, suggesting that the miR-183-5p-PNPT1 regulatory axis regulates the apoptosis of BC cells and might represent a potential therapeutic avenue for the treatment of BC.
Mon Aug 01 00:00:00 UTC 2022
SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington's disease.
NPJ Regenerative medicine
Park HJ,Han A,Kim JY,Choi J,Bae HS,Cho GB,Shin H,Shin EJ,Lee KI,Kim S,Lee JY,Song J
Wed Jan 19 00:00:00 UTC 2022
Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations.
Cell cycle (Georgetown, Tex.)
Kristiansen CK,Chen A,Høyland LE,Ziegler M,Sullivan GJ,Bindoff LA,Liang KX
100-18B was used in Cell Culture to show that while ESCs and iPSCs are similar at the pluripotent stage, differences in mitochondrial function may develop during differentiation and must be taken into account when extrapolating results from different cell types.
Sat Oct 01 00:00:00 UTC 2022
16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis.
iScience
Tomasello DL,Kim JL,Khodour Y,McCammon JM,Mitalipova M,Jaenisch R,Futerman AH,Sive H
100-18B was used in Cell Culture to examine the function of the FAM57B gene to further assess the predicted connection with 16p11.2 deletion syndrome.
Fri Jan 21 00:00:00 UTC 2022
Establishment of autaptic culture with human-induced pluripotent stem cell-derived astrocytes.
iScience
Uchino K,Tanaka Y,Kawaguchi S,Kubota K,Watanabe T,Katsurabayashi S,Hirose S,Iwasaki K
100-18B was used in Cell Culture to find a significantly higher Na+ current amplitude, membrane capacitance, and number of synapses, as well as longer dendrites, in HiAACs compared with neuron monocultures and show that the system can facilitate the study of CNS diseases and advance the development of drugs targeting glial cells.
Fri Aug 19 00:00:00 UTC 2022
Lrig1 regulates the balance between proliferation and quiescence in glioblastoma stem cells.
Frontiers in cell and developmental biology
Ferguson KM,Blin C,Alfazema N,Gangoso E,Pollard SM,Marques-Torrejon MA
100-18B was used in In vitro experiments to highlight important roles for Lrig1 in controlling responsiveness to both epidermal growth factor receptor and BMPR signalling, and hence the proportions of quiescent and proliferative subpopulations in GBMs.
Sat Feb 10 00:00:00 UTC 2024
The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.
eLife
Niu F,Han P,Zhang J,She Y,Yang L,Yu J,Zhuang M,Tang K,Shi Y,Yang B,Liu C,Peng B,Ji SJ
100-18B was used in Cell Culture to show that the N6-methyladenosine (m6A) reader YTHDF2 is highly expressed in mouse retinal ganglion cells.
Fri Feb 18 00:00:00 UTC 2022
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy.
Life science alliance
Rusilowicz-Jones EV,Barone FG,Lopes FM,Stephen E,Mortiboys H,Urbé S,Clague MJ
100-18B was used in Cell Culture to characterize benzosulphonamide molecule compound 39 that has previously been reported to inhibit USP30 in an in vitro enzymatic assay to providethe first pharmacological intervention with a synthetic molecule to enhance peroxisome turnover.
Tue Feb 01 00:00:00 UTC 2022
Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function.
Current protocols
Ngan SY,Quach HT,Laselva O,Huang EN,Mangos M,Xia S,Bear CE,Wong AP
Sat Jan 01 00:00:00 UTC 2022
Slit2 signaling stimulates Ewing sarcoma growth.
Genes & cancer
Suvarna K,Jayabal P,Ma X,Shiio Y
100-18B was used in In vitro experiments to report that EWS::FLI1 induces the expression of Slit2, the ligand of Roundabout (Robo) receptors implicated in axon guidance and multiple other developmental processes.
Wed Dec 21 00:00:00 UTC 2022
Matrix enrichment by black phosphorus improves ionization and reproducibility of mass spectrometry of intact cells, peptides, and amino acids.
Scientific reports
Mandal G,Moráň L,Pečinka L,Vaňhara P,Havel J
Fri Jan 21 00:00:00 UTC 2022
Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells.
Stem cell research & therapy
Song C,Wang L,Li Q,Liao B,Qiao W,Li Q,Dong N,Li L
100-18B was used in In vitro experiments to generate HLA-matched iPSCs based on patient's HLA genotyping by HLA exchanging approach to express the required HLA allele.
Wed Feb 02 00:00:00 UTC 2022
Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease.
Cell stem cell
Jin M,Xu R,Wang L,Alam MM,Ma Z,Zhu S,Martini AC,Jadali A,Bernabucci M,Xie P,Kwan KY,Pang ZP,Head E,Liu Y,Hart RP,Jiang P
100-18B was used in Cell Culture to provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.
Thu Jul 07 00:00:00 UTC 2022
RB1 loss triggers dependence on ESRRG in retinoblastoma.
Science advances
Field MG,Kuznetsoff JN,Zhang MG,Dollar JJ,Durante MA,Sayegh Y,Decatur CL,Kurtenbach S,Pelaez D,Harbour JW
100-18B was used in Cell Culture to analyze 103 whole exomes, 20 whole transcriptomes, 5 single-cell transcriptomes, and 4 whole genomes from primary Retinoblastoma (Rb) tumours to identify previously unknown Rb dependencies.
Fri Aug 19 00:00:00 UTC 2022
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction.
Cell stem cell
Gómez-Salinero JM,Izzo F,Lin Y,Houghton S,Itkin T,Geng F,Bram Y,Adelson RP,Lu TM,Inghirami G,Xiang JZ,Lis R,Redmond D,Schreiner R,Rabbany SY,Landau DA,Schwartz RE,Rafii S
100-18B was used in Cell Culture to study heterogeneity of hepatic vascular cells during mouse development through functional and single-cell RNA-sequencing.
Thu Apr 07 00:00:00 UTC 2022
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction.
Cell stem cell
Gómez-Salinero JM,Izzo F,Lin Y,Houghton S,Itkin T,Geng F,Bram Y,Adelson RP,Lu TM,Inghirami G,Xiang JZ,Lis R,Redmond D,Schreiner R,Rabbany SY,Landau DA,Schwartz RE,Rafii S
100-18B was used in Cell Culture to study heterogeneity of hepatic vascular cells during mouse development through functional and single-cell RNA-sequencing.
Thu Apr 07 00:00:00 UTC 2022
Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma.
Cancer immunology research
Xuan W,Hsu WH,Khan F,Dunterman M,Pang L,Wainwright DA,Ahmed AU,Heimberger AB,Lesniak MS,Chen P
100-18B was used in Cell Culture to show that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 (BMAL1) in glioma stem cells (GSC) drive immunosuppression in glioblastoma.
Fri Jun 03 00:00:00 UTC 2022
Microarrayed human bone marrow organoids for modeling blood stem cell dynamics.
APL bioengineering
Giger S,Hofer M,Miljkovic-Licina M,Hoehnel S,Brandenberg N,Guiet R,Ehrbar M,Kleiner E,Gegenschatz-Schmid K,Matthes T,Lutolf MP
100-18B was used in Sample Preparation (FC/FACS) to propose an organoid system as a preclinical model for pharmacokinetic assays and toxicity studies of novel drugs in a bone marrow niche-mimicking 3D environment.
Thu Sep 01 00:00:00 UTC 2022
Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.
STAR protocols
Martinez-Silgado A,Yousef Yengej FA,Puschhof J,Geurts V,Boot C,Geurts MH,Rookmaaker MB,Verhaar MC,Beumer J,Clevers H
100-18B was used in In vitro experiments to investigate the effects of BMP agonists on differentiation of human small intestinal organoids.
Fri Sep 16 00:00:00 UTC 2022
Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration.
Scientific reports
Sahu S,Albaugh ME,Martin BK,Patel NL,Riffle L,Mackem S,Kalen JD,Sharan SK
100-18B was used in Cell Culture to conclude that understanding the function of growth factors in organoids provides novel insights to cell proliferation, stem cell maintenance, tissue repair and organ regeneration in vivo.
Tue May 03 00:00:00 UTC 2022
Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select.
Nature genetics
Niu Y,Ferreira Azevedo CA,Li X,Kamali E,Haagen Nielsen O,Storgaard Sørensen C,Frödin M
100-18B was used in Tissue/organ culture to present clustered regularly interspaced short palindromic repeat (CRISPR)-SelectTIME, CRISPR-SelectSPACE and CRISPR-SelectSTATE, a set of flexible knock-in assays that introduce a genetic variant in a cell population and track its absolute frequencies relative to an internal, neutral control mutation as a function of time, space or a cell state measurable by flow cytometry.
Thu Dec 01 00:00:00 UTC 2022
Generation, expansion, and drug treatment of hematopoietic progenitor cells derived from human iPSCs.
STAR protocols
Dannenmann B,Skokowa J
100-18B was used in Cell Culture to provide protocol for generation of HPCs from iPSCs followed by HPC expansion on Sl/Sl feeder cells expressing FLT3L.
Fri Jun 17 00:00:00 UTC 2022
Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target.
Nature communications
Abdelfattah N,Kumar P,Wang C,Leu JS,Flynn WF,Gao R,Baskin DS,Pichumani K,Ijare OB,Wood SL,Powell SZ,Haviland DL,Parker Kerrigan BC,Lang FF,Prabhu SS,Huntoon KM,Jiang W,Kim BYS,George J,Yun K
100-18B was used in Cell Culture to identify molecular signatures for nine distinct myeloid cell subtypes, of which five are independent prognostic indicators of glioma patient survival.
Wed Feb 09 00:00:00 UTC 2022
Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Rios Garcia M,Meissburger B,Chan J,de Guia RM,Mattijssen F,Roessler S,Birkenfeld AL,Raschzok N,Riols F,Tokarz J,Giroud M,Gil Lozano M,Hartleben G,Nawroth P,Haid M,López M,Herzig S,Berriel Diaz M
100-18B was used in Cell Culture to show that depletion of Trip13 results in mitotic cell death through a combined mechanism employing Plin2 and linking lipid metabolism to aberrant mitosis.
Sat Oct 01 00:00:00 UTC 2022
Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments.
eLife
Dady A,Davidson L,Halley PA,Storey KG
100-18B was used in Cell Culture to describe a novel in vitro human neural-rosette assay that recapitulates dorsal spinal cord differentiation but proceeds more rapidly than in the human embryo, suggesting that it lacks endogenous signalling dynamics and demonstrate that intrinsic properties limit human differentiation pace, and that timely extrinsic signals are required for progression through an intrinsic human neural differentiation programme.
Mon Feb 21 00:00:00 UTC 2022
Routine culture and study of adult human brain cells from neurosurgical specimens.
Nature protocols
Park TI,Smyth LCD,Aalderink M,Woolf ZR,Rustenhoven J,Lee K,Jansson D,Smith A,Feng S,Correia J,Heppner P,Schweder P,Mee E,Dragunow M
100-18B was used in Cell Culture to present a protocol to enable the investigation of human brain cells and facilitate translation of neuroscience research to the clinic.
Tue Feb 01 00:00:00 UTC 2022
HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex.
Nature communications
Leisegang MS,Bains JK,Seredinski S,Oo JA,Krause NM,Kuo CC,Günther S,Sentürk Cetin N,Warwick T,Cao C,Boos F,Izquierdo Ponce J,Haydar S,Bednarz R,Valasarajan C,Fuhrmann DC,Preussner J,Looso M,Pullamsetti SS,Schulz MH,Jonker HRA,Richter C,Rezende F,Gilsbach R,Pflüger-Müller B,Wittig I,Grummt I,Ribarska T,Costa IG,Schwalbe H,Brandes RP
100-18B was used in In vitro experiments to investigate the effects and interactions of endogenous HIF1α-AS1 on cellular functions using human endothelial cells.
Wed Nov 02 00:00:00 UTC 2022
A stress-reduced passaging technique improves the viability of human pluripotent cells.
Cell reports methods
Takahashi K,Okubo C,Nakamura M,Iwasaki M,Kawahara Y,Tabata T,Miyamoto Y,Woltjen K,Yamanaka S
100-18B was used in Cell Culture to describe an improved method for the subculture of human pluripotent stem cells (PSCs) which enhances the viability of human PSCs by lowering DNA damage and apoptosis, resulting in more efficient and reproducible downstream applications such as gene editing and directed differentiation.
Mon Feb 28 00:00:00 UTC 2022
Large-Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors.
Advanced healthcare materials
Ho DLL,Lee S,Du J,Weiss JD,Tam T,Sinha S,Klinger D,Devine S,Hamfeldt A,Leng HT,Herrmann JE,He M,Fradkin LG,Tan TK,Standish D,Tomasello P,Traul D,Dianat N,Ladi R,Vicard Q,Katikireddy K,Skylar-Scott MA
100-18B was used in Cell Culture to demonstrate an optimized suspension culture-to-3D bioprinting pipeline that enables a sustainable approach to billion cell-scale organ engineering.
Thu Dec 01 00:00:00 UTC 2022
Optimized Decellularization Protocol for Large Peripheral Nerve Segments: Towards Personalized Nerve Bioengineering.
Bioengineering (Basel, Switzerland)
Hopf A,Al-Bayati L,Schaefer DJ,Kalbermatten DF,Guzman R,Madduri S
100-18B was used in Cell Culture to develop a new method of decellularizing large-diameter nerves suitable for human transplantation.
Wed Aug 24 00:00:00 UTC 2022
Ets1 mediates sorafenib resistance by regulating mitochondrial ROS pathway in hepatocellular carcinoma.
Cell death & disease
Vishnoi K,Ke R,Viswakarma N,Srivastava P,Kumar S,Das S,Singh SK,Principe DR,Rana A,Rana B
100-18B was used in Cell Culture to indicate the activation of a novel Ets-1-GPX2 signaling axis in soraR cells, targeting which might successfully antagonize resistance and increase efficacy.
Mon Jul 04 00:00:00 UTC 2022
CPEB1 directs muscle stem cell activation by reprogramming the translational landscape.
Nature communications
Zeng W,Yue L,Lam KSW,Zhang W,So WK,Tse EHY,Cheung TH
100-18B was used in Cell Culture to characterize CPEB1 as a key regulator to reprogram the translational landscape directing SC activation and subsequent proliferation.
Thu Feb 17 00:00:00 UTC 2022
Veteran-derived cerebral organoids display multifaceted pathological defects in studies on Gulf War Illness.
Frontiers in cellular neuroscience
Yates PL,Case K,Sun X,Sullivan K,Baas PW,Qiang L
100-18B was used in Cell Culture to suggest that veteran-derived human cerebral organoids not only can be used as an innovative human model to uncover the cellular responses to GW toxicants but can also serve as a platform for developing personalized medicine approaches for the veterans.
Wed Jan 11 00:00:00 UTC 2023
The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization.
iScience
Kase Y,Sato T,Okano Y,Okano H
100-18B was used in Cell Culture to investigate the effects and mechanisms involved with GADD45G on human neurons.
Fri Apr 15 00:00:00 UTC 2022
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states.
Nature communications
Song H,Weinstein HNW,Allegakoen P,Wadsworth MH,Xie J,Yang H,Castro EA,Lu KL,Stohr BA,Feng FY,Carroll PR,Wang B,Cooperberg MR,Shalek AK,Huang FW
Mon Jan 10 00:00:00 UTC 2022
Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development.
iScience
Trinh LT,Osipovich AB,Sampson L,Wong J,Wright CVE,Magnuson MA
100-18B was used in Cell Culture to study the genetic basis for the expression of multiple Sox17 mRNA forms using CRISPR/Cas9 mutagenesis of two evolutionarily conserved promoter regions (CRs).
Fri Sep 16 00:00:00 UTC 2022
Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.
Cell reports
Devoucoux M,Fort V,Khelifi G,Xu J,Alerasool N,Galloy M,Wong N,Bourriquen G,Fradet-Turcotte A,Taipale M,Hope K,Hussein SMI,Côté J
100-18B was used in In vitro experiments to indicate that the ZMYND11-MBTD1 fusion functions primarily by mistargeting the NuA4/TIP60 complex to the body of genes, altering normal transcription of specific genes, likely driving oncogenesis in part through the Myc regulatory network.
Tue Jun 14 00:00:00 UTC 2022
Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids.
Frontiers in molecular neuroscience
Zang Z,Yin H,Du Z,Xie R,Yang L,Cai Y,Wang L,Zhang D,Li X,Liu T,Gong H,Gao J,Yang H,Warner M,Gustafsson JA,Xu H,Fan X
100-18B was used in Cell Culture to establish the use of dorsal forebrain organoids as an effective platform for modeling Valproic acid-induced teratogenic pathways involved in the cortical neurogenesis and outer radial glia-like cells output, which might contribute to autism spectrum disorder pathogenesis in the developing brain.
Wed Dec 21 00:00:00 UTC 2022
ecDNA hubs drive cooperative intermolecular oncogene expression.
Nature
Hung KL,Yost KE,Xie L,Shi Q,Helmsauer K,Luebeck J,Schöpflin R,Lange JT,Chamorro González R,Weiser NE,Chen C,Valieva ME,Wong IT,Wu S,Dehkordi SR,Duffy CV,Kraft K,Tang J,Belk JA,Rose JC,Corces MR,Granja JM,Li R,Rajkumar U,Friedlein J,Bagchi A,Satpathy AT,Tjian R,Mundlos S,Bafna V,Henssen AG,Mischel PS,Liu Z,Chang HY
Wed Dec 01 00:00:00 UTC 2021
An early cell shape transition drives evolutionary expansion of the human forebrain.
Cell
Benito-Kwiecinski S,Giandomenico SL,Sutcliffe M,Riis ES,Freire-Pritchett P,Kelava I,Wunderlich S,Martin U,Wray GA,McDole K,Lancaster MA
Thu Apr 15 00:00:00 UTC 2021
An early cell shape transition drives evolutionary expansion of the human forebrain.
Cell
Benito-Kwiecinski S,Giandomenico SL,Sutcliffe M,Riis ES,Freire-Pritchett P,Kelava I,Wunderlich S,Martin U,Wray GA,McDole K,Lancaster MA
Thu Apr 15 00:00:00 UTC 2021
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Cell
Gangoso E,Southgate B,Bradley L,Rus S,Galvez-Cancino F,McGivern N,Güç E,Kapourani CA,Byron A,Ferguson KM,Alfazema N,Morrison G,Grant V,Blin C,Sou I,Marques-Torrejon MA,Conde L,Parrinello S,Herrero J,Beck S,Brandner S,Brennan PM,Bertone P,Pollard JW,Quezada SA,Sproul D,Frame MC,Serrels A,Pollard SM
Thu Apr 29 00:00:00 UTC 2021
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Cell
Gangoso E,Southgate B,Bradley L,Rus S,Galvez-Cancino F,McGivern N,Güç E,Kapourani CA,Byron A,Ferguson KM,Alfazema N,Morrison G,Grant V,Blin C,Sou I,Marques-Torrejon MA,Conde L,Parrinello S,Herrero J,Beck S,Brandner S,Brennan PM,Bertone P,Pollard JW,Quezada SA,Sproul D,Frame MC,Serrels A,Pollard SM
Thu Apr 29 00:00:00 UTC 2021
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Cell
Bowles KR,Silva MC,Whitney K,Bertucci T,Berlind JE,Lai JD,Garza JC,Boles NC,Mahali S,Strang KH,Marsh JA,Chen C,Pugh DA,Liu Y,Gordon RE,Goderie SK,Chowdhury R,Lotz S,Lane K,Crary JF,Haggarty SJ,Karch CM,Ichida JK,Goate AM,Temple S
Thu Aug 19 00:00:00 UTC 2021
Automated segmentation and tracking of mitochondria in live-cell time-lapse images.
Nature methods
Lefebvre AEYT,Ma D,Kessenbrock K,Lawson DA,Digman MA
Wed Sep 01 00:00:00 UTC 2021
RAB31 marks and controls an ESCRT-independent exosome pathway.
Cell research
Wei D,Zhan W,Gao Y,Huang L,Gong R,Wang W,Zhang R,Wu Y,Gao S,Kang T
Mon Feb 01 00:00:00 UTC 2021
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response.
Nature genetics
Johnson KC,Anderson KJ,Courtois ET,Gujar AD,Barthel FP,Varn FS,Luo D,Seignon M,Yi E,Kim H,Estecio MRH,Zhao D,Tang M,Navin NE,Maurya R,Ngan CY,Verburg N,de Witt Hamer PC,Bulsara K,Samuels ML,Das S,Robson P,Verhaak RGW
100-18B was used in Cell Culture to integrate 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes and bulk multi-omic profiles across 11 adult IDH mutant or IDH wild-type gliomas to delineate sources of intratumoral heterogeneity to identify an epigenetically facilitated adaptive stress response process and highlights the importance of epigenetic heterogeneity in shaping therapeutic outcomes.
Fri Oct 01 00:00:00 UTC 2021
Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription.
Cancer cell
Zhu Y,Gujar AD,Wong CH,Tjong H,Ngan CY,Gong L,Chen YA,Kim H,Liu J,Li M,Mil-Homens A,Maurya R,Kuhlberg C,Sun F,Yi E,deCarvalho AC,Ruan Y,Verhaak RGW,Wei CL
Mon May 10 00:00:00 UTC 2021
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms.
Cancer cell
Hu H,Piotrowska Z,Hare PJ,Chen H,Mulvey HE,Mayfield A,Noeen S,Kattermann K,Greenberg M,Williams A,Riley AK,Wilson JJ,Mao YQ,Huang RP,Banwait MK,Ho J,Crowther GS,Hariri LP,Heist RS,Kodack DP,Pinello L,Shaw AT,Mino-Kenudson M,Hata AN,Sequist LV,Benes CH,Niederst MJ,Engelman JA
Mon Nov 08 00:00:00 UTC 2021
An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence.
Cancer cell
Dhimolea E,de Matos Simoes R,Kansara D,Al'Khafaji A,Bouyssou J,Weng X,Sharma S,Raja J,Awate P,Shirasaki R,Tang H,Glassner BJ,Liu Z,Gao D,Bryan J,Bender S,Roth J,Scheffer M,Jeselsohn R,Gray NS,Georgakoudi I,Vazquez F,Tsherniak A,Chen Y,Welm A,Duy C,Melnick A,Bartholdy B,Brown M,Culhane AC,Mitsiades CS
Mon Feb 08 00:00:00 UTC 2021
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.
Cancer cell
Haag D,Mack N,Benites Goncalves da Silva P,Statz B,Clark J,Tanabe K,Sharma T,Jäger N,Jones DTW,Kawauchi D,Wernig M,Pfister SM
Mon Mar 08 00:00:00 UTC 2021
Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3.
Signal transduction and targeted therapy
Sun H,Wang C,Hu B,Gao X,Zou T,Luo Q,Chen M,Fu Y,Sheng Y,Zhang K,Zheng Y,Ren X,Yan S,Geng Y,Yang L,Dong Q,Qin L
Wed May 26 00:00:00 UTC 2021
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape.
Cell metabolism
Salvadori G,Zanardi F,Iannelli F,Lobefaro R,Vernieri C,Longo VD
100-18B was used in Cell Culture to investigate fast-mimicking diet in tripe-negative breast cancer treatment.
Tue Nov 02 00:00:00 UTC 2021
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape.
Cell metabolism
Salvadori G,Zanardi F,Iannelli F,Lobefaro R,Vernieri C,Longo VD
100-18B was used in Cell Culture to investigate fast-mimicking diet in tripe-negative breast cancer treatment.
Tue Nov 02 00:00:00 UTC 2021
The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.
Nature neuroscience
Rhea EM,Logsdon AF,Hansen KM,Williams LM,Reed MJ,Baumann KK,Holden SJ,Raber J,Banks WA,Erickson MA
100-18B was used in Cell Culture to investigare if the COVID-19 S1 protein is capable of allowing the virus to cross the blood-brain barrier in mice.
Mon Mar 01 00:00:00 UTC 2021
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
Nature neuroscience
Kang Y,Zhou Y,Li Y,Han Y,Xu J,Niu W,Li Z,Liu S,Feng H,Huang W,Duan R,Xu T,Raj N,Zhang F,Dou J,Xu C,Wu H,Bassell GJ,Warren ST,Allen EG,Jin P,Wen Z
Fri Oct 01 00:00:00 UTC 2021
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly.
Cell stem cell
Krenn V,Bosone C,Burkard TR,Spanier J,Kalinke U,Calistri A,Salata C,Rilo Christoff R,Pestana Garcez P,Mirazimi A,Knoblich JA
Thu Aug 05 00:00:00 UTC 2021
Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function.
Cell stem cell
Xiong M,Tao Y,Gao Q,Feng B,Yan W,Zhou Y,Kotsonis TA,Yuan T,You Z,Wu Z,Xi J,Haberman A,Graham J,Block J,Zhou W,Chen Y,Zhang SC
Thu Jan 07 00:00:00 UTC 2021
Visualization of individual cell division history in complex tissues using iCOUNT.
Cell stem cell
Denoth-Lippuner A,Jaeger BN,Liang T,Royall LN,Chie SE,Buthey K,Machado D,Korobeynyk VI,Kruse M,Munz CM,Gerbaulet A,Simons BD,Jessberger S
100-18B was used in Cell Culture to developed an inducible cell division counter (iCOUNT) that reports cell division events in human and mouse tissues in vitro and in vivo.
Thu Nov 04 00:00:00 UTC 2021
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants.
Cell stem cell
Bressan RB,Southgate B,Ferguson KM,Blin C,Grant V,Alfazema N,Wills JC,Marques-Torrejon MA,Morrison GM,Ashmore J,Robertson F,Williams CAC,Bradley L,von Kriegsheim A,Anderson RA,Tomlinson SR,Pollard SM
Thu May 06 00:00:00 UTC 2021
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.
Cell stem cell
Manian KV,Galloway CA,Dalvi S,Emanuel AA,Mereness JA,Black W,Winschel L,Soto C,Li Y,Song Y,DeMaria W,Kumar A,Slukvin I,Schwartz MP,Murphy WL,Anand-Apte B,Chung M,Benoit DSW,Singh R
100-18B was used in Cell Culture to represent that the human 3D model described here provides a platform for investigating RPE-CC biology, AMD/MD pathophysiology, and testing new therapeutic interventions.
Thu May 06 00:00:00 UTC 2021
Principles of signaling pathway modulation for enhancing human naive pluripotency induction.
Cell stem cell
Bayerl J,Ayyash M,Shani T,Manor YS,Gafni O,Massarwa R,Kalma Y,Aguilera-Castrejon A,Zerbib M,Amir H,Sheban D,Geula S,Mor N,Weinberger L,Naveh Tassa S,Krupalnik V,Oldak B,Livnat N,Tarazi S,Tawil S,Wildschutz E,Ashouokhi S,Lasman L,Rotter V,Hanna S,Ben-Yosef D,Novershtern N,Viukov S,Hanna JH
Thu Sep 02 00:00:00 UTC 2021
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma.
The Journal of clinical investigation
Osuka S,Zhu D,Zhang Z,Li C,Stackhouse CT,Sampetrean O,Olson JJ,Gillespie GY,Saya H,Willey CD,Van Meir EG
Mon Mar 15 00:00:00 UTC 2021
N-cadherin upregulation mediates adaptive radioresistance in glioblastoma.
The Journal of clinical investigation
Osuka S,Zhu D,Zhang Z,Li C,Stackhouse CT,Sampetrean O,Olson JJ,Gillespie GY,Saya H,Willey CD,Van Meir EG
Mon Mar 15 00:00:00 UTC 2021
Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
Molecular cell
Thomas HF,Kotova E,Jayaram S,Pilz A,Romeike M,Lackner A,Penz T,Bock C,Leeb M,Halbritter F,Wysocka J,Buecker C
Thu Mar 04 00:00:00 UTC 2021
UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model.
Neuron
Zhang K,Wang A,Zhong K,Qi S,Wei C,Shu X,Tu WY,Xu W,Xia C,Xiao Y,Chen A,Bai L,Zhang J,Luo B,Wang W,Shen C
Wed Jun 16 00:00:00 UTC 2021
Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury.
The Journal of experimental medicine
Jiang L,Cheng L,Chen H,Dai H,An D,Ma Q,Zheng Y,Zhang X,Hu W,Chen Z
Mon Jan 04 00:00:00 UTC 2021
Modeling genetic epileptic encephalopathies using brain organoids.
EMBO molecular medicine
Steinberg DJ,Repudi S,Saleem A,Kustanovich I,Viukov S,Abudiab B,Banne E,Mahajnah M,Hanna JH,Stern S,Carlen PL,Aqeilan RI
Mon Aug 09 00:00:00 UTC 2021
Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
The EMBO journal
Lindhout FW,Portegies S,Kooistra R,Herstel LJ,Stucchi R,Hummel JJA,Scheefhals N,Katrukha EA,Altelaar M,MacGillavry HD,Wierenga CJ,Hoogenraad CC
Mon May 17 00:00:00 UTC 2021
Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2 S production.
The EMBO journal
Wang W,Ren S,Lu Y,Chen X,Qu J,Ma X,Deng Q,Hu Z,Jin Y,Zhou Z,Ge W,Zhu Y,Yang N,Li Q,Pu J,Chen G,Ye C,Wang H,Zhao X,Liu Z,Zhu S
100-18B was used in Cell Culture to show that inhibition of spleen tyrosine kinase by R406 significantly promotes mouse chemical reprogramming.
Tue Jun 01 00:00:00 UTC 2021
WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling.
Molecular psychiatry
Wang M,Tang C,Xing R,Liu X,Han X,Liu Y,Wang L,Yang C,Guo W
Mon Feb 01 00:00:00 UTC 2021
Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition.
Developmental cell
Price CJ,Stavish D,Gokhale PJ,Stevenson BA,Sargeant S,Lacey J,Rodriguez TA,Barbaric I
Mon Sep 13 00:00:00 UTC 2021
Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease.
Molecular therapy : the journal of the American Society of Gene Therapy
Heller GJ,Marshall MS,Issa Y,Marshall JN,Nguyen D,Rue E,Pathmasiri KC,Domowicz MS,van Breemen RB,Tai LM,Cologna SM,Crocker SJ,Givogri MI,Sands MS,Bongarzone ER
Wed May 05 00:00:00 UTC 2021
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate.
Proceedings of the National Academy of Sciences of the United States of America
Lu TM,Houghton S,Magdeldin T,Durán JGB,Minotti AP,Snead A,Sproul A,Nguyen DT,Xiang J,Fine HA,Rosenwaks Z,Studer L,Rafii S,Agalliu D,Redmond D,Lis R
Tue Feb 23 00:00:00 UTC 2021
Early-life midazolam exposure persistently changes chromatin accessibility to impair adult hippocampal neurogenesis and cognition.
Proceedings of the National Academy of Sciences of the United States of America
Doi H,Matsuda T,Sakai A,Matsubara S,Hoka S,Yamaura K,Nakashima K
Tue Sep 21 00:00:00 UTC 2021
GSK3B induces autophagy by phosphorylating ULK1.
Experimental & molecular medicine
Ryu HY,Kim LE,Jeong H,Yeo BK,Lee JW,Nam H,Ha S,An HK,Park H,Jung S,Chung KM,Kim J,Lee BH,Cheong H,Kim EK,Yu SW
Mon Mar 01 00:00:00 UTC 2021
Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats.
Experimental & molecular medicine
Yang JM,Chung S,Yun K,Kim B,So S,Kang S,Kang E,Lee JY
Thu Apr 01 00:00:00 UTC 2021
Myogenesis modelled by human pluripotent stem cells: a multi-omic study of Duchenne myopathy early onset.
Journal of cachexia, sarcopenia and muscle
Mournetas V,Massouridès E,Dupont JB,Kornobis E,Polvèche H,Jarrige M,Dorval ARL,Gosselin MRF,Manousopoulou A,Garbis SD,Górecki DC,Pinset C
Mon Feb 01 00:00:00 UTC 2021
TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression.
Cell systems
Kälin RE,Cai L,Li Y,Zhao D,Zhang H,Cheng J,Zhang W,Wu Y,Eisenhut K,Janssen P,Schmitt L,Enard W,Michels F,Flüh C,Hou M,Kirchleitner SV,Siller S,Schiemann M,Andrä I,Montanez E,Giachino C,Taylor V,Synowitz M,Tonn JC,von Baumgarten L,Schulz C,Hellmann I,Glass R
Wed Mar 17 00:00:00 UTC 2021
TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression.
Cell systems
Kälin RE,Cai L,Li Y,Zhao D,Zhang H,Cheng J,Zhang W,Wu Y,Eisenhut K,Janssen P,Schmitt L,Enard W,Michels F,Flüh C,Hou M,Kirchleitner SV,Siller S,Schiemann M,Andrä I,Montanez E,Giachino C,Taylor V,Synowitz M,Tonn JC,von Baumgarten L,Schulz C,Hellmann I,Glass R
Wed Mar 17 00:00:00 UTC 2021
EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin deposition.
Matrix biology : journal of the International Society for Matrix Biology
Finney AC,Scott ML,Reeves KA,Wang D,Alfaidi M,Schwartz JC,Chitmon CM,Acosta CH,Murphy JM,Alexander JS,Pattillo CB,Lim ST,Orr AW
100-18B was used in Cell Culture to identify EphA2 as a novel regulator of fibrillar adhesion elongation and provide the first data identifying a role for EphA2 signaling in integrin adhesions.
Wed Sep 01 00:00:00 UTC 2021
Aspirin enhances the therapeutic efficacy of cisplatin in oesophageal squamous cell carcinoma by inhibition of putative cancer stem cells.
British journal of cancer
Zou Z,Zheng W,Fan H,Deng G,Lu SH,Jiang W,Yu X
Wed Sep 01 00:00:00 UTC 2021
A splicing factor switch controls hematopoietic lineage specification of pluripotent stem cells.
EMBO reports
Li Y,Wang D,Wang H,Huang X,Wen Y,Wang B,Xu C,Gao J,Liu J,Tong J,Wang M,Su P,Ren S,Ma F,Li HD,Bresnick EH,Zhou J,Shi L
Thu Jan 07 00:00:00 UTC 2021
ANO5 ensures trafficking of annexins in wounded myofibers.
The Journal of cell biology
Foltz SJ,Cui YY,Choo HJ,Hartzell HC
100-18B was used in Cell Culture to show that loss of ANO5 results in impairment in trafficking of annexin proteins to the site of wounded myofibres, in the context of limb-girdle muscular dystrophy.
Mon Mar 01 00:00:00 UTC 2021
Intranasal mesenchymal stem cell therapy to boost myelination after encephalopathy of prematurity.
Glia
Vaes JEG,van Kammen CM,Trayford C,van der Toorn A,Ruhwedel T,Benders MJNL,Dijkhuizen RM,Möbius W,van Rijt SH,Nijboer CH
100-18B was used in Cell Culture to show that MSCs adapt their secretome after ex vivo exposure to dWMI milieu and identified several factors including IGF1, EGF, LIF, and IL11 that potently boost OL maturation.
Mon Mar 01 00:00:00 UTC 2021
Intranasal mesenchymal stem cell therapy to boost myelination after encephalopathy of prematurity.
Glia
Vaes JEG,van Kammen CM,Trayford C,van der Toorn A,Ruhwedel T,Benders MJNL,Dijkhuizen RM,Möbius W,van Rijt SH,Nijboer CH
100-18B was used in Cell Culture to show that MSCs adapt their secretome after ex vivo exposure to dWMI milieu and identified several factors including IGF1, EGF, LIF, and IL11 that potently boost OL maturation.
Mon Mar 01 00:00:00 UTC 2021
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.
Stem cells translational medicine
Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H
Tue Jun 01 00:00:00 UTC 2021
A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury.
Stem cells translational medicine
Kamata Y,Isoda M,Sanosaka T,Shibata R,Ito S,Okubo T,Shinozaki M,Inoue M,Koya I,Shibata S,Shindo T,Matsumoto M,Nakamura M,Okano H,Nagoshi N,Kohyama J
Mon Mar 01 00:00:00 UTC 2021
Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model.
Stem cells translational medicine
Castelli V,Antonucci I,d'Angelo M,Tessitore A,Zelli V,Benedetti E,Ferri C,Desideri G,Borlongan C,Stuppia L,Cimini A
Mon Feb 01 00:00:00 UTC 2021
Coadministration of endothelial and smooth muscle cells derived from human induced pluripotent stem cells as a therapy for critical limb ischemia.
Stem cells translational medicine
Park JJ,Kwon YW,Kim JW,Park GT,Yoon JW,Kim YS,Kim DS,Kwon SM,Bae SS,Ko K,Kim CS,Kim JH
Mon Mar 01 00:00:00 UTC 2021
Uncoupling protein 2-mediated metabolic adaptations define cardiac cell function in the heart during transition from young to old age.
Stem cells translational medicine
Kurian J,Yuko AE,Kasatkin N,Rigaud VOC,Busch K,Harlamova D,Wagner M,Recchia FA,Wang H,Mohsin S,Houser SR,Khan M
Fri Jan 01 00:00:00 UTC 2021
Exosomal lncRNA PVT1/VEGFA Axis Promotes Colon Cancer Metastasis and Stemness by Downregulation of Tumor Suppressor miR-152-3p.
Oxidative medicine and cellular longevity
Lai SW,Chen MY,Bamodu OA,Hsieh MS,Huang TY,Yeh CT,Lee WH,Cherng YG
Fri Jan 28 00:00:00 UTC 2022
Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media.
Acta pharmacologica Sinica
Zeng P,Hua QH,Gong JY,Shi CJ,Pi XP,Xie X,Zhang R
100-18B was used in Cell Culture to suggest that neonatal astrocytes from certain brain regions possess intrinsic potential to differentiate/transdifferentiate into neurons which may have clinical relevance in the future.
Mon Nov 01 00:00:00 UTC 2021
The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury.
Neurobiology of disease
Triplet EM,Kim HN,Yoon H,Radulovic M,Kleppe L,Simon WL,Choi CI,Walsh PJ,Dutton JR,Scarisbrick IA
100-18B was used in In vitro experiments to identify the thrombin receptor (Protease Activated Receptor 1 (PAR1)) as an integral facet of this machine with roles in regulating neurite growth through a growth factor- and cholesterol-dependent mechanism.
Sat May 01 00:00:00 UTC 2021
Characterization of primary models of human trophoblast.
Development (Cambridge, England)
Sheridan MA,Zhao X,Fernando RC,Gardner L,Perez-Garcia V,Li Q,Marsh SGE,Hamilton R,Moffett A,Turco MY
100-18B was used in Cell Culture to show that our results can be used to select the most suitable model for the study of trophoblast development, function and pathology.
Mon Nov 01 00:00:00 UTC 2021
Bruton's tyrosine kinase (BTK) mediates resistance to EGFR inhibition in non-small-cell lung carcinoma.
Oncogenesis
Yeh CT,Chen TT,Satriyo PB,Wang CH,Wu ATH,Chao TY,Lee KY,Hsiao M,Wang LS,Kuo KT
Tue Jul 27 00:00:00 UTC 2021
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
Mon Feb 01 00:00:00 UTC 2021
Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells.
Cancer science
Huang Y,Tsubota S,Nishio N,Takahashi Y,Kadomatsu K
Mon Feb 01 00:00:00 UTC 2021
Selective sodium iodide symporter (NIS) genetherapy of glioblastoma mediatedby EGFR-targeted lipopolyplexes.
Molecular therapy oncolytics
Spellerberg R,Benli-Hoppe T,Kitzberger C,Berger S,Schmohl KA,Schwenk N,Yen HY,Zach C,Schilling F,Weber WA,Kälin RE,Glass R,Nelson PJ,Wagner E,Spitzweg C
Fri Dec 17 00:00:00 UTC 2021
Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma.
Molecular therapy oncolytics
Wirsching HG,Silginer M,Ventura E,Macnair W,Burghardt I,Claassen M,Gatti S,Wichmann J,Riemer C,Schneider H,Weller M
Fri Mar 26 00:00:00 UTC 2021
HDAC1 Regulates Neuronal Differentiation.
Frontiers in molecular neuroscience
Nieto-Estevez V,Changarathil G,Adeyeye AO,Coppin MO,Kassim RS,Zhu J,Hsieh J
100-18B was used in Cell Culture to decipher the role of individual histone deacetylases in adult hippocampal neurogenesis.
Tue Feb 01 00:00:00 UTC 2022
Depletion of Demethylase KDM6 Enhances Early Neuroectoderm Commitment of Human PSCs.
Frontiers in cell and developmental biology
Meng Y,Zhang T,Zheng R,Ding S,Yang J,Liu R,Jiang Y,Jiang W
100-18B was used in In vitro experiments to use a system of directed neuroectoderm differentiation from human embryonic stem cells to show that that KDM6B, an enzyme responsible to erase H3K27me3, is the most upregulated enzyme of histone methylation during neuroectoderm differentiation by transcriptome analysis.
Wed Sep 29 00:00:00 UTC 2021
Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction.
Frontiers in cell and developmental biology
Zhang H,Zhao C,Jiang G,Hu B,Zheng H,Hong Y,Cui Z,Shi L,Li X,Lin F,Ding Y,Wei L,Li M,Liang X,Zhang Y
100-18B was used in Cell Culture to study whether the Apelin ligand regulates mesenchymal stem cell (MSC) senescence and whether its overexpression could rejuvenate aged MSCs (AMSCs) to improve cardiac protection following infarction in mice.
Sat Mar 20 00:00:00 UTC 2021
Urine stem cells are equipped to provide B cell survival signals.
Stem cells (Dayton, Ohio)
Zidan AA,Perkins GB,Al-Hawwas M,Elhossiny A,Yang J,Bobrovskaya L,Mourad GM,Zhou XF,Hurtado PR
Tue Jun 01 00:00:00 UTC 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 UTC 2021
CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment.
Stem cells (Dayton, Ohio)
Galat Y,Gu H,Perepitchka M,Taylor R,Yoon JW,Glukhova XA,Li XN,Beletsky IP,Walterhouse DO,Galat V,Iannaccone PM
Sat May 01 00:00:00 UTC 2021
FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells.
Stem cells (Dayton, Ohio)
Harada S,Mabuchi Y,Kohyama J,Shimojo D,Suzuki S,Kawamura Y,Araki D,Suyama T,Kajikawa M,Akazawa C,Okano H,Matsuzaki Y
Mon Mar 01 00:00:00 UTC 2021
CCAAT/enhancer-binding protein beta promotes muscle stem cell quiescence through regulation of quiescence-associated genes.
Stem cells (Dayton, Ohio)
Lala-Tabbert N,AlSudais H,Marchildon F,Fu D,Wiper-Bergeron N
Mon Mar 01 00:00:00 UTC 2021
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells.
Stem cells (Dayton, Ohio)
Mishra S,Taelman J,Popovic M,Tilleman L,Duthoo E,van der Jeught M,Deforce D,van Nieuwerburgh F,Menten B,de Sutter P,Boel A,Chuva De Sousa Lopes SM,Heindryckx B
Sat May 01 00:00:00 UTC 2021
Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells.
Stem cells (Dayton, Ohio)
Mishra S,Taelman J,Popovic M,Tilleman L,Duthoo E,van der Jeught M,Deforce D,van Nieuwerburgh F,Menten B,de Sutter P,Boel A,Chuva De Sousa Lopes SM,Heindryckx B
Sat May 01 00:00:00 UTC 2021
Wnt/β-Catenin Inhibition Disrupts Carboplatin Resistance in Isogenic Models of Triple-Negative Breast Cancer.
Frontiers in oncology
Abreu de Oliveira WA,Moens S,El Laithy Y,van der Veer BK,Athanasouli P,Cortesi EE,Baietti MF,Koh KP,Ventura JJ,Amant F,Annibali D,Lluis F
100-18B was used in Cell Culture to provide evidence for a prominent role of Wnt signaling in mediating resistance to carboplatin, and we establish that combinatorial targeting of Wnt signaling overcomes carboplatin resistance enhancing chemotherapeutic drug efficacy.
Tue Aug 10 00:00:00 UTC 2021
The stabilization of yes-associated protein by TGFβ-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells.
Journal of cellular and molecular medicine
Wang G,Sun Q,Zhu H,Bi Y,Zhu H,Xu A
Thu Jul 01 00:00:00 UTC 2021
Effect of porcine corneal stromal extract on keratocytes from SMILE-derived lenticules.
Journal of cellular and molecular medicine
Li S,Cui Z,Gu J,Wang Y,Tang S,Chen J
Fri Jan 01 00:00:00 UTC 2021
AS602801 sensitizes glioma cells to temozolomide and vincristine by blocking gap junction communication between glioma cells and astrocytes.
Journal of cellular and molecular medicine
Zhang S,Gong Y,Wang H,Li Z,Huang Y,Fu X,Xiang P,Fan T
Thu Apr 01 00:00:00 UTC 2021
The aberrant expression in epithelial cells of the mesenchymal isoform of FGFR2 controls the negative crosstalk between EMT and autophagy.
Journal of cellular and molecular medicine
Ranieri D,Nanni M,Guttieri L,Torrisi MR,Belleudi F
Thu Apr 01 00:00:00 UTC 2021
Dendritic cells loaded with exosomes derived from cancer stem cell-enriched spheroids as a potential immunotherapeutic option.
Journal of cellular and molecular medicine
Naseri M,Zöller M,Hadjati J,Ghods R,Ranaei Pirmardan E,Kiani J,Eini L,Bozorgmehr M,Madjd Z
Thu Apr 01 00:00:00 UTC 2021
Cytological Effects of Serum Isolated from Polytraumatized Patients on Human Bone Marrow-Derived Mesenchymal Stem Cells.
Stem cells international
Long Y,Bundkirchen K,Gräff P,Krettek C,Noack S,Neunaber C
Mon Aug 19 00:00:00 UTC 2024
Cytological Effects of Serum Isolated from Polytraumatized Patients on Human Bone Marrow-Derived Mesenchymal Stem Cells.
Stem cells international
Long Y,Bundkirchen K,Gräff P,Krettek C,Noack S,Neunaber C
Mon Aug 19 00:00:00 UTC 2024
SOX12 Promotes Stem Cell-Like Phenotypes and Osteosarcoma Tumor Growth by Upregulating JAGGED1.
Stem cells international
Zhang W,Yu F,Weng J,Zheng Y,Lin J,Qi T,Wei Y,Wang D,Zeng H
Wed Nov 03 00:00:00 UTC 2021
Characteristics of Mesenchymal Stem Cells Are Independent of Bone Marrow Storage Temperatures.
Stem cells international
Schrodi V,Neunaber C,Bundkirchen K,Ye W,Jiang Z,Petri M,Krettek C,Noack S
Sat Oct 30 00:00:00 UTC 2021
VEGF Contributes to Mesenchymal Stem Cell-Mediated Reversion of Nor1-Dependent Hypertrophy in iPS Cell-Derived Cardiomyocytes.
Stem cells international
Philipp D,Holthaus M,Basoah V,Pfannkuche K,Suhr L,Wahlers T,Paunel-Görgülü A
Sun May 02 00:00:00 UTC 2021
Identification of a Novel Cancer Stemness-Associated ceRNA Axis in Lung Adenocarcinoma via Stemness Indices Analysis.
Oncology research
Han P,Yang H,Li X,Wu J,Wang P,Liu D,Xiao G,Sun X,Ren H
100-18B was used in Cell Culture to identify the mechanisms involved in a novel cancer stemness-related ceRNA regulatory axis in lung adenocarcinoma.
Tue Sep 07 00:00:00 UTC 2021
Scale-up of an intensified bioprocess for the expansion of bovine adipose-derived stem cells (bASCs) in stirred tank bioreactors.
Biotechnology and bioengineering
Hanga MP,de la Raga FA,Moutsatsou P,Hewitt CJ,Nienow AW,Wall I
Sun Aug 01 00:00:00 UTC 2021
Endocannabinoids increase human adipose stem cell differentiation and growth factor secretion in vitro.
Journal of tissue engineering and regenerative medicine
Ruhl T,Schneider PA,Kim BS,Beier JP
Fri Jan 01 00:00:00 UTC 2021
Impact of Human Epidermal Growth Factor on Tissue-Engineered Skeletal Muscle Structure and Function.
Tissue engineering. Part A
Wroblewski OM,Vega-Soto EE,Nguyen MH,Cederna PS,Larkin LM
100-18B was used in Cell Culture to study how human epidermal growth factor (hEGF) serves as a critical growth factor in enhancing in vitro skeletal muscle cell proliferation and differentiation during myogenesis and advances human skeletal muscle engineered tissues toward a more native adult skeletal muscle phenotype.
Wed Sep 01 00:00:00 UTC 2021
The expression of tenascin-C in neural stem/progenitor cells is stimulated by the growth factors EGF and FGF-2, but not by TGFβ1.
Cell and tissue research
Theocharidis U,Roll L,Faissner A
100-18B was used in Cell Culture to evaluate the use of neural stem/progenitor cells to regulate Tnc gene expression under the influence of different growth factors.
Wed Sep 01 00:00:00 UTC 2021
The inflammatory signalling mediator TAK1 mediates lymphocyte recruitment to lipopolysaccharide-activated murine mesenchymal stem cells through interleukin-6.
Molecular and cellular biochemistry
Oelze B,Elger K,Schadzek P,Burmeister L,Hamm A,Laggies S,Seiffart V,Gross G,Hoffmann A
100-18B was used in Sample Preparation (FC/FACS) to investigate relationship of mesenchymal stem cells and TAK1 expression levels.
Fri Oct 01 00:00:00 UTC 2021
Heparan sulfate proteoglycan-mediated dynamin-dependent transport of neural stem cell exosomes in an in vitro blood-brain barrier model.
The European journal of neuroscience
Joshi BS,Zuhorn IS
100-18B was used in Cell Culture to support the view that NSC exosomes may act as biological nanocarriers for efficient passage across the BBB.
Mon Feb 01 00:00:00 UTC 2021
Cell sheet technology: Influence of culture conditions on in vitro-cultivated corneal stromal tissue for regenerative therapies of the ocular surface.
Journal of biomedical materials research. Part B, Applied biomaterials
Hasenzahl M,Müsken M,Mertsch S,Schrader S,Reichl S
Fri Oct 01 00:00:00 UTC 2021
Electroacupuncture Promotes the Survival of the Grafted Human MGE Neural Progenitors in Rats with Cerebral Ischemia by Promoting Angiogenesis and Inhibiting Inflammation.
Neural plasticity
Li J,Chen L,Li D,Lu M,Huang X,Han X,Chen H
Wed Mar 02 00:00:00 UTC 2022
Modeling human-specific interlaminar astrocytes in the mouse cerebral cortex.
The Journal of comparative neurology
Padmashri R,Ren B,Oldham B,Jung Y,Gough R,Dunaevsky A
Mon Mar 01 00:00:00 UTC 2021
Three Dimensional Cell Culturing for Modeling Adrenal and Pituitary Tumors.
Pathology oncology research : POR
Krokker L,Szabó B,Németh K,Tóháti R,Sarkadi B,Mészáros K,Patócs A,Butz H
100-18B was used in Cell Culture to help understanding the pathogenesis of endocrine tumors and revealing potential biomarkers and therapeutic targets.
Mon Jan 03 00:00:00 UTC 2022
Three Dimensional Cell Culturing for Modeling Adrenal and Pituitary Tumors.
Pathology oncology research : POR
Krokker L,Szabó B,Németh K,Tóháti R,Sarkadi B,Mészáros K,Patócs A,Butz H
100-18B was used in Cell Culture to help understanding the pathogenesis of endocrine tumors and revealing potential biomarkers and therapeutic targets.
Mon Jan 03 00:00:00 UTC 2022
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma.
Nature communications
Vinel C,Rosser G,Guglielmi L,Constantinou M,Pomella N,Zhang X,Boot JR,Jones TA,Millner TO,Dumas AA,Rakyan V,Rees J,Thompson JL,Vuononvirta J,Nadkarni S,El Assan T,Aley N,Lin YY,Liu P,Nelander S,Sheer D,Merry CLR,Marelli-Berg F,Brandner S,Marino S
Thu Oct 21 00:00:00 UTC 2021
Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition.
Nature communications
Zhang B,Wang L,Zhan A,Wang M,Tian L,Guo W,Pan Y
Fri Feb 19 00:00:00 UTC 2021
GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small-cell lung cancer.
Cell death & disease
Song JW,Zhu J,Wu XX,Tu T,Huang JQ,Chen GZ,Liang LY,Zhou CH,Xu X,Gong LY
Thu Oct 21 00:00:00 UTC 2021
Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate.
NPJ Regenerative medicine
Casanova MR,Osório H,Reis RL,Martins A,Neves NM
Fri Nov 19 00:00:00 UTC 2021
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Nature communications
Hu D,Sun X,Magpusao A,Fedorov Y,Thompson M,Wang B,Lundberg K,Adams DJ,Qi X
Mon Sep 06 00:00:00 UTC 2021
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas.
Nature communications
Amoozgar Z,Kloepper J,Ren J,Tay RE,Kazer SW,Kiner E,Krishnan S,Posada JM,Ghosh M,Mamessier E,Wong C,Ferraro GB,Batista A,Wang N,Badeaux M,Roberge S,Xu L,Huang P,Shalek AK,Fukumura D,Kim HJ,Jain RK
Tue May 11 00:00:00 UTC 2021
Attenuation of apoptotic cell detection triggers thymic regeneration after damage.
Cell reports
Kinsella S,Evandy CA,Cooper K,Iovino L,deRoos PC,Hopwo KS,Granadier DW,Smith CW,Rafii S,Dudakov JA
Tue Oct 05 00:00:00 UTC 2021
GD2 CAR T cells against human glioblastoma.
NPJ precision oncology
Prapa M,Chiavelli C,Golinelli G,Grisendi G,Bestagno M,Di Tinco R,Dall'Ora M,Neri G,Candini O,Spano C,Petrachi T,Bertoni L,Carnevale G,Pugliese G,Depenni R,Feletti A,Iaccarino C,Pavesi G,Dominici M
Wed Oct 27 00:00:00 UTC 2021
DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.
Life science alliance
Homma H,Tanaka H,Jin M,Jin X,Huang Y,Yoshioka Y,Bertens CJ,Tsumaki K,Kondo K,Shiwaku H,Tagawa K,Akatsu H,Atsuta N,Katsuno M,Furukawa K,Ishiki A,Waragai M,Ohtomo G,Iwata A,Yokota T,Inoue H,Arai H,Sobue G,Sone M,Fujita K,Okazawa H
100-18B was used in Cell Culture to study developmental stress followed by early-stage neuronal necrosis is a potential target for therapeutics and one of the earliest general biomarkers for FTLD.
Thu Jul 01 00:00:00 UTC 2021
Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation.
Cell death & disease
Juric V,Hudson L,Fay J,Richards CE,Jahns H,Verreault M,Bielle F,Idbaih A,Lamfers MLM,Hopkins AM,Rehm M,Murphy BM
Tue Aug 03 00:00:00 UTC 2021
Low folate induces abnormal neuronal maturation and DNA hypomethylation of neuronal differentiation-related genes in cultured mouse neural stem and progenitor cells.
Heliyon
Araki R,Nishida S,Nakajima Y,Iwakumo A,Tachioka H,Kita A,Yabe T
Wed Sep 01 00:00:00 UTC 2021
Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut.
Molecular systems biology
Triana S,Metz-Zumaran C,Ramirez C,Kee C,Doldan P,Shahraz M,Schraivogel D,Gschwind AR,Sharma AK,Steinmetz LM,Herrmann C,Alexandrov T,Boulant S,Stanifer ML
Thu Apr 01 00:00:00 UTC 2021
Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.
Nature communications
Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H
Fri May 21 00:00:00 UTC 2021
Generation and functional characterization of a single-chain variable fragment (scFv) of the anti-FGF2 3F12E7 monoclonal antibody.
Scientific reports
de Aguiar RB,da Silva TA,Costa BA,Machado MFM,Yamada RY,Braggion C,Perez KR,Mori MAS,Oliveira V,de Moraes JZ
Thu Jan 14 00:00:00 UTC 2021
Focused ultrasound mediated blood-brain barrier opening is safe and feasible in a murine pontine glioma model.
Scientific reports
Englander ZK,Wei HJ,Pouliopoulos AN,Bendau E,Upadhyayula P,Jan CI,Spinazzi EF,Yoh N,Tazhibi M,McQuillan NM,Wang TJC,Bruce JN,Canoll P,Feldstein NA,Zacharoulis S,Konofagou EE,Wu CC
Mon Mar 22 00:00:00 UTC 2021
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity.
Communications biology
Mandrup OA,Ong SC,Lykkemark S,Dinesen A,Rudnik-Jansen I,Dagnæs-Hansen NF,Andersen JT,Alvarez-Vallina L,Howard KA
Mon Mar 08 00:00:00 UTC 2021
S100A4 Is Involved in Stimulatory Effects Elicited by the FGF2/FGFR1 Signaling Pathway in Triple-Negative Breast Cancer (TNBC) Cells.
International journal of molecular sciences
Santolla MF,Talia M,Maggiolini M
100-18B was used in In vitro experiments to study the expression of FGF2 and S100A4 in triple-negative breast cancer (TNBC) compared to non-TNBC patients when analyzing The Invasive Breast Cancer Cohort of The Cancer Genome Atlas" (TCGA) dataset."
Thu Apr 29 00:00:00 UTC 2021
S100A4 Is Involved in Stimulatory Effects Elicited by the FGF2/FGFR1 Signaling Pathway in Triple-Negative Breast Cancer (TNBC) Cells.
International journal of molecular sciences
Santolla MF,Talia M,Maggiolini M
100-18B was used in In vitro experiments to study the expression of FGF2 and S100A4 in triple-negative breast cancer (TNBC) compared to non-TNBC patients when analyzing The Invasive Breast Cancer Cohort of The Cancer Genome Atlas" (TCGA) dataset."
Thu Apr 29 00:00:00 UTC 2021
Protocol for measurement of calcium dysregulation in human induced pluripotent stem cell-derived dopaminergic neurons.
STAR protocols
Yin X,Kim JW,Liu S,Dawson TM,Dawson VL
100-18B was used in Cell Culture to investigate Ca2+ levels for homeostasis in dopaminergic neurons on human induced pluripotent stem cells.
Fri Jun 18 00:00:00 UTC 2021
The Human TOR Signaling Regulator Is the Key Indicator of Liver Cancer Patients' Overall Survival: TIPRL/LC3/CD133/CD44 as Potential Biomarkers for Early Liver Cancers.
Cancers
Jun SY,Yoon HR,Yoon JY,Jeon SJ,Lee JJ,Halder D,Kim JM,Kim NS
100-18B was used in Cell Culture to analyze the prognostic and diagnostic potentials of TIPRL/LC3/CD133/CD44/CD46 using the receiver-operating characteristic curve, a Kaplan-Meier and uni-/multi-Cox analyses.
Fri Jun 11 00:00:00 UTC 2021
Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells.
Stem cell reports
Watson AES,de Almeida MMA,Dittmann NL,Li Y,Torabi P,Footz T,Vetere G,Galleguillos D,Sipione S,Cardona AE,Voronova A
Tue Aug 10 00:00:00 UTC 2021
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.
Nature communications
Bassil R,Shields K,Granger K,Zein I,Ng S,Chih B
Wed Sep 01 00:00:00 UTC 2021
Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders.
Nature communications
Afshar Y,Dong J,Zhao P,Li L,Wang S,Zhang RY,Zhang C,Yin O,Han CS,Einerson BD,Gonzalez TL,Zhang H,Zhou A,Yang Z,Chou SJ,Sun N,Cheng J,Zhu H,Wang J,Zhang TX,Lee YT,Wang JJ,Teng PC,Yang P,Qi D,Zhao M,Sim MS,Zhe R,Goldstein JD,Williams J,Wang X,Zhang Q,Platt LD,Zou C,Pisarska MD,Tseng HR,Zhu Y
Tue Aug 03 00:00:00 UTC 2021
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination.
Cell reports
Martirosian V,Deshpande K,Zhou H,Shen K,Smith K,Northcott P,Lin M,Stepanosyan V,Das D,Remsik J,Isakov D,Boire A,De Feyter H,Hurth K,Li S,Wiemels J,Nakamura B,Shao L,Danilov C,Chen T,Neman J
Tue Jun 29 00:00:00 UTC 2021
Protocol for automated production of human stem cell derived liver spheres.
STAR protocols
Meseguer-Ripolles J,Kasarinaite A,Lucendo-Villarin B,Hay DC
Fri Jun 18 00:00:00 UTC 2021
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion.
Nature communications
Gonçalves CA,Larsen M,Jung S,Stratmann J,Nakamura A,Leuschner M,Hersemann L,Keshara R,Perlman S,Lundvall L,Thuesen LL,Hare KJ,Amit I,Jørgensen A,Kim YH,Del Sol A,Grapin-Botton A
Tue May 25 00:00:00 UTC 2021
Increasing salinity of fibrinogen solvent generates stable fibrin hydrogels for cell delivery or tissue engineering.
PloS one
Jarrell DK,Vanderslice EJ,Lennon ML,Lyons AC,VeDepo MC,Jacot JG
100-18B was used in In vitro experiments to show the simplest method reported for the fabrication of fibrin gels with tunable degradation properties and will be useful for implementing fibrin gels in a wide range of research and clinical applications.
Thu Oct 07 00:00:00 UTC 2021
CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma.
Cell death discovery
Wang SM,Lin WC,Lin HY,Chen YL,Ko CY,Wang JM
Tue Jan 12 00:00:00 UTC 2021
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.
Communications biology
Tanaka H,Kondo K,Fujita K,Homma H,Tagawa K,Jin X,Jin M,Yoshioka Y,Takayama S,Masuda H,Tokuyama R,Nakazaki Y,Saito T,Saido T,Murayama S,Ikura T,Ito N,Yamamori Y,Tomii K,Bianchi ME,Okazawa H
Mon Oct 11 00:00:00 UTC 2021
Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation.
Hepatology (Baltimore, Md.)
Peaslee C,Esteva-Font C,Su T,Munoz-Howell A,Duwaerts CC,Liu Z,Rao S,Liu K,Medina M,Sneddon JB,Maher JJ,Mattis AN
100-18B was used in In vitro experiments to test this protocol in >70 iPSC lines, 90% of which consistently formed complete sheets of endoderm.
Fri Oct 01 00:00:00 UTC 2021
Patient-specific iPSC-derived endothelial cells reveal aberrant p38 MAPK signaling in atypical hemolytic uremic syndrome.
Stem cell reports
Zhou D,Tan Y,Liu X,Tang L,Wang H,Shen J,Wang W,Zhuang L,Tao J,Su J,Gong T,Liu X,Liang P,Yu F,Zhao M
Tue Sep 14 00:00:00 UTC 2021
Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury.
Cell reports
Gong C,Zheng X,Guo F,Wang Y,Zhang S,Chen J,Sun X,Shah SZA,Zheng Y,Li X,Yin Y,Li Q,Huang X,Guo T,Han X,Zhang SC,Wang W,Chen H
Tue Mar 23 00:00:00 UTC 2021
PRMT5 inhibition disrupts splicing and stemness in glioblastoma.
Nature communications
Sachamitr P,Ho JC,Ciamponi FE,Ba-Alawi W,Coutinho FJ,Guilhamon P,Kushida MM,Cavalli FMG,Lee L,Rastegar N,Vu V,Sánchez-Osuna M,Coulombe-Huntington J,Kanshin E,Whetstone H,Durand M,Thibault P,Hart K,Mangos M,Veyhl J,Chen W,Tran N,Duong BC,Aman AM,Che X,Lan X,Whitley O,Zaslaver O,Barsyte-Lovejoy D,Richards LM,Restall I,Caudy A,Röst HL,Bonday ZQ,Bernstein M,Das S,Cusimano MD,Spears J,Bader GD,Pugh TJ,Tyers M,Lupien M,Haibe-Kains B,Artee Luchman H,Weiss S,Massirer KB,Prinos P,Arrowsmith CH,Dirks PB
Fri Feb 12 00:00:00 UTC 2021
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology.
Nature communications
Risbridger GP,Clark AK,Porter LH,Toivanen R,Bakshi A,Lister NL,Pook D,Pezaro CJ,Sandhu S,Keerthikumar S,Quezada Urban R,Papargiris M,Kraska J,Madsen HB,Wang H,Richards MG,Niranjan B,O'Dea S,Teng L,Wheelahan W,Li Z,Choo N,Ouyang JF,Thorne H,Devereux L,Hicks RJ,Sengupta S,Harewood L,Iddawala M,Azad AA,Goad J,Grummet J,Kourambas J,Kwan EM,Moon D,Murphy DG,Pedersen J,Clouston D,Norden S,Ryan A,Furic L,Goode DL,Frydenberg M,Lawrence MG,Taylor RA
Thu Aug 19 00:00:00 UTC 2021
Prrx1 promotes stemness and angiogenesis via activating TGF-β/smad pathway and upregulating proangiogenic factors in glioma.
Cell death & disease
Chen Z,Chen Y,Li Y,Lian W,Zheng K,Zhang Y,Zhang Y,Lin C,Liu C,Sun F,Sun X,Wang J,Zhao L,Ke Y
Tue Jun 15 00:00:00 UTC 2021
ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody.
JCI insight
Rattray Z,Deng G,Zhang S,Shirali A,May CK,Chen X,Cuffari BJ,Liu J,Zou P,Rattray NJ,Johnson CH,Dubljevic V,Campbell JA,Huttner A,Baehring JM,Zhou J,Hansen JE
100-18B was used in Cell Culture to find that DX1 penetrated brain endothelial cells and crossed the BBB, and mechanistic studies identify ENT2 as the key transporter.
Thu Jul 22 00:00:00 UTC 2021
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.
Cell stem cell
Wang C,Zhang M,Garcia G,Tian E,Cui Q,Chen X,Sun G,Wang J,Arumugaswami V,Shi Y
100-18B was used in In vitro experiments to study whether ApoE4 alters COVID-19 susceptibility or severity and the role of direct viral infection in brain cells to suggest that ApoE4 may play a causal role in COVID-19 severity.
Thu Feb 04 00:00:00 UTC 2021
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide.
Nature communications
Li F,Han M,Dai P,Xu W,He J,Tao X,Wu Y,Tong X,Xia X,Guo W,Zhou Y,Li Y,Zhu Y,Zhang X,Liu Z,Aji R,Cai X,Li Y,Qu D,Chen Y,Jiang S,Wang Q,Ji H,Xie Y,Sun Y,Lu L,Gao D
Mon Feb 08 00:00:00 UTC 2021
Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.
iScience
Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y
Fri Nov 19 00:00:00 UTC 2021
Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.
iScience
Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y
Fri Nov 19 00:00:00 UTC 2021
Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells.
Cell stem cell
Huang WK,Wong SZH,Pather SR,Nguyen PTT,Zhang F,Zhang DY,Zhang Z,Lu L,Fang W,Chen L,Fernandes A,Su Y,Song H,Ming GL
100-18B was used in Cell Culture to report the generation of ARCOs from human iPSCs to model the development of the human hypothalamic arcuate nucleus.
Thu Sep 02 00:00:00 UTC 2021
Simplification of culture conditions and feeder-free expansion of bovine embryonic stem cells.
Scientific reports
Soto DA,Navarro M,Zheng C,Halstead MM,Zhou C,Guiltinan C,Wu J,Ross PJ
Wed May 26 00:00:00 UTC 2021
3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model.
Cancers
Mokhtari RB,Qorri B,Sambi M,Baluch N,Kumar S,Das B,Szewczuk MR,Yeger H,Cheng HM
100-18B was used in Cell Culture to investigate breast cancer cells cultured in stromal stem cell factor-supplemented media to generate 3D spheroids that exhibit increased stem-like properties.
Thu Jun 03 00:00:00 UTC 2021
p107 mediated mitochondrial function controls muscle stem cell proliferative fates.
Nature communications
Bhattacharya D,Shah V,Oresajo O,Scimè A
Wed Oct 13 00:00:00 UTC 2021
CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling.
Cell death & disease
Huang Z,Yan Y,Zhu Z,Liu J,He X,Dalangood S,Li M,Tan M,Cai J,Tang P,Huang R,Shen B,Yan J
Tue May 25 00:00:00 UTC 2021
Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice.
Communications biology
Barcia Durán JG,Lu T,Houghton S,Geng F,Schreiner R,Xiang J,Rafii S,Redmond D,Lis R
Thu Mar 25 00:00:00 UTC 2021
Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.
Cell reports. Medicine
Pandya NJ,Wang C,Costa V,Lopatta P,Meier S,Zampeta FI,Punt AM,Mientjes E,Grossen P,Distler T,Tzouros M,Martí Y,Banfai B,Patsch C,Rasmussen S,Hoener M,Berrera M,Kremer T,Dunkley T,Ebeling M,Distel B,Elgersma Y,Jagasia R
Tue Aug 17 00:00:00 UTC 2021
Transcriptional cooperation of PBX1 and PAX6 in adult neural progenitor cells.
Scientific reports
Hau AC,Mommaerts E,Laub V,Müller T,Dittmar G,Schulte D
Mon Oct 25 00:00:00 UTC 2021
Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.
Scientific reports
Akasu M,Shimada S,Kabashima A,Akiyama Y,Shimokawa M,Akahoshi K,Kudo A,Yamaoka S,Tanabe M,Tanaka S
Tue Aug 24 00:00:00 UTC 2021
Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties.
NPJ Regenerative medicine
Brown WE,Huang BJ,Hu JC,Athanasiou KA
Fri Aug 06 00:00:00 UTC 2021
Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ.
Scientific reports
Bernardo A,Plumitallo C,De Nuccio C,Visentin S,Minghetti L
Tue Mar 02 00:00:00 UTC 2021
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Nature communications
Inak G,Rybak-Wolf A,Lisowski P,Pentimalli TM,Jüttner R,Glažar P,Uppal K,Bottani E,Brunetti D,Secker C,Zink A,Meierhofer D,Henke MT,Dey M,Ciptasari U,Mlody B,Hahn T,Berruezo-Llacuna M,Karaiskos N,Di Virgilio M,Mayr JA,Wortmann SB,Priller J,Gotthardt M,Jones DP,Mayatepek E,Stenzel W,Diecke S,Kühn R,Wanker EE,Rajewsky N,Schuelke M,Prigione A
Fri Mar 26 00:00:00 UTC 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 UTC 2021
Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
Cell reports
Raj N,McEachin ZT,Harousseau W,Zhou Y,Zhang F,Merritt-Garza ME,Taliaferro JM,Kalinowska M,Marro SG,Hales CM,Berry-Kravis E,Wolf-Ochoa MW,Martinez-Cerdeño V,Wernig M,Chen L,Klann E,Warren ST,Jin P,Wen Z,Bassell GJ
Tue Apr 13 00:00:00 UTC 2021
Intra-arterial transplantation of stem cells in large animals as a minimally-invasive strategy for the treatment of disseminated neurodegeneration.
Scientific reports
Malysz-Cymborska I,Golubczyk D,Kalkowski L,Kwiatkowska J,Zawadzki M,Głodek J,Holak P,Sanford J,Milewska K,Adamiak Z,Walczak P,Janowski M
Mon Mar 22 00:00:00 UTC 2021
Intra-arterial transplantation of stem cells in large animals as a minimally-invasive strategy for the treatment of disseminated neurodegeneration.
Scientific reports
Malysz-Cymborska I,Golubczyk D,Kalkowski L,Kwiatkowska J,Zawadzki M,Głodek J,Holak P,Sanford J,Milewska K,Adamiak Z,Walczak P,Janowski M
Mon Mar 22 00:00:00 UTC 2021
Rewiring of purine metabolism in response to acidosis stress in glioma stem cells.
Cell death & disease
Xu X,Wang L,Zang Q,Li S,Li L,Wang Z,He J,Qiang B,Han W,Zhang R,Peng X,Abliz Z
Mon Mar 15 00:00:00 UTC 2021
LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells.
Nature communications
Marqués-Torrejón MÁ,Williams CAC,Southgate B,Alfazema N,Clements MP,Garcia-Diaz C,Blin C,Arranz-Emparan N,Fraser J,Gammoh N,Parrinello S,Pollard SM
Mon May 10 00:00:00 UTC 2021
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Nature communications
Badodi S,Pomella N,Zhang X,Rosser G,Whittingham J,Niklison-Chirou MV,Lim YM,Brandner S,Morrison G,Pollard SM,Bennett CD,Clifford SC,Peet A,Basson MA,Marino S
Mon Apr 12 00:00:00 UTC 2021
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Cell reports
Nakashima H,Tsujimura K,Irie K,Imamura T,Trujillo CA,Ishizu M,Uesaka M,Pan M,Noguchi H,Okada K,Aoyagi K,Andoh-Noda T,Okano H,Muotri AR,Nakashima K
Tue May 18 00:00:00 UTC 2021
MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.
Cell reports
Nakashima H,Tsujimura K,Irie K,Imamura T,Trujillo CA,Ishizu M,Uesaka M,Pan M,Noguchi H,Okada K,Aoyagi K,Andoh-Noda T,Okano H,Muotri AR,Nakashima K
Tue May 18 00:00:00 UTC 2021
A universal gene correction approach for FKRP-associated dystroglycanopathies to enable autologous cell therapy.
Cell reports
Dhoke NR,Kim H,Selvaraj S,Azzag K,Zhou H,Oliveira NAJ,Tungtur S,Ortiz-Cordero C,Kiley J,Lu QL,Bang AG,Perlingeiro RCR
Tue Jul 13 00:00:00 UTC 2021
Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of Niemann Picks type C2 disease.
Journal of neurochemistry
Hede E,Christiansen CB,Heegaard CW,Moos T,Burkhart A
100-18B was used in Cell Culture to study how on-viral gene therapy to rat brain capillary endothelial cells (rBCECs) leads to protein secretion and signifies a method for NPC2 to target cells inside the central nervous system (CNS) otherwise inaccessible because of the presence of the blood-brain barrier (BBB).
Mon Feb 01 00:00:00 UTC 2021
Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations.
Cell reports
Gil-Ranedo J,Gallego-García C,Almendral JM
Tue Sep 07 00:00:00 UTC 2021
Prolactin, Estradiol and Testosterone Differentially Impact Human Hippocampal Neurogenesis in an In Vitro Model.
Neuroscience
Smeeth DM,Kourouzidou I,Duarte RRR,Powell TR,Thuret S
100-18B was used in Cell Culture to demonstrate relatively minor, and possibly short-term effects of sex hormones on hippocampal neurogenesis in human cells.
Mon Feb 01 00:00:00 UTC 2021
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports
Henderson MJ,Trychta KA,Yang SM,Bäck S,Yasgar A,Wires ES,Danchik C,Yan X,Yano H,Shi L,Wu KJ,Wang AQ,Tao D,Zahoránszky-Kőhalmi G,Hu X,Xu X,Maloney D,Zakharov AV,Rai G,Urano F,Airavaara M,Gavrilova O,Jadhav A,Wang Y,Simeonov A,Harvey BK
Tue Apr 27 00:00:00 UTC 2021
Neuroblastoma and DIPG Organoid Coculture System for Personalized Assessment of Novel Anticancer Immunotherapies.
Journal of personalized medicine
M Kholosy W,Derieppe M,van den Ham F,Ober K,Su Y,Custers L,Schild L,M J van Zogchel L,M Wellens L,R Ariese H,Szanto CL,Wienke J,Dierselhuis MP,van Vuurden D,Dolman EM,Molenaar JJ
100-18B was used in Cell Culture to provide a procedure for the establishment of an ex vivo test coculture system of paediatric tumour organoids and immune cells that enables the assessment of different immunotherpay approaches in paediatric tumour organoids.
Mon Aug 30 00:00:00 UTC 2021
Novel FMRP interaction networks linked to cellular stress.
The FEBS journal
Taha MS,Haghighi F,Stefanski A,Nakhaei-Rad S,Kazemein Jasemi NS,Al Kabbani MA,Görg B,Fujii M,Lang PA,Häussinger D,Piekorz RP,Stühler K,Ahmadian MR
100-18B was used in Cell Culture to demonstrates that FMR protein (FMRP) seems associated with multiple cellular processes both under normal and cell stress conditions in neuronal as well as non-neuronal cell types, as exemplified by its role in the formation of stress granules. The study also identified known and novel candidate FMRP-binding proteins as well as protein complexes.
Mon Feb 01 00:00:00 UTC 2021
P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas.
Nature communications
Rousso-Noori L,Mastandrea I,Talmor S,Waks T,Globerson Levin A,Haugas M,Teesalu T,Alvarez-Vallina L,Eshhar Z,Friedmann-Morvinski D
Mon Jun 14 00:00:00 UTC 2021
Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling.
Cancer medicine
Jia M,Wang Y,Guo Y,Yu P,Sun Y,Song Y,Zhao L
Sat May 01 00:00:00 UTC 2021
EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.
Cancers
Bleijs M,Pleijte C,Engels S,Ringnalda F,Meyer-Wentrup F,van de Wetering M,Clevers H
100-18B was used in Cell Culture to investigate potential treatment for desmoplastic small round cell tumour.
Thu Dec 02 00:00:00 UTC 2021
Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis.
Cell reports
Wegscheid ML,Anastasaki C,Hartigan KA,Cobb OM,Papke JB,Traber JN,Morris SM,Gutmann DH
Tue Jul 06 00:00:00 UTC 2021
SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia.
Pharmacology research & perspectives
Takouda J,Katada S,Imamura T,Sanosaka T,Nakashima K
Wed Dec 01 00:00:00 UTC 2021
Generation of mouse hippocampal neural precursor cell lines with CRISPR/Cas9-mediated gene knockouts.
STAR protocols
Zocher S,Kempermann G
100-18B was used in Cell Culture to outline CRISPR/Cas9 manipulation of knockout in mouse hippocampal neural precursor lines.
Fri Jun 18 00:00:00 UTC 2021
Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells.
Frontiers in cellular and infection microbiology
Shaharuddin SH,Wang V,Santos RS,Gross A,Wang Y,Jawanda H,Zhang Y,Hasan W,Garcia G,Arumugaswami V,Sareen D
Thu Jul 22 00:00:00 UTC 2021
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets.
Nature communications
Nording H,Baron L,Haberthür D,Emschermann F,Mezger M,Sauter M,Sauter R,Patzelt J,Knoepp K,Nording A,Meusel M,Meyer-Saraei R,Hlushchuk R,Sedding D,Borst O,Eitel I,Karsten CM,Feil R,Pichler B,Erdmann J,Verschoor A,Chavakis E,Chavakis T,von Hundelshausen P,Köhl J,Gawaz M,Langer HF
Mon Jun 07 00:00:00 UTC 2021
The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo.
Nature communications
Crispatzu G,Rehimi R,Pachano T,Bleckwehl T,Cruz-Molina S,Xiao C,Mahabir E,Bazzi H,Rada-Iglesias A
Fri Jul 16 00:00:00 UTC 2021
Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function.
eLife
Haward F,Maslon MM,Yeyati PL,Bellora N,Hansen JN,Aitken S,Lawson J,von Kriegsheim A,Wachten D,Mill P,Adams IR,Caceres JF
100-18B was used in Cell Culture to study the physiological significance of the role of SR family protein regulation of RNA splicing in the nucleus and SRSF1 shuttling between the nucleus and cytoplasm for post-splicing processes.
Mon Aug 02 00:00:00 UTC 2021
Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment.
Theranostics
Wang X,Mao J,Zhou T,Chen X,Tu H,Ma J,Li Y,Ding Y,Yang Y,Wu H,Tang X
100-18B was used in Cell Culture to study whether myeloid derived growth factor (MYDGF) could accelerate the progression of hepatocellular carcinoma (HCC) and how it works to show that MYDGF could directly affect the self-renewal of liver cells, and indirectly aggravate the inflammatory microenvironment to accelerate the progression of HCC.
Thu Aug 05 00:00:00 UTC 2021
Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction.
eLife
Le Pelletier L,Mantecon M,Gorwood J,Auclair M,Foresti R,Motterlini R,Laforge M,Atlan M,Fève B,Capeau J,Lagathu C,Bereziat V
100-18B was used in Cell Culture to study the senescence and adipogenic potential of adipose-derived stromal cells (ASCs) from abdominal subcutaneous fat obtained from healthy normal-weight young (25 years) or older women (>60 years).
Tue Sep 21 00:00:00 UTC 2021
Cultivation and characterization of primordial germ cells from blue layer hybrids (Araucana crossbreeds) and generation of germline chimeric chickens.
Scientific reports
Altgilbers S,Klein S,Dierks C,Weigend S,Kues WA
Mon Jun 21 00:00:00 UTC 2021
BASP1 labels neural stem cells in the neurogenic niches of mammalian brain.
Scientific reports
Manganas LN,Durá I,Osenberg S,Semerci F,Tosun M,Mishra R,Parkitny L,Encinas JM,Maletic-Savatic M
Wed Mar 10 00:00:00 UTC 2021
Patient-derived xenografts and organoids model therapy response in prostate cancer.
Nature communications
Karkampouna S,La Manna F,Benjak A,Kiener M,De Menna M,Zoni E,Grosjean J,Klima I,Garofoli A,Bolis M,Vallerga A,Theurillat JP,De Filippo MR,Genitsch V,Keller D,Booij TH,Stirnimann CU,Eng K,Sboner A,Ng CKY,Piscuoglio S,Gray PC,Spahn M,Rubin MA,Thalmann GN,Kruithof-de Julio M
Thu Feb 18 00:00:00 UTC 2021
Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.
iScience
de Castro Fonseca M,de Oliveira JF,Araujo BHS,Canateli C,do Prado PFV,Amorim Neto DP,Bosque BP,Rodrigues PV,de Godoy JVP,Tostes K,Filho HVR,Nascimento AFZ,Saito A,Tonoli CCC,Batista FAH,de Oliveira PSL,Figueira AC,Souza da Costa S,Krepischi ACV,Rosenberg C,Westfahl H,da Silva AJR,Franchini KG
Fri Aug 20 00:00:00 UTC 2021
Identification of SUMO Targets Associated With the Pluripotent State in Human Stem Cells.
Molecular & cellular proteomics : MCP
Mojsa B,Tatham MH,Davidson L,Liczmanska M,Branigan E,Hay RT
Thu Mar 24 00:00:00 UTC 2022
Protocol for mouse adult neural stem cell isolation and culture.
STAR protocols
Ahmed AKMA,Isaksen TJ,Yamashita T
Fri Jun 18 00:00:00 UTC 2021
Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation.
Cell death & disease
Meier S,Cantilena S,Niklison Chirou MV,Anderson J,Hargrave D,Salomoni P,de Boer J,Michod D
Wed Aug 11 00:00:00 UTC 2021
Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro.
Nature communications
Tan JJ,Guyette JP,Miki K,Xiao L,Kaur G,Wu T,Zhu L,Hansen KJ,Ling KH,Milan DJ,Ott HC
Tue Aug 17 00:00:00 UTC 2021
Adipose-Derived Stromal Cell-Sheets Sandwiched, Book-Shaped Acellular Dermal Matrix Capable of Sustained Release of Basic Fibroblast Growth Factor Promote Diabetic Wound Healing.
Frontiers in cell and developmental biology
Shi X,Jiang L,Zhao X,Chen B,Shi W,Cao Y,Chen Y,Li X,He Y,Li C,Liu X,Li X,Lu H,Chen C,Liu J
100-18B was used in Control to demonstrate that ASCs/CBD-bFGF/BDDM could be applicable for diabetic wound healing.
Tue Apr 13 00:00:00 UTC 2021
Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas.
Cell reports
Isaev K,Jiang L,Wu S,Lee CA,Watters V,Fort V,Tsai R,Coutinho FJ,Hussein SMI,Zhang J,Wu J,Dirks PB,Schramek D,Reimand J
Tue Oct 19 00:00:00 UTC 2021
Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling.
Cell reports
Chen J,Dong X,Cheng X,Zhu Q,Zhang J,Li Q,Huang X,Wang M,Li L,Guo W,Sun B,Shu Q,Yi W,Li X
Tue Mar 30 00:00:00 UTC 2021
Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells.
The Journal of biological chemistry
Wang X,Wang X,Zhang X,Zhang Y,Zhu Z,Li Y,Zhang M,Ji J,Yu Y,Ye SD
Mon Nov 01 00:00:00 UTC 2021
Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates.
Cell discovery
Chen H,Xia K,Huang W,Li H,Wang C,Ma Y,Chen J,Luo P,Zheng S,Wang J,Wang Y,Dong L,Tan Z,Lai X,Mao FF,Li W,Liang X,Wang T,Xiang AP,Ke Q
Tue Aug 31 00:00:00 UTC 2021
A Parkinson's Disease-relevant Mitochondrial and Neuronal Morphology High-throughput Screening Assay in LUHMES Cells.
Bio-protocol
Leah T,Vazquez-Villaseñor I,Ferraiuolo L,Wharton SB,Mortiboys H
100-18B was used in Cell Culture to provide detailed instructions for data and statistical analysis, including example calculations of Z'-score to assess statistical effect size across independent experiments.
Tue Jan 05 00:00:00 UTC 2021
Comparing Tumor Cell Invasion and Myeloid Cell Composition in Compatible Primary and Relapsing Glioblastoma.
Cancers
Zhao D,Zhang H,Uyar R,Hossain JA,Miletic H,Tonn JC,Glass R,Kälin RE
100-18B was used in Cell Culture to interpret that factors released from viable primary GBM cells preferentially attract microglia whereas relapsing tumors preponderantly release chemoattractants for MDM.
Tue Jul 20 00:00:00 UTC 2021
Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD.
Brain sciences
Ramic M,Andrade NS,Rybin MJ,Esanov R,Wahlestedt C,Benatar M,Zeier Z
100-18B was used in Cell Culture to characterize the nucleocytoplasmic transport and increased DNA damage disturbances and determine the relative contribution of different dipeptide repeat proteins (DPRs) needed to facilitate the development of novel therapeutics for C9ALS/ frontotemporal dementia (FTD).
Sat Nov 20 00:00:00 UTC 2021
Potential Therapeutic Effect of Micrornas in Extracellular Vesicles from Mesenchymal Stem Cells against SARS-CoV-2.
Cells
Park JH,Choi Y,Lim CW,Park JM,Yu SH,Kim Y,Han HJ,Kim CH,Song YS,Kim C,Yu SR,Oh EY,Lee SM,Moon J
Sun Sep 12 00:00:00 UTC 2021
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection.
Cell reports
Duan X,Tang X,Nair MS,Zhang T,Qiu Y,Zhang W,Wang P,Huang Y,Xiang J,Wang H,Schwartz RE,Ho DD,Evans T,Chen S
Tue Nov 09 00:00:00 UTC 2021
Heterozygous APC germline mutations impart predisposition to colorectal cancer.
Scientific reports
Preisler L,Habib A,Shapira G,Kuznitsov-Yanovsky L,Mayshar Y,Carmel-Gross I,Malcov M,Azem F,Shomron N,Kariv R,Hershkovitz D,Ben-Yosef D
Thu Mar 04 00:00:00 UTC 2021
PI3K/mTOR Dual Inhibitor PF-04691502 Is a Schedule-Dependent Radiosensitizer for Gastroenteropancreatic Neuroendocrine Tumors.
Cells
Chow Z,Johnson J,Chauhan A,Izumi T,Cavnar M,Weiss H,Townsend CM,Anthony L,Wasilchenko C,Melton ML,Schrader J,Evers BM,Rychahou P
100-18B was used in Sample Preparation to study a new treatment strategy combining PI3K/mTOR dual inhibition and radiotherapy to suggest that radiotherapy, in combination with timed PI3K/mTOR inhibition, may be a promising therapeutic regimen for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET).
Thu May 20 00:00:00 UTC 2021
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.
Scientific reports
Shono K,Mizobuchi Y,Yamaguchi I,Nakajima K,Fujiwara Y,Fujihara T,Kitazato K,Matsuzaki K,Uto Y,Sampetrean O,Saya H,Takagi Y
Fri Jul 23 00:00:00 UTC 2021
22(R)-hydroxycholesterol for dopaminergic neuronal specification of MSCs and amelioration of Parkinsonian symptoms in rats.
Cell death discovery
Singh M,Jain M,Bose S,Halder A,Nag TC,Dinda AK,Mohanty S
Sat Jan 16 00:00:00 UTC 2021
AKT Signaling Modifies the Balance between Cell Proliferation and Migration in Neural Crest Cells from Patients Affected with Bosma Arhinia and Microphthalmia Syndrome.
Biomedicines
Laberthonnière C,Novoa-Del-Toro EM,Chevalier R,Broucqsault N,Rao VV,Trani JP,Nguyen K,Xue S,Reversade B,Robin JD,Baudot A,Magdinier F
100-18B was used in Cell Culture to provide further insights into the distinct mechanism by which defects in neural crest migration might contribute to the craniofacial anomalies in BAMS.
Tue Jun 29 00:00:00 UTC 2021
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
Communications biology
Qiu R,Wu J,Gudenas B,Northcott PA,Wechsler-Reya RJ,Lu Q
Tue May 11 00:00:00 UTC 2021
Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression.
Nature communications
Bolis M,Bossi D,Vallerga A,Ceserani V,Cavalli M,Impellizzieri D,Di Rito L,Zoni E,Mosole S,Elia AR,Rinaldi A,Pereira Mestre R,D'Antonio E,Ferrari M,Stoffel F,Jermini F,Gillessen S,Bubendorf L,Schraml P,Calcinotto A,Corey E,Moch H,Spahn M,Thalmann G,Kruithof-de Julio M,Rubin MA,Theurillat JP
100-18B was used in Cell Culture to provide a user-friendly web-resource enabling the investigation of dynamic transcriptional perturbations linked to disease progression.
Thu Dec 02 00:00:00 UTC 2021
Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog.
Frontiers in veterinary science
Chandrasekaran A,Thomsen BB,Agerholm JS,Pessôa LVF,Godoy Pieri NC,Sabaghidarmiyan V,Langley K,Kolko M,de Andrade AFC,Bressan FF,Hyttel P,Berendt M,Freude K
100-18B was used in Cell Culture to use domestic dog models for translational medicine to develop the canine-derived in vitro model for neurodegenerative diseases through the generation of induced pluripotent stem cells from a 14-year, 9-month-old female West Highland white terrier with mild cognitive impairment (MCI).
Tue Nov 23 00:00:00 UTC 2021
In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells.
Scientific reports
Nakai K,Shiga T,Yasuhara R,Sarkar AK,Abe Y,Nakamura S,Hoashi Y,Kotani K,Tatsumoto S,Ishikawa H,Go Y,Inoue T,Mishima K,Akamatsu W,Baba K
Thu Jul 29 00:00:00 UTC 2021
Apatinib suppresses lung cancer stem-like cells by complex interplay between β-catenin signaling and mitochondrial ROS accumulation.
Cell death discovery
Zhu J,Li X,Liang C,Zhou X,Ge M,Chen Y,Jin J,Yin J,Xu H,Xie C,Zhong C
Wed May 12 00:00:00 UTC 2021
Integrated Metabolomics and Transcriptomics Analysis of Monolayer and Neurospheres from Established Glioblastoma Cell Lines.
Cancers
Peixoto J,Janaki-Raman S,Schlicker L,Schmitz W,Walz S,Winkelkotte AM,Herold-Mende C,Soares P,Schulze A,Lima J
100-18B was used in Cell Culture to investigate the transcriptome of cancer-like stem cells in glioblastoma.
Tue Mar 16 00:00:00 UTC 2021
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost.
Cell reports. Medicine
de Gooijer MC,Kemper EM,Buil LCM,Çitirikkaya CH,Buckle T,Beijnen JH,van Tellingen O
Tue Jan 19 00:00:00 UTC 2021
Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.
Stem cell research & therapy
Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N
100-18B was used in In vitro experiments to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.
Tue Sep 28 00:00:00 UTC 2021
Defective autophagy and increased apoptosis contribute toward the pathogenesis of FKRP-associated muscular dystrophies.
Stem cell reports
Ortiz-Cordero C,Bincoletto C,Dhoke NR,Selvaraj S,Magli A,Zhou H,Kim DH,Bang AG,Perlingeiro RCR
Tue Nov 09 00:00:00 UTC 2021
Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides.
Cell reports
Melacarne A,Ferrari V,Tiraboschi L,Mishto M,Liepe J,Aralla M,Marconato L,Lizier M,Pozzi C,Zeira O,Penna G,Rescigno M
Tue Jul 06 00:00:00 UTC 2021
Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature.
Frontiers in cell and developmental biology
Wang S,Wu T,Sun J,Li Y,Yuan Z,Sun W
100-18B was used in Cell Culture to study the molecular mechanisms involved in hair follicle development and wool curvature of sheep.
Sat Jan 08 00:00:00 UTC 2022
The multi-target small-molecule inhibitor SB747651A shows in vitro and in vivo anticancer efficacy in glioblastomas.
Scientific reports
Knudsen AM,Boldt HB,Jakobsen EV,Kristensen BW
Tue Mar 16 00:00:00 UTC 2021
In Vitro Generation of Posterior Motor Neurons from Human Pluripotent Stem Cells.
Current protocols
Wind M,Tsakiridis A
Wed Sep 01 00:00:00 UTC 2021
The effects of 3D culture on the expansion and maintenance of nucleus pulposus progenitor cell multipotency.
JOR spine
Guerrero J,Häckel S,Croft AS,Albers CE,Gantenbein B
Mon Mar 01 00:00:00 UTC 2021
Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.
Scientific reports
Stahlhut M,Ha TC,Takmakova E,Morgan MA,Schwarzer A,Schaudien D,Eder M,Schambach A,Kustikova OS
Fri Mar 05 00:00:00 UTC 2021
RANK promotes colorectal cancer migration and invasion by activating the Ca2+-calcineurin/NFATC1-ACP5 axis.
Cell death & disease
Liang Q,Wang Y,Lu Y,Zhu Q,Xie W,Tang N,Huang L,An T,Zhang D,Yan A,Liu S,Ye L,Zhu C
Thu Apr 01 00:00:00 UTC 2021
Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation.
Nature communications
Ramosaj M,Madsen S,Maillard V,Scandella V,Sudria-Lopez D,Yuizumi N,Telley L,Knobloch M
Tue Dec 21 00:00:00 UTC 2021
Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry.
Pathogens (Basel, Switzerland)
Suryawanshi RK,Patil CD,Koganti R,Singh SK,Ames JM,Shukla D
100-18B was used in Cell Culture to confirm the possible use of cationic peptides to inhibit the entry of SARS-CoV-2.
Thu Jun 24 00:00:00 UTC 2021
Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology.
Nature communications
Osuna de la Peña D,Trabulo SMD,Collin E,Liu Y,Sharma S,Tatari M,Behrens D,Erkan M,Lawlor RT,Scarpa A,Heeschen C,Mata A,Loessner D
Fri Sep 24 00:00:00 UTC 2021
HES1 protein oscillations are necessary for neural stem cells to exit from quiescence.
iScience
Marinopoulou E,Biga V,Sabherwal N,Miller A,Desai J,Adamson AD,Papalopulu N
Fri Oct 22 00:00:00 UTC 2021
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination.
Nature communications
Saraswat D,Shayya HJ,Polanco JJ,Tripathi A,Welliver RR,Pol SU,Seidman RA,Broome JE,O'Bara MA,van Kuppervelt TH,Phillips JJ,Dutta R,Sim FJ
Fri Mar 26 00:00:00 UTC 2021
5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease.
Cell reports
Kuehner JN,Chen J,Bruggeman EC,Wang F,Li Y,Xu C,McEachin ZT,Li Z,Chen L,Hales CM,Wen Z,Yang J,Yao B
100-18B was used in Tissue/organ culture to generate 5hmC and transcriptome profiles encompassing several developmental time points of healthy forebrain organoids and organoids derived from several familial Alzheimer's disease (AD) patients.
Tue Apr 27 00:00:00 UTC 2021
CD44 expression in the tumor periphery predicts the responsiveness to bevacizumab in the treatment of recurrent glioblastoma.
Cancer medicine
Nishikawa M,Inoue A,Ohnishi T,Yano H,Kanemura Y,Kohno S,Ohue S,Ozaki S,Matsumoto S,Suehiro S,Nakamura Y,Shigekawa S,Watanabe H,Kitazawa R,Tanaka J,Kunieda T
Mon Mar 01 00:00:00 UTC 2021
Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity.
The Journal of biological chemistry
Pajarillo E,Digman A,Nyarko-Danquah I,Son DS,Soliman KFA,Aschner M,Lee E
Wed Dec 01 00:00:00 UTC 2021
Using the Microwell-mesh to culture microtissues in vitro and as a carrier to implant microtissues in vivo into mice.
Scientific reports
Monterosso ME,Futrega K,Lott WB,Vela I,Williams ED,Doran MR
Thu Mar 04 00:00:00 UTC 2021
Differentiation of Brain Pericyte-Like Cells from Human Pluripotent Stem Cell-Derived Neural Crest.
Current protocols
Gastfriend BD,Stebbins MJ,Du F,Shusta EV,Palecek SP
100-18B was used in In vitro experiments to describe a protocol to differentiate hPSCs to NG2+ PDGFRβ+ αSMAlow brain pericyte-like cells in 22-25 days through a p75-NGFR+ HNK-1+ neural crest intermediate, which mimics the developmental origin of forebrain pericytes and protocols for maintenance, cryopreservation, and recovery of the neural crest intermediate, and for molecular and functional characterization of the resulting cells.
Fri Jan 01 00:00:00 UTC 2021
An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement.
Communications biology
O'Donnell JC,Purvis EM,Helm KVT,Adewole DO,Zhang Q,Le AD,Cullen DK
Thu Jul 15 00:00:00 UTC 2021
An in vivo model allowing continuous observation of human vascular formation in the same animal over time.
Scientific reports
Tsukada Y,Muramatsu F,Hayashi Y,Inagaki C,Su H,Iba T,Kidoya H,Takakura N
Tue Jan 12 00:00:00 UTC 2021
Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis.
Cell reports
Yucer N,Ahdoot R,Workman MJ,Laperle AH,Recouvreux MS,Kurowski K,Naboulsi DJ,Liang V,Qu Y,Plummer JT,Gayther SA,Orsulic S,Karlan BY,Svendsen CN
100-18B was used in Cell Culture to generate induced pluripotent stem cells (iPSCs) from healthy individuals and young ovarian cancer patients with germline pathogenic BRCA1 mutations (BRCA1mut).
Tue Dec 28 00:00:00 UTC 2021
SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
Nature communications
Kim JH,Jeong K,Li J,Murphy JM,Vukadin L,Stone JK,Richard A,Tran J,Gillespie GY,Flemington EK,Sobol RW,Lim SS,Ahn EE
Tue Sep 21 00:00:00 UTC 2021
Cilium induction triggers differentiation of glioma stem cells.
Cell reports
Goranci-Buzhala G,Mariappan A,Ricci-Vitiani L,Josipovic N,Pacioni S,Gottardo M,Ptok J,Schaal H,Callaini G,Rajalingam K,Dynlacht B,Hadian K,Papantonis A,Pallini R,Gopalakrishnan J
Tue Sep 07 00:00:00 UTC 2021
GDF15 promotes glioma stem cell-like phenotype via regulation of ERK1/2-c-Fos-LIF signaling.
Cell death discovery
Zhu S,Yang N,Guan Y,Wang X,Zang G,Lv X,Deng S,Wang W,Li T,Chen J
Mon Jan 11 00:00:00 UTC 2021
Enhancers with tissue-specific activity are enriched in intronic regions.
Genome research
Borsari B,Villegas-Mirón P,Pérez-Lluch S,Turpin I,Laayouni H,Segarra-Casas A,Bertranpetit J,Guigó R,Acosta S
100-18B was used in Cell Culture to explore the correlation between the genomic location of enhancers and their role in tissue-specific gene expression.
Sun Aug 01 00:00:00 UTC 2021
ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma.
Cell reports
De Bacco F,Orzan F,Erriquez J,Casanova E,Barault L,Albano R,D'Ambrosio A,Bigatto V,Reato G,Patanè M,Pollo B,Kuesters G,Dell'Aglio C,Casorzo L,Pellegatta S,Finocchiaro G,Comoglio PM,Boccaccio C
Tue Jul 27 00:00:00 UTC 2021
Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation.
eLife
Cirnaru MD,Song S,Tshilenge KT,Corwin C,Mleczko J,Galicia Aguirre C,Benlhabib H,Bendl J,Apontes P,Fullard J,Creus-Muncunill J,Reyahi A,Nik AM,Carlsson P,Roussos P,Mooney SD,Ellerby LM,Ehrlich ME
100-18B was used in Cell Culture to dissect and manipulate the transcription factor networks regulating medium spiny neurone compartmentation and differentiation,.
Tue Oct 05 00:00:00 UTC 2021
Central Cholinergic Synapse Formation in Optimized Primary Septal-Hippocampal Co-cultures.
Cellular and molecular neurobiology
Djemil S,Ressel CR,Abdel-Ghani M,Schneeweis AK,Pak DTS
100-18B was used in Cell Culture to develop an optimised primary septal-hippocampal co-culture system and identify conditions that produced robust septal-hippocampal synapse formation.
Mon Nov 01 00:00:00 UTC 2021
SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis.
Cell reports
Jung HS,Uenishi G,Park MA,Liu P,Suknuntha K,Raymond M,Choi YJ,Thomson JA,Ong IM,Slukvin II
100-18B was used in In vitro experiments to investigate the role and mechanisms of SOX17 in human pluripotent stem cells.
Tue Feb 16 00:00:00 UTC 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
Tue Jun 08 00:00:00 UTC 2021
On the role of p53 in the cellular response to aneuploidy.
Cell reports
Narkar A,Johnson BA,Bharne P,Zhu J,Padmanaban V,Biswas D,Fraser A,Iglesias PA,Ewald AJ,Li R
Tue Mar 23 00:00:00 UTC 2021
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Nature
Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ,Shido K,Spence JR,Zhou QJ,Schwartz RE,De Coppi P,Rabbany SY,Rafii S
Tue Sep 01 00:00:00 UTC 2020
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nature
Nikolaev M,Mitrofanova O,Broguiere N,Geraldo S,Dutta D,Tabata Y,Elci B,Brandenberg N,Kolotuev I,Gjorevski N,Clevers H,Lutolf MP
Tue Sep 01 00:00:00 UTC 2020
An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.
Cell
Kawasaki K,Toshimitsu K,Matano M,Fujita M,Fujii M,Togasaki K,Ebisudani T,Shimokawa M,Takano A,Takahashi S,Ohta Y,Nanki K,Igarashi R,Ishimaru K,Ishida H,Sukawa Y,Sugimoto S,Saito Y,Maejima K,Sasagawa S,Lee H,Kim HG,Ha K,Hamamoto J,Fukunaga K,Maekawa A,Tanabe M,Ishihara S,Hamamoto Y,Yasuda H,Sekine S,Kudo A,Kitagawa Y,Kanai T,Nakagawa H,Sato T
Wed Nov 25 00:00:00 UTC 2020
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.
Cell
Michealraj KA,Kumar SA,Kim LJY,Cavalli FMG,Przelicki D,Wojcik JB,Delaidelli A,Bajic A,Saulnier O,MacLeod G,Vellanki RN,Vladoiu MC,Guilhamon P,Ong W,Lee JJY,Jiang Y,Holgado BL,Rasnitsyn A,Malik AA,Tsai R,Richman CM,Juraschka K,Haapasalo J,Wang EY,De Antonellis P,Suzuki H,Farooq H,Balin P,Kharas K,Van Ommeren R,Sirbu O,Rastan A,Krumholtz SL,Ly M,Ahmadi M,Deblois G,Srikanthan D,Luu B,Loukides J,Wu X,Garzia L,Ramaswamy V,Kanshin E,Sánchez-Osuna M,El-Hamamy I,Coutinho FJ,Prinos P,Singh S,Donovan LK,Daniels C,Schramek D,Tyers M,Weiss S,Stein LD,Lupien M,Wouters BG,Garcia BA,Arrowsmith CH,Sorensen PH,Angers S,Jabado N,Dirks PB,Mack SC,Agnihotri S,Rich JN,Taylor MD
Thu Jun 11 00:00:00 UTC 2020
An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility.
Circulation
Madsen A,Höppner G,Krause J,Hirt MN,Laufer SD,Schweizer M,Tan WLW,Mosqueira D,Anene-Nzelu CG,Lim I,Foo RSY,Hansen A,Eschenhagen T,Stenzig J
100-18B was used in In vitro experiments to investigate the role of DNA methylation in the normal homeostasis of cardiomyocytes and during cardiac stress.
Tue Oct 20 00:00:00 UTC 2020
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Signal transduction and targeted therapy
Ouyang L,Yan B,Liu Y,Mao C,Wang M,Liu N,Wang Z,Liu S,Shi Y,Chen L,Wang X,Cheng Y,Cao Y,Xiao D,Zhang L,Liu S,Tao Y
Wed Jun 17 00:00:00 UTC 2020
Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and protein factors.
Military Medical Research
Qin H,Zhao AD,Sun ML,Ma K,Fu XB
100-18B was used in Sample Preparation to develope a chemical cocktail of small molecules and protein factors to convert human fibroblasts into DA neuron-like cells without passing through a neural progenitor/stem cell intermediate stage.
Sun Nov 01 00:00:00 UTC 2020
Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras.
Cell stem cell
Cohen MA,Zhang S,Sengupta S,Ma H,Bell GW,Horton B,Sharma B,George RE,Spranger S,Jaenisch R
100-18B was used in Sample Preparation to develop an experimental platform for studying neuroblastoma using mouse-human neural crest chimeras.
Thu Apr 02 00:00:00 UTC 2020
Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit.
Cell stem cell
Morrow CS,Porter TJ,Xu N,Arndt ZP,Ako-Asare K,Heo HJ,Thompson EAN,Moore DL
100-18B was used in Cell Culture to demonstrate that adult neural stem cells (NSCs) utilize aggresomes to recover from disrupted proteostasis and describe a novel function for the intermediate filament vimentin in proteostasis as a spatial coordinator of proteasomes to the aggresome.
Thu Apr 02 00:00:00 UTC 2020
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.
Cell stem cell
Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A
100-18B was used in In vitro experiments to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.
Thu Nov 05 00:00:00 UTC 2020
An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering.
Advanced functional materials
Ritzau-Reid KI,Spicer CD,Gelmi A,Grigsby CL,Ponder JF,Bemmer V,Creamer A,Vilar R,Serio A,Stevens MM
Thu Oct 15 00:00:00 UTC 2020
Methylation in pericytes after acute injury promotes chronic kidney disease.
The Journal of clinical investigation
Chou YH,Pan SY,Shao YH,Shih HM,Wei SY,Lai CF,Chiang WC,Schrimpf C,Yang KC,Lai LC,Chen YM,Chu TS,Lin SL
Tue Sep 01 00:00:00 UTC 2020
Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma.
EMBO molecular medicine
Han M,Wang S,Yang N,Wang X,Zhao W,Saed HS,Daubon T,Huang B,Chen A,Li G,Miletic H,Thorsen F,Bjerkvig R,Li X,Wang J
Thu Jan 09 00:00:00 UTC 2020
Antagonism of interferon signaling by fibroblast growth factors promotes viral replication.
EMBO molecular medicine
Maddaluno L,Urwyler C,Rauschendorfer T,Meyer M,Stefanova D,Spörri R,Wietecha M,Ferrarese L,Stoycheva D,Bender D,Li N,Strittmatter G,Nasirujjaman K,Beer HD,Staeheli P,Hildt E,Oxenius A,Werner S
Mon Sep 07 00:00:00 UTC 2020
Antagonism of interferon signaling by fibroblast growth factors promotes viral replication.
EMBO molecular medicine
Maddaluno L,Urwyler C,Rauschendorfer T,Meyer M,Stefanova D,Spörri R,Wietecha M,Ferrarese L,Stoycheva D,Bender D,Li N,Strittmatter G,Nasirujjaman K,Beer HD,Staeheli P,Hildt E,Oxenius A,Werner S
Mon Sep 07 00:00:00 UTC 2020
Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.
EMBO molecular medicine
Liang KX,Kristiansen CK,Mostafavi S,Vatne GH,Zantingh GA,Kianian A,Tzoulis C,Høyland LE,Ziegler M,Perez RM,Furriol J,Zhang Z,Balafkan N,Hong Y,Siller R,Sullivan GJ,Bindoff LA
Wed Oct 07 00:00:00 UTC 2020
A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming.
EMBO molecular medicine
Cangkrama M,Wietecha M,Mathis N,Okumura R,Ferrarese L,Al-Nuaimi D,Antsiferova M,Dummer R,Innocenti M,Werner S
Tue Apr 07 00:00:00 UTC 2020
Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency.
The EMBO journal
Sun H,Yang X,Liang L,Zhang M,Li Y,Chen J,Wang F,Yang T,Meng F,Lai X,Li C,He J,He M,Xu Q,Li Q,Lin L,Pei D,Zheng H
Wed Apr 15 00:00:00 UTC 2020
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
The EMBO journal
Cinque L,De Leonibus C,Iavazzo M,Krahmer N,Intartaglia D,Salierno FG,De Cegli R,Di Malta C,Svelto M,Lanzara C,Maddaluno M,Wanderlingh LG,Huebner AK,Cesana M,Bonn F,Polishchuk E,Hübner CA,Conte I,Dikic I,Mann M,Ballabio A,Sacco F,Grumati P,Settembre C
Tue Sep 01 00:00:00 UTC 2020
A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cell-derived neurons.
Proceedings of the National Academy of Sciences of the United States of America
Hsu CC,Xu J,Brinkhof B,Wang H,Cui Z,Huang WE,Ye H
Tue Aug 04 00:00:00 UTC 2020
A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Smith BA,Balanis NG,Tsai BL,Nguyen K,Cheng MW,Obusan MB,Esedebe FN,Patel SJ,Zhang H,Clark PM,Sisk AE,Said JW,Huang J,Graeber TG,Witte ON,Chin AI,Park JW
Tue Jan 07 00:00:00 UTC 2020
A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Smith BA,Balanis NG,Tsai BL,Nguyen K,Cheng MW,Obusan MB,Esedebe FN,Patel SJ,Zhang H,Clark PM,Sisk AE,Said JW,Huang J,Graeber TG,Witte ON,Chin AI,Park JW
Tue Jan 07 00:00:00 UTC 2020
B3GALT5 knockout alters gycosphingolipid profile and facilitates transition to human naïve pluripotency.
Proceedings of the National Academy of Sciences of the United States of America
Lin RJ,Kuo MW,Yang BC,Tsai HH,Chen K,Huang JR,Lee YS,Yu AL,Yu J
Tue Nov 03 00:00:00 UTC 2020
Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells.
Experimental & molecular medicine
Park JH,Lee NK,Lim HJ,Ji ST,Kim YJ,Jang WB,Kim DY,Kang S,Yun J,Ha JS,Kim H,Lee D,Baek SH,Kwon SM
Wed Apr 01 00:00:00 UTC 2020
Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle.
Cell death and differentiation
Giovarelli M,Zecchini S,Martini E,Garrè M,Barozzi S,Ripolone M,Napoli L,Coazzoli M,Vantaggiato C,Roux-Biejat P,Cervia D,Moscheni C,Perrotta C,Parazzoli D,Clementi E,De Palma C
Sat Aug 01 00:00:00 UTC 2020
One-Step Photoactivation of a Dual-Functionalized Bioink as Cell Carrier and Cartilage-Binding Glue for Chondral Regeneration.
Advanced healthcare materials
Lim KS,Abinzano F,Bernal PN,Albillos Sanchez A,Atienza-Roca P,Otto IA,Peiffer QC,Matsusaki M,Woodfield TBF,Malda J,Levato R
Sat Aug 01 00:00:00 UTC 2020
High-Throughput Screening and Hierarchical Topography-Mediated Neural Differentiation of Mesenchymal Stem Cells.
Advanced healthcare materials
Yang L,Jurczak KM,Ge L,van Rijn P
Mon Jun 01 00:00:00 UTC 2020
miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction.
Aging cell
Hong Y,He H,Jiang G,Zhang H,Tao W,Ding Y,Yuan D,Liu J,Fan H,Lin F,Liang X,Li X,Zhang Y
Wed Apr 01 00:00:00 UTC 2020
Chemotherapy exacerbates ovarian cancer cell migration and cancer stem cell-like characteristics through GLI1.
British journal of cancer
Zhao Y,He M,Cui L,Gao M,Zhang M,Yue F,Shi T,Yang X,Pan Y,Zheng X,Jia Y,Shao D,Li J,He K,Chen L
100-18B was used in Cell Culture to investigate effect of chemotherapeutic treatment of ovarian cancer on its subsequent metastasis.
Fri May 01 00:00:00 UTC 2020
ECE2 regulates neurogenesis and neuronal migration during human cortical development.
EMBO reports
Buchsbaum IY,Kielkowski P,Giorgio G,O'Neill AC,Di Giaimo R,Kyrousi C,Khattak S,Sieber SA,Robertson SP,Cappello S
Wed May 06 00:00:00 UTC 2020
Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant.
Oncogene
Veschi V,Mangiapane LR,Nicotra A,Di Franco S,Scavo E,Apuzzo T,Sardina DS,Fiori M,Benfante A,Colorito ML,Cocorullo G,Giuliante F,Cipolla C,Pistone G,Bongiorno MR,Rizzo A,Tate CM,Wu X,Rowlinson S,Stancato LF,Todaro M,De Maria R,Stassi G
Wed Jan 01 00:00:00 UTC 2020
A novel method to improve the osteogenesis capacity of hUCMSCs with dual-directional pre-induction under screened co-culture conditions.
Cell proliferation
Rong Q,Li S,Zhou Y,Geng Y,Liu S,Wu W,Forouzanfar T,Wu G,Zhang Z,Zhou M
Sat Feb 01 00:00:00 UTC 2020
Evidence for endothelial-to-mesenchymal transition in human brain arteriovenous malformations.
Clinical and translational medicine
Shoemaker LD,McCormick AK,Allen BM,Chang SD
Mon Jun 01 00:00:00 UTC 2020
Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology.
Glia
Zhao C,Devlin AC,Chouhan AK,Selvaraj BT,Stavrou M,Burr K,Brivio V,He X,Mehta AR,Story D,Shaw CE,Dando O,Hardingham GE,Miles GB,Chandran S
Fri May 01 00:00:00 UTC 2020
CRISPR/Cas9-mediated introduction of the sodium/iodide symporter gene enables noninvasive in vivo tracking of induced pluripotent stem cell-derived cardiomyocytes.
Stem cells translational medicine
Ostrominski JW,Yada RC,Sato N,Klein M,Blinova K,Patel D,Valadez R,Palisoc M,Pittaluga S,Peng KW,San H,Lin Y,Basuli F,Zhang X,Swenson RE,Haigney M,Choyke PL,Zou J,Boehm M,Hong SG,Dunbar CE
Thu Oct 01 00:00:00 UTC 2020
Grafted human pluripotent stem cell-derived cortical neurons integrate into adult human cortical neural circuitry.
Stem cells translational medicine
Grønning Hansen M,Laterza C,Palma-Tortosa S,Kvist G,Monni E,Tsupykov O,Tornero D,Uoshima N,Soriano J,Bengzon J,Martino G,Skibo G,Lindvall O,Kokaia Z
Sun Nov 01 00:00:00 UTC 2020
Antibacterial activity of human mesenchymal stem cells mediated directly by constitutively secreted factors and indirectly by activation of innate immune effector cells.
Stem cells translational medicine
Chow L,Johnson V,Impastato R,Coy J,Strumpf A,Dow S
Sat Feb 01 00:00:00 UTC 2020
Downregulation of STK4 promotes colon cancer invasion/migration through blocking β-catenin degradation.
Molecular oncology
Lin CH,Hsu TI,Chiou PY,Hsiao M,Wang WC,Chen YC,Lin JT,Wang JY,Lin PC,Lin FC,Tseng YK,Cheng HC,Chen CL,Lu PJ
Thu Oct 01 00:00:00 UTC 2020
TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion.
Molecular oncology
Navarro R,Tapia-Galisteo A,Martín-García L,Tarín C,Corbacho C,Gómez-López G,Sánchez-Tirado E,Campuzano S,González-Cortés A,Yáñez-Sedeño P,Compte M,Álvarez-Vallina L,Sanz L
Thu Oct 01 00:00:00 UTC 2020
The long non-coding RNA DANCR regulates the inflammatory phenotype of breast cancer cells and promotes breast cancer progression via EZH2-dependent suppression of SOCS3 transcription.
Molecular oncology
Zhang KJ,Tan XL,Guo L
Sat Feb 01 00:00:00 UTC 2020
Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib.
International journal of cancer
Englinger B,Laemmerer A,Moser P,Kallus S,Röhrl C,Pirker C,Baier D,Mohr T,Niederstaetter L,Meier-Menches SM,Gerner C,Gabler L,Gojo J,Timelthaler G,Senkiv J,Jäger W,Kowol CR,Heffeter P,Berger W
Tue Sep 15 00:00:00 UTC 2020
Cerebral organoids transplantation improves neurological motor function in rat brain injury.
CNS neuroscience & therapeutics
Wang Z,Wang SN,Xu TY,Hong C,Cheng MH,Zhu PX,Lin JS,Su DF,Miao CY
Wed Jul 01 00:00:00 UTC 2020
Herpes Simplex Virus 1 Strains 17syn+ and KOS(M) Differ Greatly in Their Ability To Reactivate from Human Neurons In Vitro.
Journal of virology
Grams TR,Edwards TG,Bloom DC
100-18B was used in Cell Culture to suggest that the epigenetic state of the viral genome is an important determinant of reactivation that varies in a strain-specific manner.
Thu Jul 16 00:00:00 UTC 2020
Both Hypoxia-Inducible Factor 1 and MAPK Signaling Pathway Attenuate PI3K/AKT via Suppression of Reactive Oxygen Species in Human Pluripotent Stem Cells.
Frontiers in cell and developmental biology
Fojtík P,Beckerová D,Holomková K,Šenfluk M,Rotrekl V
100-18B was used in Cell Culture to provide new insights into the regulation of cancer stem cell signaling.
Wed Feb 10 00:00:00 UTC 2021
Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions.
Neural regeneration research
Nguyen LH,Ong W,Wang K,Wang M,Nizetic D,Chew SY
100-18B was used in Cell Culture to study the effects of miR-219/miR-338 treatment on microglia and astrocytes in vitro and in vivo and suggest that miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries.
Wed Apr 01 00:00:00 UTC 2020
Glioma stem cell (GSC)-derived autoschizis-like products confer GSC niche properties involving M1-like tumor-associated macrophages.
Stem cells (Dayton, Ohio)
Tabu K,Liu W,Kosaku A,Terashima K,Murota Y,Aimaitijiang A,Nobuhisa I,Hide T,Taga T
Sat Aug 01 00:00:00 UTC 2020
Implantation of the clinical-grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease.
Stem cells (Dayton, Ohio)
Yoon Y,Kim HS,Jeon I,Noh JE,Park HJ,Lee S,Park IH,Stevanato L,Hicks C,Corteling R,Barker RA,Sinden JD,Song J
Sat Aug 01 00:00:00 UTC 2020
MMP13 and TIMP1 are functional markers for two different potential modes of action by mesenchymal stem/stromal cells when treating osteoarthritis.
Stem cells (Dayton, Ohio)
Salerno A,Brady K,Rikkers M,Li C,Caamaño-Gutierrez E,Falciani F,Blom AW,Whitehouse MR,Hollander AP
Sun Nov 01 00:00:00 UTC 2020
Single-cell profiling of long noncoding RNAs and their cell lineage commitment roles via RNA-DNA-DNA triplex formation in mammary epithelium.
Stem cells (Dayton, Ohio)
Xu H,Yang X,Huang W,Ma Y,Ke H,Zou L,Yang Q,Jiao B
Tue Sep 15 00:00:00 UTC 2020
Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population.
Stem cells (Dayton, Ohio)
Walsh P,Truong V,Nayak S,Saldías Montivero M,Low WC,Parr AM,Dutton JR
Sun Nov 01 00:00:00 UTC 2020
cPLA2α reversibly regulates different subsets of cancer stem cells transformation in cervical cancer.
Stem cells (Dayton, Ohio)
He Y,Xiao M,Fu H,Chen L,Qi L,Liu D,Guo P,Chen L,Luo Y,Xiao H,Zhang N,Guo H
Wed Apr 01 00:00:00 UTC 2020
Peroxidasin is essential for endothelial cell survival and growth signaling by sulfilimine crosslink-dependent matrix assembly.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lee SW,Kim HK,Naidansuren P,Ham KA,Choi HS,Ahn HY,Kim M,Kang DH,Kang SW,Joe YA
Sat Aug 01 00:00:00 UTC 2020
Heterochromatin protein 1γ deficiency decreases histone H3K27 methylation in mouse neurosphere neuronal genes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Naruse C,Abe K,Yoshihara T,Kato T,Nishiuchi T,Asano M
Sun Mar 01 00:00:00 UTC 2020
Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ghosh R,Wood-Kaczmar A,Dobson L,Smith EJ,Sirinathsinghji EC,Kriston-Vizi J,Hargreaves IP,Heaton R,Herrmann F,Abramov AY,Lam AJ,Heales SJ,Ketteler R,Bates GP,Andre R,Tabrizi SJ
Mon Jun 01 00:00:00 UTC 2020
In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dungan CM,Peck BD,Walton RG,Huang Z,Bamman MM,Kern PA,Peterson CA
Fri May 01 00:00:00 UTC 2020
Myeloid-derived suppressor cells promote epithelial ovarian cancer cell stemness by inducing the CSF2/p-STAT3 signalling pathway.
The FEBS journal
Li X,Wang J,Wu W,Gao H,Liu N,Zhan G,Li L,Han L,Guo X
Tue Dec 01 00:00:00 UTC 2020
A new FGFR inhibitor disrupts the TGF-β1-induced fibrotic process.
Journal of cellular and molecular medicine
Kim MH,Jung SY,Song KH,Park JI,Ahn J,Kim EH,Park JK,Hwang SG,Woo HJ,Song JY
Wed Jan 01 00:00:00 UTC 2020
LncRNA SPRY4-IT1 regulates breast cancer cell stemness through competitively binding miR-6882-3p with TCF7L2.
Journal of cellular and molecular medicine
Song X,Zhang X,Wang X,Chen L,Jiang L,Zheng A,Zhang M,Zhao L,Wei M
Wed Jan 01 00:00:00 UTC 2020
Reprogramming fibroblasts and peripheral blood cells from a C9ORF72 patient: A proof-of-principle study.
Journal of cellular and molecular medicine
Bardelli D,Sassone F,Colombrita C,Volpe C,Gumina V,Peverelli S,Catusi I,Ratti A,Silani V,Bossolasco P
Wed Apr 01 00:00:00 UTC 2020
Lysophosphatidic acid improves corneal endothelial density in tissue culture by stimulating stromal secretion of interleukin-1β.
Journal of cellular and molecular medicine
Hsueh YJ,Meir YJ,Lai JY,Chen HC,Ma DH,Huang CC,Lu TT,Cheng CM,Wu WC
Mon Jun 01 00:00:00 UTC 2020
microRNA-124 inhibits stem-like properties and enhances radiosensitivity in nasopharyngeal carcinoma cells via direct repression of expression of JAMA.
Journal of cellular and molecular medicine
Tian Y,Tian Y,Tu Y,Zhang G,Zeng X,Lin J,Ai M,Mao Z,Zheng R,Yuan Y
Tue Sep 01 00:00:00 UTC 2020
Odontogenesis and neuronal differentiation characteristics of periodontal ligament stem cells from beagle dog.
Journal of cellular and molecular medicine
Li X,Liao D,Sun G,Chu H
Fri May 01 00:00:00 UTC 2020
Differential response to hepatic differentiation stimuli of amniotic epithelial cells isolated from four regions of the amniotic membrane.
Journal of cellular and molecular medicine
Passaretta F,Bosco D,Centurione L,Centurione MA,Marongiu F,Di Pietro R
Wed Apr 01 00:00:00 UTC 2020
Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors.
American journal of physiology. Cell physiology
Sepehrimanesh M,Ding B
Thu Oct 01 00:00:00 UTC 2020
Cardiotoxicity induced by the combination therapy of chloroquine and azithromycin in human embryonic stem cell-derived cardiomyocytes.
BMB reports
Kim YS,Lee SY,Yoon JW,Kim D,Yu S,Kim JS,Kim JH
100-18B was used in Cell Culture to suggest that azithromycin reinforces the cardiotoxicity induced by chloroquine in hESC-CMs.
Sun Nov 01 00:00:00 UTC 2020
CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10.
Investigative ophthalmology & visual science
Bucher F,Aguilar E,Marra KV,Rapp J,Arnold J,Diaz-Aguilar S,Lange C,Agostini H,Schlunck G,Stahl A,Friedlander M
100-18B was used in In vitro experiments to investigate the effects of of ciliary neurotrophic factor on outer retinal and choroidal angiogenesis and the mechanisms underpinning any changes in outer retinal neovascularisation following this treatment.
Mon Aug 03 00:00:00 UTC 2020
Combined targeting of EGFR and HER2 against prostate cancer stem cells.
Cancer biology & therapy
Rossini A,Giussani M,Ripamonti F,Aiello P,Regondi V,Balsari A,Triulzi T,Tagliabue E
100-18B was used in Cell Culture to provide the preclinical evidence that the dual inhibition of EGFR and HER2 by targeting tumor-initiating cells may improve the efficacy of the current chemotherapy regimen, bringing benefits especially to castration-resistant patients with activated STAT3, and preventing disease progression.
Sun May 03 00:00:00 UTC 2020
Bioprocess development for scalable production of cultivated meat.
Biotechnology and bioengineering
Hanga MP,Ali J,Moutsatsou P,de la Raga FA,Hewitt CJ,Nienow A,Wall I
Thu Oct 01 00:00:00 UTC 2020
Effective Inhibition of MYC-Amplified Group 3 Medulloblastoma Through Targeting EIF4A1.
Cancer management and research
Zhao Y,Li T,Tian S,Meng W,Sui Y,Yang J,Wang B,Liang Z,Zhao H,Han Y,Tang Y,Zhang L,Ma J
100-18B was used in Cell Culture to study the identification of novel effective therapeutic strategies against MYC-amplified group 3 (G3)-medulloblastoma (MB) via targeting MYC translation to show that interrupting MYC translation by EIF4A1 inhibition could be a potential effective therapeutic approach when treating patients with MYC-amplified G3-MB.
Mon Apr 18 00:00:00 UTC 2022
Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering.
Journal of biomedical materials research. Part B, Applied biomaterials
Reid JA,Callanan A
Wed Apr 01 00:00:00 UTC 2020
Long-Term Expansion of Functional Human Pluripotent Stem Cell-Derived Hepatic Organoids.
International journal of stem cells
Mun SJ,Hong YH,Ahn HS,Ryu JS,Chung KS,Son MJ
100-18B was used in Cell Culture to test long-term prolonged culture of organoids to increase their maturity to demonstrate that organoids can be exponentially expanded by serial passaging, while maintaining long-term functional maturation potential, hence are a practical and renewable cell source for human cell-based and personalized 3D liver models.
Thu Jul 30 00:00:00 UTC 2020
Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina.
Nature communications
Park TS,Zimmerlin L,Evans-Moses R,Thomas J,Huo JS,Kanherkar R,He A,Ruzgar N,Grebe R,Bhutto I,Barbato M,Koldobskiy MA,Lutty G,Zambidis ET
Thu Mar 05 00:00:00 UTC 2020
The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic Performance.
Theranostics
Heidel JS,Fischer AG,Tang XL,Sadri G,Wu WJ,Moisa CR,Stowers H,Sandella N,Wysoczynski M,Uchida S,Moore Iv JB
100-18B was used in Cell Culture to study the consequences of enhanced cardiogenic factor expression via lentiviral delivery of GMT (GATA4, MEF2C, and TBX5), on cardiac mesenchymal cell (CMC) anti-fibrogenic paracrine signaling dynamics, in vitro, and cardiac reparative capacity, in vivo to show that CMC cardiomyogenic lineage commitment biases cardiac repair and, further, that enhanced anti-fibrogenic paracrine signaling potency may underlie, in part, their improved therapeutic utility.
Tue Apr 13 00:00:00 UTC 2021
Genetically Engineered Mouse Model of Brainstem High-Grade Glioma.
STAR protocols
Nunez FM,Gauss JC,Mendez FM,Haase S,Lowenstein PR,Castro MG
100-18B was used in Cell Culture to study the effect of these mutations in tumor progression and response to treatments can be studied within a relevant in vivo context.
Fri Dec 18 00:00:00 UTC 2020
Raloxifene prevents stress granule dissolution, impairs translational control and promotes cell death during hypoxia in glioblastoma cells.
Cell death & disease
Attwood KM,Robichaud A,Westhaver LP,Castle EL,Brandman DM,Balgi AD,Roberge M,Colp P,Croul S,Kim I,McCormick C,Corcoran JA,Weeks A
Tue Nov 17 00:00:00 UTC 2020
Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons.
Scientific reports
Schwartzentruber A,Boschian C,Lopes FM,Myszczynska MA,New EJ,Beyrath J,Smeitink J,Ferraiuolo L,Mortiboys H
Wed Sep 23 00:00:00 UTC 2020
Generation of Human Neutrophils from Induced Pluripotent Stem Cells in Chemically Defined Conditions Using ETV2 Modified mRNA.
STAR protocols
Majumder A,Suknuntha K,Bennin D,Klemm L,Brok-Volchanskaya VS,Huttenlocher A,Slukvin I
100-18B was used in Cell Culture to create neutrophils from human induced pluripotent stem cells using mRNA.
Fri Sep 18 00:00:00 UTC 2020
A Novel Function for KLF4 in Modulating the De-differentiation of EpCAM-/CD133- nonStem Cells into EpCAM+/CD133+ Liver Cancer Stem Cells in HCC Cell Line HuH7.
Cells
Karagonlar ZF,Akbari S,Karabicici M,Sahin E,Avci ST,Ersoy N,Ates KE,Balli T,Karacicek B,Kaplan KN,Celiker C,Atabey N,Erdal E
100-18B was used in Cell Culture to study how KLF4 as a transcription factor that can induce a cancer stem cell (CSC)-like phenotype in non-CSCs through upregulating the EpCAM and E-CAD expression.
Tue May 12 00:00:00 UTC 2020
An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding.
Scientific reports
Oostdyk LT,Wang Z,Zang C,Li H,McConnell MJ,Paschal BM
Mon Mar 16 00:00:00 UTC 2020
Neural Transplants From Human Induced Pluripotent Stem Cells Rescue the Pathology and Behavioral Defects in a Rodent Model of Huntington's Disease.
Frontiers in neuroscience
Yoon Y,Kim HS,Hong CP,Li E,Jeon I,Park HJ,Lee N,Pei Z,Song J
100-18B was used in Cell Culture to investigate spiny neurone formation from hiPSC in Huntington’s disease.
Thu Oct 22 00:00:00 UTC 2020
Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical neurons.
Scientific reports
Satir TM,Nazir FH,Vizlin-Hodzic D,Hardselius E,Blennow K,Wray S,Zetterberg H,Agholme L,Bergström P
Fri Jan 17 00:00:00 UTC 2020
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities.
Nature communications
Narayan RS,Molenaar P,Teng J,Cornelissen FMG,Roelofs I,Menezes R,Dik R,Lagerweij T,Broersma Y,Petersen N,Marin Soto JA,Brands E,van Kuiken P,Lecca MC,Lenos KJ,In 't Veld SGJG,van Wieringen W,Lang FF,Sulman E,Verhaak R,Baumert BG,Stalpers LJA,Vermeulen L,Watts C,Bailey D,Slotman BJ,Versteeg R,Noske D,Sminia P,Tannous BA,Wurdinger T,Koster J,Westerman BA
Wed Jun 10 00:00:00 UTC 2020
A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior.
Nature communications
Schiano Lomoriello I,Giangreco G,Iavarone C,Tordonato C,Caldieri G,Serio G,Confalonieri S,Freddi S,Bianchi F,Pirroni S,Bertalot G,Viale G,Disalvatore D,Tosoni D,Malabarba MG,Disanza A,Scita G,Pece S,Pilcher BK,Vecchi M,Sigismund S,Di Fiore PP
Mon Jun 15 00:00:00 UTC 2020
Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids.
Nature communications
Zafeiriou MP,Bao G,Hudson J,Halder R,Blenkle A,Schreiber MK,Fischer A,Schild D,Zimmermann WH
Wed Jul 29 00:00:00 UTC 2020
Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca).
Cells
Horváth A,Christ T,Koivumäki JT,Prondzynski M,Zech ATL,Spohn M,Saleem U,Mannhardt I,Ulmer B,Girdauskas E,Meyer C,Hansen A,Eschenhagen T,Lemoine MD
100-18B was used in Sample Preparation (FC/FACS) to investigate hiPSC-derived cardiomyocytes for drug research.
Mon Jan 20 00:00:00 UTC 2020
Anti-Adhesion Behavior from Ring-Strain Amine Cyclic Monolayers Grafted on Silicon (111) Surfaces.
Scientific reports
Ching JY,Huang BJ,Hsu YT,Khung YL
Fri May 29 00:00:00 UTC 2020
A simple and highly efficient method for multi-allelic CRISPR-Cas9 editing in primary cell cultures.
Cancer reports (Hoboken, N.J.)
Hoellerbauer P,Kufeld M,Arora S,Wu HJ,Feldman HM,Paddison PJ
Thu Oct 01 00:00:00 UTC 2020
Robust production of uniform human cerebral organoids from pluripotent stem cells.
Life science alliance
Sivitilli AA,Gosio JT,Ghoshal B,Evstratova A,Trcka D,Ghiasi P,Hernandez JJ,Beaulieu JM,Wrana JL,Attisano L
100-18B was used in Cell Culture to study the production of organoids with reproducible cell type heterogeneity and macroscopic morphology.
Fri May 01 00:00:00 UTC 2020
Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus.
Nature communications
Nastały P,Purushothaman D,Marchesi S,Poli A,Lendenmann T,Kidiyoor GR,Beznoussenko GV,Lavore S,Romano OM,Poulikakos D,Lagomarsino MC,Mironov AA,Ferrari A,Maiuri P
Fri May 01 00:00:00 UTC 2020
Long noncoding RNA FOXD2-AS1 enhances chemotherapeutic resistance of laryngeal squamous cell carcinoma via STAT3 activation.
Cell death & disease
Li R,Chen S,Zhan J,Li X,Liu W,Sheng X,Lu Z,Zhong R,Chen L,Luo X,Hu Y,Ouyang Y,Liu T,Zhang Q,Zhang S
Mon Jan 20 00:00:00 UTC 2020
Benzothiazole amphiphiles promote RasGRF1-associated dendritic spine formation in human stem cell-derived neurons.
FEBS open bio
Cifelli JL,Berg KR,Yang J
Sun Mar 01 00:00:00 UTC 2020
The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs.
Cell reports
Michielin F,Giobbe GG,Luni C,Hu Q,Maroni I,Orford MR,Manfredi A,Di Filippo L,David AL,Cacchiarelli D,De Coppi P,Eaton S,Elvassore N
100-18B was used in In vitro experiments to find high abundancy of extracellular matrix (ECM)-associated proteins.
Tue Dec 01 00:00:00 UTC 2020
A new protocol for long-term culture of a specific subpopulation of liver cancer stem cells enriched by cell surface markers.
FEBS open bio
Zhang B,Wang HY,Wang DX,Zeng Q,Fan Z,Xi JF,Nan X,He LJ,Zhou JN,Pei XT,Yue W
Tue Sep 01 00:00:00 UTC 2020
Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice.
Nature communications
Sun J,Huang Y,Gong J,Wang J,Fan Y,Cai J,Wang Y,Qiu Y,Wei Y,Xiong C,Chen J,Wang B,Ma Y,Huang L,Chen X,Zheng S,Huang W,Ke Q,Wang T,Li X,Zhang W,Xiang AP,Li W
Thu Oct 15 00:00:00 UTC 2020
iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.
Stem cell reports
Themeli M,Chhatta A,Boersma H,Prins HJ,Cordes M,de Wilt E,Farahani AS,Vandekerckhove B,van der Burg M,Hoeben RC,Staal FJT,Mikkers HMM
Tue Feb 11 00:00:00 UTC 2020
The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity.
The Journal of biological chemistry
Pajarillo E,Rizor A,Son DS,Aschner M,Lee E
Fri Mar 06 00:00:00 UTC 2020
Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells.
Nature communications
Hwang YS,Suzuki S,Seita Y,Ito J,Sakata Y,Aso H,Sato K,Hermann BP,Sasaki K
Mon Nov 09 00:00:00 UTC 2020
The Effects of Engineered Skeletal Muscle on Volumetric Muscle Loss in The Tibialis Anterior Of Rat After Three Months In Vivo.
Regenerative engineering and translational medicine
Nutter GP,VanDusen KW,Florida SE,Syverud BC,Larkin LM
100-18B was used in Cell Culture to suggest that following a 30% VML of the TA muscle, all surgical groups were able to recover TA mass, maximum tetanic and specific force production.
Tue Dec 01 00:00:00 UTC 2020
Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Lienemann PS,Vallmajo-Martin Q,Papageorgiou P,Blache U,Metzger S,Kiveliö AS,Milleret V,Sala A,Hoehnel S,Roch A,Reuten R,Koch M,Naveiras O,Weber FE,Weber W,Lutolf MP,Ehrbar M
100-18B was used in Cell Culture to investigate BMP-2 treatment of bone defects.
Wed Apr 01 00:00:00 UTC 2020
Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential.
Stem cell reports
Lange L,Hoffmann D,Schwarzer A,Ha TC,Philipp F,Lenz D,Morgan M,Schambach A
Tue Jan 14 00:00:00 UTC 2020
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.
Cell reports
Takahashi K,Jeong D,Wang S,Narita M,Jin X,Iwasaki M,Perli SD,Conklin BR,Yamanaka S
100-18B was used in Cell Culture to investigate NAT1 and eIF4G1 expression in pluripotent stem cells.
Tue Jun 02 00:00:00 UTC 2020
Hyaluronan regulates synapse formation and function in developing neural networks.
Scientific reports
Wilson E,Knudson W,Newell-Litwa K
Mon Oct 05 00:00:00 UTC 2020
NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotype.
Oncoimmunology
Marcon F,Zuo J,Pearce H,Nicol S,Margielewska-Davies S,Farhat M,Mahon B,Middleton G,Brown R,Roberts KJ,Moss P
100-18B was used in Cell Culture to analyze the phenotype and function of natural killer (NK) cells in the blood and in tumor tissue from patients with pancreatic ductal adenocarcinoma (PDAC).
Thu Nov 19 00:00:00 UTC 2020
BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson's disease model.
Journal of neurochemistry
Kataura T,Saiki S,Ishikawa KI,Akamatsu W,Sasazawa Y,Hattori N,Imoto M
100-18B was used in Cell Culture to reveal that BRUP-1 potently restores cellular bilirubin levels and exhibits neuroprotective activity, making it a good contender for PD treatment.
Thu Oct 01 00:00:00 UTC 2020
Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1-JNK axis.
The Journal of biological chemistry
Suzuki S,Okada M,Sanomachi T,Togashi K,Seino S,Sato A,Yamamoto M,Kitanaka C
Fri Dec 25 00:00:00 UTC 2020
Human pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells.
Scientific reports
Constantinou C,Miranda AMA,Chaves P,Bellahcene M,Massaia A,Cheng K,Samari S,Rothery SM,Chandler AM,Schwarz RP,Harding SE,Punjabi P,Schneider MD,Noseda M
Mon Aug 03 00:00:00 UTC 2020
A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models.
Journal of experimental neurology
Biery MC,Noll A,Myers C,Morris SM,Winter CA,Pakiam F,Cole BL,Browd SR,Olson JM,Vitanza NA
100-18B was used in Cell Culture to provide a protocol for the generation of treatment-naïve biopsy-derived diffuse intrinsic pontine glioma (DIPG)/DMG models.
Tue Dec 01 00:00:00 UTC 2020
Association between glioblastoma cell-derived vessels and poor prognosis of the patients.
Cancer communications (London, England)
Mei X,Chen YS,Zhang QP,Chen FR,Xi SY,Long YK,Zhang J,Cai HP,Ke C,Wang J,Chen ZP
Fri May 01 00:00:00 UTC 2020
High Density Display of an Anti-Angiogenic Peptide on Micelle Surfaces Enhances Their Inhibition of αvβ3 Integrin-Mediated Neovascularization In Vitro.
Nanomaterials (Basel, Switzerland)
Nagaraj R,Stack T,Yi S,Mathew B,Shull KR,Scott EA,Mathew MT,Bijukumar DR
100-18B was used in Cell Culture to investigate the effect of an anti-angiogenic peptide coating on micelle surfaces on neovascularization.
Sun Mar 22 00:00:00 UTC 2020
Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.
Cell death & disease
Peng X,Wu Y,Brouwer U,van Vliet T,Wang B,Demaria M,Barazzuol L,Coppes RP
Wed Oct 14 00:00:00 UTC 2020
Modulating electrospun polycaprolactone scaffold morphology and composition to alter endothelial cell proliferation and angiogenic gene response.
PloS one
Reid JA,McDonald A,Callanan A
Tue Dec 08 00:00:00 UTC 2020
Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype.
Nature communications
Wu Y,Fletcher M,Gu Z,Wang Q,Costa B,Bertoni A,Man KH,Schlotter M,Felsberg J,Mangei J,Barbus M,Gaupel AC,Wang W,Weiss T,Eils R,Weller M,Liu H,Reifenberger G,Korshunov A,Angel P,Lichter P,Herrmann C,Radlwimmer B
Fri Dec 18 00:00:00 UTC 2020
Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection.
Stem cell reports
Sumer SA,Hoffmann S,Laue S,Campbell B,Raedecke K,Frajs V,Clauss S,Kääb S,Janssen JWG,Jauch A,Laugwitz KL,Dorn T,Moretti A,Rappold GA
Tue Oct 13 00:00:00 UTC 2020
Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations.
Stem cell reports
Anastasaki C,Wegscheid ML,Hartigan K,Papke JB,Kopp ND,Chen J,Cobb O,Dougherty JD,Gutmann DH
Tue Apr 14 00:00:00 UTC 2020
X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics.
Scientific reports
Licursi V,Anzellotti S,Favaro J,Sineri S,Carucci N,Cundari E,Fiore M,Guarguaglini G,Pippa S,Nisi PS,Vernì F,Biagioni S,Cacci E,Amendola R,Lupo G,Negri R
Thu Apr 16 00:00:00 UTC 2020
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.
Nature communications
Sarkar TJ,Quarta M,Mukherjee S,Colville A,Paine P,Doan L,Tran CM,Chu CR,Horvath S,Qi LS,Bhutani N,Rando TA,Sebastiano V
100-18B was used in Cell Culture to show that transient expression of nuclear reprogramming factors, mediated by expression of mRNAs, promotes a rapid and broad amelioration of cellular aging.
Tue Mar 24 00:00:00 UTC 2020
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.
Nature communications
Sarkar TJ,Quarta M,Mukherjee S,Colville A,Paine P,Doan L,Tran CM,Chu CR,Horvath S,Qi LS,Bhutani N,Rando TA,Sebastiano V
100-18B was used in Cell Culture to show that transient expression of nuclear reprogramming factors, mediated by expression of mRNAs, promotes a rapid and broad amelioration of cellular aging.
Tue Mar 24 00:00:00 UTC 2020
Endothelin-1 signaling maintains glial progenitor proliferation in the postnatal subventricular zone.
Nature communications
Adams KL,Riparini G,Banerjee P,Breur M,Bugiani M,Gallo V
Fri May 01 00:00:00 UTC 2020
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits.
Cell stem cell
Bowers M,Liang T,Gonzalez-Bohorquez D,Zocher S,Jaeger BN,Kovacs WJ,Röhrl C,Cramb KML,Winterer J,Kruse M,Dimitrieva S,Overall RW,Wegleiter T,Najmabadi H,Semenkovich CF,Kempermann G,Földy C,Jessberger S
100-18B was used in Cell Culture to investigate lipid metabolism and cognitive function in neural stem/progenitor cells and human embryonic stem cells.
Thu Jul 02 00:00:00 UTC 2020
YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.
Nature communications
Tanaka H,Homma H,Fujita K,Kondo K,Yamada S,Jin X,Waragai M,Ohtomo G,Iwata A,Tagawa K,Atsuta N,Katsuno M,Tomita N,Furukawa K,Saito Y,Saito T,Ichise A,Shibata S,Arai H,Saido T,Sudol M,Muramatsu SI,Okano H,Mufson EJ,Sobue G,Murayama S,Okazawa H
Fri Jan 24 00:00:00 UTC 2020
Molecular basis of CTCF binding polarity in genome folding.
Nature communications
Nora EP,Caccianini L,Fudenberg G,So K,Kameswaran V,Nagle A,Uebersohn A,Hajj B,Saux AL,Coulon A,Mirny LA,Pollard KS,Dahan M,Bruneau BG
Thu Nov 05 00:00:00 UTC 2020
Phosphoregulated orthogonal signal transduction in mammalian cells.
Nature communications
Scheller L,Schmollack M,Bertschi A,Mansouri M,Saxena P,Fussenegger M
Thu Jun 18 00:00:00 UTC 2020
Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib.
Cell death & disease
Florent R,Weiswald LB,Lambert B,Brotin E,Abeilard E,Louis MH,Babin G,Poulain L,N'Diaye M
Mon May 18 00:00:00 UTC 2020
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency.
Nature communications
Huang Y,Zhang H,Wang L,Tang C,Qin X,Wu X,Pan M,Tang Y,Yang Z,Babarinde IA,Lin R,Ji G,Lai Y,Xu X,Su J,Wen X,Satoh T,Ahmed T,Malik V,Ward C,Volpe G,Guo L,Chen J,Sun L,Li Y,Huang X,Bao X,Gao F,Liu B,Zheng H,Jauch R,Lai L,Pan G,Chen J,Testa G,Akira S,Hu J,Pei D,Hutchins AP,Esteban MA,Qin B
Thu Oct 08 00:00:00 UTC 2020
Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells.
Nature protocols
García-León JA,García-Díaz B,Eggermont K,Cáceres-Palomo L,Neyrinck K,Madeiro da Costa R,Dávila JC,Baron-Van Evercooren A,Gutiérrez A,Verfaillie CM
Sun Nov 01 00:00:00 UTC 2020
Multiscale 3D phenotyping of human cerebral organoids.
Scientific reports
Albanese A,Swaney JM,Yun DH,Evans NB,Antonucci JM,Velasco S,Sohn CH,Arlotta P,Gehrke L,Chung K
Tue Dec 08 00:00:00 UTC 2020
MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer.
Cell death & disease
Wu H,Liu B,Chen Z,Li G,Zhang Z
Thu Apr 16 00:00:00 UTC 2020
Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells.
Nature communications
Panagiotakopoulou V,Ivanyuk D,De Cicco S,Haq W,Arsić A,Yu C,Messelodi D,Oldrati M,Schöndorf DC,Perez MJ,Cassatella RP,Jakobi M,Schneiderhan-Marra N,Gasser T,Nikić-Spiegel I,Deleidi M
Wed Oct 14 00:00:00 UTC 2020
Robust and Scalable Angiogenesis Assay of Perfused 3D Human iPSC-Derived Endothelium for Anti-Angiogenic Drug Screening.
International journal of molecular sciences
van Duinen V,Stam W,Mulder E,Famili F,Reijerkerk A,Vulto P,Hankemeier T,van Zonneveld AJ
100-18B was used in Cell Culture to develop a robust and scalable angiogenesis assay supporting phyiological relavent culture conditions, suitable for screening anti-angiogenic compounds.
Tue Jul 07 00:00:00 UTC 2020
Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing.
Scientific reports
Nanki Y,Chiyoda T,Hirasawa A,Ookubo A,Itoh M,Ueno M,Akahane T,Kameyama K,Yamagami W,Kataoka F,Aoki D
Tue Jul 28 00:00:00 UTC 2020
SIRT1 inhibits chemoresistance and cancer stemness of gastric cancer by initiating an AMPK/FOXO3 positive feedback loop.
Cell death & disease
An Y,Wang B,Wang X,Dong G,Jia J,Yang Q
Wed Feb 12 00:00:00 UTC 2020
WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer.
Cell death & disease
Ertay A,Liu H,Liu D,Peng P,Hill C,Xiong H,Hancock D,Yuan X,Przewloka MR,Coldwell M,Howell M,Skipp P,Ewing RM,Downward J,Wang Y
Sat Nov 21 00:00:00 UTC 2020
Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma.
Scientific reports
Shono K,Yamaguchi I,Mizobuchi Y,Kagusa H,Sumi A,Fujihara T,Nakajima K,Kitazato KT,Matsuzaki K,Saya H,Takagi Y
Thu Sep 17 00:00:00 UTC 2020
Neurotrophic effects of GM1 ganglioside, NGF, and FGF2 on canine dorsal root ganglia neurons in vitro.
Scientific reports
Schwarz S,Lehmbecker A,Tongtako W,Hahn K,Wang Y,Felmy F,Zdora I,Brogden G,Branitzki-Heinemann K,von Köckritz-Blickwede M,Baumgärtner W,Gerhauser I
Wed Mar 25 00:00:00 UTC 2020
hiPS-Derived Astroglia Model Shows Temporal Transcriptomic Profile Related to Human Neural Development and Glia Competence Acquisition of a Maturing Astrocytic Identity.
Advanced biosystems
Lundin A,Ricchiuto P,Clausen M,Hicks R,Falk A,Herland A
Fri May 01 00:00:00 UTC 2020
Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Tian A,Kang B,Li B,Qiu B,Jiang W,Shao F,Gao Q,Liu R,Cai C,Jing R,Wang W,Chen P,Liang Q,Bao L,Man J,Wang Y,Shi Y,Li J,Yang M,Wang L,Zhang J,Hippenmeyer S,Zhu J,Bian X,Wang YJ,Liu C
Sun Nov 01 00:00:00 UTC 2020
Cell-Based Therapy for Canavan Disease Using Human iPSC-Derived NPCs and OPCs.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feng L,Chao J,Tian E,Li L,Ye P,Zhang M,Chen X,Cui Q,Sun G,Zhou T,Felix G,Qin Y,Li W,Meza ED,Klein J,Ghoda L,Hu W,Luo Y,Dang W,Hsu D,Gold J,Goldman SA,Matalon R,Shi Y
Tue Dec 01 00:00:00 UTC 2020
Tissue-scale tensional homeostasis in skin regulates structure and physiological function.
Communications biology
Kimura S,Tsuchiya A,Ogawa M,Ono M,Suda N,Sekimoto K,Takeo M,Tsuji T
Fri Oct 30 00:00:00 UTC 2020
Decreased Na+/K+ ATPase Expression and Depolarized Cell Membrane in Neurons Differentiated from Chorea-Acanthocytosis Patients.
Scientific reports
Hosseinzadeh Z,Hauser S,Singh Y,Pelzl L,Schuster S,Sharma Y,Höflinger P,Zacharopoulou N,Stournaras C,Rathbun DL,Zrenner E,Schöls L,Lang F
Thu May 21 00:00:00 UTC 2020
Umbilical cord tissue is a robust source for mesenchymal stem cells with enhanced myogenic differentiation potential compared to cord blood.
Scientific reports
Mishra S,Sevak JK,Das A,Arimbasseri GA,Bhatnagar S,Gopinath SD
Wed Nov 04 00:00:00 UTC 2020
Off-target effect of the BMI1 inhibitor PTC596 drives epithelial-mesenchymal transition in glioblastoma multiforme.
NPJ precision oncology
Flamier A,Abdouh M,Hamam R,Barabino A,Patel N,Gao A,Hanna R,Bernier G
Sat Jun 05 00:00:00 UTC 2021
Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma.
Brain communications
Merisaari J,Denisova OV,Doroszko M,Le Joncour V,Johansson P,Leenders WPJ,Kastrinsky DB,Zaware N,Narla G,Laakkonen P,Nelander S,Ohlmeyer M,Westermarck J
100-18B was used in Cell Culture to propose that, based on a demonstrated role for protein phosphatase 2A inhibition in glioblastoma cell drug resistance, small molecule activators of protein phosphatase 2A may prove to be beneficial in future glioblastoma combination therapies.
Mon Sep 28 00:00:00 UTC 2020
PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor.
Cell death & disease
Liu F,Wu X,Qian Y,Jiang X,Wang Y,Gao J
Mon Jun 08 00:00:00 UTC 2020
Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.
Nature communications
Tedeschi A,Almagro J,Renshaw MJ,Messal HA,Behrens A,Petronczki M
Wed Apr 08 00:00:00 UTC 2020
Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model.
Microsystems & nanoengineering
Cui K,Wang Y,Zhu Y,Tao T,Yin F,Guo Y,Liu H,Li F,Wang P,Chen Y,Qin J
Thu Aug 15 00:00:00 UTC 2024
Oligomeric amyloid-β induces early and widespread changes to the proteome in human iPSC-derived neurons.
Scientific reports
Sackmann C,Hallbeck M
Thu Apr 16 00:00:00 UTC 2020
Chromatin remodeling in bovine embryos indicates species-specific regulation of genome activation.
Nature communications
Halstead MM,Ma X,Zhou C,Schultz RM,Ross PJ
Thu Sep 17 00:00:00 UTC 2020
Alpha-synuclein fragments trigger distinct aggregation pathways.
Cell death & disease
Chakroun T,Evsyukov V,Nykänen NP,Höllerhage M,Schmidt A,Kamp F,Ruf VC,Wurst W,Rösler TW,Höglinger GU
Mon Feb 03 00:00:00 UTC 2020
Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD.
Molecular neurodegeneration
Andrade NS,Ramic M,Esanov R,Liu W,Rybin MJ,Gaidosh G,Abdallah A,Del'Olio S,Huff TC,Chee NT,Anatha S,Gendron TF,Wahlestedt C,Zhang Y,Benatar M,Mueller C,Zeier Z
100-18B was used in Cell Culture to study the efficiency of specific repair pathways using DNA double strand break (DSB) repair assays.
Mon Feb 24 00:00:00 UTC 2020
DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation.
Proceedings of the National Academy of Sciences of the United States of America
Cao K,Ugarenko M,Ozark PA,Wang J,Marshall SA,Rendleman EJ,Liang K,Wang L,Zou L,Smith ER,Yue F,Shilatifard A
Tue Nov 03 00:00:00 UTC 2020
Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells.
Viruses
Trus I,Berube N,Jiang P,Rak J,Gerdts V,Karniychuk U
100-18B was used in Cell Culture to study whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs).
Mon May 25 00:00:00 UTC 2020
Mutation-Specific Guide RNA for Compound Heterozygous Porphyria On-target Scarless Correction by CRISPR/Cas9 in Stem Cells.
Stem cell reports
Prat F,Toutain J,Boutin J,Amintas S,Cullot G,Lalanne M,Lamrissi-Garcia I,Moranvillier I,Richard E,Blouin JM,Dabernat S,Moreau-Gaudry F,Bedel A
Tue Sep 08 00:00:00 UTC 2020
Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein.
The Journal of biological chemistry
Sandoval DR,Gomez Toledo A,Painter CD,Tota EM,Sheikh MO,West AMV,Frank MM,Wells L,Xu D,Bicknell R,Corbett KD,Esko JD
Fri Feb 28 00:00:00 UTC 2020
Autofluorescence-based sorting removes senescent cells from mesenchymal stromal cell cultures.
Scientific reports
Bertolo A,Guerrero J,Stoyanov J
Thu Nov 05 00:00:00 UTC 2020
Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome.
Scientific reports
Aalders J,Léger L,Van der Meeren L,Van den Vreken N,Skirtach AG,Sinha S,De Backer J,van Hengel J
Wed Oct 07 00:00:00 UTC 2020
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.
Nature communications
Werner-Klein M,Grujovic A,Irlbeck C,Obradović M,Hoffmann M,Koerkel-Qu H,Lu X,Treitschke S,Köstler C,Botteron C,Weidele K,Werno C,Polzer B,Kirsch S,Gužvić M,Warfsmann J,Honarnejad K,Czyz Z,Feliciello G,Blochberger I,Grunewald S,Schneider E,Haunschild G,Patwary N,Guetter S,Huber S,Rack B,Harbeck N,Buchholz S,Rümmele P,Heine N,Rose-John S,Klein CA
Mon Oct 05 00:00:00 UTC 2020
Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence.
Communications biology
de Lucia C,Murphy T,Steves CJ,Dobson RJB,Proitsi P,Thuret S
Thu Apr 02 00:00:00 UTC 2020
Increased vasculogenesis of endothelial cells in hyaluronic acid augmented fibrin-based natural hydrogels - from in vitro to in vivo models.
European cells & materials
Lin HC,Wang CK,Tung YC,Chiu FY,Su YP
100-18B was used in Cell Culture to study the unsatisfactory mechanical strength and degree of vascularisation of Fibrin-based hydrogels.
Sun Sep 20 00:00:00 UTC 2020
Endothelial Progenitor Cells Produced From Human Pluripotent Stem Cells by a Synergistic Combination of Cytokines, Small Compounds, and Serum-Free Medium.
Frontiers in cell and developmental biology
Farkas S,Simara P,Rehakova D,Veverkova L,Koutna I
100-18B was used in In vitro experiments to devise a robust three-phase protocol exploiting the synergy of multiple differentiation effector to efficently convert hPSCs into EPCs.
Mon Sep 28 00:00:00 UTC 2020
SOX9-activated FARSA-AS1 predetermines cell growth, stemness, and metastasis in colorectal cancer through upregulating FARSA and SOX9.
Cell death & disease
Zhou T,Wu L,Ma N,Tang F,Yu Z,Jiang Z,Li Y,Zong Z,Hu K
Mon Dec 14 00:00:00 UTC 2020
Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model.
eLife
Lee H,Lee HY,Lee BE,Gerovska D,Park SY,Zaehres H,Araúzo-Bravo MJ,Kim JI,Ha Y,Schöler HR,Kim JB
100-18B was used in Cell Culture to investigate the use of induced motor neurons to treat spinal cord injury.
Tue Jun 23 00:00:00 UTC 2020
A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression.
Nature communications
Kim H,Cho Y,Kim HS,Kang D,Cheon D,Kim YJ,Chang MJ,Lee KM,Chang CB,Kang SB,Kang HG,Kim JH
Tue Oct 06 00:00:00 UTC 2020
Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells.
Cell reports
Zhang Y,Zhang Z,Chen P,Ma CY,Li C,Au TYK,Tam V,Peng Y,Wu R,Cheung KMC,Sham PC,Tse HF,Chan D,Leung VY,Cheah KSE,Lian Q
100-18B was used in Cell Culture to report a protocolfor directed in vitro differentiation of human pluripotent stem cells (hPSCs) into notochord-like and nucleus pulposus (NP)-like cells of the disc.
Tue Feb 25 00:00:00 UTC 2020
Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types.
Nature communications
Khalsa JK,Cheng N,Keegan J,Chaudry A,Driver J,Bi WL,Lederer J,Shah K
Thu Aug 06 00:00:00 UTC 2020
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways.
Nature communications
Pattwell SS,Arora S,Cimino PJ,Ozawa T,Szulzewsky F,Hoellerbauer P,Bonifert T,Hoffstrom BG,Boiani NE,Bolouri H,Correnti CE,Oldrini B,Silber JR,Squatrito M,Paddison PJ,Holland EC
Fri Jun 12 00:00:00 UTC 2020
Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma.
Cancers
Holokai L,Chakrabarti J,Lundy J,Croagh D,Adhikary P,Richards SS,Woodson C,Steele N,Kuester R,Scott A,Khreiss M,Frankel T,Merchant J,Jenkins BJ,Wang J,Shroff RT,Ahmad SA,Zavros Y
100-18B was used in Cell Culture to develop a clinically relevant in vitro organoid model to specifically target mechanisms that deplete myeloid-derived suppressor cells as a therapeutic strategy for pancreatic ductal adenocarcinoma.
Thu Dec 17 00:00:00 UTC 2020
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation.
Nature communications
Cho YH,Ro EJ,Yoon JS,Mizutani T,Kang DW,Park JC,Il Kim T,Clevers H,Choi KY
Wed Oct 21 00:00:00 UTC 2020
Repulsive Guidance Molecule A Suppresses Adult Neurogenesis.
Stem cell reports
Isaksen TJ,Fujita Y,Yamashita T
Tue Apr 14 00:00:00 UTC 2020
TGF-β induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer.
Scientific reports
Kim BN,Ahn DH,Kang N,Yeo CD,Kim YK,Lee KY,Kim TJ,Lee SH,Park MS,Yim HW,Park JY,Park CK,Kim SJ
Tue Jun 30 00:00:00 UTC 2020
Generation and trapping of a mesoderm biased state of human pluripotency.
Nature communications
Stavish D,Böiers C,Price C,Frith TJR,Halliwell J,Saldaña-Guerrero I,Wray J,Brown J,Carr J,James C,Barbaric I,Andrews PW,Enver T
Mon Oct 05 00:00:00 UTC 2020
Induced osteogenic differentiation of human smooth muscle cells as a model of vascular calcification.
Scientific reports
Pustlauk W,Westhoff TH,Claeys L,Roch T,Geißler S,Babel N
Mon Apr 06 00:00:00 UTC 2020
Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.
Bio-protocol
Chen IP
100-18B was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.
Sun Dec 20 00:00:00 UTC 2020
Metabolic alterations in Parkinson's disease astrocytes.
Scientific reports
Sonninen TM,Hämäläinen RH,Koskuvi M,Oksanen M,Shakirzyanova A,Wojciechowski S,Puttonen K,Naumenko N,Goldsteins G,Laham-Karam N,Lehtonen M,Tavi P,Koistinaho J,Lehtonen Š
Wed Sep 02 00:00:00 UTC 2020
Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming.
Nature communications
Krawczyk K,Scheller L,Kim H,Fussenegger M
Thu Jan 30 00:00:00 UTC 2020
Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6.
Cell death & disease
Zhang Y,Guo L,Han S,Chen L,Li C,Zhang Z,Hong Y,Zhang X,Zhou X,Jiang D,Liang X,Qiu J,Zhang J,Li X,Zhong S,Liao C,Yan B,Tse HF,Lian Q
Tue Dec 15 00:00:00 UTC 2020
Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors.
Cell stem cell
Soliman H,Paylor B,Scott RW,Lemos DR,Chang C,Arostegui M,Low M,Lee C,Fiore D,Braghetta P,Pospichalova V,Barkauskas CE,Korinek V,Rampazzo A,MacLeod K,Underhill TM,Rossi FMV
100-18B was used in Cell Culture to identifyheart-resident PDGFRa+ SCA-1+ cells as cardiac fibro/adipogenic progenitors (cFAPs) and show that they respond to ischemic damage by generating fibrogenic cells.
Thu Feb 06 00:00:00 UTC 2020
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.
JCI insight
Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A
100-18B was used in Cell Culture to study can serve as a foundation for trials testing immunotherapeutic approaches in patients with ovarian GCT.
Thu Aug 20 00:00:00 UTC 2020
Modelling human CNS injury with human neural stem cells in 2- and 3-Dimensional cultures.
Scientific reports
Vagaska B,Gillham O,Ferretti P
Wed Apr 22 00:00:00 UTC 2020
Variants in saposin D domain of prosaposin gene linked to Parkinson's disease.
Brain : a journal of neurology
Oji Y,Hatano T,Ueno SI,Funayama M,Ishikawa KI,Okuzumi A,Noda S,Sato S,Satake W,Toda T,Li Y,Hino-Takai T,Kakuta S,Tsunemi T,Yoshino H,Nishioka K,Hattori T,Mizutani Y,Mutoh T,Yokochi F,Ichinose Y,Koh K,Shindo K,Takiyama Y,Hamaguchi T,Yamada M,Farrer MJ,Uchiyama Y,Akamatsu W,Wu YR,Matsuda J,Hattori N
100-18B was used in Cell Culture to provide novel genetic evidence for the involvement of the PSAP saposin D domain in Parkinson's disease.
Wed Apr 01 00:00:00 UTC 2020
Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease.
Stem cell reports
Yamaguchi A,Ishikawa KI,Inoshita T,Shiba-Fukushima K,Saiki S,Hatano T,Mori A,Oji Y,Okuzumi A,Li Y,Funayama M,Imai Y,Hattori N,Akamatsu W
Tue Jun 09 00:00:00 UTC 2020
Forskolin rapidly enhances neuron-like morphological change of directly induced-neuronal cells from neurofibromatosis type 1 patients.
Neuropsychopharmacology reports
Sagata N,Kano SI,Ohgidani M,Inamine S,Sakai Y,Kato H,Masuda K,Nakahara T,Nakahara-Kido M,Ohga S,Furue M,Sawa A,Kanba S,Kato TA
Tue Dec 01 00:00:00 UTC 2020
Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway.
Molecular systems biology
Gillies TE,Pargett M,Silva JM,Teragawa CK,McCormick F,Albeck JG
Thu Oct 01 00:00:00 UTC 2020
A Comparative Analysis of Multipotent Mesenchymal Stromal Cells derived from Different Sources, with a Focus on Neuroregenerative Potential.
Scientific reports
Petrenko Y,Vackova I,Kekulova K,Chudickova M,Koci Z,Turnovcova K,Kupcova Skalnikova H,Vodicka P,Kubinova S
Mon Mar 09 00:00:00 UTC 2020
Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma.
Cell death & disease
Dai W,Jin X,Han L,Huang H,Ji Z,Xu X,Tang M,Jiang B,Chen W
Fri Sep 11 00:00:00 UTC 2020
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.
Cell reports
Stanifer ML,Kee C,Cortese M,Zumaran CM,Triana S,Mukenhirn M,Kraeusslich HG,Alexandrov T,Bartenschlager R,Boulant S
100-18B was used in Cell Culture to demonstrate that human intestinal epithelial cells are a productive site of SARS-CoV-2 replication and that the enteric phase of SARS-CoV-2 may participate in the pathologies observed in COVID-19 patients.
Tue Jul 07 00:00:00 UTC 2020
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.
Cell reports
Stanifer ML,Kee C,Cortese M,Zumaran CM,Triana S,Mukenhirn M,Kraeusslich HG,Alexandrov T,Bartenschlager R,Boulant S
100-18B was used in Cell Culture to demonstrate that human intestinal epithelial cells are a productive site of SARS-CoV-2 replication and that the enteric phase of SARS-CoV-2 may participate in the pathologies observed in COVID-19 patients.
Tue Jul 07 00:00:00 UTC 2020
Single Amino Acid Change Underlies Distinct Roles of H2A.Z Subtypes in Human Syndrome.
Cell
Greenberg RS,Long HK,Swigut T,Wysocka J
Thu Sep 05 00:00:00 UTC 2019
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.
Cell
Li R,Zhong C,Yu Y,Liu H,Sakurai M,Yu L,Min Z,Shi L,Wei Y,Takahashi Y,Liao HK,Qiao J,Deng H,Nuñez-Delicado E,Rodriguez Esteban C,Wu J,Izpisua Belmonte JC
Thu Oct 17 00:00:00 UTC 2019
Deciphering the "m6A Code" via Antibody-Independent Quantitative Profiling.
Cell
Garcia-Campos MA,Edelheit S,Toth U,Safra M,Shachar R,Viukov S,Winkler R,Nir R,Lasman L,Brandis A,Hanna JH,Rossmanith W,Schwartz S
Thu Jul 25 00:00:00 UTC 2019
Deciphering the "m6A Code" via Antibody-Independent Quantitative Profiling.
Cell
Garcia-Campos MA,Edelheit S,Toth U,Safra M,Shachar R,Viukov S,Winkler R,Nir R,Lasman L,Brandis A,Hanna JH,Rossmanith W,Schwartz S
Thu Jul 25 00:00:00 UTC 2019
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.
Cancer cell
Carugo A,Minelli R,Sapio L,Soeung M,Carbone F,Robinson FS,Tepper J,Chen Z,Lovisa S,Svelto M,Amin S,Srinivasan S,Del Poggetto E,Loponte S,Puca F,Dey P,Malouf GG,Su X,Li L,Lopez-Terrada D,Rakheja D,Lazar AJ,Netto GJ,Rao P,Sgambato A,Maitra A,Tripathi DN,Walker CL,Karam JA,Heffernan TP,Viale A,Roberts CWM,Msaouel P,Tannir NM,Draetta GF,Genovese G
Mon Feb 11 00:00:00 UTC 2019
Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.
Cancer cell
Yin N,Liu Y,Khoor A,Wang X,Thompson EA,Leitges M,Justilien V,Weems C,Murray NR,Fields AP
Mon Aug 12 00:00:00 UTC 2019
Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.
Cancer cell
Zhang L,He X,Liu X,Zhang F,Huang LF,Potter AS,Xu L,Zhou W,Zheng T,Luo Z,Berry KP,Pribnow A,Smith SM,Fuller C,Jones BV,Fouladi M,Drissi R,Yang ZJ,Gustafson WC,Remke M,Pomeroy SL,Girard EJ,Olson JM,Morrissy AS,Vladoiu MC,Zhang J,Tian W,Xin M,Taylor MD,Potter SS,Roussel MF,Weiss WA,Lu QR
Mon Sep 16 00:00:00 UTC 2019
Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.
Cancer cell
Zhang L,He X,Liu X,Zhang F,Huang LF,Potter AS,Xu L,Zhou W,Zheng T,Luo Z,Berry KP,Pribnow A,Smith SM,Fuller C,Jones BV,Fouladi M,Drissi R,Yang ZJ,Gustafson WC,Remke M,Pomeroy SL,Girard EJ,Olson JM,Morrissy AS,Vladoiu MC,Zhang J,Tian W,Xin M,Taylor MD,Potter SS,Roussel MF,Weiss WA,Lu QR
Mon Sep 16 00:00:00 UTC 2019
IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties.
Cell metabolism
Du L,Lin L,Li Q,Liu K,Huang Y,Wang X,Cao K,Chen X,Cao W,Li F,Shao C,Wang Y,Shi Y
100-18B was used in Cell Culture to demonstrate that shaping macrophage responsiveness by IGF-2 is effective in managing inflammatory diseases, and the OXPHOS commitment can be preset to determine the anti-inflammatory fate of macrophages.
Tue Jun 04 00:00:00 UTC 2019
Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes.
Blood
Hsu J,Reilly A,Hayes BJ,Clough CA,Konnick EQ,Torok-Storb B,Gulsuner S,Wu D,Becker PS,Keel SB,Abkowitz JL,Doulatov S
Thu Jul 11 00:00:00 UTC 2019
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.
Cell stem cell
Xu R,Brawner AT,Li S,Liu JJ,Kim H,Xue H,Pang ZP,Kim WY,Hart RP,Liu Y,Jiang P
100-18B was used in Tissue/organ culture to conclude that altered OLIG2 expression may underlie neurodevelopmental abnormalities and cognitive defects in DS patients.
Thu Jun 06 00:00:00 UTC 2019
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Cell stem cell
Huang M,Tailor J,Zhen Q,Gillmor AH,Miller ML,Weishaupt H,Chen J,Zheng T,Nash EK,McHenry LK,An Z,Ye F,Takashima Y,Clarke J,Ayetey H,Cavalli FMG,Luu B,Moriarity BS,Ilkhanizadeh S,Chavez L,Yu C,Kurian KM,Magnaldo T,Sevenet N,Koch P,Pollard SM,Dirks P,Snyder MP,Largaespada DA,Cho YJ,Phillips JJ,Swartling FJ,Morrissy AS,Kool M,Pfister SM,Taylor MD,Smith A,Weiss WA
100-18B was used in Cell Culture to demonstrate that human NES cells provide a potent experimental resource for dissecting genetic causation in medulloblastoma.
Thu Sep 05 00:00:00 UTC 2019
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
Cell stem cell
Huang M,Tailor J,Zhen Q,Gillmor AH,Miller ML,Weishaupt H,Chen J,Zheng T,Nash EK,McHenry LK,An Z,Ye F,Takashima Y,Clarke J,Ayetey H,Cavalli FMG,Luu B,Moriarity BS,Ilkhanizadeh S,Chavez L,Yu C,Kurian KM,Magnaldo T,Sevenet N,Koch P,Pollard SM,Dirks P,Snyder MP,Largaespada DA,Cho YJ,Phillips JJ,Swartling FJ,Morrissy AS,Kool M,Pfister SM,Taylor MD,Smith A,Weiss WA
100-18B was used in Cell Culture to demonstrate that human NES cells provide a potent experimental resource for dissecting genetic causation in medulloblastoma.
Thu Sep 05 00:00:00 UTC 2019
TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment.
Cell stem cell
Li L,Wang Y,Torkelson JL,Shankar G,Pattison JM,Zhen HH,Fang F,Duren Z,Xin J,Gaddam S,Melo SP,Piekos SN,Li J,Liaw EJ,Chen L,Li R,Wernig M,Wong WH,Chang HY,Oro AE
100-18B was used in Cell Culture to provide a general framework to infer TF networks controlling chromatin transitions that will facilitate future regenerative medicine advances.
Thu Feb 07 00:00:00 UTC 2019
TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment.
Cell stem cell
Li L,Wang Y,Torkelson JL,Shankar G,Pattison JM,Zhen HH,Fang F,Duren Z,Xin J,Gaddam S,Melo SP,Piekos SN,Li J,Liaw EJ,Chen L,Li R,Wernig M,Wong WH,Chang HY,Oro AE
100-18B was used in Cell Culture to provide a general framework to infer TF networks controlling chromatin transitions that will facilitate future regenerative medicine advances.
Thu Feb 07 00:00:00 UTC 2019
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells.
Cell stem cell
Neumann B,Baror R,Zhao C,Segel M,Dietmann S,Rawji KS,Foerster S,McClain CR,Chalut K,van Wijngaarden P,Franklin RJM
100-18B was used in Cell Culture to provide insight into aging-associated remyelination failure and suggest therapeutic interventions for reversing such declines in chronic disease.
Thu Oct 03 00:00:00 UTC 2019
The antibiotic clofoctol suppresses glioma stem cell proliferation by activating KLF13.
The Journal of clinical investigation
Hu Y,Zhang M,Tian N,Li D,Wu F,Hu P,Wang Z,Wang L,Hao W,Kang J,Yin B,Zheng Z,Jiang T,Yuan J,Qiang B,Han W,Peng X
Tue May 21 00:00:00 UTC 2019
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
The Journal of clinical investigation
Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C
Fri Mar 01 00:00:00 UTC 2019
N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer.
The Journal of clinical investigation
Berger A,Brady NJ,Bareja R,Robinson B,Conteduca V,Augello MA,Puca L,Ahmed A,Dardenne E,Lu X,Hwang I,Bagadion AM,Sboner A,Elemento O,Paik J,Yu J,Barbieri CE,Dephoure N,Beltran H,Rickman DS
Mon Jul 01 00:00:00 UTC 2019
Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition.
Molecular cell
Modic M,Grosch M,Rot G,Schirge S,Lepko T,Yamazaki T,Lee FCY,Rusha E,Shaposhnikov D,Palo M,Merl-Pham J,Cacchiarelli D,Rogelj B,Hauck SM,von Mering C,Meissner A,Lickert H,Hirose T,Ule J,Drukker M
100-18B was used in Cell Culture to study the joint role of RNA binding proteins and long non-coding RNAs in coordinating cell fate decisions.
Thu Jun 06 00:00:00 UTC 2019
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Neuron
Geraghty AC,Gibson EM,Ghanem RA,Greene JJ,Ocampo A,Goldstein AK,Ni L,Yang T,Marton RM,Paşca SP,Greenberg ME,Longo FM,Monje M
Wed Jul 17 00:00:00 UTC 2019
Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion.
Neuron
Matsuda T,Irie T,Katsurabayashi S,Hayashi Y,Nagai T,Hamazaki N,Adefuin AMD,Miura F,Ito T,Kimura H,Shirahige K,Takeda T,Iwasaki K,Imamura T,Nakashima K
Wed Feb 06 00:00:00 UTC 2019
Reversing tumor stemness via orally targeted nanoparticles achieves efficient colon cancer treatment.
Biomaterials
Xu J,Zhang Y,Xu J,Wang M,Liu G,Wang J,Zhao X,Qi Y,Shi J,Cheng K,Li Y,Qi S,Nie G
100-18B was used in In vitro experiments to show that n oral drug delivery system for sustained release of BMI-1 inhibitor (PTC209) reverses the stemness of CRC where nanoparticles modified with hyaluronic acid (HA) showed high-affinity to CD44/CD168 overexpressed-CRC cells, and efficiently targeted to tumor site in a metastatic orthotropic colon cancer mouse model by oral administration which results in tumor growth inhibition accompanied by decreased expression of stemness markers in the tumor
Sun Sep 01 00:00:00 UTC 2019
The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma.
EMBO molecular medicine
Lin S,Huang C,Sun J,Bollt O,Wang X,Martine E,Kang J,Taylor MD,Fang B,Singh PK,Koomen J,Hao J,Yang S
Sun Dec 01 00:00:00 UTC 2019
Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy.
EMBO molecular medicine
Prondzynski M,Lemoine MD,Zech AT,Horváth A,Di Mauro V,Koivumäki JT,Kresin N,Busch J,Krause T,Krämer E,Schlossarek S,Spohn M,Friedrich FW,Münch J,Laufer SD,Redwood C,Volk AE,Hansen A,Mearini G,Catalucci D,Meyer C,Christ T,Patten M,Eschenhagen T,Carrier L
Sun Dec 01 00:00:00 UTC 2019
A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes.
The EMBO journal
Maslon MM,Braunschweig U,Aitken S,Mann AR,Kilanowski F,Hunter CJ,Blencowe BJ,Kornblihtt AR,Adams IR,Cáceres JF
Thu May 02 00:00:00 UTC 2019
The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.
The EMBO journal
Sainz de Aja J,Menchero S,Rollan I,Barral A,Tiana M,Jawaid W,Cossio I,Alvarez A,Carreño-Tarragona G,Badia-Careaga C,Nichols J,Göttgens B,Isern J,Manzanares M
Mon Apr 01 00:00:00 UTC 2019
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.
Molecular psychiatry
Vasistha NA,Johnstone M,Barton SK,Mayerl SE,Thangaraj Selvaraj B,Thomson PA,Dando O,Grünewald E,Alloza C,Bastin ME,Livesey MR,Economides K,Magnani D,Makedonopolou P,Burr K,Story DJ,Blackwood DHR,Wyllie DJA,McIntosh AM,Millar JK,Ffrench-Constant C,Hardingham GE,Lawrie SM,Chandran S
Fri Nov 01 00:00:00 UTC 2019
BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.
Autophagy
Lampert MA,Orogo AM,Najor RH,Hammerling BC,Leon LJ,Wang BJ,Kim T,Sussman MA,Gustafsson ÅB
100-18B was used in Cell Culture to demonstrate the importance of mitochondrial autophagy, or mitophagy, in the differentiation process in adult cardiac progenitor cells.
Mon Jul 01 00:00:00 UTC 2019
Mouse and human urothelial cancer organoids: A tool for bladder cancer research.
Proceedings of the National Academy of Sciences of the United States of America
Mullenders J,de Jongh E,Brousali A,Roosen M,Blom JPA,Begthel H,Korving J,Jonges T,Kranenburg O,Meijer R,Clevers HC
Tue Mar 05 00:00:00 UTC 2019
Restoration of FVIII expression by targeted gene insertion in the FVIII locus in hemophilia A patient-derived iPSCs.
Experimental & molecular medicine
Sung JJ,Park CY,Leem JW,Cho MS,Kim DW
Wed Apr 17 00:00:00 UTC 2019
A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification.
Cell death and differentiation
Nicklas S,Hillje AL,Okawa S,Rudolph IM,Collmann FM,van Wuellen T,Del Sol A,Schwamborn JC
Fri Mar 01 00:00:00 UTC 2019
Self-Assembling Peptide Hydrogel Matrices Improve the Neurotrophic Potential of Human Adipose-Derived Stem Cells.
Advanced healthcare materials
Faroni A,Workman VL,Saiani A,Reid AJ
Sun Sep 01 00:00:00 UTC 2019
Perfused 3D angiogenic sprouting in a high-throughput in vitro platform.
Angiogenesis
van Duinen V,Zhu D,Ramakers C,van Zonneveld AJ,Vulto P,Hankemeier T
100-18B was used in Cell Culture to propose an in vitro platform that integrates both perfusion and the generation of stable biomolecular gradients and demonstrate its potential to study more physiologically relevant angiogenic sprouting and microvascular stabilization.
Fri Feb 01 00:00:00 UTC 2019
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.
Oncogene
He W,Liang B,Wang C,Li S,Zhao Y,Huang Q,Liu Z,Yao Z,Wu Q,Liao W,Zhang S,Liu Y,Xiang Y,Liu J,Shi M
Sat Jun 01 00:00:00 UTC 2019
Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.
Oncogene
Willems E,Dedobbeleer M,Digregorio M,Lombard A,Goffart N,Lumapat PN,Lambert J,Van den Ackerveken P,Szpakowska M,Chevigné A,Scholtes F,Rogister B
Tue Jan 01 00:00:00 UTC 2019
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Oncogene
Nishimura T,Nakata A,Chen X,Nishi K,Meguro-Horike M,Sasaki S,Kita K,Horike SI,Saitoh K,Kato K,Igarashi K,Murayama T,Kohno S,Takahashi C,Mukaida N,Yano S,Soga T,Tojo A,Gotoh N
Mon Apr 01 00:00:00 UTC 2019
RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation.
Oncogene
Ding K,Ji J,Zhang X,Huang B,Chen A,Zhang D,Li X,Wang X,Wang J
Sun Sep 01 00:00:00 UTC 2019
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Oncogene
Sun B,Zhao X,Ming J,Liu X,Liu D,Jiang C
Thu Aug 01 00:00:00 UTC 2019
Comparison of different in vitro differentiation conditions for murine female germline stem cells.
Cell proliferation
Zou K,Wang J,Bi H,Zhang Y,Tian X,Tian N,Ma W,Wu J
Tue Jan 01 00:00:00 UTC 2019
Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis.
Glia
Stojic A,Bojcevski J,Williams SK,Bas-Orth C,Nessler S,Linington C,Diem R,Fairless R
Fri Mar 01 00:00:00 UTC 2019
Low sulfated heparins target multiple proteins for central nervous system repair.
Glia
McCanney GA,McGrath MA,Otto TD,Burchmore R,Yates EA,Bavington CD,Willison HJ,Turnbull JE,Barnett SC
Mon Apr 01 00:00:00 UTC 2019
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.
Stem cells translational medicine
Kojima K,Miyoshi H,Nagoshi N,Kohyama J,Itakura G,Kawabata S,Ozaki M,Iida T,Sugai K,Ito S,Fukuzawa R,Yasutake K,Renault-Mihara F,Shibata S,Matsumoto M,Nakamura M,Okano H
Fri Mar 01 00:00:00 UTC 2019
Perfluorocarbon Labeling of Human Glial-Restricted Progenitors for 19 F Magnetic Resonance Imaging.
Stem cells translational medicine
Richard JP,Hussain U,Gross S,Taga A,Kouser M,Almad A,Campanelli JT,Bulte JWM,Maragakis NJ
Mon Apr 01 00:00:00 UTC 2019
Hypoxia-inducible factor-2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin.
Molecular oncology
He M,Wu H,Jiang Q,Liu Y,Han L,Yan Y,Wei B,Liu F,Deng X,Chen H,Zhao L,Wang M,Wu X,Yao W,Zhao H,Chen J,Wei M
Fri Feb 01 00:00:00 UTC 2019
Fibroblast growth factor signals regulate transforming growth factor-β-induced endothelial-to-myofibroblast transition of tumor endothelial cells via Elk1.
Molecular oncology
Akatsu Y,Takahashi N,Yoshimatsu Y,Kimuro S,Muramatsu T,Katsura A,Maishi N,Suzuki HI,Inazawa J,Hida K,Miyazono K,Watabe T
Thu Aug 01 00:00:00 UTC 2019
FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics.
Oxidative medicine and cellular longevity
Li X,Hong Y,He H,Jiang G,You W,Liang X,Fu Q,Han S,Lian Q,Zhang Y
100-18B was used in Cell Culture to study the mechanisms of fibroblast growth factor 21 in the regulation of mesenchymal stem cell senescence.
Thu Jan 16 00:00:00 UTC 2020
Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer.
Oncogenesis
Yang Y,Li Z,Yuan H,Ji W,Wang K,Lu T,Yu Y,Zeng Q,Li F,Xia W,Lu S
Fri Sep 06 00:00:00 UTC 2019
Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis.
Cancer science
Raja E,Morikawa M,Nishida J,Tanabe R,Takahashi K,Seeherman HJ,Saito N,Todo T,Miyazono K
Fri Nov 01 00:00:00 UTC 2019
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
International journal of oncology
Wen N,Guo B,Zheng H,Xu L,Liang H,Wang Q,Wang D,Chen X,Zhang S,Li Y,Zhang L
100-18B was used in Cell Culture to explore the underlying mechanisms of the anti-tumour effects of Brd4 and the bromodomain inhibitor JQ1 on glioma stem cells.
Tue Oct 01 00:00:00 UTC 2019
FOXD3 Suppresses Tumor-Initiating Features in Lung Cancer via Transcriptional Repression of WDR5.
Stem cells (Dayton, Ohio)
Xu W,Li J,Li L,Hou T,Cai X,Liu T,Yang X,Wei H,Jiang C,Xiao J
Wed May 01 00:00:00 UTC 2019
Poly(ADP-Ribose) Polymerase Inhibition Sensitizes Colorectal Cancer-Initiating Cells to Chemotherapy.
Stem cells (Dayton, Ohio)
Jarrar A,Lotti F,DeVecchio J,Ferrandon S,Gantt G,Mace A,Karagkounis G,Orloff M,Venere M,Hitomi M,Lathia J,Rich JN,Kalady MF
Tue Jan 01 00:00:00 UTC 2019
Adenomatous Polyposis Coli as a Major Regulator of Human Embryonic Stem Cells Self-Renewal.
Stem cells (Dayton, Ohio)
Preisler L,Ben-Yosef D,Mayshar Y
Sun Dec 01 00:00:00 UTC 2019
Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin.
Stem cells (Dayton, Ohio)
Shan J,Shen J,Wu M,Zhou H,Feng J,Yao C,Yang Z,Ma Q,Luo Y,Wang Y,Qian C
Fri Nov 01 00:00:00 UTC 2019
AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells.
Stem cells (Dayton, Ohio)
Zhang X,Wei R,Sun Y,Xia Q,Xie W,Song H,Wang W,Zou K
Thu Aug 01 00:00:00 UTC 2019
A Mass Spectrometry Survey of Chromatin-Associated Proteins in Pluripotency and Early Lineage Commitment.
Proteomics
van Mierlo G,Wester RA,Marks H
Mon Jul 01 00:00:00 UTC 2019
Efficient gene correction of an aberrant splice site in β-thalassaemia iPSCs by CRISPR/Cas9 and single-strand oligodeoxynucleotides.
Journal of cellular and molecular medicine
Xiong Z,Xie Y,Yang Y,Xue Y,Wang D,Lin S,Chen D,Lu D,He L,Song B,Yang Y,Sun X
Sun Dec 01 00:00:00 UTC 2019
Long non-coding RNA SNHG20 promotes the tumorigenesis of oral squamous cell carcinoma via targeting miR-197/LIN28 axis.
Journal of cellular and molecular medicine
Wu J,Zhao W,Wang Z,Xiang X,Zhang S,Liu L
Tue Jan 01 00:00:00 UTC 2019
Temporary blood-brain barrier disruption by low intensity pulsed ultrasound increases carboplatin delivery and efficacy in preclinical models of glioblastoma.
Journal of neuro-oncology
Dréan A,Lemaire N,Bouchoux G,Goldwirt L,Canney M,Goli L,Bouzidi A,Schmitt C,Guehennec J,Verreault M,Sanson M,Delattre JY,Mokhtari K,Sottilini F,Carpentier A,Idbaih A
100-18B was used in Cell Culture to investigate glioblastoma treatment via chemotherapy following ultrasound-induced blood-brain barrier opening.
Thu Aug 01 00:00:00 UTC 2019
BDNF-overexpressing human mesenchymal stem cells mediate increased neuronal protection in vitro.
Journal of neuroscience research
Scheper V,Schwieger J,Hamm A,Lenarz T,Hoffmann A
Fri Nov 01 00:00:00 UTC 2019
Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in the Subretinal Space of the Cat Eye.
Stem cells and development
Singh RK,Occelli LM,Binette F,Petersen-Jones SM,Nasonkin IO
Sun Sep 01 00:00:00 UTC 2019
Rational design and in vitro characterization of novel dental implant and abutment surfaces for balancing clinical and biological needs.
Clinical implant dentistry and related research
Milleret V,Lienemann PS,Gasser A,Bauer S,Ehrbar M,Wennerberg A
Fri Mar 01 00:00:00 UTC 2019
Quantitative Analysis of SSEA3+ Cells from Human Umbilical Cord after Magnetic Sorting.
Cell transplantation
Leng Z,Sun D,Huang Z,Tadmori I,Chiang N,Kethidi N,Sabra A,Kushida Y,Fu YS,Dezawa M,He X,Young W
100-18B was used in Cell Culture to allow the practical and efficient isolation and expansion of relatively pure populations of SSEA3+ Muse cells that can be matched by human leukocyte antigen for transplantation in human trials.
Mon Jul 01 00:00:00 UTC 2019
Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods.
Tissue engineering. Part C, Methods
Frauchiger DA,Tekari A,May RD,Džafo E,Chan SCW,Stoyanov J,Bertolo A,Zhang X,Guerrero J,Sakai D,Schol J,Grad S,Tryfonidou M,Benneker LM,Gantenbein B
100-18B was used in Cell Culture to investigate intervertebral disk repair.
Tue Oct 01 00:00:00 UTC 2019
The testicular soma of Tsc22d3 knockout mice supports spermatogenesis and germline transmission from spermatogonial stem cell lines upon transplantation.
Genesis (New York, N.Y. : 2000)
Zhou H,Zeng Z,Koentgen F,Khan M,Mombaerts P
100-18B was used in Cell Culture to show that the testicular soma of mice with a conditional knockout (conKO) in the X-linked gene Tsc22d3 supports spermatogenesis and germline transmission from cultured mouse SSCs upon transplantation.
Sat Jun 01 00:00:00 UTC 2019
MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.
Nature communications
Annunziata I,van de Vlekkert D,Wolf E,Finkelstein D,Neale G,Machado E,Mosca R,Campos Y,Tillman H,Roussel MF,Andrew Weesner J,Ellen Fremuth L,Qiu X,Han MJ,Grosveld GC,d'Azzo A
Fri Aug 09 00:00:00 UTC 2019
Calpain Inhibition Restores Autophagy and Prevents Mitochondrial Fragmentation in a Human iPSC Model of Diabetic Endotheliopathy.
Stem cell reports
Ong SB,Lee WH,Shao NY,Ismail NI,Katwadi K,Lim MM,Kwek XY,Michel NA,Li J,Newson J,Tahmasebi S,Rehman J,Kodo K,Jang HR,Ong SG
Tue Mar 05 00:00:00 UTC 2019
Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction.
eLife
Toubiana S,Gagliardi M,Papa M,Manco R,Tzukerman M,Matarazzo MR,Selig S
100-18B was used in Cell Culture to investigate DNA methylation in ICF syndrome type 1.
Wed Nov 20 00:00:00 UTC 2019
Chronic CagA-positive Helicobacter pylori infection with MNNG stimulation synergistically induces mesenchymal and cancer stem cell-like properties in gastric mucosal epithelial cells.
Journal of cellular biochemistry
Lin L,Wei H,Yi J,Xie B,Chen J,Zhou C,Wang L,Yang Y
100-18B was used in Cell Culture to illustrate that chronic CagA-positive H. pylori infection stimulated by MNNG induces CSC-like and mesenchymal properties of gastric mucosal epithelial cells in a synergistic manner.
Tue Oct 01 00:00:00 UTC 2019
Robust and efficient knock-in in embryonic stem cells and early-stage embryos of the common marmoset using the CRISPR-Cas9 system.
Scientific reports
Yoshimatsu S,Okahara J,Sone T,Takeda Y,Nakamura M,Sasaki E,Kishi N,Shiozawa S,Okano H
Wed Feb 06 00:00:00 UTC 2019
Assessing the reliability of gene expression measurements in very-low-numbers of human monocyte-derived macrophages.
Scientific reports
Geiß C,Alanis-Lobato G,Andrade-Navarro M,Régnier-Vigouroux A
Fri Nov 29 00:00:00 UTC 2019
The pro-apoptotic Bcl-2 family member Harakiri (HRK) induces cell death in glioblastoma multiforme.
Cell death discovery
Kaya-Aksoy E,Cingoz A,Senbabaoglu F,Seker F,Sur-Erdem I,Kayabolen A,Lokumcu T,Sahin GN,Karahuseyinoglu S,Bagci-Onder T
Tue Sep 29 00:00:00 UTC 2020
Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability.
Nature communications
Rom A,Melamed L,Gil N,Goldrich MJ,Kadir R,Golan M,Biton I,Perry RB,Ulitsky I
Fri Nov 08 00:00:00 UTC 2019
Syndecan-4 regulates extravillous trophoblast migration by coordinating protein kinase C activation.
Scientific reports
Jeyarajah MJ,Jaju Bhattad G,Kops BF,Renaud SJ
Mon Jul 15 00:00:00 UTC 2019
Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.
Nature communications
Seishima R,Leung C,Yada S,Murad KBA,Tan LT,Hajamohideen A,Tan SH,Itoh H,Murakami K,Ishida Y,Nakamizo S,Yoshikawa Y,Wong E,Barker N
100-18B was used in Sample Preparation (FC/FACS) to employ Lgr5-2A-EGFP/CreERT2/DTR mouse models to identify Lgr5-expressing cells in the developing uterus and to evaluate their stem cell identity and function.
Tue Nov 26 00:00:00 UTC 2019
Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.
Nature communications
Seishima R,Leung C,Yada S,Murad KBA,Tan LT,Hajamohideen A,Tan SH,Itoh H,Murakami K,Ishida Y,Nakamizo S,Yoshikawa Y,Wong E,Barker N
100-18B was used in Sample Preparation (FC/FACS) to employ Lgr5-2A-EGFP/CreERT2/DTR mouse models to identify Lgr5-expressing cells in the developing uterus and to evaluate their stem cell identity and function.
Tue Nov 26 00:00:00 UTC 2019
Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression.
Frontiers in cellular neuroscience
Gonçalves NP,Mohseni S,El Soury M,Ulrichsen M,Richner M,Xiao J,Wood RJ,Andersen OM,Coulson EJ,Raimondo S,Murray SS,Vægter CB
100-18B was used in Cell Culture to investigate the role of p75NTR expression in Schwann cell myelination.
Wed Jul 17 00:00:00 UTC 2024
MEK5/ERK5 activation regulates colon cancer stem-like cell properties.
Cell death discovery
Pereira DM,Gomes SE,Borralho PM,Rodrigues CMP
Tue Sep 29 00:00:00 UTC 2020
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.
Stem cell reports
Konttinen H,Cabral-da-Silva MEC,Ohtonen S,Wojciechowski S,Shakirzyanova A,Caligola S,Giugno R,Ishchenko Y,Hernández D,Fazaludeen MF,Eamen S,Budia MG,Fagerlund I,Scoyni F,Korhonen P,Huber N,Haapasalo A,Hewitt AW,Vickers J,Smith GC,Oksanen M,Graff C,Kanninen KM,Lehtonen S,Propson N,Schwartz MP,Pébay A,Koistinaho J,Ooi L,Malm T
Tue Oct 08 00:00:00 UTC 2019
Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection.
Frontiers in microbiology
Martins Gomes SF,Westermann AJ,Sauerwein T,Hertlein T,Förstner KU,Ohlsen K,Metzger M,Shusta EV,Kim BJ,Appelt-Menzel A,Schubert-Unkmeir A
100-18B was used in In vitro experiments to study Neisseria meningitidis host pathogen interactions.
Wed Sep 30 00:00:00 UTC 2020
Postinjury Inhibition of miR-181a Promotes Restoration of Hippocampal CA1 Neurons after Transient Forebrain Ischemia in Rats.
eNeuro
Griffiths BB,Ouyang YB,Xu L,Sun X,Giffard RG,Stary CM
100-18B was used in In vitro experiments to evaluate the use of anti-miR-181a for postinjury treatment of CA1 neuron recovery.
Thu Mar 05 00:00:00 UTC 2020
Central role of IP3R2-mediated Ca2+ oscillation in self-renewal of liver cancer stem cells elucidated by high-signal ER sensor.
Cell death & disease
Sun C,Shui B,Zhao W,Liu H,Li W,Lee JC,Doran R,Lee FK,Sun T,Shen QS,Wang X,Reining S,Kotlikoff MI,Zhang Z,Cheng H
Tue May 21 00:00:00 UTC 2019
Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA.
Stem cell reports
Brok-Volchanskaya VS,Bennin DA,Suknuntha K,Klemm LC,Huttenlocher A,Slukvin I
Tue Dec 10 00:00:00 UTC 2019
Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes.
Scientific reports
De Nuccio C,Bernardo A,Ferrante A,Pepponi R,Martire A,Falchi M,Visentin S,Popoli P,Minghetti L
Fri Jul 05 00:00:00 UTC 2019
The Orphan Nuclear Receptor TLX Represses Hes1 Expression, Thereby Affecting NOTCH Signaling and Lineage Progression in the Adult SEZ.
Stem cell reports
Luque-Molina I,Shi Y,Abdullah Y,Monaco S,Hölzl-Wenig G,Mandl C,Ciccolini F
Tue Jul 09 00:00:00 UTC 2019
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death.
Scientific reports
Ajmone-Cat MA,Onori A,Toselli C,Stronati E,Morlando M,Bozzoni I,Monni E,Kokaia Z,Lupo G,Minghetti L,Biagioni S,Cacci E
Thu Mar 14 00:00:00 UTC 2019
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.
Cell reports
Paonessa F,Evans LD,Solanki R,Larrieu D,Wray S,Hardy J,Jackson SP,Livesey FJ
100-18B was used in In vitro experiments to study the underlying pathogenic mechanisms in inherited frontotemporal dementia.
Tue Jan 15 00:00:00 UTC 2019
TSA restores hair follicle-inductive capacity of skin-derived precursors.
Scientific reports
Guo L,Wang X,Yuan J,Zhu M,Fu X,Xu RH,Wu C,Wu Y
Wed Feb 27 00:00:00 UTC 2019
Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs.
Stem cell reports
Arthur SA,Blaydes JP,Houghton FD
Tue Apr 09 00:00:00 UTC 2019
Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function.
eLife
Gerber D,Ghidinelli M,Tinelli E,Somandin C,Gerber J,Pereira JA,Ommer A,Figlia G,Miehe M,Nägeli LG,Suter V,Tadini V,Sidiropoulos PN,Wessig C,Toyka KV,Suter U
100-18B was used in Cell Culture to study the effects of dynamin 2 deletion on oligodendrocytes and Schwann cells.
Wed Jan 16 00:00:00 UTC 2019
A STAT3-based gene signature stratifies glioma patients for targeted therapy.
Nature communications
Tan MSY,Sandanaraj E,Chong YK,Lim SW,Koh LWH,Ng WH,Tan NS,Tan P,Ang BT,Tang C
Fri Aug 09 00:00:00 UTC 2019
UHRF genes regulate programmed interdigital tissue regression and chondrogenesis in the embryonic limb.
Cell death & disease
Sanchez-Fernandez C,Lorda-Diez CI,García-Porrero JA,Montero JA,Hurlé JM
Thu Apr 25 00:00:00 UTC 2019
Engineering transferrable microvascular meshes for subcutaneous islet transplantation.
Nature communications
Song W,Chiu A,Wang LH,Schwartz RE,Li B,Bouklas N,Bowers DT,An D,Cheong SH,Flanders JA,Pardo Y,Liu Q,Wang X,Lee VK,Dai G,Ma M
Thu Oct 10 00:00:00 UTC 2019
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis.
Acta neuropathologica communications
Gomez-Giro G,Arias-Fuenzalida J,Jarazo J,Zeuschner D,Ali M,Possemis N,Bolognin S,Halder R,Jäger C,Kuper WFE,van Hasselt PM,Zaehres H,Del Sol A,van der Putten H,Schöler HR,Schwamborn JC
100-18B was used in Cell Culture to suggest that a mutation in CLN3 severely affects brain development.
Mon Dec 30 00:00:00 UTC 2019
Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy.
Cell reports
Boscolo Sesillo F,Fox D,Sacco A
100-18B was used in Cell Culture to show that the inflammatory genes Ccl11 and Rgs5 are involved in RMS growth. Together, our results show that DMD severity drives MuSC-mediated RMS development.
Tue Jan 15 00:00:00 UTC 2019
Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.
Cell death & disease
Grassi L,Alfonsi R,Francescangeli F,Signore M,De Angelis ML,Addario A,Costantini M,Flex E,Ciolfi A,Pizzi S,Bruselles A,Pallocca M,Simone G,Haoui M,Falchi M,Milella M,Sentinelli S,Di Matteo P,Stellacci E,Gallucci M,Muto G,Tartaglia M,De Maria R,Bonci D
Wed Feb 27 00:00:00 UTC 2019
Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.
Scientific reports
Kang HM,Lim JH,Noh KH,Park D,Cho HS,Susztak K,Jung CR
Tue Nov 26 00:00:00 UTC 2019
Metabolism as an early predictor of DPSCs aging.
Scientific reports
Macrin D,Alghadeer A,Zhao YT,Miklas JW,Hussein AM,Detraux D,Robitaille AM,Madan A,Moon RT,Wang Y,Devi A,Mathieu J,Ruohola-Baker H
Mon Feb 18 00:00:00 UTC 2019
Genipin and EDC crosslinking of extracellular matrix hydrogel derived from human umbilical cord for neural tissue repair.
Scientific reports
Výborný K,Vallová J,Kočí Z,Kekulová K,Jiráková K,Jendelová P,Hodan J,Kubinová Š
Tue Jul 23 00:00:00 UTC 2019
ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma.
Cell death & disease
Liang B,Chen R,Song S,Wang H,Sun G,Yang H,Jing W,Zhou X,Fu Z,Huang G,Zhao J
Mon Nov 04 00:00:00 UTC 2019
Generation of a Mouse Model Lacking the Non-Homologous End-Joining Factor Mri/Cyren.
Biomolecules
Castañeda-Zegarra S,Huse C,Røsand Ø,Sarno A,Xing M,Gago-Fuentes R,Zhang Q,Alirezaylavasani A,Werner J,Ji P,Liabakk NB,Wang W,Bjørås M,Oksenych V
100-18B was used in Cell Culture to determine the physiological role of Mri in DNA repair and development.
Thu Nov 28 00:00:00 UTC 2019
Organoid-derived C-Kit+/SSEA4- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents.
Nature communications
Zou T,Gao L,Zeng Y,Li Q,Li Y,Chen S,Hu X,Chen X,Fu C,Xu H,Yin ZQ
Thu Mar 14 00:00:00 UTC 2019
Dysregulation of neuron differentiation in an autistic savant with exceptional memory.
Molecular brain
Song J,Yang X,Zhou Y,Chen L,Zhang X,Liu Z,Niu W,Zhan N,Fan X,Khan AA,Kuang Y,Song L,He G,Li W
100-18B was used in Cell Culture to investigate molecular mechanisms of savant syndrome.
Thu Nov 07 00:00:00 UTC 2019
CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.
Scientific reports
McKenzie LD,LeClair JW,Miller KN,Strong AD,Chan HL,Oates EL,Ligon KL,Brennan CW,Chheda MG
Thu Mar 14 00:00:00 UTC 2019
Automated Segmentation of Fluorescence Microscopy Images for 3D Cell Detection in human-derived Cardiospheres.
Scientific reports
Salvi M,Morbiducci U,Amadeo F,Santoro R,Angelini F,Chimenti I,Massai D,Messina E,Giacomello A,Pesce M,Molinari F
Tue Apr 30 00:00:00 UTC 2019
Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells.
Scientific reports
Pettinato G,Lehoux S,Ramanathan R,Salem MM,He LX,Muse O,Flaumenhaft R,Thompson MT,Rouse EA,Cummings RD,Wen X,Fisher RA
Thu Jun 20 00:00:00 UTC 2019
Isolation of Neural Stem Cells from Whole Brain Tissues of Adult Mice.
Current protocols in stem cell biology
Deshpande K,Saatian B,Martirosian V,Lin M,Julian A,Neman J
100-18B was used in Cell Culture to present a new protocol which facilitates adult neurospheres isolation, purification, maintenance, and differentiation.
Sat Jun 01 00:00:00 UTC 2019
Acquisition of a side population fraction augments malignant phenotype in ovarian cancer.
Scientific reports
Yamanoi K,Baba T,Abiko K,Hamanishi J,Yamaguchi K,Murakami R,Taki M,Hosoe Y,Murphy SK,Konishi I,Mandai M,Matsumura N
Wed Oct 02 00:00:00 UTC 2019
Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction.
Scientific reports
Gerardo H,Lima A,Carvalho J,Ramos JRD,Couceiro S,Travasso RDM,Pires das Neves R,Grãos M
Mon Jun 24 00:00:00 UTC 2019
N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration.
eLife
Kon E,Calvo-Jiménez E,Cossard A,Na Y,Cooper JA,Jossin Y
100-18B was used in Cell Culture to reveal novel functions for FGFRs in cortical projection neuron migration, suggest a physiological role for FGFR and N-Cadherin interaction in vivo and identify Reelin as an extracellular upstream regulator and Erk1/2 as downstream effectors of FGFRs during neuron migration.
Wed Oct 02 00:00:00 UTC 2019
Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells.
Nature communications
Tan L,Lacko LA,Zhou T,Tomoiaga D,Hurtado R,Zhang T,Sevilla A,Zhong A,Mason CE,Noggle S,Evans T,Stuhlmann H,Schwartz RE,Chen S
Fri Sep 13 00:00:00 UTC 2019
Muscle metabolic reprogramming underlies the resistance of liver fatty acid-binding protein (LFABP)-null mice to high-fat feeding-induced decline in exercise capacity.
The Journal of biological chemistry
Xu H,Gajda AM,Zhou YX,Panetta C,Sifnakis Z,Fatima A,Henderson GC,Storch J
Fri Oct 18 00:00:00 UTC 2019
Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Xiao Y,Kim D,Dura B,Zhang K,Yan R,Li H,Han E,Ip J,Zou P,Liu J,Chen AT,Vortmeyer AO,Zhou J,Fan R
Wed Apr 17 00:00:00 UTC 2019
Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro.
Nature communications
Feldman A,Mukha D,Maor II,Sedov E,Koren E,Yosefzon Y,Shlomi T,Fuchs Y
Tue May 28 00:00:00 UTC 2019
Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures.
Stem cell reports
Kelleher J,Dickinson A,Cain S,Hu Y,Bates N,Harvey A,Ren J,Zhang W,Moreton FC,Muir KW,Ward C,Touyz RM,Sharma P,Xu Q,Kimber SJ,Wang T
Tue Nov 12 00:00:00 UTC 2019
Functional characterization of iPSC-derived arterial- and venous-like endothelial cells.
Scientific reports
Rosa S,Praça C,Pitrez PR,Gouveia PJ,Aranguren XL,Ricotti L,Ferreira LS
Thu Mar 07 00:00:00 UTC 2019
A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer.
Cell death & disease
Mazzoldi EL,Pavan S,Pilotto G,Leone K,Pagotto A,Frezzini S,Nicoletto MO,Amadori A,Pastò A
Tue May 28 00:00:00 UTC 2019
Targeting of replicating CD133 and OCT4/SOX2 expressing glioma stem cells selects a cell population that reinitiates tumors upon release of therapeutic pressure.
Scientific reports
Guerra-Rebollo M,Garrido C,Sánchez-Cid L,Soler-Botija C,Meca-Cortés O,Rubio N,Blanco J
Tue Jul 02 00:00:00 UTC 2019
Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells.
Scientific reports
Bertolo A,Baur M,Guerrero J,Pötzel T,Stoyanov J
Thu Feb 14 00:00:00 UTC 2019
Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations.
Theranostics
Hamad S,Derichsweiler D,Papadopoulos S,Nguemo F,Šarić T,Sachinidis A,Brockmeier K,Hescheler J,Boukens BJ,Pfannkuche K
100-18B was used in Cell Culture to show that batch-to-batch variations were reduced by combinatorial use of ascorbate, IWP2, and XAV939. Conclusion: Combined inhibition of porcupine and tankyrase sub-pathways of Wnt signaling and continuous ascorbate supplementation, enable robust and efficient production of hiPSC-CMs.
Fri Sep 11 00:00:00 UTC 2020
Epitope mapping of anti-PGRMC1 antibodies reveals the non-conventional membrane topology of PGRMC1 on the cell surface.
Scientific reports
Kim JY,Kim SY,Choi HS,An S,Ryu CJ
Thu Jan 24 00:00:00 UTC 2019
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy.
Nature communications
Pascual-García M,Bonfill-Teixidor E,Planas-Rigol E,Rubio-Perez C,Iurlaro R,Arias A,Cuartas I,Sala-Hojman A,Escudero L,Martínez-Ricarte F,Huber-Ruano I,Nuciforo P,Pedrosa L,Marques C,Braña I,Garralda E,Vieito M,Squatrito M,Pineda E,Graus F,Espejo C,Sahuquillo J,Tabernero J,Seoane J
Tue Jun 11 00:00:00 UTC 2019
The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes.
Developmental cell
Bowen ME,McClendon J,Long HK,Sorayya A,Van Nostrand JL,Wysocka J,Attardi LD
100-18B was used in Cell Culture to study the basis of p53-driven developmental syndromes by leveraging an array of mouse strains to modulate the spatial expression pattern, temporal profile, and magnitude of p53 activation during embryogenesis.
Mon Jul 22 00:00:00 UTC 2019
Lifeact-GFP alters F-actin organization, cellular morphology and biophysical behaviour.
Scientific reports
Flores LR,Keeling MC,Zhang X,Sliogeryte K,Gavara N
Fri Mar 01 00:00:00 UTC 2019
The novel antidepressant ketamine enhances dentate gyrus proliferation with no effects on synaptic plasticity or hippocampal function in depressive-like rats.
Acta physiologica (Oxford, England)
Michaëlsson H,Andersson M,Svensson J,Karlsson L,Ehn J,Culley G,Engström A,Bergström N,Savvidi P,Kuhn HG,Hanse E,Seth H
100-18B was used in Cell Culture to study how there are limited effects of ketamine on hippocampal glutamatergic transmission.
Mon Apr 01 00:00:00 UTC 2019
Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes.
Translational psychiatry
Patel AM,Wierda K,Thorrez L,van Putten M,De Smedt J,Ribeiro L,Tricot T,Gajjar M,Duelen R,Van Damme P,De Waele L,Goemans N,Tanganyika-de Winter C,Costamagna D,Aartsma-Rus A,van Duyvenvoorde H,Sampaolesi M,Buyse GM,Verfaillie CM
Wed Aug 21 00:00:00 UTC 2019
PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination.
Cell reports
Falcão AM,Meijer M,Scaglione A,Rinwa P,Agirre E,Liang J,Larsen SC,Heskol A,Frawley R,Klingener M,Varas-Godoy M,Raposo AASF,Ernfors P,Castro DS,Nielsen ML,Casaccia P,Castelo-Branco G
100-18B was used in In vitro experiments to study how citrullination by peptidylarginine deiminase 2 (PAD2) contributes to normal oligodendrocyte differentiation, myelination, and motor function.
Tue Apr 23 00:00:00 UTC 2019
TGF-β-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane.
Scientific reports
Kanda A,Noda K,Hirose I,Ishida S
Thu Jan 24 00:00:00 UTC 2019
RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog.
Theranostics
Cao J,Zhao M,Liu J,Zhang X,Pei Y,Wang J,Yang X,Shen B,Zhang J
100-18B was used in Cell Culture to provide novel insights into the regulation of Nanog protein levels, as well the key role of RACK1 to enhance self-renewal and chemoresistance of CSCs in human HCC.
Tue Jan 14 00:00:00 UTC 2020
Sex-specific transcriptional and proteomic signatures in schizophrenia.
Nature communications
Tiihonen J,Koskuvi M,Storvik M,Hyötyläinen I,Gao Y,Puttonen KA,Giniatullina R,Poguzhelskaya E,Ojansuu I,Vaurio O,Cannon TD,Lönnqvist J,Therman S,Suvisaari J,Kaprio J,Cheng L,Hill AF,Lähteenvuo M,Tohka J,Giniatullin R,Lehtonen Š,Koistinaho J
Mon Sep 02 00:00:00 UTC 2019
Aquaporin 3 maintains the stemness of CD133+ hepatocellular carcinoma cells by activating STAT3.
Cell death & disease
Wang Y,Wu G,Fu X,Xu S,Wang T,Zhang Q,Yang Y
Thu Jun 13 00:00:00 UTC 2019
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors.
Scientific reports
Petroni M,Sahùn Roncero M,Ramponi V,Fabretti F,Nicolis Di Robilant V,Moretti M,Alfano V,Corsi A,De Panfilis S,Giubettini M,Di Giulio S,Capalbo C,Belardinilli F,Coppa A,Sardina F,Colicchia V,Pedretti F,Infante P,Cardinali B,Tessitore A,Canettieri G,De Smaele E,Giannini G
Mon Dec 23 00:00:00 UTC 2019
Mediator complex interaction partners organize the transcriptional network that defines neural stem cells.
Nature communications
Quevedo M,Meert L,Dekker MR,Dekkers DHW,Brandsma JH,van den Berg DLC,Ozgür Z,van IJcken WFJ,Demmers J,Fornerod M,Poot RA
Mon Jun 17 00:00:00 UTC 2019
Gene Editing in 3D Cultured Nephron Progenitor Cell Lines.
Methods in molecular biology (Clifton, N.J.)
Li Z,Araoka T,Belmonte JCI
100-18B was used in Cell Culture to study methods to derive nephron progenitor cell (NPC) lines from mouse embryonic kidneys in a 3D culture format as well as gene editing in the NPC lines.
Thu Jun 20 00:00:00 UTC 2019
Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform Neurofibromas.
Stem cell reports
Carrió M,Mazuelas H,Richaud-Patin Y,Gel B,Terribas E,Rosas I,Jimenez-Delgado S,Biayna J,Vendredy L,Blanco I,Castellanos E,Lázaro C,Raya Á,Serra E
Tue Feb 12 00:00:00 UTC 2019
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.
Nature communications
Ning JF,Stanciu M,Humphrey MR,Gorham J,Wakimoto H,Nishihara R,Lees J,Zou L,Martuza RL,Wakimoto H,Rabkin SD
Tue Jul 02 00:00:00 UTC 2019
iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds.
Stem cell reports
Faley SL,Neal EH,Wang JX,Bosworth AM,Weber CM,Balotin KM,Lippmann ES,Bellan LM
Tue Mar 05 00:00:00 UTC 2019
The Effect of Antiarrhythmic Drugs on the Beat Rate Variability of Human Embryonic and Human Induced Pluripotent Stem Cell Derived Cardiomyocytes.
Scientific reports
Niehoff J,Matzkies M,Nguemo F,Hescheler J,Reppel M
Tue Oct 01 00:00:00 UTC 2019
A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS).
Nature communications
Wu MR,Nissim L,Stupp D,Pery E,Binder-Nissim A,Weisinger K,Enghuus C,Palacios SR,Humphrey M,Zhang Z,Maria Novoa E,Kellis M,Weiss R,Rabkin SD,Tabach Y,Lu TK
Fri Jun 28 00:00:00 UTC 2019
Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives.
Stem cell reports
Cao X,Yakala GK,van den Hil FE,Cochrane A,Mummery CL,Orlova VV
Tue Jun 11 00:00:00 UTC 2019
Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors.
Cell death & disease
Mahajani S,Raina A,Fokken C,Kügler S,Bähr M
Wed Nov 27 00:00:00 UTC 2019
Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development.
Cell reports
Komabayashi-Suzuki M,Yamanishi E,Watanabe C,Okamura M,Tabata H,Iwai R,Ajioka I,Matsushita J,Kidoya H,Takakura N,Okamoto T,Kinoshita K,Ichihashi M,Nagata KI,Ema M,Mizutani KI
100-18B was used in Cell Culture to investigate blood vessel development in the brain, and this relationship with neuronal progenitors and other different cell types.
Tue Oct 29 00:00:00 UTC 2019
Transcriptomes of human mesenchymal cells isolated from the right ventricle and epicardial fat differ strikingly both directly after isolation and long-term culture.
ESC heart failure
Stępniewski J,Florczyk-Soluch U,Szade K,Bukowska-Strakova K,Czapla J,Matuszczak S,Jarosz-Biej M,Langrzyk A,Tomczyk M,Rumieńczyk I,Kulecka M,Mikuła M,Ostrowski J,Jaźwa-Kusior A,Zembala M,Józkowicz A,Zembala MO,Dulak J
Mon Apr 01 00:00:00 UTC 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 UTC 2019
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Scientific reports
Savchenko E,Teku GN,Boza-Serrano A,Russ K,Berns M,Deierborg T,Lamas NJ,Wichterle H,Rothstein J,Henderson CE,Vihinen M,Roybon L
Wed Jul 03 00:00:00 UTC 2019
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.
Scientific reports
Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II
Mon Apr 29 00:00:00 UTC 2019
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons.
Scientific reports
Calatayud C,Carola G,Fernández-Carasa I,Valtorta M,Jiménez-Delgado S,Díaz M,Soriano-Fradera J,Cappelletti G,García-Sancho J,Raya Á,Consiglio A
Thu May 02 00:00:00 UTC 2019
Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes.
eLife
Selvaraj S,Mondragon-Gonzalez R,Xu B,Magli A,Kim H,Lainé J,Kiley J,Mckee H,Rinaldi F,Aho J,Tabti N,Shen W,Perlingeiro RC
100-18B was used in Cell Culture to investigate pluripotent stem cells differentiation into myotubes in skeletal muscle disease.
Mon Nov 11 00:00:00 UTC 2019
The biological behavior optimization of human periodontal ligament stem cells via preconditioning by the combined application of fibroblast growth factor-2 and A83-01 in in vitro culture expansion.
Journal of translational medicine
Zhang C,Guo H,Yang C,Chen Q,Huang J,Liu L,Zhang Y,Jin S,Song A,Yang P
100-18B was used in Cell Culture to investigate the use of fibroblast growth factor-2 and A83-01 on cell expansion, apoptosis, stemness expression, osteogenic differentiation and mineralization and paracrine action of PDLSCs.
Thu Feb 28 00:00:00 UTC 2019
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Nature communications
Zhao Y,Sun X,Hu D,Prosdocimo DA,Hoppel C,Jain MK,Ramachandran R,Qi X
Tue Mar 26 00:00:00 UTC 2019
M2 receptors activation modulates cell growth, migration and differentiation of rat Schwann-like adipose-derived stem cells.
Cell death discovery
Piovesana R,Faroni A,Magnaghi V,Reid AJ,Tata AM
Wed Sep 30 00:00:00 UTC 2020
Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs.
Stem cell reports
Nakamura M,Shiozawa S,Tsuboi D,Amano M,Watanabe H,Maeda S,Kimura T,Yoshimatsu S,Kisa F,Karch CM,Miyasaka T,Takashima A,Sahara N,Hisanaga SI,Ikeuchi T,Kaibuchi K,Okano H
Tue Oct 08 00:00:00 UTC 2019
Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs.
Stem cell reports
Nakamura M,Shiozawa S,Tsuboi D,Amano M,Watanabe H,Maeda S,Kimura T,Yoshimatsu S,Kisa F,Karch CM,Miyasaka T,Takashima A,Sahara N,Hisanaga SI,Ikeuchi T,Kaibuchi K,Okano H
Tue Oct 08 00:00:00 UTC 2019
Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome.
Nature communications
Zhu W,Zhang B,Li M,Mo F,Mi T,Wu Y,Teng Z,Zhou Q,Li W,Hu B
Mon Feb 25 00:00:00 UTC 2019
Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis.
Nature medicine
Falcão AM,van Bruggen D,Marques S,Meijer M,Jäkel S,Agirre E,Floriddia EM,Vanichkina DP,Ffrench-Constant C,Williams A,Guerreiro-Cacais AO,Castelo-Branco G
100-18B was used in In vitro experiments to investigate the genes in oligodendrocytes in experimental autoimmune encephalomyelitis from multiple sclerosis.
Sat Dec 01 00:00:00 UTC 2018
A metabolic function of FGFR3-TACC3 gene fusions in cancer.
Nature
Frattini V,Pagnotta SM,Fan JJ,Russo MV,Lee SB,Garofano L,Zhang J,Shi P,Lewis G,Sanson H,Frederick V,Castano AM,Cerulo L,Rolland DCM,Mall R,Mokhtari K,Elenitoba-Johnson KSJ,Sanson M,Huang X,Ceccarelli M,Lasorella A,Iavarone A
Thu Jan 11 00:00:00 UTC 2018
Required growth facilitators propel axon regeneration across complete spinal cord injury.
Nature
Anderson MA,O'Shea TM,Burda JE,Ao Y,Barlatey SL,Bernstein AM,Kim JH,James ND,Rogers A,Kato B,Wollenberg AL,Kawaguchi R,Coppola G,Wang C,Deming TJ,He Z,Courtine G,Sofroniew MV
Sat Sep 01 00:00:00 UTC 2018
Required growth facilitators propel axon regeneration across complete spinal cord injury.
Nature
Anderson MA,O'Shea TM,Burda JE,Ao Y,Barlatey SL,Bernstein AM,Kim JH,James ND,Rogers A,Kato B,Wollenberg AL,Kawaguchi R,Coppola G,Wang C,Deming TJ,He Z,Courtine G,Sofroniew MV
Sat Sep 01 00:00:00 UTC 2018
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.
Nature
Sulli G,Rommel A,Wang X,Kolar MJ,Puca F,Saghatelian A,Plikus MV,Verma IM,Panda S
Thu Jan 18 00:00:00 UTC 2018
The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ.
Nature
Chang L,Azzolin L,Di Biagio D,Zanconato F,Battilana G,Lucon Xiccato R,Aragona M,Giulitti S,Panciera T,Gandin A,Sigismondo G,Krijgsveld J,Fassan M,Brusatin G,Cordenonsi M,Piccolo S
Thu Nov 01 00:00:00 UTC 2018
CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness.
Cell
Su S,Chen J,Yao H,Liu J,Yu S,Lao L,Wang M,Luo M,Xing Y,Chen F,Huang D,Zhao J,Yang L,Liao D,Su F,Li M,Liu Q,Song E
Thu Feb 08 00:00:00 UTC 2018
Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.
Cell
Cho SW,Xu J,Sun R,Mumbach MR,Carter AC,Chen YG,Yost KE,Kim J,He J,Nevins SA,Chin SF,Caldas C,Liu SJ,Horlbeck MA,Lim DA,Weissman JS,Curtis C,Chang HY
Thu May 31 00:00:00 UTC 2018
Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.
Cell
Fiddes IT,Lodewijk GA,Mooring M,Bosworth CM,Ewing AD,Mantalas GL,Novak AM,van den Bout A,Bishara A,Rosenkrantz JL,Lorig-Roach R,Field AR,Haeussler M,Russo L,Bhaduri A,Nowakowski TJ,Pollen AA,Dougherty ML,Nuttle X,Addor MC,Zwolinski S,Katzman S,Kriegstein A,Eichler EE,Salama SR,Jacobs FMJ,Haussler D
Thu May 31 00:00:00 UTC 2018
The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis.
Cell
de la Torre-Ubieta L,Stein JL,Won H,Opland CK,Liang D,Lu D,Geschwind DH
Thu Jan 11 00:00:00 UTC 2018
Nervous System Regionalization Entails Axial Allocation before Neural Differentiation.
Cell
Metzis V,Steinhauser S,Pakanavicius E,Gouti M,Stamataki D,Ivanovitch K,Watson T,Rayon T,Mousavy Gharavy SN,Lovell-Badge R,Luscombe NM,Briscoe J
Thu Nov 01 00:00:00 UTC 2018
Nervous System Regionalization Entails Axial Allocation before Neural Differentiation.
Cell
Metzis V,Steinhauser S,Pakanavicius E,Gouti M,Stamataki D,Ivanovitch K,Watson T,Rayon T,Mousavy Gharavy SN,Lovell-Badge R,Luscombe NM,Briscoe J
Thu Nov 01 00:00:00 UTC 2018
Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.
Nature methods
Di Stefano B,Ueda M,Sabri S,Brumbaugh J,Huebner AJ,Sahakyan A,Clement K,Clowers KJ,Erickson AR,Shioda K,Gygi SP,Gu H,Shioda T,Meissner A,Takashima Y,Plath K,Hochedlinger K
Sat Sep 01 00:00:00 UTC 2018
Generation and post-injury integration of human spinal cord neural stem cells.
Nature methods
Kumamaru H,Kadoya K,Adler AF,Takashima Y,Graham L,Coppola G,Tuszynski MH
Sat Sep 01 00:00:00 UTC 2018
Generation and post-injury integration of human spinal cord neural stem cells.
Nature methods
Kumamaru H,Kadoya K,Adler AF,Takashima Y,Graham L,Coppola G,Tuszynski MH
Sat Sep 01 00:00:00 UTC 2018
Rapid and efficient induction of functional astrocytes from human pluripotent stem cells.
Nature methods
Canals I,Ginisty A,Quist E,Timmerman R,Fritze J,Miskinyte G,Monni E,Hansen MG,Hidalgo I,Bryder D,Bengzon J,Ahlenius H
Sat Sep 01 00:00:00 UTC 2018
NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.
Cancer cell
Garancher A,Lin CY,Morabito M,Richer W,Rocques N,Larcher M,Bihannic L,Smith K,Miquel C,Leboucher S,Herath NI,Dupuy F,Varlet P,Haberler C,Walczak C,El Tayara N,Volk A,Puget S,Doz F,Delattre O,Druillennec S,Ayrault O,Wechsler-Reya RJ,Eychène A,Bourdeaut F,Northcott PA,Pouponnot C
Mon Mar 12 00:00:00 UTC 2018
NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.
Cancer cell
Garancher A,Lin CY,Morabito M,Richer W,Rocques N,Larcher M,Bihannic L,Smith K,Miquel C,Leboucher S,Herath NI,Dupuy F,Varlet P,Haberler C,Walczak C,El Tayara N,Volk A,Puget S,Doz F,Delattre O,Druillennec S,Ayrault O,Wechsler-Reya RJ,Eychène A,Bourdeaut F,Northcott PA,Pouponnot C
Mon Mar 12 00:00:00 UTC 2018
Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors.
Cancer cell
Pavlyukov MS,Yu H,Bastola S,Minata M,Shender VO,Lee Y,Zhang S,Wang J,Komarova S,Wang J,Yamaguchi S,Alsheikh HA,Shi J,Chen D,Mohyeldin A,Kim SH,Shin YJ,Anufrieva K,Evtushenko EG,Antipova NV,Arapidi GP,Govorun V,Pestov NB,Shakhparonov MI,Lee LJ,Nam DH,Nakano I
Mon Jul 09 00:00:00 UTC 2018
Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.
Cancer discovery
Hill SJ,Decker B,Roberts EA,Horowitz NS,Muto MG,Worley MJ,Feltmate CM,Nucci MR,Swisher EM,Nguyen H,Yang C,Morizane R,Kochupurakkal BS,Do KT,Konstantinopoulos PA,Liu JF,Bonventre JV,Matulonis UA,Shapiro GI,Berkowitz RS,Crum CP,D'Andrea AD
100-18B was used in Tissue/organ culture to demonstrate a platform for functional profiling of DNA repair in short-term patient-derived high-grade serous ovarian cancer (HGSC) organoids as a means of assessing targetable defects in the parent tumors, offering more suitable treatment options.
Thu Nov 01 00:00:00 UTC 2018
Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.
Cell stem cell
Peruzzotti-Jametti L,Bernstock JD,Vicario N,Costa ASH,Kwok CK,Leonardi T,Booty LM,Bicci I,Balzarotti B,Volpe G,Mallucci G,Manferrari G,Donegà M,Iraci N,Braga A,Hallenbeck JM,Murphy MP,Edenhofer F,Frezza C,Pluchino S
100-18B was used in Cell Culture to deterimne a role for the succinate-SUCNR1 axis in somatic and directly induced neural stem cells to inflammatory metabolic signals released by type 1 MPs in the chronically inflamed-brain.
Thu Mar 01 00:00:00 UTC 2018
Human Brain Organoids on a Chip Reveal the Physics of Folding.
Nature physics
Karzbrun E,Kshirsagar A,Cohen SR,Hanna JH,Reiner O
Tue May 01 00:00:00 UTC 2018
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Neuron
Lin YT,Seo J,Gao F,Feldman HM,Wen HL,Penney J,Cam HP,Gjoneska E,Raja WK,Cheng J,Rueda R,Kritskiy O,Abdurrob F,Peng Z,Milo B,Yu CJ,Elmsaouri S,Dey D,Ko T,Yankner BA,Tsai LH
Wed Jun 27 00:00:00 UTC 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 UTC 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 UTC 2018
Generation of human brain region-specific organoids using a miniaturized spinning bioreactor.
Nature protocols
Qian X,Jacob F,Song MM,Nguyen HN,Song H,Ming GL
Thu Mar 01 00:00:00 UTC 2018
Selective depletion of metastatic stem cells as therapy for human colorectal cancer.
EMBO molecular medicine
Céspedes MV,Unzueta U,Aviñó A,Gallardo A,Álamo P,Sala R,Sánchez-Chardi A,Casanova I,Mangues MA,Lopez-Pousa A,Eritja R,Villaverde A,Vázquez E,Mangues R
Mon Oct 01 00:00:00 UTC 2018
Selective depletion of metastatic stem cells as therapy for human colorectal cancer.
EMBO molecular medicine
Céspedes MV,Unzueta U,Aviñó A,Gallardo A,Álamo P,Sala R,Sánchez-Chardi A,Casanova I,Mangues MA,Lopez-Pousa A,Eritja R,Villaverde A,Vázquez E,Mangues R
Mon Oct 01 00:00:00 UTC 2018
Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain.
Developmental cell
Dave JM,Mirabella T,Weatherbee SD,Greif DM
100-18B was used in In vitro experiments to reveal a key role for PC ALK5 in regulating brain endothelial morphogenesis and a substantial therapeutic potential for TIMP3 during GMH-IVH.
Mon Mar 26 00:00:00 UTC 2018
Creation of disease-inspired biomaterial environments to mimic pathological events in early calcific aortic valve disease.
Proceedings of the National Academy of Sciences of the United States of America
Porras AM,Westlund JA,Evans AD,Masters KS
Tue Jan 16 00:00:00 UTC 2018
Post-translational modification of OCT4 in breast cancer tumorigenesis.
Cell death and differentiation
Cho Y,Kang HG,Kim SJ,Lee S,Jee S,Ahn SG,Kang MJ,Song JS,Chung JY,Yi EC,Chun KH
Thu Nov 01 00:00:00 UTC 2018
Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis.
Cell death and differentiation
Petrillo S,Chiabrando D,Genova T,Fiorito V,Ingoglia G,Vinchi F,Mussano F,Carossa S,Silengo L,Altruda F,Merlo GR,Munaron L,Tolosano E
Thu Mar 01 00:00:00 UTC 2018
Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1.
Oncogene
Al Shareef Z,Kardooni H,Murillo-Garzón V,Domenici G,Stylianakis E,Steel JH,Rabano M,Gorroño-Etxebarria I,Zabalza I,Vivanco MD,Waxman J,Kypta RM
Sat Sep 01 00:00:00 UTC 2018
FBXW7 suppresses epithelial-mesenchymal transition and chemo-resistance of non-small-cell lung cancer cells by targeting snai1 for ubiquitin-dependent degradation.
Cell proliferation
Xiao G,Li Y,Wang M,Li X,Qin S,Sun X,Liang R,Zhang B,Du N,Xu C,Ren H,Liu D
100-18B was used in Cell Culture to conclude that FBXW7 conduction of tumour suppression was partly through degrading Snai1 directly for ubiquitylating regulation in NSCLC.
Mon Oct 01 00:00:00 UTC 2018
Intact Cell Mass Spectrometry as a Quality Control Tool for Revealing Minute Phenotypic Changes of Cultured Human Embryonic Stem Cells.
Stem cells translational medicine
Vaňhara P,Kučera L,Prokeš L,Jurečková L,Peña-Méndez EM,Havel J,Hampl A
Mon Jan 01 00:00:00 UTC 2018
Intact Cell Mass Spectrometry as a Quality Control Tool for Revealing Minute Phenotypic Changes of Cultured Human Embryonic Stem Cells.
Stem cells translational medicine
Vaňhara P,Kučera L,Prokeš L,Jurečková L,Peña-Méndez EM,Havel J,Hampl A
Mon Jan 01 00:00:00 UTC 2018
Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production.
Stem cells translational medicine
Brick RM,Sun AX,Tuan RS
Mon Jan 01 00:00:00 UTC 2018
Microparticles Carrying Peroxisome Proliferator-Activated Receptor Alpha Restore the Reduced Differentiation and Functionality of Bone Marrow-Derived Cells Induced by High-Fat Diet.
Stem cells translational medicine
Vergori L,Lauret E,Soleti R,Andriantsitohaina R,Carmen Martinez M
Mon Jan 01 00:00:00 UTC 2018
ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy.
Oncogenesis
Veenstra VL,Damhofer H,Waasdorp C,van Rijssen LB,van de Vijver MJ,Dijk F,Wilmink HW,Besselink MG,Busch OR,Chang DK,Bailey PJ,Biankin AV,Kocher HM,Medema JP,Li JS,Jiang R,Pierce DW,van Laarhoven HWM,Bijlsma MF
Fri Nov 16 00:00:00 UTC 2018
Cigarette smoke stimulates the stemness of renal cancer stem cells via Sonic Hedgehog pathway.
Oncogenesis
Qian W,Kong X,Zhang T,Wang D,Song J,Li Y,Li X,Geng H,Min J,Kong Q,Liu J,Liu Z,Wang D,Zhang Z,Yu D,Zhong C
Tue Mar 13 00:00:00 UTC 2018
Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells.
American journal of physiology. Lung cellular and molecular physiology
Tamò L,Hibaoui Y,Kallol S,Alves MP,Albrecht C,Hostettler KE,Feki A,Rougier JS,Abriel H,Knudsen L,Gazdhar A,Geiser T
Sat Dec 01 00:00:00 UTC 2018
Prior Treatment with Anti-High Mobility Group Box-1 Antibody Boosts Human Neural Stem Cell Transplantation-Mediated Functional Recovery After Spinal Cord Injury.
Stem cells (Dayton, Ohio)
Uezono N,Zhu Y,Fujimoto Y,Yasui T,Matsuda T,Nakajo M,Abematsu M,Setoguchi T,Mori S,Takahashi HK,Komiya S,Nishibori M,Nakashima K
Tue May 01 00:00:00 UTC 2018
Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury.
Stem cells (Dayton, Ohio)
Gazdhar A,Ravikumar P,Pastor J,Heller M,Ye J,Zhang J,Moe OW,Geiser T,Hsia CCW
Sun Apr 01 00:00:00 UTC 2018
Barrier Properties and Transcriptome Expression in Human iPSC-Derived Models of the Blood-Brain Barrier.
Stem cells (Dayton, Ohio)
Delsing L,Dönnes P,Sánchez J,Clausen M,Voulgaris D,Falk A,Herland A,Brolén G,Zetterberg H,Hicks R,Synnergren J
Sat Dec 01 00:00:00 UTC 2018
Polarization-insensitive one-dimensional guided-mode resonance filter operating at conical mounting.
Optics letters
Wang W,Cai W,Shi Z,Shen X,Wang Y
Thu Nov 01 00:00:00 UTC 2018
Selective enrichment of CD133+/SOX2+ glioblastoma stem cells via adherent culture.
Oncology letters
Lv K,Chen Z,Zhang X,Zhang Q,Liu L
100-18B was used in Cell Culture to investigate cancer stem cells in brain tumours.
Mon Oct 01 00:00:00 UTC 2018
Transplanted enteric neural stem cells integrate within the developing chick spinal cord: implications for spinal cord repair.
Journal of anatomy
Jevans B,McCann CJ,Thapar N,Burns AJ
Thu Nov 01 00:00:00 UTC 2018
HMGB1 represses the anti-cancer activity of sunitinib by governing TP53 autophagic degradation via its nucleus-to-cytoplasm transport.
Autophagy
Luo P,Xu Z,Li G,Yan H,Zhu Y,Zhu H,Ma S,Yang B,He Q
100-18B was used in Cell Culture to identify an alternative HMGB1-mediated TP53 protein turnover mechanism that participates in the resistance of sunitinib and suggest HMGB1 as a potential therapeutic target for improving clinical outcomes of sunitinib.
Tue Oct 22 00:00:00 UTC 2019
Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.
Scientific reports
Acosta MI,Urbach S,Doye A,Ng YW,Boudeau J,Mettouchi A,Debant A,Manser E,Visvikis O,Lemichez E
Tue Jan 23 00:00:00 UTC 2018
Mesenchymal Stromal Cells-Derived β2-Microglobulin Promotes Epithelial-Mesenchymal Transition of Esophageal Squamous Cell Carcinoma Cells.
Scientific reports
Wang J,Yang W,Wang T,Chen X,Wang J,Zhang X,Cai C,Zhong B,Wu J,Chen Z,Xiang AP,Huang W
Tue Apr 03 00:00:00 UTC 2018
Human pluripotent reprogramming with CRISPR activators.
Nature communications
Weltner J,Balboa D,Katayama S,Bespalov M,Krjutškov K,Jouhilahti EM,Trokovic R,Kere J,Otonkoski T
Fri Jul 06 00:00:00 UTC 2018
Inertial-Based Filtration Method for Removal of Microcarriers from Mesenchymal Stem Cell Suspensions.
Scientific reports
Moloudi R,Oh S,Yang C,Teo KL,Lam AT,Warkiani ME,Naing MW
Mon Aug 20 00:00:00 UTC 2018
Renal cancer: new models and approach for personalizing therapy.
Journal of experimental & clinical cancer research : CR
di Martino S,De Luca G,Grassi L,Federici G,Alfonsi R,Signore M,Addario A,De Salvo L,Francescangeli F,Sanchez M,Tirelli V,Muto G,Sperduti I,Sentinelli S,Costantini M,Pasquini L,Milella M,Haoui M,Simone G,Gallucci M,De Maria R,Bonci D
100-18B was used in Cell Culture to investigate clear cell renal cancer therapeutic options.
Wed Sep 05 00:00:00 UTC 2018
VDAC2 interacts with PFKP to regulate glucose metabolism and phenotypic reprogramming of glioma stem cells.
Cell death & disease
Zhou K,Yao YL,He ZC,Chen C,Zhang XN,Yang KD,Liu YQ,Liu Q,Fu WJ,Chen YP,Niu Q,Ma QH,Zhou R,Yao XH,Zhang X,Cui YH,Bian XW,Shi Y,Ping YF
Mon Sep 24 00:00:00 UTC 2018
Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib.
Scientific reports
Karademir B,Sari G,Jannuzzi AT,Musunuri S,Wicher G,Grune T,Mi J,Hacioglu-Bay H,Forsberg-Nilsson K,Bergquist J,Jung T
Mon Nov 05 00:00:00 UTC 2018
Grey matter OPCs are less mature and less sensitive to IFNγ than white matter OPCs: consequences for remyelination.
Scientific reports
Lentferink DH,Jongsma JM,Werkman I,Baron W
Thu Feb 01 00:00:00 UTC 2018
Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells.
Nature communications
Ma X,Chen X,Jin Y,Ge W,Wang W,Kong L,Ji J,Guo X,Huang J,Feng XH,Fu J,Zhu S
Tue Apr 03 00:00:00 UTC 2018
Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins.
Scientific reports
Gratte FD,Pasic S,Olynyk JK,Yeoh GCT,Tosh D,Coombe DR,Tirnitz-Parker JEE
Mon Mar 12 00:00:00 UTC 2018
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.
Cell stem cell
Fujii M,Matano M,Toshimitsu K,Takano A,Mikami Y,Nishikori S,Sugimoto S,Sato T
100-18B was used in Tissue/organ culture to investigate maintenance of intestinal organoid culture with reflective cellular diversity.
Thu Dec 06 00:00:00 UTC 2018
Premyogenic progenitors derived from human pluripotent stem cells expand in floating culture and differentiate into transplantable myogenic progenitors.
Scientific reports
Sakai-Takemura F,Narita A,Masuda S,Wakamatsu T,Watanabe N,Nishiyama T,Nogami K,Blanc M,Takeda S,Miyagoe-Suzuki Y
Thu Apr 26 00:00:00 UTC 2018
BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells.
Scientific reports
Armenteros T,Andreu Z,Hortigüela R,Lie DC,Mira H
Mon Jun 18 00:00:00 UTC 2018
Interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells.
Scientific reports
Göbel C,Goetzke R,Eggermann T,Wagner W
Fri Aug 03 00:00:00 UTC 2018
Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.
Nature communications
Ackermann M,Kempf H,Hetzel M,Hesse C,Hashtchin AR,Brinkert K,Schott JW,Haake K,Kühnel MP,Glage S,Figueiredo C,Jonigk D,Sewald K,Schambach A,Wronski S,Moritz T,Martin U,Zweigerdt R,Munder A,Lachmann N
Fri Nov 30 00:00:00 UTC 2018
ALS-related human cortical and motor neurons survival is differentially affected by Sema3A.
Cell death & disease
Birger A,Ottolenghi M,Perez L,Reubinoff B,Behar O
Thu Feb 15 00:00:00 UTC 2018
Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes.
Scientific reports
Schöbel A,Rösch K,Herker E
Thu Mar 01 00:00:00 UTC 2018
Gαi-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.
Scientific reports
Kwak M,Hong C,Myeong J,Park EYJ,Jeon JH,So I
Thu Feb 22 00:00:00 UTC 2018
The functional and inflammatory response of brain endothelial cells to Toll-Like Receptor agonists.
Scientific reports
Johnson RH,Kho DT,O' Carroll SJ,Angel CE,Graham ES
Wed Jul 04 00:00:00 UTC 2018
Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs.
Scientific reports
Lin Y,Liu H,Klein M,Ostrominski J,Hong SG,Yada RC,Chen G,Navarengom K,Schwartzbeck R,San H,Yu ZX,Liu C,Linask K,Beers J,Qiu L,Dunbar CE,Boehm M,Zou J
Thu Apr 12 00:00:00 UTC 2018
PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer.
Cell death & disease
Wang Q,Shi YL,Zhou K,Wang LL,Yan ZX,Liu YL,Xu LL,Zhao SW,Chu HL,Shi TT,Ma QH,Bi J
Tue Jul 03 00:00:00 UTC 2018
Methanol fixed fibroblasts serve as feeder cells to maintain stem cells in the pluripotent state in vitro.
Scientific reports
Ren Y,Ma Z,Yu T,Ling M,Wang H
Thu May 17 00:00:00 UTC 2018
The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy.
Scientific reports
Nakamoto FK,Okamoto S,Mitsui J,Sone T,Ishikawa M,Yamamoto Y,Kanegae Y,Nakatake Y,Imaizumi K,Ishiura H,Tsuji S,Okano H
Fri Sep 21 00:00:00 UTC 2018
ALCAM+ stromal cells: role in giant cell tumor of bone progression.
Cell death & disease
Zhou Z,Li Y,Wang X,Hu J,Kuang M,Wang Z,Li S,Xu W,Xiao J
Tue Feb 20 00:00:00 UTC 2018
MSX2 Initiates and Accelerates Mesenchymal Stem/Stromal Cell Specification of hPSCs by Regulating TWIST1 and PRAME.
Stem cell reports
Zhang L,Wang H,Liu C,Wu Q,Su P,Wu D,Guo J,Zhou W,Xu Y,Shi L,Zhou J
Tue Aug 14 00:00:00 UTC 2018
Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts.
Scientific reports
Patel B,Xu Z,Pinnock CB,Kabbani LS,Lam MT
Mon Feb 19 00:00:00 UTC 2018
Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Nature communications
Caires-Júnior LC,Goulart E,Melo US,Araujo BHS,Alvizi L,Soares-Schanoski A,de Oliveira DF,Kobayashi GS,Griesi-Oliveira K,Musso CM,Amaral MS,daSilva LF,Astray RM,Suárez-Patiño SF,Ventini DC,Gomes da Silva S,Yamamoto GL,Ezquina S,Naslavsky MS,Telles-Silva KA,Weinmann K,van der Linden V,van der Linden H,de Oliveira JRM,Arrais NMR,Melo A,Figueiredo T,Santos S,Meira JGC,Passos SD,de Almeida RP,Bispo AJB,Cavalheiro EA,Kalil J,Cunha-Neto E,Nakaya H,Andreata-Santos R,de Souza Ferreira LC,Verjovski-Almeida S,Ho PL,Passos-Bueno MR,Zatz M
Fri Feb 02 00:00:00 UTC 2018
Exosomes from normal and diabetic human corneolimbal keratocytes differentially regulate migration, proliferation and marker expression of limbal epithelial cells.
Scientific reports
Leszczynska A,Kulkarni M,Ljubimov AV,Saghizadeh M
Thu Oct 11 00:00:00 UTC 2018
The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration.
Scientific reports
Sánchez-Botet A,Gasa L,Quandt E,Hernández-Ortega S,Jiménez J,Mezquita P,Carrasco-García MÀ,Kron SJ,Vidal A,Villanueva A,Ribeiro MPC,Clotet J
Tue Aug 07 00:00:00 UTC 2018
Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2.
Cell death & disease
Zhang X,Liu X,Zhou W,Yang M,Ding Y,Wang Q,Hu R
Wed Feb 07 00:00:00 UTC 2018
Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2.
Cell death & disease
Zhang X,Liu X,Zhou W,Yang M,Ding Y,Wang Q,Hu R
Wed Feb 07 00:00:00 UTC 2018
Combined RNA-seq and RAT-seq mapping of long noncoding RNAs in pluripotent reprogramming.
Scientific data
Du Z,Jia L,Wang Y,Wang C,Wen X,Chen J,Zhu Y,Yu D,Zhou L,Chen N,Zhang S,Celik I,Ay F,Gao S,Zhang S,Li W,Hoffman AR,Cui J,Hu JF
Tue Nov 20 00:00:00 UTC 2018
Nanomedicines reveal how PBOV1 promotes hepatocellular carcinoma for effective gene therapy.
Nature communications
Guo Y,Wu Z,Shen S,Guo R,Wang J,Wang W,Zhao K,Kuang M,Shuai X
Fri Aug 24 00:00:00 UTC 2018
miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA/BBC3 and BTG2.
Cell death & disease
Fiori ME,Villanova L,Barbini C,De Angelis ML,De Maria R
Fri Jan 19 00:00:00 UTC 2018
Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits.
Stem cell reports
Smith JGW,Owen T,Bhagwan JR,Mosqueira D,Scott E,Mannhardt I,Patel A,Barriales-Villa R,Monserrat L,Hansen A,Eschenhagen T,Harding SE,Marston S,Denning C
Tue Nov 13 00:00:00 UTC 2018
Differentiation potential of Pluripotent Stem Cells correlates to the level of CHD7.
Scientific reports
Yamamoto T,Takenaka C,Yoda Y,Oshima Y,Kagawa K,Miyajima H,Sasaki T,Kawamata S
Wed Jan 10 00:00:00 UTC 2018
Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines.
Stem cell reports
Perriot S,Mathias A,Perriard G,Canales M,Jonkmans N,Merienne N,Meunier C,El Kassar L,Perrier AL,Laplaud DA,Schluep M,Déglon N,Du Pasquier R
Tue Nov 13 00:00:00 UTC 2018
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.
Nature communications
Decaesteker B,Denecker G,Van Neste C,Dolman EM,Van Loocke W,Gartlgruber M,Nunes C,De Vloed F,Depuydt P,Verboom K,Rombaut D,Loontiens S,De Wyn J,Kholosy WM,Koopmans B,Essing AHW,Herrmann C,Dreidax D,Durinck K,Deforce D,Van Nieuwerburgh F,Henssen A,Versteeg R,Boeva V,Schleiermacher G,van Nes J,Mestdagh P,Vanhauwaert S,Schulte JH,Westermann F,Molenaar JJ,De Preter K,Speleman F
Mon Nov 19 00:00:00 UTC 2018
Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids.
Cell death & disease
Zhang B,He Y,Xu Y,Mo F,Mi T,Shen QS,Li C,Li Y,Liu J,Wu Y,Chen G,Zhu W,Qin C,Hu B,Zhou G
Mon Jun 18 00:00:00 UTC 2018
Cell-Surface Marker Signature for Enrichment of Ventricular Cardiomyocytes Derived from Human Embryonic Stem Cells.
Stem cell reports
Veevers J,Farah EN,Corselli M,Witty AD,Palomares K,Vidal JG,Emre N,Carson CT,Ouyang K,Liu C,van Vliet P,Zhu M,Hegarty JM,Deacon DC,Grinstein JD,Dirschinger RJ,Frazer KA,Adler ED,Knowlton KU,Chi NC,Martin JC,Chen J,Evans SM
Tue Sep 11 00:00:00 UTC 2018
MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1.
Stem cell reports
Wang H,Liu C,Liu X,Wang M,Wu D,Gao J,Su P,Nakahata T,Zhou W,Xu Y,Shi L,Ma F,Zhou J
Tue Feb 13 00:00:00 UTC 2018
CCAAT/Enhancer Binding Protein β inhibits myogenic differentiation via ID3.
Scientific reports
AlSudais H,Lala-Tabbert N,Wiper-Bergeron N
Fri Nov 09 00:00:00 UTC 2018
Urine-derived cells provide a readily accessible cell type for feeder-free mRNA reprogramming.
Scientific reports
Gaignerie A,Lefort N,Rousselle M,Forest-Choquet V,Flippe L,Francois-Campion V,Girardeau A,Caillaud A,Chariau C,Francheteau Q,Derevier A,Chaubron F,Knöbel S,Gaborit N,Si-Tayeb K,David L
Tue Sep 25 00:00:00 UTC 2018
TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency.
Stem cell reports
Tao Y,Yen MR,Chitiashvili T,Nakano H,Kim R,Hosohama L,Tan YC,Nakano A,Chen PY,Clark AT
Tue Jan 09 00:00:00 UTC 2018
Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance.
Cell death & disease
Yan B,Liu S,Shi Y,Liu N,Chen L,Wang X,Xiao D,Liu X,Mao C,Jiang Y,Lai W,Xin X,Tang CE,Luo D,Tan T,Jia J,Liu Y,Yang R,Huang J,Zhou H,Cheng Y,Cao Y,Yu W,Muegge K,Tao Y
Tue May 01 00:00:00 UTC 2018
Embryos and embryonic stem cells from the white rhinoceros.
Nature communications
Hildebrandt TB,Hermes R,Colleoni S,Diecke S,Holtze S,Renfree MB,Stejskal J,Hayashi K,Drukker M,Loi P,Göritz F,Lazzari G,Galli C
Wed Jul 04 00:00:00 UTC 2018
MiR34 inhibition induces human heart progenitor proliferation.
Cell death & disease
Iannolo G,Sciuto MR,Raffa GM,Pilato M,Conaldi PG
Tue Mar 06 00:00:00 UTC 2018
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation.
Nature communications
Naumann M,Pal A,Goswami A,Lojewski X,Japtok J,Vehlow A,Naujock M,Günther R,Jin M,Stanslowsky N,Reinhardt P,Sterneckert J,Frickenhaus M,Pan-Montojo F,Storkebaum E,Poser I,Freischmidt A,Weishaupt JH,Holzmann K,Troost D,Ludolph AC,Boeckers TM,Liebau S,Petri S,Cordes N,Hyman AA,Wegner F,Grill SW,Weis J,Storch A,Hermann A
Tue Jan 23 00:00:00 UTC 2018
Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells.
Stem cell reports
Abu-Bonsrah KD,Zhang D,Bjorksten AR,Dottori M,Newgreen DF
Tue Jan 09 00:00:00 UTC 2018
Integrating in vitro experiments with in silico approaches for Glioblastoma invasion: the role of cell-to-cell adhesion heterogeneity.
Scientific reports
Oraiopoulou ME,Tzamali E,Tzedakis G,Liapis E,Zacharakis G,Vakis A,Papamatheakis J,Sakkalis V
Thu Nov 01 00:00:00 UTC 2018
A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma.
Scientific reports
Saengwimol D,Rojanaporn D,Chaitankar V,Chittavanich P,Aroonroch R,Boontawon T,Thammachote W,Jinawath N,Hongeng S,Kaewkhaw R
Tue Oct 23 00:00:00 UTC 2018
Automated in situ chromatin profiling efficiently resolves cell types and gene regulatory programs.
Epigenetics & chromatin
Janssens DH,Wu SJ,Sarthy JF,Meers MP,Myers CH,Olson JM,Ahmad K,Henikoff S
100-18B was used in Cell Culture to investigate CUTRUN in gene regulation.
Fri Dec 21 00:00:00 UTC 2018
TNF inhibits catecholamine production from induced sympathetic neuron-like cells in rheumatoid arthritis and osteoarthritis in vitro.
Scientific reports
Herrmann M,Anders S,Straub RH,Jenei-Lanzl Z
Mon Jun 25 00:00:00 UTC 2018
RXRα provokes tumor suppression through p53/p21/p16 and PI3K-AKT signaling pathways during stem cell differentiation and in cancer cells.
Cell death & disease
Zhang R,Li H,Zhang S,Zhang Y,Wang N,Zhou H,He H,Hu G,Zhang TC,Ma W
Tue May 01 00:00:00 UTC 2018
Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.
Cell chemical biology
Shimada K,Reznik E,Stokes ME,Krishnamoorthy L,Bos PH,Song Y,Quartararo CE,Pagano NC,Carpizo DR,deCarvalho AC,Lo DC,Stockwell BR
100-18B was used in Cell Culture to report that the compound NSC319726 binds copper to induce oxidative stress and arrest glioblastoma-patient-derived cells at picomolar concentrations and that that metal-induced DNA damage may be a consequence of exposure to some xenobiotics, therapeutic agents, as well as other causes of copper dysregulation, and reveal a potent mechanism for targeting glioblastomas.
Thu May 17 00:00:00 UTC 2018
Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3β activity.
Cell death discovery
Zhang SQ,Lin KL,Law CY,Liu B,Fu XQ,Tse WS,Wong SSM,Sze SCW,Yung KKL
Fri Oct 22 00:00:00 UTC 2021
Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer.
Nature communications
Arechederra M,Daian F,Yim A,Bazai SK,Richelme S,Dono R,Saurin AJ,Habermann BH,Maina F
Wed Aug 08 00:00:00 UTC 2018
Progesterone Receptor Membrane Component 1 suppresses the p53 and Wnt/β-catenin pathways to promote human pluripotent stem cell self-renewal.
Scientific reports
Kim JY,Kim SY,Choi HS,Kim MK,Lee HM,Jang YJ,Ryu CJ
Wed Feb 14 00:00:00 UTC 2018
Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.
Nature communications
Shiota M,Naya M,Yamamoto T,Hishiki T,Tani T,Takahashi H,Kubo A,Koike D,Itoh M,Ohmura M,Kabe Y,Sugiura Y,Hiraoka N,Morikawa T,Takubo K,Suina K,Nagashima H,Sampetrean O,Nagano O,Saya H,Yamazoe S,Watanabe H,Suematsu M
Thu Apr 19 00:00:00 UTC 2018
NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program.
Stem cell reports
FitzPatrick LM,Hawkins KE,Delhove JMKM,Fernandez E,Soldati C,Bullen LF,Nohturfft A,Waddington SN,Medina DL,Bolaños JP,McKay TR
Tue Jun 05 00:00:00 UTC 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 UTC 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 UTC 2018
M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia.
Cell death & disease
Sheng J,Yang Y,Cui Y,He S,Wang L,Liu L,He Q,Lv T,Han W,Yu W,Hu S,Jin J
Mon Jul 09 00:00:00 UTC 2018
Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis.
Nature communications
Daynac M,Chouchane M,Collins HY,Murphy NE,Andor N,Niu J,Fancy SPJ,Stallcup WB,Petritsch CK
Tue Aug 21 00:00:00 UTC 2018
TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.
Nature communications
Iriondo O,Liu Y,Lee G,Elhodaky M,Jimenez C,Li L,Lang J,Wang P,Yu M
Fri May 18 00:00:00 UTC 2018
Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
Scientific reports
Bayó-Puxan N,Terrasso AP,Creyssels S,Simão D,Begon-Pescia C,Lavigne M,Salinas S,Bernex F,Bosch A,Kalatzis V,Levade T,Cuervo AM,Lory P,Consiglio A,Brito C,Kremer EJ
Fri Nov 09 00:00:00 UTC 2018
bFGF-mediated pluripotency maintenance in human induced pluripotent stem cells is associated with NRAS-MAPK signaling.
Cell communication and signaling : CCS
Haghighi F,Dahlmann J,Nakhaei-Rad S,Lang A,Kutschka I,Zenker M,Kensah G,Piekorz RP,Ahmadian MR
100-18B was used in Cell Culture to investigate the effect of bFGF and its downstream pathways in pluripotent vs. differentiated human induced (hi) PSCs.
Wed Dec 05 00:00:00 UTC 2018
Matrin-3 is essential for fibroblast growth factor 2-dependent maintenance of neural stem cells.
Scientific reports
Niimori-Kita K,Tamamaki N,Koizumi D,Niimori D
Fri Sep 07 00:00:00 UTC 2018
Assembly of fibronectin fibrils selectively attenuates platelet-derived growth factor-induced intracellular calcium release in fibroblasts.
The Journal of biological chemistry
Farrar CS,Hocking DC
Fri Nov 30 00:00:00 UTC 2018
Microhomology-assisted scarless genome editing in human iPSCs.
Nature communications
Kim SI,Matsumoto T,Kagawa H,Nakamura M,Hirohata R,Ueno A,Ohishi M,Sakuma T,Soga T,Yamamoto T,Woltjen K
Mon Mar 05 00:00:00 UTC 2018
Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells.
Scientific reports
Alshawaf AJ,Viventi S,Qiu W,D'Abaco G,Nayagam B,Erlichster M,Chana G,Everall I,Ivanusic J,Skafidas E,Dottori M
Fri Jan 12 00:00:00 UTC 2018
Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES.
Nature communications
Pfeiffer MJ,Quaranta R,Piccini I,Fell J,Rao J,Röpke A,Seebohm G,Greber B
Tue Jan 30 00:00:00 UTC 2018
Stem cells in middle ear cholesteatoma contribute to its pathogenesis.
Scientific reports
Nagel J,Wöllner S,Schürmann M,Brotzmann V,Müller J,Greiner JF,Goon P,Kaltschmidt B,Kaltschmidt C,Sudhoff H
Wed Apr 18 00:00:00 UTC 2018
Preserving self-renewal of porcine pluripotent stem cells in serum-free 3i culture condition and independent of LIF and b-FGF cytokines.
Cell death discovery
Ma Y,Yu T,Cai Y,Wang H
Sat Dec 01 00:00:00 UTC 2018
Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.
Cell death & disease
Fussi N,Höllerhage M,Chakroun T,Nykänen NP,Rösler TW,Koeglsperger T,Wurst W,Behrends C,Höglinger GU
Mon Jul 09 00:00:00 UTC 2018
Hydrostatic pressure-generated reactive oxygen species induce osteoarthritic conditions in cartilage pellet cultures.
Scientific reports
Rieder B,Weihs AM,Weidinger A,Szwarc D,Nürnberger S,Redl H,Rünzler D,Huber-Gries C,Teuschl AH
Mon Nov 19 00:00:00 UTC 2018
Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy.
Cell death & disease
Piñol-Jurado P,Suárez-Calvet X,Fernández-Simón E,Gallardo E,de la Oliva N,Martínez-Muriana A,Gómez-Gálvez P,Escudero LM,Pérez-Peiró M,Wollin L,de Luna N,Navarro X,Illa I,Díaz-Manera J
Tue Jul 10 00:00:00 UTC 2018
Development and Characterization of PEDOT:PSS/Alginate Soft Microelectrodes for Application in Neuroprosthetics.
Frontiers in neuroscience
Ferlauto L,D'Angelo AN,Vagni P,Airaghi Leccardi MJI,Mor FM,Cuttaz EA,Heuschkel MO,Stoppini L,Ghezzi D
100-18B was used in Cell Culture to propose an advancement in the design of soft conductive electrodes for neuroprosthetic applications.
Thu Oct 01 00:00:00 UTC 2020
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.
Nature communications
López-Arribillaga E,Rodilla V,Colomer C,Vert A,Shelton A,Cheng JH,Yan B,Gonzalez-Perez A,Junttila MR,Iglesias M,Torres F,Albanell J,Villanueva A,Bigas A,Siebel CW,Espinosa L
Tue Jul 31 00:00:00 UTC 2018
Innovative Strategy for 3D Transfection of Primary Human Stem Cells with BMP-2 Expressing Plasmid DNA: A Clinically Translatable Strategy for Ex Vivo Gene Therapy.
International journal of molecular sciences
Paidikondala M,Kadekar S,Varghese OP
100-18B was used in Cell Culture to propose that a transient transfection method, demonstrated in primary MSCs, can be adapted for other therapeutic genes for different cell-based therapeutic applications.
Sun Dec 23 00:00:00 UTC 2018
Sensitive and powerful single-cell RNA sequencing using mcSCRB-seq.
Nature communications
Bagnoli JW,Ziegenhain C,Janjic A,Wange LE,Vieth B,Parekh S,Geuder J,Hellmann I,Enard W
Thu Jul 26 00:00:00 UTC 2018
Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells.
Cell death discovery
Chung SY,Chen YH,Lin PR,Chao TC,Su JC,Shiau CW,Su Y
Wed Sep 30 00:00:00 UTC 2020
Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.
Stem cell reports
Garcia-Alegria E,Menegatti S,Fadlullah MZH,Menendez P,Lacaud G,Kouskoff V
Tue Nov 13 00:00:00 UTC 2018
Specific inhibition of ADAM17/TACE promotes neurogenesis in the injured motor cortex.
Cell death & disease
Geribaldi-Doldán N,Carrasco M,Murillo-Carretero M,Domínguez-García S,García-Cózar FJ,Muñoz-Miranda JP,Del Río-García V,Verástegui C,Castro C
Tue Aug 28 00:00:00 UTC 2018
RIF1 promotes tumor growth and cancer stem cell-like traits in NSCLC by protein phosphatase 1-mediated activation of Wnt/β-catenin signaling.
Cell death & disease
Mei Y,Liu YB,Cao S,Tian ZW,Zhou HH
Thu Sep 20 00:00:00 UTC 2018
Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity.
Cell death discovery
Li YW,Xu J,Zhu GY,Huang ZJ,Lu Y,Li XQ,Wang N,Zhang FX
Wed Sep 30 00:00:00 UTC 2020
The effect of PTC124 on choroideremia fibroblasts and iPSC-derived RPE raises considerations for therapy.
Scientific reports
Torriano S,Erkilic N,Baux D,Cereso N,De Luca V,Meunier I,Moosajee M,Roux AF,Hamel CP,Kalatzis V
Tue May 29 00:00:00 UTC 2018
Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway.
Stem cell reports
Miyazaki K,Dyson MT,Coon V JS,Furukawa Y,Yilmaz BD,Maruyama T,Bulun SE
Tue Nov 13 00:00:00 UTC 2018
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state.
Nature communications
Poli V,Fagnocchi L,Fasciani A,Cherubini A,Mazzoleni S,Ferrillo S,Miluzio A,Gaudioso G,Vaira V,Turdo A,Gaggianesi M,Chinnici A,Lipari E,Bicciato S,Bosari S,Todaro M,Zippo A
Fri Mar 09 00:00:00 UTC 2018
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state.
Nature communications
Poli V,Fagnocchi L,Fasciani A,Cherubini A,Mazzoleni S,Ferrillo S,Miluzio A,Gaudioso G,Vaira V,Turdo A,Gaggianesi M,Chinnici A,Lipari E,Bicciato S,Bosari S,Todaro M,Zippo A
Fri Mar 09 00:00:00 UTC 2018
Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models.
Stem cell reports
Lundin A,Delsing L,Clausen M,Ricchiuto P,Sanchez J,Sabirsh A,Ding M,Synnergren J,Zetterberg H,Brolén G,Hicks R,Herland A,Falk A
Tue Mar 13 00:00:00 UTC 2018
The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation.
Scientific reports
Choi CI,Yoon H,Drucker KL,Langley MR,Kleppe L,Scarisbrick IA
Tue Jun 19 00:00:00 UTC 2018
bFGF plays a neuroprotective role by suppressing excessive autophagy and apoptosis after transient global cerebral ischemia in rats.
Cell death & disease
Sun D,Wang W,Wang X,Wang Y,Xu X,Ping F,Du Y,Jiang W,Cui D
Wed Feb 07 00:00:00 UTC 2018
High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway.
Scientific reports
Xue X,Chen X,Fan W,Wang G,Zhang L,Chen Z,Liu P,Liu M,Zhao J
Wed Mar 14 00:00:00 UTC 2018
Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: A promising source of tendon progenitor cells.
Journal of tissue engineering and regenerative medicine
Gonçalves AI,Gershovich PM,Rodrigues MT,Reis RL,Gomes ME
100-18B was used in Cell Culture to indicate that tenomodulin-positive cells exhibit phenotypical features of tendon progenitor cells and can be biochemically induced towards tenogenic lineage, demonstrating that this subset of hASCs can provide a reliable source of progenitor cells for therapies targeting tendon regeneration.
Thu Mar 01 00:00:00 UTC 2018
Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids.
Cell reports
Lee J,Bӧscke R,Tang PC,Hartman BH,Heller S,Koehler KR
Tue Jan 02 00:00:00 UTC 2018
Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells.
Scientific reports
Rodrigues CFD,Serrano E,Patrício MI,Val MM,Albuquerque P,Fonseca J,Gomes CMF,Abrunhosa AJ,Paiva A,Carvalho L,Botelho MF,Almeida L,Carreira IM,Alpoim MC
Wed Aug 01 00:00:00 UTC 2018
Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors.
Nature communications
Urbani L,Camilli C,Phylactopoulos DE,Crowley C,Natarajan D,Scottoni F,Maghsoudlou P,McCann CJ,Pellegata AF,Urciuolo A,Deguchi K,Khalaf S,Aruta SF,Signorelli MC,Kiely D,Hannon E,Trevisan M,Wong RR,Baradez MO,Moulding D,Virasami A,Gjinovci A,Loukogeorgakis S,Mantero S,Thapar N,Sebire N,Eaton S,Lowdell M,Cossu G,Bonfanti P,De Coppi P
Tue Oct 16 00:00:00 UTC 2018
In vitro improvement of quail primordial germ cell expansion through activation of TGF-beta signaling pathway.
Journal of cellular biochemistry
Yakhkeshi S,Rahimi S,Sharafi M,Hassani SN,Taleahmad S,Shahverdi A,Baharvand H
100-18B was used in In vitro experiments to suggest that the application of IDE1 small molecule into the culture of quail PGCs represented a step toward achieving efficient expansion of the avian PGCs.
Fri Jun 01 00:00:00 UTC 2018
Patient derived organoids to model rare prostate cancer phenotypes.
Nature communications
Puca L,Bareja R,Prandi D,Shaw R,Benelli M,Karthaus WR,Hess J,Sigouros M,Donoghue A,Kossai M,Gao D,Cyrta J,Sailer V,Vosoughi A,Pauli C,Churakova Y,Cheung C,Deonarine LD,McNary TJ,Rosati R,Tagawa ST,Nanus DM,Mosquera JM,Sawyers CL,Chen Y,Inghirami G,Rao RA,Grandori C,Elemento O,Sboner A,Demichelis F,Rubin MA,Beltran H
Tue Jun 19 00:00:00 UTC 2018
Ex vivo biomechanical characterization of syringe-needle ejections for intracerebral cell delivery.
Scientific reports
Wahlberg B,Ghuman H,Liu JR,Modo M
Fri Jun 15 00:00:00 UTC 2018
Generation of orthotopically functional salivary gland from embryonic stem cells.
Nature communications
Tanaka J,Ogawa M,Hojo H,Kawashima Y,Mabuchi Y,Hata K,Nakamura S,Yasuhara R,Takamatsu K,Irié T,Fukada T,Sakai T,Inoue T,Nishimura R,Ohara O,Saito I,Ohba S,Tsuji T,Mishima K
Thu Oct 11 00:00:00 UTC 2018
Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions.
Molecular systems biology
Yachie-Kinoshita A,Onishi K,Ostblom J,Langley MA,Posfai E,Rossant J,Zandstra PW
100-18B was used in Sample Preparation to develop a model to predict stabilised pluripotent stem cell gene regulatory network states in response to input signals.
Mon Jan 29 00:00:00 UTC 2018
Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival.
Scientific reports
Sana J,Busek P,Fadrus P,Besse A,Radova L,Vecera M,Reguli S,Stollinova Sromova L,Hilser M,Lipina R,Lakomy R,Kren L,Smrcka M,Sedo A,Slaby O
Mon Feb 12 00:00:00 UTC 2018
Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.
Cell death & disease
Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q
Wed Mar 07 00:00:00 UTC 2018
Promoter Usage and Dynamics in Vascular Smooth Muscle Cells Exposed to Fibroblast Growth Factor-2 or Interleukin-1β.
Scientific reports
Alhendi AMN,Patrikakis M,Daub CO,Kawaji H,Itoh M,de Hoon M,Carninci P,Hayashizaki Y,Arner E,Khachigian LM
Mon Sep 03 00:00:00 UTC 2018
Honokiol induces apoptosis of lung squamous cell carcinoma by targeting FGF2-FGFR1 autocrine loop.
Cancer medicine
Cen M,Yao Y,Cui L,Yang G,Lu G,Fang L,Bao Z,Zhou J
Sat Dec 01 00:00:00 UTC 2018
Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
Cell death & disease
Cho SH,Kuo IY,Lu PF,Tzeng HT,Lai WW,Su WC,Wang YC
Wed Aug 29 00:00:00 UTC 2018
Parallel derivation of isogenic human primed and naive induced pluripotent stem cells.
Nature communications
Kilens S,Meistermann D,Moreno D,Chariau C,Gaignerie A,Reignier A,Lelièvre Y,Casanova M,Vallot C,Nedellec S,Flippe L,Firmin J,Song J,Charpentier E,Lammers J,Donnart A,Marec N,Deb W,Bihouée A,Le Caignec C,Pecqueur C,Redon R,Barrière P,Bourdon J,Pasque V,Soumillon M,Mikkelsen TS,Rougeulle C,Fréour T,David L
Wed Jan 24 00:00:00 UTC 2018
Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs.
Nature communications
Ikeda T,Hikichi T,Miura H,Shibata H,Mitsunaga K,Yamada Y,Woltjen K,Miyamoto K,Hiratani I,Yamada Y,Hotta A,Yamamoto T,Okita K,Masui S
Wed Apr 11 00:00:00 UTC 2018
Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1.
Cell death & disease
Kowalski-Chauvel A,Modesto A,Gouaze-Andersson V,Baricault L,Gilhodes J,Delmas C,Lemarie A,Toulas C,Cohen-Jonathan-Moyal E,Seva C
Wed Aug 29 00:00:00 UTC 2018
ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells.
iScience
Hofsteen P,Robitaille AM,Strash N,Palpant N,Moon RT,Pabon L,Murry CE
100-18B was used in Cell Culture to study how Alpha Protein Kinase 2 (ALPK2) is a candidate negative regulator of WNT/β-catenin signaling in cardiogenesis and that ALPK2 regulates β-catenin-dependent signaling during developmental commitment of cardiomyocytes.
Fri Apr 27 00:00:00 UTC 2018
RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance.
Oncotarget
Cajigas-Du Ross CK,Martinez SR,Woods-Burnham L,Durán AM,Roy S,Basu A,Ramirez JA,Ortiz-Hernández GL,Ríos-Colón L,Chirshev E,Sanchez-Hernandez ES,Soto U,Greco C,Boucheix C,Chen X,Unternaehrer J,Wang C,Casiano CA
100-18B was used in Cell Culture to study the identification of molecular pathways underlying docetaxel (DTX) resistance in cancer to develop novel combinatorial therapies to prevent or reverse resistance.
Fri Jul 13 00:00:00 UTC 2018
Modeling Short QT Syndrome Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Journal of the American Heart Association
El-Battrawy I,Lan H,Cyganek L,Zhao Z,Li X,Buljubasic F,Lang S,Yücel G,Sattler K,Zimmermann WH,Utikal J,Wieland T,Ravens U,Borggrefe M,Zhou XB,Akin I
100-18B was used in Cell Culture to establish a cellular model of short QT syndrome, using human-induced pluripotent stem cell-derived cardiomyocytes.
Sat Mar 24 00:00:00 UTC 2018
Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization.
Stem cell research & therapy
Philipp D,Suhr L,Wahlers T,Choi YH,Paunel-Görgülü A
Thu Oct 25 00:00:00 UTC 2018
A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.
Cell reports
Smith BA,Balanis NG,Nanjundiah A,Sheu KM,Tsai BL,Zhang Q,Park JW,Thompson M,Huang J,Witte ON,Graeber TG
100-18B was used in Cell Culture to develop gene signatures for normal human stem cell populations to understand the relationship between epithelial cancers and stem cell transcriptional programs to better understand how aggressive cancer phenotypes involve aspects of stem cell biology.
Tue Sep 18 00:00:00 UTC 2018
Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Nature
Sigal M,Logan CY,Kapalczynska M,Mollenkopf HJ,Berger H,Wiedenmann B,Nusse R,Amieva MR,Meyer TF
Thu Aug 24 00:00:00 UTC 2017
Guided self-organization and cortical plate formation in human brain organoids.
Nature biotechnology
Lancaster MA,Corsini NS,Wolfinger S,Gustafson EH,Phillips AW,Burkard TR,Otani T,Livesey FJ,Knoblich JA
100-18B was used in Cell Culture to study how the combination of 3D cell culture with bioengineering can increase reproducibility and improve tissue architecture.
Sat Jul 01 00:00:00 UTC 2017
Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells.
Nature biotechnology
Koehler KR,Nie J,Longworth-Mills E,Liu XP,Lee J,Holt JR,Hashino E
100-18B was used in Cell Culture to investigate human inner ear tissue derivation from pluripotent stem cells.
Thu Jun 01 00:00:00 UTC 2017
Interspecies Chimerism with Mammalian Pluripotent Stem Cells.
Cell
Wu J,Platero-Luengo A,Sakurai M,Sugawara A,Gil MA,Yamauchi T,Suzuki K,Bogliotti YS,Cuello C,Morales Valencia M,Okumura D,Luo J,Vilariño M,Parrilla I,Soto DA,Martinez CA,Hishida T,Sánchez-Bautista S,Martinez-Martinez ML,Wang H,Nohalez A,Aizawa E,Martinez-Redondo P,Ocampo A,Reddy P,Roca J,Maga EA,Esteban CR,Berggren WT,Nuñez Delicado E,Lajara J,Guillen I,Guillen P,Campistol JM,Martinez EA,Ross PJ,Izpisua Belmonte JC
Thu Jan 26 00:00:00 UTC 2017
Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation.
Cell
Yoon KJ,Ringeling FR,Vissers C,Jacob F,Pokrass M,Jimenez-Cyrus D,Su Y,Kim NS,Zhu Y,Zheng L,Kim S,Wang X,Doré LC,Jin P,Regot S,Zhuang X,Canzar S,He C,Ming GL,Song H
Thu Nov 02 00:00:00 UTC 2017
Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
Cell
Yang Y,Liu B,Xu J,Wang J,Wu J,Shi C,Xu Y,Dong J,Wang C,Lai W,Zhu J,Xiong L,Zhu D,Li X,Yang W,Yamauchi T,Sugawara A,Li Z,Sun F,Li X,Li C,He A,Du Y,Wang T,Zhao C,Li H,Chi X,Zhang H,Liu Y,Li C,Duo S,Yin M,Shen H,Belmonte JCI,Deng H
Thu Apr 06 00:00:00 UTC 2017
Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
Cell
Yang Y,Liu B,Xu J,Wang J,Wu J,Shi C,Xu Y,Dong J,Wang C,Lai W,Zhu J,Xiong L,Zhu D,Li X,Yang W,Yamauchi T,Sugawara A,Li Z,Sun F,Li X,Li C,He A,Du Y,Wang T,Zhao C,Li H,Chi X,Zhang H,Liu Y,Li C,Duo S,Yin M,Shen H,Belmonte JCI,Deng H
Thu Apr 06 00:00:00 UTC 2017
Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.
Cell
Nora EP,Goloborodko A,Valton AL,Gibcus JH,Uebersohn A,Abdennur N,Dekker J,Mirny LA,Bruneau BG
Thu May 18 00:00:00 UTC 2017
H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.
Cancer cell
Pathania M,De Jay N,Maestro N,Harutyunyan AS,Nitarska J,Pahlavan P,Henderson S,Mikael LG,Richard-Londt A,Zhang Y,Costa JR,Hébert S,Khazaei S,Ibrahim NS,Herrero J,Riccio A,Albrecht S,Ketteler R,Brandner S,Kleinman CL,Jabado N,Salomoni P
Mon Nov 13 00:00:00 UTC 2017
MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma.
Cancer cell
Huang T,Kim CK,Alvarez AA,Pangeni RP,Wan X,Song X,Shi T,Yang Y,Sastry N,Horbinski CM,Lu S,Stupp R,Kessler JA,Nishikawa R,Nakano I,Sulman EP,Lu X,James CD,Yin XM,Hu B,Cheng SY
Mon Dec 11 00:00:00 UTC 2017
Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade.
Cancer cell
Saha D,Martuza RL,Rabkin SD
Mon Aug 14 00:00:00 UTC 2017
A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.
The Journal of experimental medicine
Schwerd T,Twigg SRF,Aschenbrenner D,Manrique S,Miller KA,Taylor IB,Capitani M,McGowan SJ,Sweeney E,Weber A,Chen L,Bowness P,Riordan A,Cant A,Freeman AF,Milner JD,Holland SM,Frede N,Müller M,Schmidt-Arras D,Grimbacher B,Wall SA,Jones EY,Wilkie AOM,Uhlig HH
Mon Sep 04 00:00:00 UTC 2017
Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells.
Nature protocols
Morizane R,Bonventre JV
100-18B was used in Cell Culture to develop a high-efficiency protocol with quick turn-around to generate nephron progenitor cells (NPCs) and kidney organoids from hPSCs.
Sun Jan 01 00:00:00 UTC 2017
Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors.
Developmental cell
Koch F,Scholze M,Wittler L,Schifferl D,Sudheer S,Grote P,Timmermann B,Macura K,Herrmann BG
100-18B was used in Cell Culture to determine the roles and interactions of Sox2, Brachyury and Tbx6 in neuro-mesodermal progenitor potency and lineage choice.
Mon Sep 11 00:00:00 UTC 2017
GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency.
Proceedings of the National Academy of Sciences of the United States of America
Krendl C,Shaposhnikov D,Rishko V,Ori C,Ziegenhain C,Sass S,Simon L,Müller NS,Straub T,Brooks KE,Chavez SL,Enard W,Theis FJ,Drukker M
Tue Nov 07 00:00:00 UTC 2017
GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency.
Proceedings of the National Academy of Sciences of the United States of America
Krendl C,Shaposhnikov D,Rishko V,Ori C,Ziegenhain C,Sass S,Simon L,Müller NS,Straub T,Brooks KE,Chavez SL,Enard W,Theis FJ,Drukker M
Tue Nov 07 00:00:00 UTC 2017
Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification.
Cell death and differentiation
Vicinanza C,Aquila I,Scalise M,Cristiano F,Marino F,Cianflone E,Mancuso T,Marotta P,Sacco W,Lewis FC,Couch L,Shone V,Gritti G,Torella A,Smith AJ,Terracciano CM,Britti D,Veltri P,Indolfi C,Nadal-Ginard B,Ellison-Hughes GM,Torella D
Fri Dec 01 00:00:00 UTC 2017
Co-Inflammatory Roles of TGFβ1 in the Presence of TNFα Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells.
Frontiers in immunology
Lerrer S,Liubomirski Y,Bott A,Abnaof K,Oren N,Yousaf A,Körner C,Meshel T,Wiemann S,Ben-Baruch A
100-18B was used in Cell Culture to demonstrate a TNFα + TGFβ1-driven pro-inflammatory fate in MSCs, identify specific molecular mechanisms involved, and propose that TNFα + TGFβ1-stimulated MSCs influence the tumor niche.
Fri May 31 00:00:00 UTC 2024
Differential expression of miR16 in glioblastoma and glioblastoma stem cells: their correlation with proliferation, differentiation, metastasis and prognosis.
Oncogene
Tian R,Wang J,Yan H,Wu J,Xu Q,Zhan X,Gui Z,Ding M,He J
Thu Oct 19 00:00:00 UTC 2017
Filopodyan: An open-source pipeline for the analysis of filopodia.
The Journal of cell biology
Urbančič V,Butler R,Richier B,Peter M,Mason J,Livesey FJ,Holt CE,Gallop JL
Mon Oct 02 00:00:00 UTC 2017
Efficacy and Safety of Immuno-Magnetically Sorted Smooth Muscle Progenitor Cells Derived from Human-Induced Pluripotent Stem Cells for Restoring Urethral Sphincter Function.
Stem cells translational medicine
Li Y,Green M,Wen Y,Wei Y,Wani P,Wang Z,Reijo Pera R,Chen B
Sat Apr 01 00:00:00 UTC 2017
Repair of Torn Avascular Meniscal Cartilage Using Undifferentiated Autologous Mesenchymal Stem Cells: From In Vitro Optimization to a First-in-Human Study.
Stem cells translational medicine
Whitehouse MR,Howells NR,Parry MC,Austin E,Kafienah W,Brady K,Goodship AE,Eldridge JD,Blom AW,Hollander AP
Sat Apr 01 00:00:00 UTC 2017
Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes.
Stem cells translational medicine
Lin Y,Linask KL,Mallon B,Johnson K,Klein M,Beers J,Xie W,Du Y,Liu C,Lai Y,Zou J,Haigney M,Yang H,Rao M,Chen G
Wed Feb 01 00:00:00 UTC 2017
The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis.
Development (Cambridge, England)
Soady KJ,Tornillo G,Kendrick H,Meniel V,Olijnyk-Dallis D,Morris JS,Stein T,Gusterson BA,Isacke CM,Smalley MJ
Sun Oct 15 00:00:00 UTC 2017
FAM83A is amplified and promotes cancer stem cell-like traits and chemoresistance in pancreatic cancer.
Oncogenesis
Chen S,Huang J,Liu Z,Liang Q,Zhang N,Jin Y
Mon Mar 13 00:00:00 UTC 2017
SOX2 is required to maintain cancer stem cells in ovarian cancer.
Cancer science
Wen Y,Hou Y,Huang Z,Cai J,Wang Z
Sat Apr 01 00:00:00 UTC 2017
Genetic Evolution of Glioblastoma Stem-Like Cells From Primary to Recurrent Tumor.
Stem cells (Dayton, Ohio)
Orzan F,De Bacco F,Crisafulli G,Pellegatta S,Mussolin B,Siravegna G,D'Ambrosio A,Comoglio PM,Finocchiaro G,Boccaccio C
Wed Nov 01 00:00:00 UTC 2017
The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation.
Stem cells (Dayton, Ohio)
Dickinson SC,Sutton CA,Brady K,Salerno A,Katopodi T,Williams RL,West CC,Evseenko D,Wu L,Pang S,Ferro de Godoy R,Goodship AE,Péault B,Blom AW,Kafienah W,Hollander AP
Wed Nov 01 00:00:00 UTC 2017
Electrospun Nanofibrous Meshes Cultured With Wharton's Jelly Stem Cell: An Alternative for Cartilage Regeneration, Without the Need of Growth Factors.
Biotechnology journal
Alves da Silva M,Martins A,Costa-Pinto AR,Monteiro N,Faria S,Reis RL,Neves NM
100-18B was used in Cell Culture to demonstarte the enhanced efficency of electrospun nanofibrous scaffolds coupled with Wharton's Jelly Stem Cells for autologous chondrogenic regeneration, potentially replacing the commercialy available alternates.
Fri Dec 01 00:00:00 UTC 2017
Diverse impact of xeno-free conditions on biological and regenerative properties of hUC-MSCs and their extracellular vesicles.
Journal of molecular medicine (Berlin, Germany)
Bobis-Wozowicz S,Kmiotek K,Kania K,Karnas E,Labedz-Maslowska A,Sekula M,Kedracka-Krok S,Kolcz J,Boruczkowski D,Madeja Z,Zuba-Surma EK
100-18B was used in Cell Culture to analyse the influence of xeno-free expansion media on biological properties of human umbilical cord mesenchymal stem cells and their extracellular vesicles.
Wed Feb 01 00:00:00 UTC 2017
Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-β and Furin in Glioma-Initiating Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ventura E,Weller M,Burghardt I
Thu Jun 15 00:00:00 UTC 2017
17β-Oestradiol promotes differentiation of human embryonic stem cells into dopamine neurons via cross-talk between insulin-like growth factors-1 and oestrogen receptor β.
Journal of cellular and molecular medicine
Li H,Ding C,Ding ZL,Ling M,Wang T,Wang W,Huang B
Tue Aug 01 00:00:00 UTC 2017
FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.
Journal of cellular and molecular medicine
Kubo E,Shibata S,Shibata T,Kiyokawa E,Sasaki H,Singh DP
Mon May 01 00:00:00 UTC 2017
FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.
Journal of cellular and molecular medicine
Kubo E,Shibata S,Shibata T,Kiyokawa E,Sasaki H,Singh DP
Mon May 01 00:00:00 UTC 2017
The antiviral cytokine interferon-gamma restricts neural stem/progenitor cell proliferation through activation of STAT1 and modulation of retinoblastoma protein phosphorylation.
Journal of neuroscience research
Kulkarni A,Scully TJ,O'Donnell LA
Tue Aug 01 00:00:00 UTC 2017
The Role of Cellular Proliferation in Adipogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells.
Stem cells and development
Marquez MP,Alencastro F,Madrigal A,Jimenez JL,Blanco G,Gureghian A,Keagy L,Lee C,Liu R,Tan L,Deignan K,Armstrong B,Zhao Y
100-18B was used in In vitro experiments to investigate cellular regulation of mitotic cell expansion in adipogenesis.
Wed Nov 01 00:00:00 UTC 2017
Long noncoding RNA ASAP1-IT1 promotes cancer stemness and predicts a poor prognosis in patients with bladder cancer.
Neoplasma
Yang L,Xue Y,Liu J,Zhuang J,Shen L,Shen B,Yan J,Guo H
100-18B was used in In vitro experiments to suggest that ASAP1-IT1 plays an oncogenic role in bladder cancer and can be used as a potential prognostic and therapeutic target.
Mon Apr 29 00:00:00 UTC 2019
An Optimized 3D Coculture Assay for Preclinical Testing of Pro- and Antiangiogenic Drugs.
SLAS discovery : advancing life sciences R & D
Unterleuthner D,Kramer N,Pudelko K,Burian A,Hengstschläger M,Dolznig H
100-18B was used in In vitro experiments to investigate methods of preventing angiogenesis.
Thu Jun 01 00:00:00 UTC 2017
An Optimized 3D Coculture Assay for Preclinical Testing of Pro- and Antiangiogenic Drugs.
SLAS discovery : advancing life sciences R & D
Unterleuthner D,Kramer N,Pudelko K,Burian A,Hengstschläger M,Dolznig H
100-18B was used in In vitro experiments to investigate methods of preventing angiogenesis.
Thu Jun 01 00:00:00 UTC 2017
Licochalcone A specifically induces cell death in glioma stem cells via mitochondrial dysfunction.
FEBS open bio
Kuramoto K,Suzuki S,Sakaki H,Takeda H,Sanomachi T,Seino S,Narita Y,Kayama T,Kitanaka C,Okada M
Thu Jun 01 00:00:00 UTC 2017
WRN conditioned media is sufficient for in vitro propagation of intestinal organoids from large farm and small companion animals.
Biology open
Powell RH,Behnke MS
100-18B was used in Sample Preparation to investigate organoid development of intestinal crypts.
Mon May 15 00:00:00 UTC 2017
Fluid Shear Stress and Fibroblast Growth Factor-2 Increase Endothelial Cell-Associated Vitronectin.
Applied bionics and biomechanics
Mathew JG,Basehore S,Clyne AM
Wed Sep 30 00:00:00 UTC 2020
Fluid Shear Stress and Fibroblast Growth Factor-2 Increase Endothelial Cell-Associated Vitronectin.
Applied bionics and biomechanics
Mathew JG,Basehore S,Clyne AM
Wed Sep 30 00:00:00 UTC 2020
Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice.
Stem cell reports
Shinohara T,Kazuki K,Ogonuki N,Morimoto H,Matoba S,Hiramatsu K,Honma K,Suzuki T,Hara T,Ogura A,Oshimura M,Kanatsu-Shinohara M,Kazuki Y
Tue Oct 10 00:00:00 UTC 2017
Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.
Stem cell reports
Rodrigues GMC,Gaj T,Adil MM,Wahba J,Rao AT,Lorbeer FK,Kulkarni RU,Diogo MM,Cabral JMS,Miller EW,Hockemeyer D,Schaffer DV
Tue Jun 06 00:00:00 UTC 2017
Modeling cadmium-induced endothelial toxicity using human pluripotent stem cell-derived endothelial cells.
Scientific reports
Tang L,Su J,Liang P
Wed Nov 01 00:00:00 UTC 2017
Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease.
Frontiers in neuroscience
Naphade S,Embusch A,Madushani KL,Ring KL,Ellerby LM
100-18B was used in Cell Culture to investigate matrix metalloproteases in Huntington’s Disease.
Wed Sep 30 00:00:00 UTC 2020
Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors.
Scientific reports
Choi WI,Sahu A,Vilos C,Kamaly N,Jo SM,Lee JH,Tae G
Mon Oct 30 00:00:00 UTC 2017
Development of Hepatocyte-like Cell Derived from Human Induced Pluripotent Stem cell as a Host for Clinically Isolated Hepatitis C Virus.
Current protocols in stem cell biology
Sa-Ngiamsuntorn K,Hongeng S,Wongkajornsilp A
100-18B was used in In vitro experiments to devise protocols to generate hepatocyte-like cells from mesenchymal stem cells, with the ability to host hepatitis C virus clinical isolate or conventional JFH-1 genotype.
Mon Aug 14 00:00:00 UTC 2017
A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK.
Stem cell reports
Jaraíz-Rodríguez M,Tabernero MD,González-Tablas M,Otero A,Orfao A,Medina JM,Tabernero A
Tue Aug 08 00:00:00 UTC 2017
Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells.
Stem cell reports
Yang J,Wang Y,Zhou T,Wong LY,Tian XY,Hong X,Lai WH,Au KW,Wei R,Liu Y,Cheng LH,Liang G,Huang Z,Fan W,Zhao P,Wang X,Ibañez DP,Luo Z,Li Y,Zhong X,Chen S,Wang D,Li L,Lai L,Qin B,Bao X,Hutchins AP,Siu CW,Huang Y,Esteban MA,Tse HF
Tue Mar 14 00:00:00 UTC 2017
Elevated expression of Tie1 is accompanied by acquisition of cancer stemness properties in colorectal cancer.
Cancer medicine
Torigata M,Yamakawa D,Takakura N
Thu Jun 01 00:00:00 UTC 2017
TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis.
Scientific reports
Kuhn A,Ackermann M,Mussolino C,Cathomen T,Lachmann N,Moritz T
Thu Nov 09 00:00:00 UTC 2017
TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis.
Scientific reports
Kuhn A,Ackermann M,Mussolino C,Cathomen T,Lachmann N,Moritz T
Thu Nov 09 00:00:00 UTC 2017
Metformin reverses bFGF-induced epithelial-mesenchymal transition in HCC cells.
Oncotarget
Chengye W,Yu T,Ping S,Deguang S,Keyun W,Yan W,Rixin Z,Rui L,Zhenming G,Mingliang Y,Liming W
Tue Nov 28 00:00:00 UTC 2017
Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.
JCI insight
Shimizu T,Narang N,Chen P,Yu B,Knapp M,Janardanan J,Blair J,Liao JK
Thu Jul 06 00:00:00 UTC 2017
Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes.
Stem cell reports
Shinozawa T,Nakamura K,Shoji M,Morita M,Kimura M,Furukawa H,Ueda H,Shiramoto M,Matsuguma K,Kaji Y,Ikushima I,Yono M,Liou SY,Nagai H,Nakanishi A,Yamamoto K,Izumo S
Tue Feb 14 00:00:00 UTC 2017
Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes.
Stem cell reports
Shinozawa T,Nakamura K,Shoji M,Morita M,Kimura M,Furukawa H,Ueda H,Shiramoto M,Matsuguma K,Kaji Y,Ikushima I,Yono M,Liou SY,Nagai H,Nakanishi A,Yamamoto K,Izumo S
Tue Feb 14 00:00:00 UTC 2017
Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells.
ASN neuro
Amos PJ,Fung S,Case A,Kifelew J,Osnis L,Smith CL,Green K,Naydenov A,Aloi M,Hubbard JJ,Ramakrishnan A,Garden GA,Jayadev S
100-18B was used in Cell Culture to investigate microglia-like cell generation in vitro.
Fri Dec 08 00:00:00 UTC 2017
lncTCF7 is a negative prognostic factor, and knockdown of lncTCF7 inhibits migration, proliferation and tumorigenicity in glioma.
Scientific reports
Gao X,Guo X,Xue H,Qiu W,Guo X,Zhang J,Qian M,Li T,Liu Q,Shen J,Deng L,Li G
Tue Dec 12 00:00:00 UTC 2017
Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study.
Scientific reports
Sagata N,Kato TA,Kano SI,Ohgidani M,Shimokawa N,Sato-Kasai M,Hayakawa K,Kuwano N,Wilson AM,Ishizuka K,Kato S,Nakahara T,Nakahara-Kido M,Setoyama D,Sakai Y,Ohga S,Furue M,Sawa A,Kanba S
Tue Oct 24 00:00:00 UTC 2017
Primary patient-derived lung adenocarcinoma cell culture challenges the association of cancer stem cells with epithelial-to-mesenchymal transition.
Scientific reports
Tiran V,Lindenmann J,Brcic L,Heitzer E,Stanzer S,Tabrizi-Wizsy NG,Stacher E,Stoeger H,Popper HH,Balic M,Dandachi N
Wed Aug 30 00:00:00 UTC 2017
Differentiation of Human Induced Pluripotent Stem Cells (iPS Cells) and Embryonic Stem Cells (ES Cells) into Dendritic Cell (DC) Subsets.
Bio-protocol
Sontag S,Förster M,Seré K,Zenke M
100-18B was used in Sample Preparation to study subset specification and function of human dendritic cells (DCs) using a protocol which generates classical cDC1, classical cDC2 and plasmacytoid pDC in vitro from human induced pluripotent stem cells (iPS) cells or ES cells.
Sat Aug 05 00:00:00 UTC 2017
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.
Stem cell reports
Muratore CR,Zhou C,Liao M,Fernandez MA,Taylor WM,Lagomarsino VN,Pearse RV,Rice HC,Negri JM,He A,Srikanth P,Callahan DG,Shin T,Zhou M,Bennett DA,Noggle S,Love JC,Selkoe DJ,Young-Pearse TL
Tue Dec 12 00:00:00 UTC 2017
Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells.
Stem cell reports
Yasui T,Uezono N,Nakashima H,Noguchi H,Matsuda T,Noda-Andoh T,Okano H,Nakashima K
Tue Jun 06 00:00:00 UTC 2017
Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level.
Stem cell reports
Pode-Shakked N,Gershon R,Tam G,Omer D,Gnatek Y,Kanter I,Oriel S,Katz G,Harari-Steinberg O,Kalisky T,Dekel B
Tue Jul 11 00:00:00 UTC 2017
Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models.
Scientific reports
Jain M,Gamage NH,Alsulami M,Shankar A,Achyut BR,Angara K,Rashid MH,Iskander A,Borin TF,Wenbo Z,Ara R,Ali MM,Lebedyeva I,Chwang WB,Guo A,Bagher-Ebadian H,Arbab AS
Tue Jan 31 00:00:00 UTC 2017
The Differentiation Stage of Transplanted Stem Cells Modulates Nerve Regeneration.
Scientific reports
Huang CW,Huang WC,Qiu X,Fernandes Ferreira da Silva F,Wang A,Patel S,Nesti LJ,Poo MM,Li S
Tue Dec 12 00:00:00 UTC 2017
Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts.
Nature communications
Kitano K,Schwartz DM,Zhou H,Gilpin SE,Wojtkiewicz GR,Ren X,Sommer CA,Capilla AV,Mathisen DJ,Goldstein AM,Mostoslavsky G,Ott HC
Tue Oct 10 00:00:00 UTC 2017
In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting.
Nature communications
Chen X,Janssen JM,Liu J,Maggio I,'t Jong AEJ,Mikkers HMM,Gonçalves MAFV
Fri Sep 22 00:00:00 UTC 2017
In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting.
Nature communications
Chen X,Janssen JM,Liu J,Maggio I,'t Jong AEJ,Mikkers HMM,Gonçalves MAFV
Fri Sep 22 00:00:00 UTC 2017
CD95 ligand induces senescence in mismatch repair-deficient human colon cancer via chronic caspase-mediated induction of DNA damage.
Cell death & disease
Raats DA,Frenkel N,van Schelven SJ,Rinkes IH,Laoukili J,Kranenburg O
100-18B was used in Cell Culture to investigate the context dependency of the consequences of CD95 activation in colon cancer.
Thu Mar 16 00:00:00 UTC 2017
Implantation of Human Peripheral Corneal Spheres into Cadaveric Human Corneal Tissue.
Bio-protocol
Mathan JJ,Ismail S,McGhee JJ,Sherwin T
100-18B was used in Cell Culture to produce protocols of human corneal spheres into cadaveric human corneal tissue.
Thu Jul 20 00:00:00 UTC 2017
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models.
Nature communications
Tyzack GE,Hall CE,Sibley CR,Cymes T,Forostyak S,Carlino G,Meyer IF,Schiavo G,Zhang SC,Gibbons GM,Newcombe J,Patani R,Lakatos A
Fri Oct 27 00:00:00 UTC 2017
Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.
Nature communications
Wei Z,Batagov AO,Schinelli S,Wang J,Wang Y,El Fatimy R,Rabinovsky R,Balaj L,Chen CC,Hochberg F,Carter B,Breakefield XO,Krichevsky AM
Thu Oct 26 00:00:00 UTC 2017
Cell sex affects extracellular matrix protein expression and proliferation of smooth muscle progenitor cells derived from human pluripotent stem cells.
Stem cell research & therapy
Li Y,Wen Y,Green M,Cabral EK,Wani P,Zhang F,Wei Y,Baer TM,Chen B
100-18B was used in Cell Culture to explore differences in stem cell differentiation between male and female human pluripotent stem cells (hPSCs) and the effect of oestrogen on hPSC-derived smooth muscle progenitor cells.
Tue Jul 04 00:00:00 UTC 2017
Small molecule-based lineage switch of human adipose-derived stem cells into neural stem cells and functional GABAergic neurons.
Scientific reports
Park J,Lee N,Lee J,Choe EK,Kim MK,Lee J,Byun MS,Chon MW,Kim SW,Lee CJ,Kim JH,Kwon JS,Chang MS
Thu Aug 31 00:00:00 UTC 2017
iASPP facilitates tumor growth by promoting mTOR-dependent autophagy in human non-small-cell lung cancer.
Cell death & disease
Xue Y,Han H,Wu L,Pan B,Dong B,Yin CC,Tian Z,Liu X,Yang Y,Zhang H,Chen Y,Chen J
Thu Oct 26 00:00:00 UTC 2017
ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.
Nature communications
Le TM,Poddar S,Capri JR,Abt ER,Kim W,Wei L,Uong NT,Cheng CM,Braas D,Nikanjam M,Rix P,Merkurjev D,Zaretsky J,Kornblum HI,Ribas A,Herschman HR,Whitelegge J,Faull KF,Donahue TR,Czernin J,Radu CG
Mon Aug 14 00:00:00 UTC 2017
Delivery of large transgene cassettes by foamy virus vector.
Scientific reports
Sweeney NP,Meng J,Patterson H,Morgan JE,McClure M
Mon Aug 14 00:00:00 UTC 2017
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.
Stem cell reports
Oksanen M,Petersen AJ,Naumenko N,Puttonen K,Lehtonen Š,Gubert Olivé M,Shakirzyanova A,Leskelä S,Sarajärvi T,Viitanen M,Rinne JO,Hiltunen M,Haapasalo A,Giniatullin R,Tavi P,Zhang SC,Kanninen KM,Hämäläinen RH,Koistinaho J
Tue Dec 12 00:00:00 UTC 2017
RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells.
Stem cell reports
King HO,Brend T,Payne HL,Wright A,Ward TA,Patel K,Egnuni T,Stead LF,Patel A,Wurdak H,Short SC
Tue Jan 10 00:00:00 UTC 2017
Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.
The Journal of biological chemistry
Ludtmann MHR,Arber C,Bartolome F,de Vicente M,Preza E,Carro E,Houlden H,Gandhi S,Wray S,Abramov AY
Fri May 26 00:00:00 UTC 2017
Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.
The Journal of biological chemistry
Ludtmann MHR,Arber C,Bartolome F,de Vicente M,Preza E,Carro E,Houlden H,Gandhi S,Wray S,Abramov AY
Fri May 26 00:00:00 UTC 2017
Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production.
Cell death & disease
Zhang M,Wang J,Deng C,Jiang MH,Feng X,Xia K,Li W,Lai X,Xiao H,Ge RS,Gao Y,Xiang AP
Thu Oct 12 00:00:00 UTC 2017
Isolation, Culture and Differentiation of Adult Hippocampal Precursor Cells.
Bio-protocol
Bernas SN,Leiter O,Walker TL,Kempermann G
100-18B was used in Cell Culture to describe the isolation, culturing methods and differentiation of neural precursor cells in both the neurosphere assay and monolayer culture.
Sun Nov 05 00:00:00 UTC 2017
Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells.
Cell death & disease
Pagotto A,Pilotto G,Mazzoldi EL,Nicoletto MO,Frezzini S,Pastò A,Amadori A
Thu Jul 20 00:00:00 UTC 2017
Functional expression and pharmaceutical efficacy of cardiac-specific ion channels in human embryonic stem cell-derived cardiomyocytes.
Scientific reports
Kim HS,Yoon JW,Li H,Jeong GO,Park JJ,Shin SE,Jang IH,Kim JH,Park WS
Mon Oct 23 00:00:00 UTC 2017
Functional expression and pharmaceutical efficacy of cardiac-specific ion channels in human embryonic stem cell-derived cardiomyocytes.
Scientific reports
Kim HS,Yoon JW,Li H,Jeong GO,Park JJ,Shin SE,Jang IH,Kim JH,Park WS
Mon Oct 23 00:00:00 UTC 2017
Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model.
Nature communications
Bosnakovski D,Chan SSK,Recht OO,Hartweck LM,Gustafson CJ,Athman LL,Lowe DA,Kyba M
Fri Sep 15 00:00:00 UTC 2017
Therapy of corneal endothelial dysfunction with corneal endothelial cell-like cells derived from skin-derived precursors.
Scientific reports
Shen L,Sun P,Zhang C,Yang L,Du L,Wu X
Tue Oct 17 00:00:00 UTC 2017
The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells.
Nature communications
Huggins IJ,Bos T,Gaylord O,Jessen C,Lonquich B,Puranen A,Richter J,Rossdam C,Brafman D,Gaasterland T,Willert K
Wed Oct 18 00:00:00 UTC 2017
Generation of Otic Sensory Neurons from Mouse Embryonic Stem Cells in 3D Culture.
Frontiers in cellular neuroscience
Perny M,Ting CC,Kleinlogel S,Senn P,Roccio M
Wed Sep 30 00:00:00 UTC 2020
Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.
Stem cell reports
Li Y,Brauer PM,Singh J,Xhiku S,Yoganathan K,Zúñiga-Pflücker JC,Anderson MK
Tue Sep 12 00:00:00 UTC 2017
Canonical NFκB signaling in myeloid cells is required for the glioblastoma growth.
Scientific reports
Achyut BR,Angara K,Jain M,Borin TF,Rashid MH,Iskander ASM,Ara R,Kolhe R,Howard S,Venugopal N,Rodriguez PC,Bradford JW,Arbab AS
Mon Oct 23 00:00:00 UTC 2017
Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Zeng J,Tang SY,Toh LL,Wang S
Tue Dec 12 00:00:00 UTC 2017
In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts.
Stem cell reports
Kadota S,Pabon L,Reinecke H,Murry CE
Tue Feb 14 00:00:00 UTC 2017
Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives.
Stem cell reports
Itakura G,Kawabata S,Ando M,Nishiyama Y,Sugai K,Ozaki M,Iida T,Ookubo T,Kojima K,Kashiwagi R,Yasutake K,Nakauchi H,Miyoshi H,Nagoshi N,Kohyama J,Iwanami A,Matsumoto M,Nakamura M,Okano H
Tue Mar 14 00:00:00 UTC 2017
Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin.
The Journal of biological chemistry
Schmidt EGW,Hvam ML,Antunes F,Cameron J,Viuff D,Andersen B,Kristensen NN,Howard KA
Fri Aug 11 00:00:00 UTC 2017
Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells.
Stem cell reports
Fujimori K,Matsumoto T,Kisa F,Hattori N,Okano H,Akamatsu W
Tue Nov 14 00:00:00 UTC 2017
RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis.
Stem cell reports
Karunanithi S,Levi L,DeVecchio J,Karagkounis G,Reizes O,Lathia JD,Kalady MF,Noy N
Tue Aug 08 00:00:00 UTC 2017
RNA polymerase II primes Polycomb-repressed developmental genes throughout terminal neuronal differentiation.
Molecular systems biology
Ferrai C,Torlai Triglia E,Risner-Janiczek JR,Rito T,Rackham OJ,de Santiago I,Kukalev A,Nicodemi M,Akalin A,Li M,Ungless MA,Pombo A
100-18B was used in Cell Culture to study how NA polymerase II (RNAPII) poising is intrinsically associated with Polycomb repression throughout differentiation to suggest that the tight interplay between RNAPII poising and Polycomb repression not only instructs promoter state transitions, but also may enable promoter plasticity in differentiated cells.
Mon Oct 16 00:00:00 UTC 2017
Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation.
Stem cell reports
Kisa F,Shiozawa S,Oda K,Yoshimatsu S,Nakamura M,Koya I,Kawai K,Suzuki S,Okano H
Tue Dec 12 00:00:00 UTC 2017
Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation.
Stem cell reports
Kisa F,Shiozawa S,Oda K,Yoshimatsu S,Nakamura M,Koya I,Kawai K,Suzuki S,Okano H
Tue Dec 12 00:00:00 UTC 2017
Different culture conditions affect the growth of human tendon stem/progenitor cells (TSPCs) within a mixed tendon cells (TCs) population.
Journal of experimental orthopaedics
Viganò M,Perucca Orfei C,Colombini A,Stanco D,Randelli P,Sansone V,de Girolamo L
Fri Dec 01 00:00:00 UTC 2017
FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development.
Nature communications
Sahu SK,Tiwari N,Pataskar A,Zhuang Y,Borisova M,Diken M,Strand S,Beli P,Tiwari VK
Wed Nov 15 00:00:00 UTC 2017
Canine dorsal root ganglia satellite glial cells represent an exceptional cell population with astrocytic and oligodendrocytic properties.
Scientific reports
Tongtako W,Lehmbecker A,Wang Y,Hahn K,Baumgärtner W,Gerhauser I
Tue Oct 24 00:00:00 UTC 2017
NMR Metabolomics for Stem Cell type discrimination.
Scientific reports
Castiglione F,Ferro M,Mavroudakis E,Pellitteri R,Bossolasco P,Zaccheo D,Morbidelli M,Silani V,Mele A,Moscatelli D,Cova L
Fri Nov 17 00:00:00 UTC 2017
SOX7 Is Required for Muscle Satellite Cell Development and Maintenance.
Stem cell reports
Rajgara RF,Lala-Tabbert N,Marchildon F,Lamarche É,MacDonald JK,Scott DA,Blais A,Skerjanc IS,Wiper-Bergeron N
Tue Oct 10 00:00:00 UTC 2017
Magnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells.
Scientific reports
Díaz-Tocados JM,Herencia C,Martínez-Moreno JM,Montes de Oca A,Rodríguez-Ortiz ME,Vergara N,Blanco A,Steppan S,Almadén Y,Rodríguez M,Muñoz-Castañeda JR
Thu Aug 10 00:00:00 UTC 2017
LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.
Cell death & disease
Cao HZ,Liu XF,Yang WT,Chen Q,Zheng PS
Thu Sep 07 00:00:00 UTC 2017
CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.
Scientific reports
Hirose M,Hasegawa A,Mochida K,Matoba S,Hatanaka Y,Inoue K,Goto T,Kaneda H,Yamada I,Furuse T,Abe K,Uenoyama Y,Tsukamura H,Wakana S,Honda A,Ogura A
Tue Feb 14 00:00:00 UTC 2017
Surface functionalisation of nanodiamonds for human neural stem cell adhesion and proliferation.
Scientific reports
Taylor AC,González CH,Miller BS,Edgington RJ,Ferretti P,Jackman RB
Fri Aug 04 00:00:00 UTC 2017
Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.
Cell reports
Palpant NJ,Wang Y,Hadland B,Zaunbrecher RJ,Redd M,Jones D,Pabon L,Jain R,Epstein J,Ruzzo WL,Zheng Y,Bernstein I,Margolin A,Murry CE
100-18B was used in Cell Culture to analyze chromatin dynamics and transcriptional activity of human embryonic stem cell (hESC)-derived cardiac progenitor cells (CPCs) and KDR+/CD34+ endothelial cells generated from different mesodermal origins for the identification of regulators of mesodermal specification and demonstrate a conserved role for HOPX in governing primitive hematopoiesis.
Tue Aug 15 00:00:00 UTC 2017
Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells.
Scientific reports
Matsuo K,Sone M,Honda-Kohmo K,Toyohara T,Sonoyama T,Taura D,Kojima K,Fukuda Y,Ohno Y,Inoue M,Ohta A,Osafune K,Nakao K,Inagaki N
Thu Nov 09 00:00:00 UTC 2017
Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells.
Scientific reports
Matsuo K,Sone M,Honda-Kohmo K,Toyohara T,Sonoyama T,Taura D,Kojima K,Fukuda Y,Ohno Y,Inoue M,Ohta A,Osafune K,Nakao K,Inagaki N
Thu Nov 09 00:00:00 UTC 2017
Directed Differentiation of Human Bone Marrow Stromal Cells to Fate-Committed Schwann Cells.
Stem cell reports
Cai S,Tsui YP,Tam KW,Shea GK,Chang RS,Ao Q,Shum DK,Chan YS
Tue Oct 10 00:00:00 UTC 2017
HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.
Scientific reports
Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B
Thu Nov 02 00:00:00 UTC 2017
Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.
Nature communications
Bicker F,Vasic V,Horta G,Ortega F,Nolte H,Kavyanifar A,Keller S,Stankovic ND,Harter PN,Benedito R,Lutz B,Bäuerle T,Hartwig J,Baumgart J,Krüger M,Radyushkin K,Alberi L,Berninger B,Schmidt MHH
Wed Jun 28 00:00:00 UTC 2017
Common microRNA-mRNA interactions exist among distinct porcine iPSC lines independent of their metastable pluripotent states.
Cell death & disease
Zhang S,Xie Y,Cao H,Wang H
Thu Aug 31 00:00:00 UTC 2017
Evidence for Pro-angiogenic Functions of VEGF-Ax.
Cell
Xin H,Zhong C,Nudleman E,Ferrara N
Thu Sep 22 00:00:00 UTC 2016
CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance.
Cell research
Li G,Wu X,Qian W,Cai H,Sun X,Zhang W,Tan S,Wu Z,Qian P,Ding K,Lu X,Zhang X,Yan H,Song H,Guang S,Wu Q,Lobie PE,Shan G,Zhu T
Wed Jun 01 00:00:00 UTC 2016
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
Cancer cell
Vo BT,Wolf E,Kawauchi D,Gebhardt A,Rehg JE,Finkelstein D,Walz S,Murphy BL,Youn YH,Han YG,Eilers M,Roussel MF
Mon Jan 11 00:00:00 UTC 2016
Sulfated hydrogel matrices direct mitogenicity and maintenance of chondrocyte phenotype through activation of FGF signaling.
Advanced functional materials
Öztürk E,Arlov Ø,Aksel S,Li L,Ornitz DM,Skjåk-Bræk G,Zenobi-Wong M
Tue Jun 07 00:00:00 UTC 2016
TRAF6 regulates satellite stem cell self-renewal and function during regenerative myogenesis.
The Journal of clinical investigation
Hindi SM,Kumar A
Fri Jan 01 00:00:00 UTC 2016
Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.
Arthritis & rheumatology (Hoboken, N.J.)
Shu CC,Jackson MT,Smith MM,Smith SM,Penm S,Lord MS,Whitelock JM,Little CB,Melrose J
Fri Apr 01 00:00:00 UTC 2016
Systemic AAV9-IFNβ gene delivery treats highly invasive glioblastoma.
Neuro-oncology
GuhaSarkar D,Su Q,Gao G,Sena-Esteves M
100-18B was used in Cell Culture to exhibit that systemically infusing scAAV9-hIFNβ in a dose-dependant manner is an effective and attrative strategy for invasive and multifocal GBM treatment.
Tue Nov 01 00:00:00 UTC 2016
Dual Therapeutic Action of a Neutralizing Anti-FGF2 Aptamer in Bone Disease and Bone Cancer Pain.
Molecular therapy : the journal of the American Society of Gene Therapy
Jin L,Nonaka Y,Miyakawa S,Fujiwara M,Nakamura Y
Tue Nov 01 00:00:00 UTC 2016
Dual Therapeutic Action of a Neutralizing Anti-FGF2 Aptamer in Bone Disease and Bone Cancer Pain.
Molecular therapy : the journal of the American Society of Gene Therapy
Jin L,Nonaka Y,Miyakawa S,Fujiwara M,Nakamura Y
Tue Nov 01 00:00:00 UTC 2016
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
Genes & development
Kwan J,Sczaniecka A,Heidary Arash E,Nguyen L,Chen CC,Ratkovic S,Klezovitch O,Attisano L,McNeill H,Emili A,Vasioukhin V
100-18B was used in Cell Culture to report here that DLG5 functions as an evolutionarily conserved scaffold and negative regulator of Hippo signaling, which controls organ size through the modulation of cell proliferation and differentiation.
Thu Dec 15 00:00:00 UTC 2016
Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.
Proceedings of the National Academy of Sciences of the United States of America
Cohen MA,Wert KJ,Goldmann J,Markoulaki S,Buganim Y,Fu D,Jaenisch R
Tue Feb 09 00:00:00 UTC 2016
Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.
Proceedings of the National Academy of Sciences of the United States of America
Cohen MA,Wert KJ,Goldmann J,Markoulaki S,Buganim Y,Fu D,Jaenisch R
Tue Feb 09 00:00:00 UTC 2016
Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.
Proceedings of the National Academy of Sciences of the United States of America
Cohen MA,Wert KJ,Goldmann J,Markoulaki S,Buganim Y,Fu D,Jaenisch R
Tue Feb 09 00:00:00 UTC 2016
Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting.
Proceedings of the National Academy of Sciences of the United States of America
Ma X,Qu X,Zhu W,Li YS,Yuan S,Zhang H,Liu J,Wang P,Lai CS,Zanella F,Feng GS,Sheikh F,Chien S,Chen S
Tue Feb 23 00:00:00 UTC 2016
B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Klotz L,Kuzmanov I,Hucke S,Gross CC,Posevitz V,Dreykluft A,Schulte-Mecklenbeck A,Janoschka C,Lindner M,Herold M,Schwab N,Ludwig-Portugall I,Kurts C,Meuth SG,Kuhlmann T,Wiendl H
Tue Oct 11 00:00:00 UTC 2016
Optogenetic toolkit reveals the role of Ca2+ sparklets in coordinated cell migration.
Proceedings of the National Academy of Sciences of the United States of America
Kim JM,Lee M,Kim N,Heo WD
Tue May 24 00:00:00 UTC 2016
Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction.
Basic research in cardiology
Malan D,Zhang M,Stallmeyer B,Müller J,Fleischmann BK,Schulze-Bahr E,Sasse P,Greber B
100-18B was used in Cell Culture to report the analysis of LQT3 human induced pluripotent stem cell-derived cardiomyocytes.
Tue Mar 01 00:00:00 UTC 2016
Age-related changes in miR-143-3p:Igfbp5 interactions affect muscle regeneration.
Aging cell
Soriano-Arroquia A,McCormick R,Molloy AP,McArdle A,Goljanek-Whysall K
100-18B was used in Cell Culture to use satellite cells and primary myoblasts from mice and humans and an in vitro regeneration model, to show that disrupted expression of microRNA-143-3p and its target gene, Igfbp5, plays an important role in muscle regeneration in vitro.
Fri Apr 01 00:00:00 UTC 2016
Helicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer.
Cancer letters
Yong X,Tang B,Xiao YF,Xie R,Qin Y,Luo G,Hu CJ,Dong H,Yang SM
100-18B was used in Sample Preparation to investigate Helicobacter pylori infection effects on cancer stem cells.
Sun May 01 00:00:00 UTC 2016
SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans.
Oncogene
Zhang L,Zhang W,Li Y,Alvarez A,Li Z,Wang Y,Song L,Lv D,Nakano I,Hu B,Cheng SY,Feng H
Thu Oct 27 00:00:00 UTC 2016
Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression.
Development (Cambridge, England)
Audette DS,Anand D,So T,Rubenstein TB,Lachke SA,Lovicu FJ,Duncan MK
Fri Jan 15 00:00:00 UTC 2016
Galectin-3 modulates the EGFR signalling-mediated regulation of Sox2 expression via c-Myc in lung cancer.
Glycobiology
Kuo HY,Hsu HT,Chen YC,Chang YW,Liu FT,Wu CW
100-18B was used in Cell Culture to investigate the mechanisms of galectin-3 involved in the regulation of cancer stem-like cells.
Mon Feb 01 00:00:00 UTC 2016
Functional Interference in the Bone Marrow Microenvironment by Disseminated Breast Cancer Cells.
Stem cells (Dayton, Ohio)
Dhawan A,von Bonin M,Bray LJ,Freudenberg U,Pishali Bejestani E,Werner C,Hofbauer LC,Wobus M,Bornhäuser M
Mon Aug 01 00:00:00 UTC 2016
Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes.
Stem cells (Dayton, Ohio)
Livesey MR,Magnani D,Cleary EM,Vasistha NA,James OT,Selvaraj BT,Burr K,Story D,Shaw CE,Kind PC,Hardingham GE,Wyllie DJ,Chandran S
Fri Apr 01 00:00:00 UTC 2016
β-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived Sacs.
Stem cells (Dayton, Ohio)
Fujita A,Uchida N,Haro-Mora JJ,Winkler T,Tisdale J
Wed Jun 01 00:00:00 UTC 2016
β-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived Sacs.
Stem cells (Dayton, Ohio)
Fujita A,Uchida N,Haro-Mora JJ,Winkler T,Tisdale J
Wed Jun 01 00:00:00 UTC 2016
Systems Genetics Analysis of a Recombinant Inbred Mouse Cell Culture Panel Reveals Wnt Pathway Member Lrp6 as a Regulator of Adult Hippocampal Precursor Cell Proliferation.
Stem cells (Dayton, Ohio)
Kannan S,Nicola Z,Overall RW,Ichwan M,Ramírez-Rodríguez G,N Grzyb A,Patone G,Saar K,Hübner N,Kempermann G
Tue Mar 01 00:00:00 UTC 2016
Modulation of the Innate Immune Response by Human Neural Precursors Prevails over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model of Pelizaeus-Merzbacher Disease.
Stem cells (Dayton, Ohio)
Marteyn A,Sarrazin N,Yan J,Bachelin C,Deboux C,Santin MD,Gressens P,Zujovic V,Baron-Van Evercooren A
Fri Apr 01 00:00:00 UTC 2016
MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1.
Stem cells (Dayton, Ohio)
Jung KH,McCarthy RL,Zhou C,Uprety N,Barton MC,Beretta L
Sun May 01 00:00:00 UTC 2016
Brain Insulin-Like Growth Factor-I Directs the Transition from Stem Cells to Mature Neurons During Postnatal/Adult Hippocampal Neurogenesis.
Stem cells (Dayton, Ohio)
Nieto-Estévez V,Oueslati-Morales CO,Li L,Pickel J,Morales AV,Vicario-Abejón C
Mon Aug 01 00:00:00 UTC 2016
4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells.
Stem cells (Dayton, Ohio)
Naujock M,Stanslowsky N,Bufler S,Naumann M,Reinhardt P,Sterneckert J,Kefalakes E,Kassebaum C,Bursch F,Lojewski X,Storch A,Frickenhaus M,Boeckers TM,Putz S,Demestre M,Liebau S,Klingenstein M,Ludolph AC,Dengler R,Kim KS,Hermann A,Wegner F,Petri S
Wed Jun 01 00:00:00 UTC 2016
4-Aminopyridine Induced Activity Rescues Hypoexcitable Motor Neurons from Amyotrophic Lateral Sclerosis Patient-Derived Induced Pluripotent Stem Cells.
Stem cells (Dayton, Ohio)
Naujock M,Stanslowsky N,Bufler S,Naumann M,Reinhardt P,Sterneckert J,Kefalakes E,Kassebaum C,Bursch F,Lojewski X,Storch A,Frickenhaus M,Boeckers TM,Putz S,Demestre M,Liebau S,Klingenstein M,Ludolph AC,Dengler R,Kim KS,Hermann A,Wegner F,Petri S
Wed Jun 01 00:00:00 UTC 2016
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Stem cells (Dayton, Ohio)
Dafinca R,Scaber J,Ababneh N,Lalic T,Weir G,Christian H,Vowles J,Douglas AG,Fletcher-Jones A,Browne C,Nakanishi M,Turner MR,Wade-Martins R,Cowley SA,Talbot K
Mon Aug 01 00:00:00 UTC 2016
Knockdown of DNMT1 and DNMT3a Promotes the Angiogenesis of Human Mesenchymal Stem Cells Leading to Arterial Specific Differentiation.
Stem cells (Dayton, Ohio)
Zhang R,Wang N,Zhang LN,Huang N,Song TF,Li ZZ,Li M,Luo XG,Zhou H,He HP,Zhang XY,Ma W,Zhang TC
Sun May 01 00:00:00 UTC 2016
The Repair of Skeletal Muscle Requires Iron Recycling through Macrophage Ferroportin.
Journal of immunology (Baltimore, Md. : 1950)
Corna G,Caserta I,Monno A,Apostoli P,Manfredi AA,Camaschella C,Rovere-Querini P
Thu Sep 01 00:00:00 UTC 2016
Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion.
International journal of molecular medicine
Yang X,Steinberg F,Zhuang L,Bessey R,Trueb B
Fri Jul 01 00:00:00 UTC 2016
Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 T.
NMR in biomedicine
Porcari P,Hegi ME,Lei H,Hamou MF,Vassallo I,Capuani S,Gruetter R,Mlynarik V
100-18B was used in In vitro experiments to study whether diffusion MRI might be a useful technique for early detection and characterization of slow-growing and diffuse infiltrative gliomas, such as the proposed new models, LN-2669GS and LN-2540GS glioma sphere xenografts.
Tue Nov 01 00:00:00 UTC 2016
Fibroblast Growth Factor Ligand Dependent Proliferation and Chondrogenic Differentiation of Synovium-Derived Stem Cells and Concomitant Adaptation of Wnt/Mitogen-Activated Protein Kinase Signals.
Tissue engineering. Part A
Pizzute T,Li J,Zhang Y,Davis ME,Pei M
Mon Aug 01 00:00:00 UTC 2016
Human Schwann-like cells derived from adipose-derived mesenchymal stem cells rapidly de-differentiate in the absence of stimulating medium.
The European journal of neuroscience
Faroni A,Smith RJ,Lu L,Reid AJ
Mon Feb 01 00:00:00 UTC 2016
Stage-specific roles of FGF2 signaling in human neural development.
Stem cell research
Grabiec M,Hříbková H,Vařecha M,Střítecká D,Hampl A,Dvořák P,Sun YM
Thu Sep 01 00:00:00 UTC 2016
Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates.
Stem cell reports
Quattrocelli M,Giacomazzi G,Broeckx SY,Ceelen L,Bolca S,Spaas JH,Sampaolesi M
Tue Jan 12 00:00:00 UTC 2016
ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing.
Nature methods
Chen X,Shen Y,Draper W,Buenrostro JD,Litzenburger U,Cho SW,Satpathy AT,Carter AC,Ghosh RP,East-Seletsky A,Doudna JA,Greenleaf WJ,Liphardt JT,Chang HY
100-18B was used in Cell Culture to demonstrate the assay of transposase-accessible chromatin with visualization (ATAC-see), a transposase-mediated imaging technology that employs direct imaging of the accessible genome in situ, cell sorting, and deep sequencing to reveal the identity of the imaged elements.
Thu Dec 01 00:00:00 UTC 2016
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Nature communications
Guo X,Sun X,Hu D,Wang YJ,Fujioka H,Vyas R,Chakrapani S,Joshi AU,Luo Y,Mochly-Rosen D,Qi X
Fri Aug 26 00:00:00 UTC 2016
The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells.
Scientific reports
Legeay S,Clere N,Hilairet G,Do QT,Bernard P,Quignard JF,Apaire-Marchais V,Lapied B,Faure S
Mon Jun 27 00:00:00 UTC 2016
Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma.
Nature communications
Bagó JR,Alfonso-Pecchio A,Okolie O,Dumitru R,Rinkenbaugh A,Baldwin AS,Miller CR,Magness ST,Hingtgen SD
Tue Feb 02 00:00:00 UTC 2016
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.
Nature communications
Liu XP,Koehler KR,Mikosz AM,Hashino E,Holt JR
Tue May 24 00:00:00 UTC 2016
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.
Nature communications
Huang T,Alvarez AA,Pangeni RP,Horbinski CM,Lu S,Kim SH,James CD,J Raizer J,A Kessler J,Brenann CW,Sulman EP,Finocchiaro G,Tan M,Nishikawa R,Lu X,Nakano I,Hu B,Cheng SY
Tue Oct 04 00:00:00 UTC 2016
Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.
Stem cell reports
Ichiyanagi N,Fujimori K,Yano M,Ishihara-Fujisaki C,Sone T,Akiyama T,Okada Y,Akamatsu W,Matsumoto T,Ishikawa M,Nishimoto Y,Ishihara Y,Sakuma T,Yamamoto T,Tsuiji H,Suzuki N,Warita H,Aoki M,Okano H
Tue Apr 12 00:00:00 UTC 2016
A novel fibroblast growth factor receptor 1 inhibitor protects against cartilage degradation in a murine model of osteoarthritis.
Scientific reports
Xu W,Xie Y,Wang Q,Wang X,Luo F,Zhou S,Wang Z,Huang J,Tan Q,Jin M,Qi H,Tang J,Chen L,Du X,Zhao C,Liang G,Chen L
Mon Apr 04 00:00:00 UTC 2016
miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma.
Journal of experimental & clinical cancer research : CR
Zhang X,Jiang P,Shuai L,Chen K,Li Z,Zhang Y,Jiang Y,Li X
100-18B was used in Cell Culture to investigate the role of MicroRNAs in the regulation of CD90+ cancer stem cells.
Fri Nov 11 00:00:00 UTC 2016
Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues.
Scientific reports
Lourenço T,Paes de Faria J,Bippes CA,Maia J,Lopes-da-Silva JA,Relvas JB,Grãos M
Tue Feb 16 00:00:00 UTC 2016
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Scientific reports
Borgs L,Peyre E,Alix P,Hanon K,Grobarczyk B,Godin JD,Purnelle A,Krusy N,Maquet P,Lefebvre P,Seutin V,Malgrange B,Nguyen L
Mon Sep 19 00:00:00 UTC 2016
Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.
Journal of neuroinflammation
López de Maturana R,Lang V,Zubiarrain A,Sousa A,Vázquez N,Gorostidi A,Águila J,López de Munain A,Rodríguez M,Sánchez-Pernaute R
100-18B was used in Cell Culture to show that LRRK2 mutations affect α-synuclein regulation and impair NF-κB canonical signaling in iPSC-derived neurons.
Fri Nov 18 00:00:00 UTC 2016
The Gq signalling pathway inhibits brown and beige adipose tissue.
Nature communications
Klepac K,Kilić A,Gnad T,Brown LM,Herrmann B,Wilderman A,Balkow A,Glöde A,Simon K,Lidell ME,Betz MJ,Enerbäck S,Wess J,Freichel M,Blüher M,König G,Kostenis E,Insel PA,Pfeifer A
Wed Mar 09 00:00:00 UTC 2016
Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action.
Scientific reports
Lombardo G,Dentelli P,Togliatto G,Rosso A,Gili M,Gallo S,Deregibus MC,Camussi G,Brizzi MF
Mon May 09 00:00:00 UTC 2016
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.
Scientific reports
Fleury A,Hoch L,Martinez MC,Faure H,Taddei M,Petricci E,Manetti F,Girard N,Mann A,Jacques C,Larghero J,Ruat M,Andriantsitohaina R,Le Lay S
Thu Mar 24 00:00:00 UTC 2016
MHC-class-II are expressed in a subpopulation of human neural stem cells in vitro in an IFNγ-independent fashion and during development.
Scientific reports
Vagaska B,New SE,Alvarez-Gonzalez C,D'Acquisto F,Gomez SG,Bulstrode NW,Madrigal A,Ferretti P
Fri Apr 15 00:00:00 UTC 2016
Co-delivery of VEGF and bFGF via a PLGA nanoparticle-modified BAM for effective contracture inhibition of regenerated bladder tissue in rabbits.
Scientific reports
Jiang X,Lin H,Jiang D,Xu G,Fang X,He L,Xu M,Tang B,Wang Z,Cui D,Chen F,Geng H
Mon Feb 08 00:00:00 UTC 2016
Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.
Scientific reports
Yamada K,Miyamoto Y,Tsujii A,Moriyama T,Ikuno Y,Shiromizu T,Serada S,Fujimoto M,Tomonaga T,Naka T,Yoneda Y,Oka M
Thu Feb 18 00:00:00 UTC 2016
NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase.
Scientific reports
Kuek V,Yang Z,Chim SM,Zhu S,Xu H,Chow ST,Tickner J,Rosen V,Erber W,Li X,Qin A,Qian Y,Xu J
Wed Oct 26 00:00:00 UTC 2016
VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination.
Nature communications
Miyamoto Y,Torii T,Tanoue A,Yamauchi J
Wed Nov 23 00:00:00 UTC 2016
Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials.
Scientific reports
Jeon OH,Panicker LM,Lu Q,Chae JJ,Feldman RA,Elisseeff JH
Thu May 26 00:00:00 UTC 2016
Fetal Bovine Serum RNA Interferes with the Cell Culture derived Extracellular RNA.
Scientific reports
Wei Z,Batagov AO,Carter DR,Krichevsky AM
Tue Aug 09 00:00:00 UTC 2016
Fetal Bovine Serum RNA Interferes with the Cell Culture derived Extracellular RNA.
Scientific reports
Wei Z,Batagov AO,Carter DR,Krichevsky AM
Tue Aug 09 00:00:00 UTC 2016
GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.
Stem cell reports
D'Souza SS,Maufort J,Kumar A,Zhang J,Smuga-Otto K,Thomson JA,Slukvin II
Tue Feb 09 00:00:00 UTC 2016
Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors.
Scientific reports
Wiltshire R,Nelson V,Kho DT,Angel CE,O'Carroll SJ,Graham ES
Wed Jan 27 00:00:00 UTC 2016
The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner.
Oncotarget
Heulot M,Chevalier N,Puyal J,Margue C,Michel S,Kreis S,Kulms D,Barras D,Nahimana A,Widmann C
100-18B was used in Sample Preparation (FC/FACS) to investigate malignancy inhibition by targeting a p120 RasGAP in cancer.
Tue Sep 27 00:00:00 UTC 2016
Estrogen-induced SDF-1α production promotes the progression of ER-negative breast cancer via the accumulation of MDSCs in the tumor microenvironment.
Scientific reports
Ouyang L,Chang W,Fang B,Qin J,Qu X,Cheng F
Tue Dec 20 00:00:00 UTC 2016
Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells.
Stem cell research & therapy
Sotthibundhu A,McDonagh K,von Kriegsheim A,Garcia-Munoz A,Klawiter A,Thompson K,Chauhan KD,Krawczyk J,McInerney V,Dockery P,Devine MJ,Kunath T,Barry F,O'Brien T,Shen S
100-18B was used in Cell Culture to demonstrate that human iPSCs express high basal levels of autophagy, including key components of APMKα, ULK1/2, BECLIN-1, ATG13, ATG101, ATG12, ATG3, ATG5, and LC3B. Block of autophagy by bafilomycin induces iPSC death and rapamycin attenuates the bafilomycin effect.
Tue Nov 15 00:00:00 UTC 2016
An inhibitor of fibroblast growth factor receptor-1 (FGFR1) promotes late-stage terminal differentiation from NGN3+ pancreatic endocrine progenitors.
Scientific reports
Yamashita-Sugahara Y,Matsumoto M,Ohtaka M,Nishimura K,Nakanishi M,Mitani K,Okazaki Y
Thu Oct 27 00:00:00 UTC 2016
Establishment of human iPSC-based models for the study and targeting of glioma initiating cells.
Nature communications
Sancho-Martinez I,Nivet E,Xia Y,Hishida T,Aguirre A,Ocampo A,Ma L,Morey R,Krause MN,Zembrzycki A,Ansorge O,Vazquez-Ferrer E,Dubova I,Reddy P,Lam D,Hishida Y,Wu MZ,Esteban CR,O'Leary D,Wahl GM,Verma IM,Laurent LC,Izpisua Belmonte JC
Mon Feb 22 00:00:00 UTC 2016
Cellular microenvironment modulates the galvanotaxis of brain tumor initiating cells.
Scientific reports
Huang YJ,Hoffmann G,Wheeler B,Schiapparelli P,Quinones-Hinojosa A,Searson P
Mon Feb 22 00:00:00 UTC 2016
Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling.
Stem cell reports
Matsumoto T,Fujimori K,Andoh-Noda T,Ando T,Kuzumaki N,Toyoshima M,Tada H,Imaizumi K,Ishikawa M,Yamaguchi R,Isoda M,Zhou Z,Sato S,Kobayashi T,Ohtaka M,Nishimura K,Kurosawa H,Yoshikawa T,Takahashi T,Nakanishi M,Ohyama M,Hattori N,Akamatsu W,Okano H
Tue Mar 08 00:00:00 UTC 2016
EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance.
Nature communications
Depner C,Zum Buttel H,Böğürcü N,Cuesta AM,Aburto MR,Seidel S,Finkelmeier F,Foss F,Hofmann J,Kaulich K,Barbus S,Segarra M,Reifenberger G,Garvalov BK,Acker T,Acker-Palmer A
Fri Jul 29 00:00:00 UTC 2016
The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity.
Scientific reports
Lazzarini E,Balbi C,Altieri P,Pfeffer U,Gambini E,Canepa M,Varesio L,Bosco MC,Coviello D,Pompilio G,Brunelli C,Cancedda R,Ameri P,Bollini S
Thu Jul 21 00:00:00 UTC 2016
Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation.
Scientific reports
Bergström P,Agholme L,Nazir FH,Satir TM,Toombs J,Wellington H,Strandberg J,Bontell TO,Kvartsberg H,Holmström M,Boreström C,Simonsson S,Kunath T,Lindahl A,Blennow K,Hanse E,Portelius E,Wray S,Zetterberg H
Thu Jul 07 00:00:00 UTC 2016
Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells.
Nature communications
Liu CC,Lin SP,Hsu HS,Yang SH,Lin CH,Yang MH,Hung MC,Hung SC
Thu Jun 16 00:00:00 UTC 2016
A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production.
Stem cell reports
Nazareth EJP,Rahman N,Yin T,Zandstra PW
Tue May 10 00:00:00 UTC 2016
Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells.
The Journal of biological chemistry
Salabei JK,Lorkiewicz PK,Mehra P,Gibb AA,Haberzettl P,Hong KU,Wei X,Zhang X,Li Q,Wysoczynski M,Bolli R,Bhatnagar A,Hill BG
Fri Jun 24 00:00:00 UTC 2016
ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly.
Cell death & disease
Ghouzzi VE,Bianchi FT,Molineris I,Mounce BC,Berto GE,Rak M,Lebon S,Aubry L,Tocco C,Gai M,Chiotto AM,Sgrò F,Pallavicini G,Simon-Loriere E,Passemard S,Vignuzzi M,Gressens P,Di Cunto F
Thu Oct 27 00:00:00 UTC 2016
Autologous skeletal muscle derived cells expressing a novel functional dystrophin provide a potential therapy for Duchenne Muscular Dystrophy.
Scientific reports
Meng J,Counsell JR,Reza M,Laval SH,Danos O,Thrasher A,Lochmüller H,Muntoni F,Morgan JE
Wed Jan 27 00:00:00 UTC 2016
Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions.
Scientific reports
Lee MC,Huang HJ,Chang TH,Huang HC,Hsieh SY,Chen YS,Chou WY,Chiang CH,Lai CH,Shiau CY
Mon Jul 04 00:00:00 UTC 2016
Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis.
Nature communications
Cui Q,Yang S,Ye P,Tian E,Sun G,Zhou J,Sun G,Liu X,Chen C,Murai K,Zhao C,Azizian KT,Yang L,Warden C,Wu X,D'Apuzzo M,Brown C,Badie B,Peng L,Riggs AD,Rossi JJ,Shi Y
Wed Feb 03 00:00:00 UTC 2016
miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a.
Scientific reports
Xue Q,Yu C,Wang Y,Liu L,Zhang K,Fang C,Liu F,Bian G,Song B,Yang A,Ju G,Wang J
Wed May 25 00:00:00 UTC 2016
Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells.
Scientific reports
Pode-Shakked N,Pleniceanu O,Gershon R,Shukrun R,Kanter I,Bucris E,Pode-Shakked B,Tam G,Tam H,Caspi R,Pri-Chen S,Vax E,Katz G,Omer D,Harari-Steinberg O,Kalisky T,Dekel B
Tue Mar 29 00:00:00 UTC 2016
Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene.
Scientific reports
Lee H,Nam D,Choi JK,Araúzo-Bravo MJ,Kwon SY,Zaehres H,Lee T,Park CY,Kang HW,Schöler HR,Kim JB
Fri Feb 05 00:00:00 UTC 2016
Analysis of induced pluripotent stem cells carrying 22q11.2 deletion.
Translational psychiatry
Toyoshima M,Akamatsu W,Okada Y,Ohnishi T,Balan S,Hisano Y,Iwayama Y,Toyota T,Matsumoto T,Itasaka N,Sugiyama S,Tanaka M,Yano M,Dean B,Okano H,Yoshikawa T
Tue Nov 01 00:00:00 UTC 2016
The Wnt/β-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells.
Scientific reports
Dong HJ,Jang GB,Lee HY,Park SR,Kim JY,Nam JS,Hong IS
Fri Mar 11 00:00:00 UTC 2016
The Wnt/β-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells.
Scientific reports
Dong HJ,Jang GB,Lee HY,Park SR,Kim JY,Nam JS,Hong IS
Fri Mar 11 00:00:00 UTC 2016
Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation.
Stem cell reports
Halevy T,Biancotti JC,Yanuka O,Golan-Lev T,Benvenisty N
Tue Oct 11 00:00:00 UTC 2016
Isolation of highly enriched primary human microglia for functional studies.
Scientific reports
Rustenhoven J,Park TI,Schweder P,Scotter J,Correia J,Smith AM,Gibbons HM,Oldfield RL,Bergin PS,Mee EW,Faull RL,Curtis MA,Scott Graham E,Dragunow M
Mon Jan 18 00:00:00 UTC 2016
Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors.
Stem cell reports
Wen W,Zhang JP,Xu J,Su RJ,Neises A,Ji GZ,Yuan W,Cheng T,Zhang XB
Tue Jun 14 00:00:00 UTC 2016
Epigenetic alteration of imprinted genes during neural differentiation of germline-derived pluripotent stem cells.
Epigenetics
Lee HJ,Choi NY,Lee SW,Ko K,Hwang TS,Han DW,Lim J,Schöler HR,Ko K
100-18B was used in Cell Culture to demonstrate epigenetic alteration of genomic imprinting during the induction of pluripotency in SSCs and neural differentiation.
Thu Mar 03 00:00:00 UTC 2016
Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis.
Scientific reports
Hsu YH,Chiu YS,Chen WY,Huang KY,Jou IM,Wu PT,Wu CH,Chang MS
Thu Apr 14 00:00:00 UTC 2016
Functional Recovery from Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training in Mice with Chronic Spinal Cord Injury.
Scientific reports
Tashiro S,Nishimura S,Iwai H,Sugai K,Zhang L,Shinozaki M,Iwanami A,Toyama Y,Liu M,Okano H,Nakamura M
Wed Aug 03 00:00:00 UTC 2016
Expression of the FGFR2 mesenchymal splicing variant in epithelial cells drives epithelial-mesenchymal transition.
Oncotarget
Ranieri D,Rosato B,Nanni M,Magenta A,Belleudi F,Torrisi MR
Tue Feb 02 00:00:00 UTC 2016
Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities.
Nature communications
Chen S,Bremer AW,Scheideler OJ,Na YS,Todhunter ME,Hsiao S,Bomdica PR,Maharbiz MM,Gartner ZJ,Schaffer DV
Tue Jan 12 00:00:00 UTC 2016
High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform.
Scientific reports
Wevers NR,van Vught R,Wilschut KJ,Nicolas A,Chiang C,Lanz HL,Trietsch SJ,Joore J,Vulto P
Fri Dec 09 00:00:00 UTC 2016
miR-612 suppresses stem cell-like property of hepatocellular carcinoma cells by modulating Sp1/Nanog signaling.
Cell death & disease
Liu Y,Liu DL,Dong LL,Wen D,Shi DM,Zhou J,Fan J,Wu WZ
Thu Sep 29 00:00:00 UTC 2016
Modeling familial cancer with induced pluripotent stem cells.
Cell
Lee DF,Su J,Kim HS,Chang B,Papatsenko D,Zhao R,Yuan Y,Gingold J,Xia W,Darr H,Mirzayans R,Hung MC,Schaniel C,Lemischka IR
Thu Apr 09 00:00:00 UTC 2015
Direct conversion of human amniotic cells into endothelial cells without transitioning through a pluripotent state.
Nature protocols
Ginsberg M,Schachterle W,Shido K,Rafii S
100-18B was used in Cell Culture to develop a method to directly convert human mid-gestation lineage-committed amniotic fluid-derived cells into vascular endothelial cells.
Tue Dec 01 00:00:00 UTC 2015
Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile.
The EMBO journal
Sugawa F,Araúzo-Bravo MJ,Yoon J,Kim KP,Aramaki S,Wu G,Stehling M,Psathaki OE,Hübner K,Schöler HR
Wed Apr 15 00:00:00 UTC 2015
Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile.
The EMBO journal
Sugawa F,Araúzo-Bravo MJ,Yoon J,Kim KP,Aramaki S,Wu G,Stehling M,Psathaki OE,Hübner K,Schöler HR
Wed Apr 15 00:00:00 UTC 2015
FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12-ATG5 conjugate, leading to the delay of cartilage development in achondroplasia.
Autophagy
Wang X,Qi H,Wang Q,Zhu Y,Wang X,Jin M,Tan Q,Huang Q,Xu W,Li X,Kuang L,Tang Y,Du X,Chen D,Chen L
Mon Nov 02 00:00:00 UTC 2015
Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Wang F,Tidei JJ,Polich ED,Gao Y,Zhao H,Perrone-Bizzozero NI,Guo W,Zhao X
Tue Sep 08 00:00:00 UTC 2015
Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration.
Proceedings of the National Academy of Sciences of the United States of America
Sekiya T,Holley MC,Hashido K,Ono K,Shimomura K,Horie RT,Hamaguchi K,Yoshida A,Sakamoto T,Ito J
Tue Jun 30 00:00:00 UTC 2015
Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Bartesaghi S,Graziano V,Galavotti S,Henriquez NV,Betts J,Saxena J,Minieri V,A D,Karlsson A,Martins LM,Capasso M,Nicotera P,Brandner S,De Laurenzi V,Salomoni P
Tue Jan 27 00:00:00 UTC 2015
Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.
The Journal of cell biology
de la Fuente AG,Errea O,van Wijngaarden P,Gonzalez GA,Kerninon C,Jarjour AA,Lewis HJ,Jones CA,Nait-Oumesmar B,Zhao C,Huang JK,ffrench-Constant C,Franklin RJ
Mon Dec 07 00:00:00 UTC 2015
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
The Journal of cell biology
Tornavaca O,Chia M,Dufton N,Almagro LO,Conway DE,Randi AM,Schwartz MA,Matter K,Balda MS
Mon Mar 16 00:00:00 UTC 2015
HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial-mesenchymal transition.
International journal of cancer
Ranieri D,Belleudi F,Magenta A,Torrisi MR
Wed Jul 01 00:00:00 UTC 2015
Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes.
Development (Cambridge, England)
Palpant NJ,Pabon L,Roberts M,Hadland B,Jones D,Jones C,Moon RT,Ruzzo WL,Bernstein I,Zheng Y,Murry CE
100-18B was used in Cell Culture to conclude that activin/BMP gradients specify distinct mesodermal subpopulations that generate cell derivatives with unique angiogenic, hemogenic and cardiogenic properties that should be useful for understanding embryogenesis and developing therapeutics.
Tue Sep 15 00:00:00 UTC 2015
Comparison between the cultures of human induced pluripotent stem cells (hiPSCs) on feeder-and serum-free system (Matrigel matrix), MEF and HDF feeder cell lines.
Journal of cell communication and signaling
Ghasemi-Dehkordi P,Allahbakhshian-Farsani M,Abdian N,Mirzaeian A,Saffari-Chaleshtori J,Heybati F,Mardani G,Karimi-Taghanaki A,Doosti A,Jami MS,Abolhasani M,Hashemzadeh-Chaleshtori M
100-18B was used in Cell Culture to show that HDFs have homologous source with hiPSCs and can be used as feeder instead of MEF but in therapeutic approaches the cells contamination is a problem.
Tue Sep 01 00:00:00 UTC 2015
Multiple roles of extracellular fibroblast growth factors in lung cancer cells.
International journal of oncology
Suzuki T,Yasuda H,Funaishi K,Arai D,Ishioka K,Ohgino K,Tani T,Hamamoto J,Ohashi A,Naoki K,Betsuyaku T,Soejima K
Thu Jan 01 00:00:00 UTC 2015
Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells.
Stem cells (Dayton, Ohio)
Duggal G,Warrier S,Ghimire S,Broekaert D,Van der Jeught M,Lierman S,Deroo T,Peelman L,Van Soom A,Cornelissen R,Menten B,Mestdagh P,Vandesompele J,Roost M,Slieker RC,Heijmans BT,Deforce D,De Sutter P,De Sousa Lopes SC,Heindryckx B
Tue Sep 01 00:00:00 UTC 2015
Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells.
Stem cells (Dayton, Ohio)
Duggal G,Warrier S,Ghimire S,Broekaert D,Van der Jeught M,Lierman S,Deroo T,Peelman L,Van Soom A,Cornelissen R,Menten B,Mestdagh P,Vandesompele J,Roost M,Slieker RC,Heijmans BT,Deforce D,De Sutter P,De Sousa Lopes SC,Heindryckx B
Tue Sep 01 00:00:00 UTC 2015
Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells.
Stem cells (Dayton, Ohio)
Duggal G,Warrier S,Ghimire S,Broekaert D,Van der Jeught M,Lierman S,Deroo T,Peelman L,Van Soom A,Cornelissen R,Menten B,Mestdagh P,Vandesompele J,Roost M,Slieker RC,Heijmans BT,Deforce D,De Sutter P,De Sousa Lopes SC,Heindryckx B
Tue Sep 01 00:00:00 UTC 2015
TGF-β1, GDF-5, and BMP-2 stimulation induces chondrogenesis in expanded human articular chondrocytes and marrow-derived stromal cells.
Stem cells (Dayton, Ohio)
Murphy MK,Huey DJ,Hu JC,Athanasiou KA
Sun Mar 01 00:00:00 UTC 2015
Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.
Stem cells (Dayton, Ohio)
Yang J,Wang W,Ooi J,Campos LS,Lu L,Liu P
Fri May 01 00:00:00 UTC 2015
Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells.
Stem cells (Dayton, Ohio)
Hung BP,Hutton DL,Kozielski KL,Bishop CJ,Naved B,Green JJ,Caplan AI,Gimble JM,Dorafshar AH,Grayson WL
Tue Sep 01 00:00:00 UTC 2015
The cyclin-dependent kinase inhibitor p27 kip1 regulates radial stem cell quiescence and neurogenesis in the adult hippocampus.
Stem cells (Dayton, Ohio)
Andreu Z,Khan MA,González-Gómez P,Negueruela S,Hortigüela R,San Emeterio J,Ferrón SR,Martínez G,Vidal A,Fariñas I,Lie DC,Mira H
Thu Jan 01 00:00:00 UTC 2015
Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.
Stem cells (Dayton, Ohio)
Zhang M,Schulte JS,Heinick A,Piccini I,Rao J,Quaranta R,Zeuschner D,Malan D,Kim KP,Röpke A,Sasse P,Araúzo-Bravo M,Seebohm G,Schöler H,Fabritz L,Kirchhof P,Müller FU,Greber B
Fri May 01 00:00:00 UTC 2015
Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells.
Stem cells (Dayton, Ohio)
Nakagomi T,Kubo S,Nakano-Doi A,Sakuma R,Lu S,Narita A,Kawahara M,Taguchi A,Matsuyama T
Mon Jun 01 00:00:00 UTC 2015
Brain vascular pericytes following ischemia have multipotential stem cell activity to differentiate into neural and vascular lineage cells.
Stem cells (Dayton, Ohio)
Nakagomi T,Kubo S,Nakano-Doi A,Sakuma R,Lu S,Narita A,Kawahara M,Taguchi A,Matsuyama T
Mon Jun 01 00:00:00 UTC 2015
Combination of systemic chemotherapy with local stem cell delivered S-TRAIL in resected brain tumors.
Stem cells (Dayton, Ohio)
Redjal N,Zhu Y,Shah K
Thu Jan 01 00:00:00 UTC 2015
Notch1 stimulation induces a vascularization switch with pericyte-like cell differentiation of glioblastoma stem cells.
Stem cells (Dayton, Ohio)
Guichet PO,Guelfi S,Teigell M,Hoppe L,Bakalara N,Bauchet L,Duffau H,Lamszus K,Rothhut B,Hugnot JP
Thu Jan 01 00:00:00 UTC 2015
Live fluorescent RNA-based detection of pluripotency gene expression in embryonic and induced pluripotent stem cells of different species.
Stem cells (Dayton, Ohio)
Lahm H,Doppler S,Dreßen M,Werner A,Adamczyk K,Schrambke D,Brade T,Laugwitz KL,Deutsch MA,Schiemann M,Lange R,Moretti A,Krane M
Sun Feb 01 00:00:00 UTC 2015
Live fluorescent RNA-based detection of pluripotency gene expression in embryonic and induced pluripotent stem cells of different species.
Stem cells (Dayton, Ohio)
Lahm H,Doppler S,Dreßen M,Werner A,Adamczyk K,Schrambke D,Brade T,Laugwitz KL,Deutsch MA,Schiemann M,Lange R,Moretti A,Krane M
Sun Feb 01 00:00:00 UTC 2015
Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system.
Stem cells (Dayton, Ohio)
Denham M,Hasegawa K,Menheniott T,Rollo B,Zhang D,Hough S,Alshawaf A,Febbraro F,Ighaniyan S,Leung J,Elliott DA,Newgreen DF,Pera MF,Dottori M
Mon Jun 01 00:00:00 UTC 2015
Glutamine Regulates Cardiac Progenitor Cell Metabolism and Proliferation.
Stem cells (Dayton, Ohio)
Salabei JK,Lorkiewicz PK,Holden CR,Li Q,Hong KU,Bolli R,Bhatnagar A,Hill BG
Sat Aug 01 00:00:00 UTC 2015
Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/Bim pathway.
Stem cells (Dayton, Ohio)
Gargini R,Cerliani JP,Escoll M,Antón IM,Wandosell F
Sun Mar 01 00:00:00 UTC 2015
Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts.
Stem cells (Dayton, Ohio)
Kitajima S,Kohno S,Kondoh A,Sasaki N,Nishimoto Y,Li F,Abdallah Mohammed MS,Muranaka H,Nagatani N,Suzuki M,Kido Y,Takahashi C
Fri May 01 00:00:00 UTC 2015
NTPDase2 and purinergic signaling control progenitor cell proliferation in neurogenic niches of the adult mouse brain.
Stem cells (Dayton, Ohio)
Gampe K,Stefani J,Hammer K,Brendel P,Pötzsch A,Enikolopov G,Enjyoji K,Acker-Palmer A,Robson SC,Zimmermann H
Thu Jan 01 00:00:00 UTC 2015
Notch signaling regulates motor neuron differentiation of human embryonic stem cells.
Stem cells (Dayton, Ohio)
Ben-Shushan E,Feldman E,Reubinoff BE
Sun Feb 01 00:00:00 UTC 2015
Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis.
The American journal of pathology
Yuan K,Orcholski ME,Panaroni C,Shuffle EM,Huang NF,Jiang X,Tian W,Vladar EK,Wang L,Nicolls MR,Wu JY,de Jesus Perez VA
100-18B was used in In vitro experiments to identify whether impaired endothelial-pericyte interaction contributes to small vessel loss in pulmonary arterial hypertension.
Thu Jan 01 00:00:00 UTC 2015
Cytosolic Low Molecular Weight FGF2 Orchestrates RIG-I-Mediated Innate Immune Response.
Journal of immunology (Baltimore, Md. : 1950)
Liu X,Luo D,Yang N
Sun Nov 15 00:00:00 UTC 2015
CXCL10 triggers early microglial activation in the cuprizone model.
Journal of immunology (Baltimore, Md. : 1950)
Clarner T,Janssen K,Nellessen L,Stangel M,Skripuletz T,Krauspe B,Hess FM,Denecke B,Beutner C,Linnartz-Gerlach B,Neumann H,Vallières L,Amor S,Ohl K,Tenbrock K,Beyer C,Kipp M
Wed Apr 01 00:00:00 UTC 2015
Targeting lung cancer stem-like cells with TRAIL gene armed oncolytic adenovirus.
Journal of cellular and molecular medicine
Yang Y,Xu H,Huang W,Ding M,Xiao J,Yang D,Li H,Liu XY,Chu L
Fri May 01 00:00:00 UTC 2015
Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab.
Nature communications
Mitsuhashi A,Goto H,Saijo A,Trung VT,Aono Y,Ogino H,Kuramoto T,Tabata S,Uehara H,Izumi K,Yoshida M,Kobayashi H,Takahashi H,Gotoh M,Kakiuchi S,Hanibuchi M,Yano S,Yokomise H,Sakiyama S,Nishioka Y
Fri Dec 04 00:00:00 UTC 2015
APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation.
Cell death & disease
Shu R,Wong W,Ma QH,Yang ZZ,Zhu H,Liu FJ,Wang P,Ma J,Yan S,Polo JM,Bernard CC,Stanton LW,Dawe GS,Xiao ZC
Thu Feb 19 00:00:00 UTC 2015
Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury.
Scientific reports
Imberti B,Tomasoni S,Ciampi O,Pezzotta A,Derosas M,Xinaris C,Rizzo P,Papadimou E,Novelli R,Benigni A,Remuzzi G,Morigi M
Fri Mar 06 00:00:00 UTC 2015
Dysfunction of platelet-derived growth factor receptor α (PDGFRα) represses the production of oligodendrocytes from arylsulfatase A-deficient multipotential neural precursor cells.
The Journal of biological chemistry
Pituch KC,Moyano AL,Lopez-Rosas A,Marottoli FM,Li G,Hu C,van Breemen R,Månsson JE,Givogri MI
Fri Mar 13 00:00:00 UTC 2015
Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.
Scientific reports
Maekawa M,Iwayama Y,Ohnishi T,Toyoshima M,Shimamoto C,Hisano Y,Toyota T,Balan S,Matsuzaki H,Iwata Y,Takagai S,Yamada K,Ota M,Fukuchi S,Okada Y,Akamatsu W,Tsujii M,Kojima N,Owada Y,Okano H,Mori N,Yoshikawa T
Mon Nov 09 00:00:00 UTC 2015
Giant Panda (Ailuropoda melanoleuca) Buccal Mucosa Tissue as a Source of Multipotent Progenitor Cells.
PloS one
Prescott HM,Manning C,Gardner A,Ritchie WA,Pizzi R,Girling S,Valentine I,Wang C,Jahoda CA
100-18B was used in Cell Culture to demonstrate that giant panda cheek skin can be a useful source of m-SKP multipotent progenitors.
Tue May 31 00:00:00 UTC 2016
Giant Panda (Ailuropoda melanoleuca) Buccal Mucosa Tissue as a Source of Multipotent Progenitor Cells.
PloS one
Prescott HM,Manning C,Gardner A,Ritchie WA,Pizzi R,Girling S,Valentine I,Wang C,Jahoda CA
100-18B was used in Cell Culture to demonstrate that giant panda cheek skin can be a useful source of m-SKP multipotent progenitors.
Tue May 31 00:00:00 UTC 2016
Basic Fibroblast Growth Factor Stimulates the Proliferation of Bone Marrow Mesenchymal Stem Cells in Giant Panda (Ailuropoda melanoleuca).
PloS one
Wang JJ,Liu YL,Sun YC,Ge W,Wang YY,Dyce PW,Hou R,Shen W
100-18B was used in Cell Culture to study the role of basic fibroblast growth factor (bFGF) on promoting the proliferation of mesenchymal stem cells (MSCs) derived from giant panda bone marrow (BM).
Thu May 26 00:00:00 UTC 2016
EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury.
Cell death & disease
Tsenkina Y,Ricard J,Runko E,Quiala-Acosta MM,Mier J,Liebl DJ
Thu Oct 15 00:00:00 UTC 2015
PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium.
Nature communications
Noseda M,Harada M,McSweeney S,Leja T,Belian E,Stuckey DJ,Abreu Paiva MS,Habib J,Macaulay I,de Smith AJ,al-Beidh F,Sampson R,Lumbers RT,Rao P,Harding SE,Blakemore AI,Jacobsen SE,Barahona M,Schneider MD
Mon May 18 00:00:00 UTC 2015
Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture.
Nature communications
Fridriksdottir AJ,Kim J,Villadsen R,Klitgaard MC,Hopkinson BM,Petersen OW,Rønnov-Jessen L
Fri Nov 13 00:00:00 UTC 2015
Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture.
Nature communications
Fridriksdottir AJ,Kim J,Villadsen R,Klitgaard MC,Hopkinson BM,Petersen OW,Rønnov-Jessen L
Fri Nov 13 00:00:00 UTC 2015
Stem and progenitor cell division kinetics during postnatal mouse mammary gland development.
Nature communications
Giraddi RR,Shehata M,Gallardo M,Blasco MA,Simons BD,Stingl J
Thu Oct 29 00:00:00 UTC 2015
Derivation of highly purified cardiomyocytes from human induced pluripotent stem cells using small molecule-modulated differentiation and subsequent glucose starvation.
Journal of visualized experiments : JoVE
Sharma A,Li G,Rajarajan K,Hamaguchi R,Burridge PW,Wu SM
100-18B was used in Cell Culture to conclude that these highly purified cardiomyocytes should enhance the reliability of results from human iPSC-based in vitro disease modeling studies and drug screening assays.
Wed Mar 18 00:00:00 UTC 2015
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.
Nature communications
Jiang H,Xu Z,Zhong P,Ren Y,Liang G,Schilling HA,Hu Z,Zhang Y,Wang X,Chen S,Yan Z,Feng J
Mon Dec 07 00:00:00 UTC 2015
Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine.
Molecular cancer
Yang MC,Wang HC,Hou YC,Tung HL,Chiu TJ,Shan YS
100-18B was used in Cell Culture to investigate the role of autophagy in regulating cancer stemness and chemoresistance of pancreatic cancer.
Mon Oct 12 00:00:00 UTC 2015
Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.
Scientific reports
Wang S,Wang B,Pan N,Fu L,Wang C,Song G,An J,Liu Z,Zhu W,Guan Y,Xu ZQ,Chan P,Chen Z,Zhang YA
Wed Mar 18 00:00:00 UTC 2015
Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.
Scientific reports
Wang S,Wang B,Pan N,Fu L,Wang C,Song G,An J,Liu Z,Zhu W,Guan Y,Xu ZQ,Chan P,Chen Z,Zhang YA
Wed Mar 18 00:00:00 UTC 2015
BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells.
Nature communications
Khaled WT,Choon Lee S,Stingl J,Chen X,Raza Ali H,Rueda OM,Hadi F,Wang J,Yu Y,Chin SF,Stratton M,Futreal A,Jenkins NA,Aparicio S,Copeland NG,Watson CJ,Caldas C,Liu P
Fri Jan 09 00:00:00 UTC 2015
BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy.
Investigative ophthalmology & visual science
Rivera JC,Noueihed B,Omri S,Barrueco J,Hilberg F,Chemtob S
100-18B was used in Cell Culture to evaluate the effects of BIBF1120, a novel triple angiokinase inhibitor against pathological retinal neovascularization to reveal efficacy of BIBF1120 on preretinal neovascularization and, of greater interest, on acceleration of normal vascularization, consistent with interference of major repulsive cues expressed in the retina during OIR.
Tue Dec 01 00:00:00 UTC 2015
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
Nature communications
Matsuda T,Murao N,Katano Y,Juliandi B,Kohyama J,Akira S,Kawai T,Nakashima K
Mon Mar 09 00:00:00 UTC 2015
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem cell reports
Garate Z,Quintana-Bustamante O,Crane AM,Olivier E,Poirot L,Galetto R,Kosinski P,Hill C,Kung C,Agirre X,Orman I,Cerrato L,Alberquilla O,Rodriguez-Fornes F,Fusaki N,Garcia-Sanchez F,Maia TM,Ribeiro ML,Sevilla J,Prosper F,Jin S,Mountford J,Guenechea G,Gouble A,Bueren JA,Davis BR,Segovia JC
Tue Dec 08 00:00:00 UTC 2015
Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.
Scientific reports
Palm T,Bolognin S,Meiser J,Nickels S,Träger C,Meilenbrock RL,Brockhaus J,Schreitmüller M,Missler M,Schwamborn JC
Fri Nov 06 00:00:00 UTC 2015
Identification of thiostrepton as a novel therapeutic agent that targets human colon cancer stem cells.
Cell death & disease
Ju SY,Huang CY,Huang WC,Su Y
Thu Jul 02 00:00:00 UTC 2015
High glutathione and glutathione peroxidase-2 levels mediate cell-type-specific DNA damage protection in human induced pluripotent stem cells.
Stem cell reports
Dannenmann B,Lehle S,Hildebrand DG,Kübler A,Grondona P,Schmid V,Holzer K,Fröschl M,Essmann F,Rothfuss O,Schulze-Osthoff K
Tue May 12 00:00:00 UTC 2015
GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells.
Scientific reports
Christensen DR,Calder PC,Houghton FD
Mon Dec 07 00:00:00 UTC 2015
Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.
Stem cell reports
Imaizumi K,Sone T,Ibata K,Fujimori K,Yuzaki M,Akamatsu W,Okano H
Tue Dec 08 00:00:00 UTC 2015
Differentiation of early germ cells from human skin-derived stem cells without exogenous gene integration.
Scientific reports
Ge W,Ma HG,Cheng SF,Sun YC,Sun LL,Sun XF,Li L,Dyce P,Li J,Shi QH,Shen W
Tue Sep 08 00:00:00 UTC 2015
Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.
Nature communications
Devlin AC,Burr K,Borooah S,Foster JD,Cleary EM,Geti I,Vallier L,Shaw CE,Chandran S,Miles GB
Mon Jan 12 00:00:00 UTC 2015
DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression.
Nature communications
Cho MH,Park JH,Choi HJ,Park MK,Won HY,Park YJ,Lee CH,Oh SH,Song YS,Kim HS,Oh YH,Lee JY,Kong G
Wed Jul 22 00:00:00 UTC 2015
Induced pluripotent stem cells as a model for diabetes investigation.
Scientific reports
Stepniewski J,Kachamakova-Trojanowska N,Ogrocki D,Szopa M,Matlok M,Beilharz M,Dyduch G,Malecki MT,Jozkowicz A,Dulak J
Thu Feb 26 00:00:00 UTC 2015
Artificial membrane-binding proteins stimulate oxygenation of stem cells during engineering of large cartilage tissue.
Nature communications
Armstrong JPK,Shakur R,Horne JP,Dickinson SC,Armstrong CT,Lau K,Kadiwala J,Lowe R,Seddon A,Mann S,Anderson JLR,Perriman AW,Hollander AP
Wed Jun 17 00:00:00 UTC 2015
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
Nature communications
Freedman BS,Brooks CR,Lam AQ,Fu H,Morizane R,Agrawal V,Saad AF,Li MK,Hughes MR,Werff RV,Peters DT,Lu J,Baccei A,Siedlecki AM,Valerius MT,Musunuru K,McNagny KM,Steinman TI,Zhou J,Lerou PH,Bonventre JV
Fri Oct 23 00:00:00 UTC 2015
A stable chimeric fibroblast growth factor (FGF) can successfully replace basic FGF in human pluripotent stem cell culture.
PloS one
Onuma Y,Higuchi K,Aiki Y,Shu Y,Asada M,Asashima M,Suzuki M,Imamura T,Ito Y
Tue Apr 12 00:00:00 UTC 2016
Simultaneous MR imaging for tissue engineering in a rat model of stroke.
Scientific reports
Nicholls FJ,Ling W,Ferrauto G,Aime S,Modo M
Wed Sep 30 00:00:00 UTC 2015
Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion.
Scientific reports
Tian C,Li Y,Huang Y,Wang Y,Chen D,Liu J,Deng X,Sun L,Anderson K,Qi X,Li Y,Lee Mosley R,Chen X,Huang J,Zheng JC
Thu Jul 30 00:00:00 UTC 2015
A cost-effective system for differentiation of intestinal epithelium from human induced pluripotent stem cells.
Scientific reports
Ogaki S,Morooka M,Otera K,Kume S
Mon Nov 30 00:00:00 UTC 2015
miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance.
Cell death & disease
De Cola A,Volpe S,Budani MC,Ferracin M,Lattanzio R,Turdo A,D'Agostino D,Capone E,Stassi G,Todaro M,Di Ilio C,Sala G,Piantelli M,Negrini M,Veronese A,De Laurenzi V
Thu Jul 16 00:00:00 UTC 2015
Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion.
Scientific reports
Ma J,Zhang J,Hou WW,Wu XH,Liao RJ,Chen Y,Wang Z,Zhang XN,Zhang LS,Zhou YD,Chen Z,Hu WW
Wed Jul 15 00:00:00 UTC 2015
p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activation in renal cell carcinoma.
Cell death & disease
Zhu Y,Liu H,Xu L,An H,Liu W,Liu Y,Lin Z,Xu J
Thu Feb 12 00:00:00 UTC 2015
Computer-assisted quantification of motile and invasive capabilities of cancer cells.
Scientific reports
Kumar KS,Pillong M,Kunze J,Burghardt I,Weller M,Grotzer MA,Schneider G,Baumgartner M
Wed Oct 21 00:00:00 UTC 2015
TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair.
Nature communications
Ogura Y,Hindi SM,Sato S,Xiong G,Akira S,Kumar A
Wed Dec 09 00:00:00 UTC 2015
CD24 tracks divergent pluripotent states in mouse and human cells.
Nature communications
Shakiba N,White CA,Lipsitz YY,Yachie-Kinoshita A,Tonge PD,Hussein SMI,Puri MC,Elbaz J,Morrissey-Scoot J,Li M,Munoz J,Benevento M,Rogers IM,Hanna JH,Heck AJR,Wollscheid B,Nagy A,Zandstra PW
Tue Jun 16 00:00:00 UTC 2015
In Vitro Derivation of Melanocytes from Embryonic Neural Crest Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Shakhova O,Sommer L
100-18B was used in Cell Culture to investigate the differentiation of multipotent embryonic neural crest stem cells into differentiated pigmented melanocytes.
Sun Dec 13 00:00:00 UTC 2015
Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis.
Scientific reports
Thiel A,Yavanian G,Nastke MD,Morales P,Kouris NA,Kimbrel EA,Lanza R
Wed Dec 02 00:00:00 UTC 2015
MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death.
The Journal of biological chemistry
Chaudhuri AD,Kabaria S,Choi DC,Mouradian MM,Junn E
Fri May 08 00:00:00 UTC 2015
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Scientific reports
Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP
Mon Nov 09 00:00:00 UTC 2015
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Scientific reports
Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP
Mon Nov 09 00:00:00 UTC 2015
Derivation of Equine-Induced Pluripotent Stem Cell Lines Using a piggyBac Transposon Delivery System and Temporal Control of Transgene Expression.
Methods in molecular biology (Clifton, N.J.)
Nagy K,Nagy A
100-18B was used in Cell Culture to describe the derivation of iPSCs from equine embryonic fibroblasts using a non-viral method developed in our laboratory and originally applied to the murine and human systems (Woltjen et al., Nature 458:766-770, 2009).
Thu Sep 15 00:00:00 UTC 2016
Comparative proteomics reveals human pluripotent stem cell-derived limbal epithelial stem cells are similar to native ocular surface epithelial cells.
Scientific reports
Mikhailova A,Jylhä A,Rieck J,Nättinen J,Ilmarinen T,Veréb Z,Aapola U,Beuerman R,Petrovski G,Uusitalo H,Skottman H
Thu Oct 01 00:00:00 UTC 2015
Chemically Defined Culture and Cardiomyocyte Differentiation of Human Pluripotent Stem Cells.
Current protocols in human genetics
Burridge PW,Holmström A,Wu JC
Tue Oct 06 00:00:00 UTC 2015
Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells.
Skeletal muscle
Massouridès E,Polentes J,Mangeot PE,Mournetas V,Nectoux J,Deburgrave N,Nusbaum P,Leturcq F,Popplewell L,Dickson G,Wein N,Flanigan KM,Peschanski M,Chelly J,Pinset C
100-18B was used in Cell Culture to demonstrate the feasibility of exon skipping validation with this BMP4-inducible hiPSCs model.
Mon Nov 16 00:00:00 UTC 2015
RGD-modifided oncolytic adenovirus exhibited potent cytotoxic effect on CAR-negative bladder cancer-initiating cells.
Cell death & disease
Yang Y,Xu H,Shen J,Yang Y,Wu S,Xiao J,Xu Y,Liu XY,Chu L
Thu May 14 00:00:00 UTC 2015
Domains of genome-wide gene expression dysregulation in Down's syndrome.
Nature
Letourneau A,Santoni FA,Bonilla X,Sailani MR,Gonzalez D,Kind J,Chevalier C,Thurman R,Sandstrom RS,Hibaoui Y,Garieri M,Popadin K,Falconnet E,Gagnebin M,Gehrig C,Vannier A,Guipponi M,Farinelli L,Robyr D,Migliavacca E,Borel C,Deutsch S,Feki A,Stamatoyannopoulos JA,Herault Y,van Steensel B,Guigo R,Antonarakis SE
Thu Apr 17 00:00:00 UTC 2014
Organoid cultures derived from patients with advanced prostate cancer.
Cell
Gao D,Vela I,Sboner A,Iaquinta PJ,Karthaus WR,Gopalan A,Dowling C,Wanjala JN,Undvall EA,Arora VK,Wongvipat J,Kossai M,Ramazanoglu S,Barboza LP,Di W,Cao Z,Zhang QF,Sirota I,Ran L,MacDonald TY,Beltran H,Mosquera JM,Touijer KA,Scardino PT,Laudone VP,Curtis KR,Rathkopf DE,Morris MJ,Danila DC,Slovin SF,Solomon SB,Eastham JA,Chi P,Carver B,Rubin MA,Scher HI,Clevers H,Sawyers CL,Chen Y
Thu Sep 25 00:00:00 UTC 2014
Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
Cell
Karthaus WR,Iaquinta PJ,Drost J,Gracanin A,van Boxtel R,Wongvipat J,Dowling CM,Gao D,Begthel H,Sachs N,Vries RGJ,Cuppen E,Chen Y,Sawyers CL,Clevers HC
Thu Sep 25 00:00:00 UTC 2014
RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.
Cell
Kitambi SS,Toledo EM,Usoskin D,Wee S,Harisankar A,Svensson R,Sigmundsson K,Kalderén C,Niklasson M,Kundu S,Aranda S,Westermark B,Uhrbom L,Andäng M,Damberg P,Nelander S,Arenas E,Artursson P,Walfridsson J,Forsberg Nilsson K,Hammarström LGJ,Ernfors P
Thu Apr 10 00:00:00 UTC 2014
Chemically defined generation of human cardiomyocytes.
Nature methods
Burridge PW,Matsa E,Shukla P,Lin ZC,Churko JM,Ebert AD,Lan F,Diecke S,Huber B,Mordwinkin NM,Plews JR,Abilez OJ,Cui B,Gold JD,Wu JC
Fri Aug 01 00:00:00 UTC 2014
Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.
Cell research
Jiang MH,Cai B,Tuo Y,Wang J,Zang ZJ,Tu X,Gao Y,Su Z,Li W,Li G,Zhang M,Jiao J,Wan Z,Deng C,Lahn BT,Xiang AP
Mon Dec 01 00:00:00 UTC 2014
Leukemia propagating cells rebuild an evolving niche in response to therapy.
Cancer cell
Duan CW,Shi J,Chen J,Wang B,Yu YH,Qin X,Zhou XC,Cai YJ,Li ZQ,Zhang F,Yin MZ,Tao Y,Mi JQ,Li LH,Enver T,Chen GQ,Hong DL
Mon Jun 16 00:00:00 UTC 2014
Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations.
Blood
Traer E,Javidi-Sharifi N,Agarwal A,Dunlap J,English I,Martinez J,Tyner JW,Wong M,Druker BJ
Thu Mar 06 00:00:00 UTC 2014
Sphere-forming-like cells (squamospheres) with cancer stem-like cell traits from VX2 rabbit buccal squamous cell carcinoma.
International journal of oral science
Chen YK,Huang AH,Lin LM
Mon Dec 01 00:00:00 UTC 2014
EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.
The Journal of clinical investigation
Feng H,Lopez GY,Kim CK,Alvarez A,Duncan CG,Nishikawa R,Nagane M,Su AJ,Auron PE,Hedberg ML,Wang L,Raizer JJ,Kessler JA,Parsa AT,Gao WQ,Kim SH,Minata M,Nakano I,Grandis JR,McLendon RE,Bigner DD,Lin HK,Furnari FB,Cavenee WK,Hu B,Yan H,Cheng SY
Mon Sep 01 00:00:00 UTC 2014
Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion.
EMBO molecular medicine
Coleman SJ,Chioni AM,Ghallab M,Anderson RK,Lemoine NR,Kocher HM,Grose RP
Tue Apr 01 00:00:00 UTC 2014
Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.
Proceedings of the National Academy of Sciences of the United States of America
Kanatsu-Shinohara M,Onoyama I,Nakayama KI,Shinohara T
Tue Jun 17 00:00:00 UTC 2014
Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs.
Proceedings of the National Academy of Sciences of the United States of America
Park CY,Kim J,Kweon J,Son JS,Lee JS,Yoo JE,Cho SR,Kim JH,Kim JS,Kim DW
Tue Jun 24 00:00:00 UTC 2014
Transcription factor induction of human oligodendrocyte progenitor fate and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Wang J,Pol SU,Haberman AK,Wang C,O'Bara MA,Sim FJ
Tue Jul 15 00:00:00 UTC 2014
Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133(+) liver cancer stem cells.
Experimental & molecular medicine
Lee YK,Hur W,Lee SW,Hong SW,Kim SW,Choi JE,Yoon SK
Fri Feb 21 00:00:00 UTC 2014
Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors.
Stem cells translational medicine
Kaitsuka T,Noguchi H,Shiraki N,Kubo T,Wei FY,Hakim F,Kume S,Tomizawa K
Wed Jan 01 00:00:00 UTC 2014
Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
He Q,Yang X,Gong Y,Kovalenko D,Canalis E,Rosen CJ,Friesel RE
Tue Dec 09 00:00:00 UTC 2014
Conversion of human fibroblasts into monocyte-like progenitor cells.
Stem cells (Dayton, Ohio)
Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI
Sat Nov 01 00:00:00 UTC 2014
Conversion of human fibroblasts into monocyte-like progenitor cells.
Stem cells (Dayton, Ohio)
Pulecio J,Nivet E,Sancho-Martinez I,Vitaloni M,Guenechea G,Xia Y,Kurian L,Dubova I,Bueren J,Laricchia-Robbio L,Belmonte JCI
Sat Nov 01 00:00:00 UTC 2014
Peritoneal milky spots serve as a hypoxic niche and favor gastric cancer stem/progenitor cell peritoneal dissemination through hypoxia-inducible factor 1α.
Stem cells (Dayton, Ohio)
Miao ZF,Wang ZN,Zhao TT,Xu YY,Gao J,Miao F,Xu HM
Mon Dec 01 00:00:00 UTC 2014
Systemic anticancer neural stem cells in combination with a cardiac glycoside for glioblastoma therapy.
Stem cells (Dayton, Ohio)
Teng J,Hejazi S,Badr CE,Tannous BA
Fri Aug 01 00:00:00 UTC 2014
Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks.
Stem cells (Dayton, Ohio)
Dowell KG,Simons AK,Bai H,Kell B,Wang ZZ,Yun K,Hibbs MA
Thu May 01 00:00:00 UTC 2014
Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks.
Stem cells (Dayton, Ohio)
Dowell KG,Simons AK,Bai H,Kell B,Wang ZZ,Yun K,Hibbs MA
Thu May 01 00:00:00 UTC 2014
A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal.
Stem cells (Dayton, Ohio)
Bizen N,Inoue T,Shimizu T,Tabu K,Kagawa T,Taga T
Sun Jun 01 00:00:00 UTC 2014
Inhibition of Akt/mTOR attenuates age-related changes in mesenchymal stem cells.
Stem cells (Dayton, Ohio)
Gharibi B,Farzadi S,Ghuman M,Hughes FJ
Fri Aug 01 00:00:00 UTC 2014
HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.
Stem cells (Dayton, Ohio)
Prigione A,Rohwer N,Hoffmann S,Mlody B,Drews K,Bukowiecki R,Blümlein K,Wanker EE,Ralser M,Cramer T,Adjaye J
Sat Feb 01 00:00:00 UTC 2014
sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets.
Stem cells (Dayton, Ohio)
Hinton A,Hunter SE,Afrikanova I,Jones GA,Lopez AD,Fogel GB,Hayek A,King CC
Mon Sep 01 00:00:00 UTC 2014
sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets.
Stem cells (Dayton, Ohio)
Hinton A,Hunter SE,Afrikanova I,Jones GA,Lopez AD,Fogel GB,Hayek A,King CC
Mon Sep 01 00:00:00 UTC 2014
BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2.
Stem cells (Dayton, Ohio)
Richter A,Valdimarsdottir L,Hrafnkelsdottir HE,Runarsson JF,Omarsdottir AR,Ward-van Oostwaard D,Mummery C,Valdimarsdottir G
Sat Mar 01 00:00:00 UTC 2014
Targeting the bHLH transcriptional networks by mutated E proteins in experimental glioma.
Stem cells (Dayton, Ohio)
Beyeler S,Joly S,Fries M,Obermair FJ,Burn F,Mehmood R,Tabatabai G,Raineteau O
Wed Oct 01 00:00:00 UTC 2014
Nitric oxide controls fat deposition in dystrophic skeletal muscle by regulating fibro-adipogenic precursor differentiation.
Stem cells (Dayton, Ohio)
Cordani N,Pisa V,Pozzi L,Sciorati C,Clementi E
Tue Apr 01 00:00:00 UTC 2014
Neutralization of nerve growth factor impairs proliferation and differentiation of adult neural progenitors in the subventricular zone.
Stem cells (Dayton, Ohio)
Scardigli R,Capelli P,Vignone D,Brandi R,Ceci M,La Regina F,Piras E,Cintoli S,Berardi N,Capsoni S,Cattaneo A
Mon Sep 01 00:00:00 UTC 2014
A novel oncogenic role of inositol phosphatase SHIP2 in ER-negative breast cancer stem cells: involvement of JNK/vimentin activation.
Stem cells (Dayton, Ohio)
Fu CH,Lin RJ,Yu J,Chang WW,Liao GS,Chang WY,Tseng LM,Tsai YF,Yu JC,Yu AL
Fri Aug 01 00:00:00 UTC 2014
Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation.
Stem cells (Dayton, Ohio)
Kim TG,Yao R,Monnell T,Cho JH,Vasudevan A,Koh A,Peeyush KT,Moon M,Datta D,Bolshakov VY,Kim KS,Chung S
Tue Jul 01 00:00:00 UTC 2014
TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Langlois T,da Costa Reis Monte-Mor B,Lenglet G,Droin N,Marty C,Le Couédic JP,Almire C,Auger N,Mercher T,Delhommeau F,Christensen J,Helin K,Debili N,Fuks F,Bernard OA,Solary E,Vainchenker W,Plo I
Fri Aug 01 00:00:00 UTC 2014
TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Langlois T,da Costa Reis Monte-Mor B,Lenglet G,Droin N,Marty C,Le Couédic JP,Almire C,Auger N,Mercher T,Delhommeau F,Christensen J,Helin K,Debili N,Fuks F,Bernard OA,Solary E,Vainchenker W,Plo I
Fri Aug 01 00:00:00 UTC 2014
Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4.
Journal of immunology (Baltimore, Md. : 1950)
Volonté A,Di Tomaso T,Spinelli M,Todaro M,Sanvito F,Albarello L,Bissolati M,Ghirardelli L,Orsenigo E,Ferrone S,Doglioni C,Stassi G,Dellabona P,Staudacher C,Parmiani G,Maccalli C
Wed Jan 01 00:00:00 UTC 2014
IL-32 promotes angiogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Nold-Petry CA,Rudloff I,Baumer Y,Ruvo M,Marasco D,Botti P,Farkas L,Cho SX,Zepp JA,Azam T,Dinkel H,Palmer BE,Boisvert WA,Cool CD,Taraseviciene-Stewart L,Heinhuis B,Joosten LA,Dinarello CA,Voelkel NF,Nold MF
Wed Jan 15 00:00:00 UTC 2014
NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival.
Journal of immunology (Baltimore, Md. : 1950)
Gras Navarro A,Kmiecik J,Leiss L,Zelkowski M,Engelsen A,Bruserud Ø,Zimmer J,Enger PØ,Chekenya M
Mon Dec 15 00:00:00 UTC 2014
Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
Journal of cellular and molecular medicine
Dambrot C,Braam SR,Tertoolen LG,Birket M,Atsma DE,Mummery CL
Fri Aug 01 00:00:00 UTC 2014
Maintenance and neuronal differentiation of chicken induced pluripotent stem-like cells.
Stem cells international
Dai R,Rossello R,Chen CC,Kessler J,Davison I,Hochgeschwender U,Jarvis ED
100-18B was used in Cell Culture to demonstrate an efficient method of maintaining chicken induced pluripotent stem (iPSC)-like cells and for differentiating them into action potential generating neurons.
Thu Jan 22 00:00:00 UTC 2015
Cancer stem cells and cisplatin-resistant cells isolated from non-small-lung cancer cell lines constitute related cell populations.
Cancer medicine
Lopez-Ayllon BD,Moncho-Amor V,Abarrategi A,Ibañez de Cáceres I,Castro-Carpeño J,Belda-Iniesta C,Perona R,Sastre L
Wed Oct 01 00:00:00 UTC 2014
Cancer stem cells and cisplatin-resistant cells isolated from non-small-lung cancer cell lines constitute related cell populations.
Cancer medicine
Lopez-Ayllon BD,Moncho-Amor V,Abarrategi A,Ibañez de Cáceres I,Castro-Carpeño J,Belda-Iniesta C,Perona R,Sastre L
Wed Oct 01 00:00:00 UTC 2014
Improvement of cardiac stem cell sheet therapy for chronic ischemic injury by adding endothelial progenitor cell transplantation: analysis of layer-specific regional cardiac function.
Cell transplantation
Kamata S,Miyagawa S,Fukushima S,Nakatani S,Kawamoto A,Saito A,Harada A,Shimizu T,Daimon T,Okano T,Asahara T,Sawa Y
100-18B was used in Sample Preparation (FC/FACS) to observe that transplantation of CSC sheets induced significant functional recovery of the ischemic epicardium, and concomitant EPC transplantation elicited transmural improvement in chronic ischemic injury.
Tue Jun 30 00:00:00 UTC 2015
Human cardiac stem cells with reduced notch signaling show enhanced therapeutic potential in a rat acute infarction model.
Circulation journal : official journal of the Japanese Circulation Society
Matsuda T,Miyagawa S,Fukushima S,Kitagawa-Sakakida S,Akimaru H,Horii-Komatsu M,Kawamoto A,Saito A,Asahara T,Sawa Y
100-18B was used in Cell Culture to investigate CSC therapeutic potential in rat models.
Mon Aug 18 00:00:00 UTC 2014
Human Schwann cells seeded on a novel collagen-based microstructured nerve guide survive, proliferate, and modify neurite outgrowth.
BioMed research international
van Neerven SG,Krings L,Haastert-Talini K,Vogt M,Tolba RH,Brook G,Pallua N,Bozkurt A
100-18B was used in Cell Culture to indicate that Perimaix provides a matrix that promotes attachment and supports process extension, migration, and proliferation of human Schwann cells.
Mon Jan 05 00:00:00 UTC 2015
PHD3 regulates EGFR internalization and signalling in tumours.
Nature communications
Garvalov BK,Foss F,Henze AT,Bethani I,Gräf-Höchst S,Singh D,Filatova A,Dopeso H,Seidel S,Damm M,Acker-Palmer A,Acker T
Tue Nov 25 00:00:00 UTC 2014
Integrin inhibition promotes atypical anoikis in glioma cells.
Cell death & disease
Silginer M,Weller M,Ziegler U,Roth P
Thu Jan 23 00:00:00 UTC 2014
Integrin inhibition promotes atypical anoikis in glioma cells.
Cell death & disease
Silginer M,Weller M,Ziegler U,Roth P
Thu Jan 23 00:00:00 UTC 2014
Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.
Nature communications
Lee H,Lee JK,Park MH,Hong YR,Marti HH,Kim H,Okada Y,Otsu M,Seo EJ,Park JH,Bae JH,Okino N,He X,Schuchman EH,Bae JS,Jin HK
Mon Nov 24 00:00:00 UTC 2014
Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.
Nature communications
Lee H,Lee JK,Park MH,Hong YR,Marti HH,Kim H,Okada Y,Otsu M,Seo EJ,Park JH,Bae JH,Okino N,He X,Schuchman EH,Bae JS,Jin HK
Mon Nov 24 00:00:00 UTC 2014
Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models.
Scientific reports
Chwalek K,Tsurkan MV,Freudenberg U,Werner C
Wed Mar 19 00:00:00 UTC 2014
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation.
The Journal of biological chemistry
Kichev A,Rousset CI,Baburamani AA,Levison SW,Wood TL,Gressens P,Thornton C,Hagberg H
Fri Mar 28 00:00:00 UTC 2014
Human retinal progenitor cell transplantation preserves vision.
The Journal of biological chemistry
Luo J,Baranov P,Patel S,Ouyang H,Quach J,Wu F,Qiu A,Luo H,Hicks C,Zeng J,Zhu J,Lu J,Sfeir N,Wen C,Zhang M,Reade V,Patel S,Sinden J,Sun X,Shaw P,Young M,Zhang K
Fri Mar 07 00:00:00 UTC 2014
Proof of concept for AAV2/5-mediated gene therapy in iPSC-derived retinal pigment epithelium of a choroideremia patient.
Molecular therapy. Methods & clinical development
Cereso N,Pequignot MO,Robert L,Becker F,De Luca V,Nabholz N,Rigau V,De Vos J,Hamel CP,Kalatzis V
Wed May 27 00:00:00 UTC 2015
Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells.
The Journal of biological chemistry
Bruntz RC,Taylor HE,Lindsley CW,Brown HA
Fri Jan 10 00:00:00 UTC 2014
Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne muscular dystrophy patient-derived cardiomyocytes.
Molecular therapy. Methods & clinical development
Zatti S,Martewicz S,Serena E,Uno N,Giobbe G,Kazuki Y,Oshimura M,Elvassore N
Wed May 27 00:00:00 UTC 2015
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Nature communications
Henze AT,Garvalov BK,Seidel S,Cuesta AM,Ritter M,Filatova A,Foss F,Dopeso H,Essmann CL,Maxwell PH,Reifenberger G,Carmeliet P,Acker-Palmer A,Acker T
Tue Nov 25 00:00:00 UTC 2014
Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance.
Cell death & disease
Dahan P,Martinez Gala J,Delmas C,Monferran S,Malric L,Zentkowski D,Lubrano V,Toulas C,Cohen-Jonathan Moyal E,Lemarie A
Thu Nov 27 00:00:00 UTC 2014
Notch signaling regulates myogenic regenerative capacity of murine and human mesoangioblasts.
Cell death & disease
Quattrocelli M,Costamagna D,Giacomazzi G,Camps J,Sampaolesi M
Thu Oct 09 00:00:00 UTC 2014
Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency.
Cell death & disease
Carlessi L,Fusar Poli E,Bechi G,Mantegazza M,Pascucci B,Narciso L,Dogliotti E,Sala C,Verpelli C,Lecis D,Delia D
Thu Jul 17 00:00:00 UTC 2014
Enrichment of c-Met+ tumorigenic stromal cells of giant cell tumor of bone and targeting by cabozantinib.
Cell death & disease
Liu L,Aleksandrowicz E,Fan P,Schönsiegel F,Zhang Y,Sähr H,Gladkich J,Mattern J,Depeweg D,Lehner B,Fellenberg J,Herr I
Thu Oct 16 00:00:00 UTC 2014
Contribution of TIP30 to chemoresistance in laryngeal carcinoma.
Cell death & disease
Zhu M,Yin F,Yang L,Chen S,Chen R,Zhou X,Jing W,Fan X,Jia R,Wang H,Zheng H,Zhao J,Guo Y
Thu Oct 16 00:00:00 UTC 2014
The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases.
Scientific reports
Chen L,Fan J,Chen H,Meng Z,Chen Z,Wang P,Liu L
Fri Aug 01 00:00:00 UTC 2014
Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation.
Glia
Dai J,Bercury KK,Macklin WB
100-18B was used in Cell Culture to clarify the interactions between the Akt, mTOR, and Erk 1/2 major signaling pathways and understand more specifically the crosstalk between them.
Mon Dec 01 00:00:00 UTC 2014
High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells.
The Journal of biological chemistry
Hakim F,Kaitsuka T,Raeed JM,Wei FY,Shiraki N,Akagi T,Yokota T,Kume S,Tomizawa K
Fri Apr 04 00:00:00 UTC 2014
High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells.
The Journal of biological chemistry
Hakim F,Kaitsuka T,Raeed JM,Wei FY,Shiraki N,Akagi T,Yokota T,Kume S,Tomizawa K
Fri Apr 04 00:00:00 UTC 2014
A single-cell and feeder-free culture system for monkey embryonic stem cells.
PloS one
Ono T,Suzuki Y,Kato Y,Fujita R,Araki T,Yamashita T,Kato H,Torii R,Sato N
100-18B was used in Cell Culture to report a new single-cell and feeder-free culture system for primate pluripotent stem cells (PSCs), the key feature of which is an originally formulated serum-free medium containing FGF and activin to serve as a reliable platform to prepare primate PSCs useful for future research and application.
Mon Sep 29 00:00:00 UTC 2014
A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype.
Cell death & disease
Gangoso E,Thirant C,Chneiweiss H,Medina JM,Tabernero A
Thu Jan 23 00:00:00 UTC 2014
Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis.
The Journal of biological chemistry
Bolós M,Hu Y,Young KM,Foa L,Small DH
Fri Nov 07 00:00:00 UTC 2014
Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer.
Cell death & disease
Feng Y,Zhu M,Dangelmajer S,Lee YM,Wijesekera O,Castellanos CX,Denduluri A,Chaichana KL,Li Q,Zhang H,Levchenko A,Guerrero-Cazares H,Quiñones-Hinojosa A
Thu Dec 11 00:00:00 UTC 2014
Bioreactor cultivation of anatomically shaped human bone grafts.
Methods in molecular biology (Clifton, N.J.)
Temple JP,Yeager K,Bhumiratana S,Vunjak-Novakovic G,Grayson WL
100-18B was used in Cell Culture to describe a method for engineering bone grafts in vitro with the specific geometry of the temporomandibular joint (TMJ) condyle for creating patient-specific bone grafts of varying shapes and sizes.
Thu Feb 12 00:00:00 UTC 2015
Cerebral organoids model human brain development and microcephaly.
Nature
Lancaster MA,Renner M,Martin CA,Wenzel D,Bicknell LS,Hurles ME,Homfray T,Penninger JM,Jackson AP,Knoblich JA
Thu Sep 19 00:00:00 UTC 2013
Derivation of novel human ground state naive pluripotent stem cells.
Nature
Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH
Thu Dec 12 00:00:00 UTC 2013
Derivation of novel human ground state naive pluripotent stem cells.
Nature
Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH
Thu Dec 12 00:00:00 UTC 2013
Deterministic direct reprogramming of somatic cells to pluripotency.
Nature
Rais Y,Zviran A,Geula S,Gafni O,Chomsky E,Viukov S,Mansour AA,Caspi I,Krupalnik V,Zerbib M,Maza I,Mor N,Baran D,Weinberger L,Jaitin DA,Lara-Astiaso D,Blecher-Gonen R,Shipony Z,Mukamel Z,Hagai T,Gilad S,Amann-Zalcenstein D,Tanay A,Amit I,Novershtern N,Hanna JH
Thu Oct 03 00:00:00 UTC 2013
Deterministic direct reprogramming of somatic cells to pluripotency.
Nature
Rais Y,Zviran A,Geula S,Gafni O,Chomsky E,Viukov S,Mansour AA,Caspi I,Krupalnik V,Zerbib M,Maza I,Mor N,Baran D,Weinberger L,Jaitin DA,Lara-Astiaso D,Blecher-Gonen R,Shipony Z,Mukamel Z,Hagai T,Gilad S,Amann-Zalcenstein D,Tanay A,Amit I,Novershtern N,Hanna JH
Thu Oct 03 00:00:00 UTC 2013
High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias.
Nature methods
Nazareth EJ,Ostblom JE,Lücker PB,Shukla S,Alvarez MM,Oh SK,Yin T,Zandstra PW
Sun Dec 01 00:00:00 UTC 2013
Optogenetic protein clustering and signaling activation in mammalian cells.
Nature methods
Bugaj LJ,Choksi AT,Mesuda CK,Kane RS,Schaffer DV
Fri Mar 01 00:00:00 UTC 2013
Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA.
Cell research
Lui KO,Zangi L,Silva EA,Bu L,Sahara M,Li RA,Mooney DJ,Chien KR
Tue Oct 01 00:00:00 UTC 2013
CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age.
Blood
Gekas C,Graf T
Thu May 30 00:00:00 UTC 2013
Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells.
Blood
Merling RK,Sweeney CL,Choi U,De Ravin SS,Myers TG,Otaizo-Carrasquero F,Pan J,Linton G,Chen L,Koontz S,Theobald NL,Malech HL
Thu Apr 04 00:00:00 UTC 2013
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.
Blood
Amabile G,Welner RS,Nombela-Arrieta C,D'Alise AM,Di Ruscio A,Ebralidze AK,Kraytsberg Y,Ye M,Kocher O,Neuberg DS,Khrapko K,Silberstein LE,Tenen DG
Thu Feb 21 00:00:00 UTC 2013
Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer.
Blood
Zhang H,Maric I,DiPrima MJ,Khan J,Orentas RJ,Kaplan RN,Mackall CL
Thu Aug 15 00:00:00 UTC 2013
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.
The Journal of clinical investigation
Niola F,Zhao X,Singh D,Sullivan R,Castano A,Verrico A,Zoppoli P,Friedmann-Morvinski D,Sulman E,Barrett L,Zhuang Y,Verma I,Benezra R,Aldape K,Iavarone A,Lasorella A
Tue Jan 01 00:00:00 UTC 2013
Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques.
The Journal of clinical investigation
Hayashi T,Wakao S,Kitada M,Ose T,Watabe H,Kuroda Y,Mitsunaga K,Matsuse D,Shigemoto T,Ito A,Ikeda H,Fukuyama H,Onoe H,Tabata Y,Dezawa M
Tue Jan 01 00:00:00 UTC 2013
Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.
The Journal of clinical investigation
Pozo N,Zahonero C,Fernández P,Liñares JM,Ayuso A,Hagiwara M,Pérez A,Ricoy JR,Hernández-Laín A,Sepúlveda JM,Sánchez-Gómez P
Sat Jun 01 00:00:00 UTC 2013
Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.
The Journal of clinical investigation
Winkler T,Hong SG,Decker JE,Morgan MJ,Wu C,Hughes WM,Yang Y,Wangsa D,Padilla-Nash HM,Ried T,Young NS,Dunbar CE,Calado RT
Wed May 01 00:00:00 UTC 2013
Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.
The Journal of clinical investigation
Winkler T,Hong SG,Decker JE,Morgan MJ,Wu C,Hughes WM,Yang Y,Wangsa D,Padilla-Nash HM,Ried T,Young NS,Dunbar CE,Calado RT
Wed May 01 00:00:00 UTC 2013
Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells.
The Journal of clinical investigation
Chen X,Ying Z,Lin X,Lin H,Wu J,Li M,Song L
Sat Jun 01 00:00:00 UTC 2013
In vitro growth factor-induced bio engineering of mature articular cartilage.
Biomaterials
Khan IM,Francis L,Theobald PS,Perni S,Young RD,Prokopovich P,Conlan RS,Archer CW
Fri Feb 01 00:00:00 UTC 2013
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery.
Genes & development
Bezzi M,Teo SX,Muller J,Mok WC,Sahu SK,Vardy LA,Bonday ZQ,Guccione E
100-18B was used in Cell Culture to investigate splicing by PRMT5 in mammalian development.
Sun Sep 01 00:00:00 UTC 2013
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.
Proceedings of the National Academy of Sciences of the United States of America
Serio A,Bilican B,Barmada SJ,Ando DM,Zhao C,Siller R,Burr K,Haghi G,Story D,Nishimura AL,Carrasco MA,Phatnani HP,Shum C,Wilmut I,Maniatis T,Shaw CE,Finkbeiner S,Chandran S
Tue Mar 19 00:00:00 UTC 2013
Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model.
Proceedings of the National Academy of Sciences of the United States of America
Cheema TA,Wakimoto H,Fecci PE,Ning J,Kuroda T,Jeyaretna DS,Martuza RL,Rabkin SD
Tue Jul 16 00:00:00 UTC 2013
Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Anacker C,Cattaneo A,Musaelyan K,Zunszain PA,Horowitz M,Molteni R,Luoni A,Calabrese F,Tansey K,Gennarelli M,Thuret S,Price J,Uher R,Riva MA,Pariante CM
Tue May 21 00:00:00 UTC 2013
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.
Proceedings of the National Academy of Sciences of the United States of America
Shchors K,Persson AI,Rostker F,Tihan T,Lyubynska N,Li N,Swigart LB,Berger MS,Hanahan D,Weiss WA,Evan GI
Tue Apr 16 00:00:00 UTC 2013
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.
Proceedings of the National Academy of Sciences of the United States of America
Shchors K,Persson AI,Rostker F,Tihan T,Lyubynska N,Li N,Swigart LB,Berger MS,Hanahan D,Weiss WA,Evan GI
Tue Apr 16 00:00:00 UTC 2013
PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.
Proceedings of the National Academy of Sciences of the United States of America
Iwanami A,Gini B,Zanca C,Matsutani T,Assuncao A,Nael A,Dang J,Yang H,Zhu S,Kohyama J,Kitabayashi I,Cavenee WK,Cloughesy TF,Furnari FB,Nakamura M,Toyama Y,Okano H,Mischel PS
Tue Mar 12 00:00:00 UTC 2013
Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress.
Proceedings of the National Academy of Sciences of the United States of America
Kristensen U,Epanchintsev A,Rauschendorf MA,Laugel V,Stevnsner T,Bohr VA,Coin F,Egly JM
Tue Jun 18 00:00:00 UTC 2013
Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress.
Proceedings of the National Academy of Sciences of the United States of America
Kristensen U,Epanchintsev A,Rauschendorf MA,Laugel V,Stevnsner T,Bohr VA,Coin F,Egly JM
Tue Jun 18 00:00:00 UTC 2013
Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America
Zhou J,Patel TR,Sirianni RW,Strohbehn G,Zheng MQ,Duong N,Schafbauer T,Huttner AJ,Huang Y,Carson RE,Zhang Y,Sullivan DJ,Piepmeier JM,Saltzman WM
Tue Jul 16 00:00:00 UTC 2013
Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles.
Proceedings of the National Academy of Sciences of the United States of America
Hikichi T,Matoba R,Ikeda T,Watanabe A,Yamamoto T,Yoshitake S,Tamura-Nakano M,Kimura T,Kamon M,Shimura M,Kawakami K,Okuda A,Okochi H,Inoue T,Suzuki A,Masui S
Tue Apr 16 00:00:00 UTC 2013
Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme.
Oncogene
Wang Y,Moncayo G,Morin P,Xue G,Grzmil M,Lino MM,Clément-Schatlo V,Frank S,Merlo A,Hemmings BA
Thu Feb 14 00:00:00 UTC 2013
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.
The Journal of cell biology
Ahmed Z,Lin CC,Suen KM,Melo FA,Levitt JA,Suhling K,Ladbury JE
Mon Feb 18 00:00:00 UTC 2013
Fibroblast growth factor-2 and bone morphogenetic protein-2 have a synergistic stimulatory effect on bone formation in cell cultures from elderly mouse and human bone.
The journals of gerontology. Series A, Biological sciences and medical sciences
Kuhn LT,Ou G,Charles L,Hurley MM,Rodner CM,Gronowicz G
Tue Oct 01 00:00:00 UTC 2013
Fibroblast growth factor-2 and bone morphogenetic protein-2 have a synergistic stimulatory effect on bone formation in cell cultures from elderly mouse and human bone.
The journals of gerontology. Series A, Biological sciences and medical sciences
Kuhn LT,Ou G,Charles L,Hurley MM,Rodner CM,Gronowicz G
Tue Oct 01 00:00:00 UTC 2013
MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.
Stem cells (Dayton, Ohio)
Joshi K,Banasavadi-Siddegowda Y,Mo X,Kim SH,Mao P,Kig C,Nardini D,Sobol RW,Chow LM,Kornblum HI,Waclaw R,Beullens M,Nakano I
Sat Jun 01 00:00:00 UTC 2013
Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.
Stem cells (Dayton, Ohio)
White MP,Rufaihah AJ,Liu L,Ghebremariam YT,Ivey KN,Cooke JP,Srivastava D
Tue Jan 01 00:00:00 UTC 2013
Promoting reprogramming by FGF2 reveals that the extracellular matrix is a barrier for reprogramming fibroblasts to pluripotency.
Stem cells (Dayton, Ohio)
Jiao J,Dang Y,Yang Y,Gao R,Zhang Y,Kou Z,Sun XF,Gao S
Mon Apr 01 00:00:00 UTC 2013
Promoting reprogramming by FGF2 reveals that the extracellular matrix is a barrier for reprogramming fibroblasts to pluripotency.
Stem cells (Dayton, Ohio)
Jiao J,Dang Y,Yang Y,Gao R,Zhang Y,Kou Z,Sun XF,Gao S
Mon Apr 01 00:00:00 UTC 2013
Zac1 regulates astroglial differentiation of neural stem cells through Socs3.
Stem cells (Dayton, Ohio)
Schmidt-Edelkraut U,Hoffmann A,Daniel G,Spengler D
Thu Aug 01 00:00:00 UTC 2013
Zac1 regulates astroglial differentiation of neural stem cells through Socs3.
Stem cells (Dayton, Ohio)
Schmidt-Edelkraut U,Hoffmann A,Daniel G,Spengler D
Thu Aug 01 00:00:00 UTC 2013
Wnt and Notch signals guide embryonic stem cell differentiation into the intestinal lineages.
Stem cells (Dayton, Ohio)
Ogaki S,Shiraki N,Kume K,Kume S
Sat Jun 01 00:00:00 UTC 2013
Wnt and Notch signals guide embryonic stem cell differentiation into the intestinal lineages.
Stem cells (Dayton, Ohio)
Ogaki S,Shiraki N,Kume K,Kume S
Sat Jun 01 00:00:00 UTC 2013
IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.
Stem cells (Dayton, Ohio)
Osuka S,Sampetrean O,Shimizu T,Saga I,Onishi N,Sugihara E,Okubo J,Fujita S,Takano S,Matsumura A,Saya H
Mon Apr 01 00:00:00 UTC 2013
IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.
Stem cells (Dayton, Ohio)
Osuka S,Sampetrean O,Shimizu T,Saga I,Onishi N,Sugihara E,Okubo J,Fujita S,Takano S,Matsumura A,Saya H
Mon Apr 01 00:00:00 UTC 2013
Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration.
Stem cells (Dayton, Ohio)
Kim C,Schneider G,Abdel-Latif A,Mierzejewska K,Sunkara M,Borkowska S,Ratajczak J,Morris AJ,Kucia M,Ratajczak MZ
Fri Mar 01 00:00:00 UTC 2013
Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNFα and the hormonal and growth-supporting arms of the tumor microenvironment.
Mediators of inflammation
Weitzenfeld P,Meron N,Leibovich-Rivkin T,Meshel T,Ben-Baruch A
100-18B was used in In vitro experiments to indicate that TNF α can turn into a strong prometastatic factor, suggesting a paradigm shift in which clinically approved inhibitors of TNFα would be applied in breast cancer therapy.
Thu Jun 05 00:00:00 UTC 2014
Glioma stem cell-targeted dendritic cells as a tumor vaccine against malignant glioma.
Yonsei medical journal
Ji B,Chen Q,Liu B,Wu L,Tian D,Guo Z,Yi W
Tue Jan 01 00:00:00 UTC 2013
Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model.
Journal of translational medicine
Touboul C,Lis R,Al Farsi H,Raynaud CM,Warfa M,Althawadi H,Mery E,Mirshahi M,Rafii A
Thu Jan 31 00:00:00 UTC 2013
Understanding the role of growth factors in modulating stem cell tenogenesis.
PloS one
Gonçalves AI,Rodrigues MT,Lee SJ,Atala A,Yoo JJ,Reis RL,Gomes ME
100-18B was used in Cell Culture to study the tenogenic differentiation potential of human- amniotic fluid stem cells (hAFSCs) and adipose-derived stem cells (hASCs) with associated GFs like EGF, bFGF, PDGF-BB and TGF-β1. EGF and bFGF influenced the expression of tendon-related genes in hAFSCs, while EGF and PDGF-BB stimulated the genetic expression in hASCs leading to a conclusion that hASCs and hAFSCs have potential for tendon regeneration.
Tue Sep 16 00:00:00 UTC 2014
In vitro expansion of fetal neural progenitors as adherent cell lines.
Methods in molecular biology (Clifton, N.J.)
Pollard SM
100-18B was used in Cell Culture to describe protocols and troubleshooting advice for establishing adherent NS cell lines from the mouse fetal forebrain.
Tue Feb 25 00:00:00 UTC 2014
Demarcation of stable subpopulations within the pluripotent hESC compartment.
PloS one
Bhatia S,Pilquil C,Roth-Albin I,Draper JS
Tue Aug 06 00:00:00 UTC 2013
Separate developmental programs for HLA-A and -B cell surface expression during differentiation from embryonic stem cells to lymphocytes, adipocytes and osteoblasts.
PloS one
Sabir HJ,Nehlin JO,Qanie D,Harkness L,Prokhorova TA,Blagoev B,Kassem M,Isa A,Barington T
Fri Jul 19 00:00:00 UTC 2013
Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.
PloS one
Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG
Thu Aug 08 00:00:00 UTC 2013
Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.
PloS one
Pick M,Azzola L,Osborne E,Stanley EG,Elefanty AG
Thu Aug 08 00:00:00 UTC 2013
A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice.
The Journal of biological chemistry
Hennen E,Safina D,Haussmann U,Wörsdörfer P,Edenhofer F,Poetsch A,Faissner A
Fri Jun 07 00:00:00 UTC 2013
Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow.
The Journal of biological chemistry
Ferreira E,Porter RM,Wehling N,O'Sullivan RP,Liu F,Boskey A,Estok DM,Harris MB,Vrahas MS,Evans CH,Wells JW
Fri Oct 11 00:00:00 UTC 2013
Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury.
Molecular brain
Nishimura S,Yasuda A,Iwai H,Takano M,Kobayashi Y,Nori S,Tsuji O,Fujiyoshi K,Ebise H,Toyama Y,Okano H,Nakamura M
Tue Jan 08 00:00:00 UTC 2013
mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions.
Scientific reports
Matsubara S,Ding Q,Miyazaki Y,Kuwahata T,Tsukasa K,Takao S
Fri Nov 15 00:00:00 UTC 2013
A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation.
PloS one
Nieto-Estévez V,Pignatelli J,Araúzo-Bravo MJ,Hurtado-Chong A,Vicario-Abejón C
Tue Jul 02 00:00:00 UTC 2013
FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo.
PloS one
Brun J,Dieudonné FX,Marty C,Müller J,Schüle R,Patiño-García A,Lecanda F,Fromigué O,Marie PJ
Fri Jul 19 00:00:00 UTC 2013
Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening.
Translational psychiatry
Boissart C,Poulet A,Georges P,Darville H,Julita E,Delorme R,Bourgeron T,Peschanski M,Benchoua A
Tue Aug 20 00:00:00 UTC 2013
Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.
The Journal of biological chemistry
Gourlaouen M,Welti JC,Vasudev NS,Reynolds AR
Fri Mar 15 00:00:00 UTC 2013
Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.
The Journal of biological chemistry
Tugues S,Honjo S,König C,Padhan N,Kroon J,Gualandi L,Li X,Barkefors I,Thijssen VL,Griffioen AW,Claesson-Welsh L
Fri Jun 28 00:00:00 UTC 2013
Identification and characterization of cells with cancer stem cell properties in human primary lung cancer cell lines.
PloS one
Wang P,Gao Q,Suo Z,Munthe E,Solberg S,Ma L,Wang M,Westerdaal NA,Kvalheim G,Gaudernack G
Tue Aug 27 00:00:00 UTC 2013
Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.
PloS one
McNamara CR,Ahuja R,Osafo-Addo AD,Barrows D,Kettenbach A,Skidan I,Teng X,Cuny GD,Gerber S,Degterev A
Tue Aug 27 00:00:00 UTC 2013
N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.
The Journal of biological chemistry
Long PM,Moffett JR,Namboodiri AMA,Viapiano MS,Lawler SE,Jaworski DM
Fri Sep 06 00:00:00 UTC 2013
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
The Journal of biological chemistry
Yamaguchi Y,Shao Z,Sharif S,Du XY,Myles T,Merchant M,Harsh G,Glantz M,Recht L,Morser J,Leung LL
Fri Feb 01 00:00:00 UTC 2013
Interdigital cell death in the embryonic limb is associated with depletion of Reelin in the extracellular matrix.
Cell death & disease
Díaz-Mendoza MJ,Lorda-Diez CI,Montero JA,García-Porrero JA,Hurlé JM
Thu Sep 12 00:00:00 UTC 2013
Krüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells.
PloS one
Leng Z,Tao K,Xia Q,Tan J,Yue Z,Chen J,Xi H,Li J,Zheng H
Tue Aug 27 00:00:00 UTC 2013
Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells.
The Journal of biological chemistry
Hu Y,Hung AC,Cui H,Dawkins E,Bolós M,Foa L,Young KM,Small DH
Fri Jun 28 00:00:00 UTC 2013
Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis.
PloS one
Attoub S,Arafat K,Gélaude A,Al Sultan MA,Bracke M,Collin P,Takahashi T,Adrian TE,De Wever O
Mon Jul 01 00:00:00 UTC 2013
Cancer-initiating cells derived from human rectal adenocarcinoma tissues carry mesenchymal phenotypes and resist drug therapies.
Cell death & disease
Fan CW,Chen T,Shang YN,Gu YZ,Zhang SL,Lu R,OuYang SR,Zhou X,Li Y,Meng WT,Hu JK,Lu Y,Sun XF,Bu H,Zhou ZG,Mo XM
Thu Oct 03 00:00:00 UTC 2013
Cancer-initiating cells derived from human rectal adenocarcinoma tissues carry mesenchymal phenotypes and resist drug therapies.
Cell death & disease
Fan CW,Chen T,Shang YN,Gu YZ,Zhang SL,Lu R,OuYang SR,Zhou X,Li Y,Meng WT,Hu JK,Lu Y,Sun XF,Bu H,Zhou ZG,Mo XM
Thu Oct 03 00:00:00 UTC 2013
The neurosphere assay applied to neural stem cells and cancer stem cells.
Methods in molecular biology (Clifton, N.J.)
Galli R
100-18B was used in Cell Culture to describe the methods currently employed to enrich for NSCs/CSCs based on the NeuroSphere Assay (NSA) and their adaptation to specific assays for testing the efficacy of neuroactive compounds.
Wed Aug 07 00:00:00 UTC 2013
Epigenetic regulation during fetal femur development: DNA methylation matters.
PloS one
de Andrés MC,Kingham E,Imagawa K,Gonzalez A,Roach HI,Wilson DI,Oreffo RO
Fri Jul 19 00:00:00 UTC 2013
Epigenetic regulation during fetal femur development: DNA methylation matters.
PloS one
de Andrés MC,Kingham E,Imagawa K,Gonzalez A,Roach HI,Wilson DI,Oreffo RO
Fri Jul 19 00:00:00 UTC 2013
Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.
Development (Cambridge, England)
Palpant NJ,Pabon L,Rabinowitz JS,Hadland BK,Stoick-Cooper CL,Paige SL,Bernstein ID,Moon RT,Murry CE
100-18B was used in Cell Culture to study how transmembrane protein 88 (TMEM88) is crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development through inhibition of Wnt/β-catenin signaling.
Sun Sep 01 00:00:00 UTC 2013
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.
Nature
Turcan S,Rohle D,Goenka A,Walsh LA,Fang F,Yilmaz E,Campos C,Fabius AW,Lu C,Ward PS,Thompson CB,Kaufman A,Guryanova O,Levine R,Heguy A,Viale A,Morris LG,Huse JT,Mellinghoff IK,Chan TA
Wed Feb 15 00:00:00 UTC 2012
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Nature
Wilson TR,Fridlyand J,Yan Y,Penuel E,Burton L,Chan E,Peng J,Lin E,Wang Y,Sosman J,Ribas A,Li J,Moffat J,Sutherlin DP,Koeppen H,Merchant M,Neve R,Settleman J
Thu Jul 26 00:00:00 UTC 2012
The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.
Nature
Mansour AA,Gafni O,Weinberger L,Zviran A,Ayyash M,Rais Y,Krupalnik V,Zerbib M,Amann-Zalcenstein D,Maza I,Geula S,Viukov S,Holtzman L,Pribluda A,Canaani E,Horn-Saban S,Amit I,Novershtern N,Hanna JH
Thu Aug 16 00:00:00 UTC 2012
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development.
Cell
Paige SL,Thomas S,Stoick-Cooper CL,Wang H,Maves L,Sandstrom R,Pabon L,Reinecke H,Pratt G,Keller G,Moon RT,Stamatoyannopoulos J,Murry CE
Fri Sep 28 00:00:00 UTC 2012
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.
Cell
Van Handel B,Montel-Hagen A,Sasidharan R,Nakano H,Ferrari R,Boogerd CJ,Schredelseker J,Wang Y,Hunter S,Org T,Zhou J,Li X,Pellegrini M,Chen JN,Orkin SH,Kurdistani SK,Evans SM,Nakano A,Mikkola HK
Fri Aug 03 00:00:00 UTC 2012
A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy.
Cell
Cabianca DS,Casa V,Bodega B,Xynos A,Ginelli E,Tanaka Y,Gabellini D
Fri May 11 00:00:00 UTC 2012
Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice.
Cell research
Wang Y,Zheng CG,Jiang Y,Zhang J,Chen J,Yao C,Zhao Q,Liu S,Chen K,Du J,Yang Z,Gao S
Sun Apr 01 00:00:00 UTC 2012
The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas.
Cancer cell
Binda E,Visioli A,Giani F,Lamorte G,Copetti M,Pitter KL,Huse JT,Cajola L,Zanetti N,DiMeco F,De Filippis L,Mangiola A,Maira G,Anile C,De Bonis P,Reynolds BA,Pasquale EB,Vescovi AL
Tue Dec 11 00:00:00 UTC 2012
A mouse model of the most aggressive subgroup of human medulloblastoma.
Cancer cell
Kawauchi D,Robinson G,Uziel T,Gibson P,Rehg J,Gao C,Finkelstein D,Qu C,Pounds S,Ellison DW,Gilbertson RJ,Roussel MF
Tue Feb 14 00:00:00 UTC 2012
Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.
Blood
Kumano K,Arai S,Hosoi M,Taoka K,Takayama N,Otsu M,Nagae G,Ueda K,Nakazaki K,Kamikubo Y,Eto K,Aburatani H,Nakauchi H,Kurokawa M
Thu Jun 28 00:00:00 UTC 2012
APELIN promotes hematopoiesis from human embryonic stem cells.
Blood
Yu QC,Hirst CE,Costa M,Ng ES,Schiesser JV,Gertow K,Stanley EG,Elefanty AG
Thu Jun 28 00:00:00 UTC 2012
Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells.
The Journal of clinical investigation
Varela C,Denis JA,Polentes J,Feyeux M,Aubert S,Champon B,Piétu G,Peschanski M,Lefort N
Wed Feb 01 00:00:00 UTC 2012
Transposon-mediated BAC transgenesis in human ES cells.
Nucleic acids research
Rostovskaya M,Fu J,Obst M,Baer I,Weidlich S,Wang H,Smith AJ,Anastassiadis K,Stewart AF
Mon Oct 01 00:00:00 UTC 2012
Transposon-mediated BAC transgenesis in human ES cells.
Nucleic acids research
Rostovskaya M,Fu J,Obst M,Baer I,Weidlich S,Wang H,Smith AJ,Anastassiadis K,Stewart AF
Mon Oct 01 00:00:00 UTC 2012
Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression.
Nature protocols
Dowey SN,Huang X,Chou BK,Ye Z,Cheng L
100-18B was used in Cell Culture to describe a detailed, validated protocol for effective generation of integration-free human induced pluripotent stem cells from blood mononuclear cells by plasmid vectors.
Thu Nov 01 00:00:00 UTC 2012
Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.
EMBO molecular medicine
Sánchez-Danés A,Richaud-Patin Y,Carballo-Carbajal I,Jiménez-Delgado S,Caig C,Mora S,Di Guglielmo C,Ezquerra M,Patel B,Giralt A,Canals JM,Memo M,Alberch J,López-Barneo J,Vila M,Cuervo AM,Tolosa E,Consiglio A,Raya A
Tue May 01 00:00:00 UTC 2012
Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach.
Molecular therapy : the journal of the American Society of Gene Therapy
Moschidou D,Mukherjee S,Blundell MP,Drews K,Jones GN,Abdulrazzak H,Nowakowska B,Phoolchund A,Lay K,Ramasamy TS,Cananzi M,Nettersheim D,Sullivan M,Frost J,Moore G,Vermeesch JR,Fisk NM,Thrasher AJ,Atala A,Adjaye J,Schorle H,De Coppi P,Guillot PV
Mon Oct 01 00:00:00 UTC 2012
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.
Proceedings of the National Academy of Sciences of the United States of America
Bilican B,Serio A,Barmada SJ,Nishimura AL,Sullivan GJ,Carrasco M,Phatnani HP,Puddifoot CA,Story D,Fletcher J,Park IH,Friedman BA,Daley GQ,Wyllie DJ,Hardingham GE,Wilmut I,Finkbeiner S,Maniatis T,Shaw CE,Chandran S
Tue Apr 10 00:00:00 UTC 2012
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.
Proceedings of the National Academy of Sciences of the United States of America
Bilican B,Serio A,Barmada SJ,Nishimura AL,Sullivan GJ,Carrasco M,Phatnani HP,Puddifoot CA,Story D,Fletcher J,Park IH,Friedman BA,Daley GQ,Wyllie DJ,Hardingham GE,Wilmut I,Finkbeiner S,Maniatis T,Shaw CE,Chandran S
Tue Apr 10 00:00:00 UTC 2012
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.
Proceedings of the National Academy of Sciences of the United States of America
Giorgetti A,Marchetto MC,Li M,Yu D,Fazzina R,Mu Y,Adamo A,Paramonov I,Cardoso JC,Monasterio MB,Bardy C,Cassiani-Ingoni R,Liu GH,Gage FH,Izpisua Belmonte JC
Tue Jul 31 00:00:00 UTC 2012
ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America
Hinohara K,Kobayashi S,Kanauchi H,Shimizu S,Nishioka K,Tsuji E,Tada K,Umezawa K,Mori M,Ogawa T,Inoue J,Tojo A,Gotoh N
Tue Apr 24 00:00:00 UTC 2012
Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells.
Environmental health perspectives
Kim MJ,Pelloux V,Guyot E,Tordjman J,Bui LC,Chevallier A,Forest C,Benelli C,Clément K,Barouki R
Sun Apr 01 00:00:00 UTC 2012
INS(GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells.
Diabetologia
Micallef SJ,Li X,Schiesser JV,Hirst CE,Yu QC,Lim SM,Nostro MC,Elliott DA,Sarangi F,Harrison LC,Keller G,Elefanty AG,Stanley EG
Thu Mar 01 00:00:00 UTC 2012
The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation.
British journal of cancer
Isham CR,Tibodeau JD,Bossou AR,Merchan JR,Bible KC
Tue Jan 17 00:00:00 UTC 2012
EGF signalling pathway regulates colon cancer stem cell proliferation and apoptosis.
Cell proliferation
Feng Y,Dai X,Li X,Wang H,Liu J,Zhang J,Du Y,Xia L
Mon Oct 01 00:00:00 UTC 2012
Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.
Stem cells translational medicine
Hasegawa K,Yasuda SY,Teo JL,Nguyen C,McMillan M,Hsieh CL,Suemori H,Nakatsuji N,Yamamoto M,Miyabayashi T,Lutzko C,Pera MF,Kahn M
Sun Jan 01 00:00:00 UTC 2012
From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols.
Stem cells translational medicine
Karumbayaram S,Lee P,Azghadi SF,Cooper AR,Patterson M,Kohn DB,Pyle A,Clark A,Byrne J,Zack JA,Plath K,Lowry WE
Sun Jan 01 00:00:00 UTC 2012
Treatment of breast cancer stem cells with oncolytic herpes simplex virus.
Cancer gene therapy
Li J,Zeng W,Huang Y,Zhang Q,Hu P,Rabkin SD,Liu R
Mon Oct 01 00:00:00 UTC 2012
Grafted neuronal precursor cells differentiate and integrate in injured hippocampus in experimental pneumococcal meningitis.
Stem cells (Dayton, Ohio)
Hofer S,Magloire V,Streit J,Leib SL
Fri Jun 01 00:00:00 UTC 2012
Rai is a new regulator of neural progenitor migration and glioblastoma invasion.
Stem cells (Dayton, Ohio)
Ortensi B,Osti D,Pellegatta S,Pisati F,Brescia P,Fornasari L,Levi D,Gaetani P,Colombo P,Ferri A,Nicolis S,Finocchiaro G,Pelicci G
Tue May 01 00:00:00 UTC 2012
MicroRNAs regulate p21(Waf1/Cip1) protein expression and the DNA damage response in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Dolezalova D,Mraz M,Barta T,Plevova K,Vinarsky V,Holubcova Z,Jaros J,Dvorak P,Pospisilova S,Hampl A
Sun Jul 01 00:00:00 UTC 2012
Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio)
Nefzger CM,Su CT,Fabb SA,Hartley BJ,Beh SJ,Zeng WR,Haynes JM,Pouton CW
Sun Jul 01 00:00:00 UTC 2012
Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity.
Stem cells (Dayton, Ohio)
Voon DC,Wang H,Koo JK,Nguyen TA,Hor YT,Chu YS,Ito K,Fukamachi H,Chan SL,Thiery JP,Ito Y
Mon Oct 01 00:00:00 UTC 2012
Two preferentially expressed proteins protect vascular endothelial cells from an attack by peptide-specific CTL.
Journal of immunology (Baltimore, Md. : 1950)
Thommen DS,Schuster H,Keller M,Kapoor S,Weinzierl AO,Chennakesava CS,Wang X,Rohrer L,von Eckardstein A,Stevanovic S,Biedermann BC
Fri Jun 01 00:00:00 UTC 2012
Synergistic action of fibroblast growth factor-2 and transforming growth factor-beta1 enhances bioprinted human neocartilage formation.
Biotechnology and bioengineering
Cui X,Breitenkamp K,Lotz M,D'Lima D
Sat Sep 01 00:00:00 UTC 2012
FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast.
Stem cells and development
Sudheer S,Bhushan R,Fauler B,Lehrach H,Adjaye J
Thu Nov 01 00:00:00 UTC 2012
FGF2 mediates DNA repair in epidermoid carcinoma cells exposed to ionizing radiation.
International journal of radiation biology
Marie M,Hafner S,Moratille S,Vaigot P,Mine S,Rigaud O,Martin MT
Mon Oct 01 00:00:00 UTC 2012
Sca-1 is involved in the adhesion of myosphere cells to αVβ3 integrin.
Biology open
Penvose A,Westerman KA
Sat Sep 15 00:00:00 UTC 2012
Isolation and biological characterization of chicken amnion epithelial cells.
European journal of histochemistry : EJH
Gao Y,Pu Y,Wang D,Hou L,Guan W,Ma Y
Wed Aug 29 00:00:00 UTC 2012
Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2.
The Journal of biological chemistry
Wang YN,Lee HH,Lee HJ,Du Y,Yamaguchi H,Hung MC
Fri May 11 00:00:00 UTC 2012
Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN.
PloS one
Han M,Liu M,Wang Y,Chen X,Xu J,Sun Y,Zhao L,Qu H,Fan Y,Wu C
Thu Mar 21 00:00:00 UTC 2013
Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism.
PloS one
Killian RL,Flippin JD,Herrera CM,Almenar-Queralt A,Goldstein LS
Mon Jun 11 00:00:00 UTC 2012
Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons.
PloS one
Park TI,Monzo H,Mee EW,Bergin PS,Teoh HH,Montgomery JM,Faull RL,Curtis MA,Dragunow M
Thu Oct 11 00:00:00 UTC 2012
Directed induction of functional motor neuron-like cells from genetically engineered human mesenchymal stem cells.
PloS one
Park HW,Cho JS,Park CK,Jung SJ,Park CH,Lee SJ,Oh SB,Park YS,Chang MS
Thu Aug 23 00:00:00 UTC 2012
Retinoic acid-dependent signaling pathways and lineage events in the developing mouse spinal cord.
PloS one
Paschaki M,Lin SC,Wong RL,Finnell RH,Dollé P,Niederreither K
Mon Jul 23 00:00:00 UTC 2012
Characterization and retinal neuron differentiation of WERI-Rb1 cancer stem cells.
Molecular vision
Hu H,Deng F,Liu Y,Chen M,Zhang X,Sun X,Dong Z,Liu X,Ge J
Tue Jan 29 00:00:00 UTC 2013
Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling.
The Journal of biological chemistry
Amaddii M,Meister M,Banning A,Tomasovic A,Mooz J,Rajalingam K,Tikkanen R
Fri Mar 02 00:00:00 UTC 2012
Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma.
Molecular systems biology
Setty M,Helmy K,Khan AA,Silber J,Arvey A,Neezen F,Agius P,Huse JT,Holland EC,Leslie CS
Mon Jan 14 00:00:00 UTC 2013
Human pluripotent stem cell-derived cardiomyocytes: response to TTX and lidocain reveals strong cell to cell variability.
PloS one
Sheng X,Reppel M,Nguemo F,Mohammad FI,Kuzmenkin A,Hescheler J,Pfannkuche K
Tue Mar 05 00:00:00 UTC 2013
Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.
PloS one
Danova-Alt R,Heider A,Egger D,Cross M,Alt R
Tue Aug 07 00:00:00 UTC 2012
Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells.
PloS one
Zhu R,Yang Y,Tian Y,Bai J,Zhang X,Li X,Peng Z,He Y,Chen L,Pan Q,Fang D,Chen W,Qian C,Bian X,Wang R
Mon Aug 27 00:00:00 UTC 2012
Self-renewal and pluripotency acquired through somatic reprogramming to human cancer stem cells.
PloS one
Nagata S,Hirano K,Kanemori M,Sun LT,Tada T
Thu May 09 00:00:00 UTC 2013
Self-renewal and pluripotency acquired through somatic reprogramming to human cancer stem cells.
PloS one
Nagata S,Hirano K,Kanemori M,Sun LT,Tada T
Thu May 09 00:00:00 UTC 2013
Nuclear translocation of β-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype.
PloS one
Herencia C,Martínez-Moreno JM,Herrera C,Corrales F,Santiago-Mora R,Espejo I,Barco M,Almadén Y,de la Mata M,Rodríguez-Ariza A,Muñoz-Castañeda JR
Wed Oct 17 00:00:00 UTC 2012
Molecular signatures to define spermatogenic cells in common marmoset (Callithrix jacchus).
Reproduction (Cambridge, England)
Lin ZY,Imamura M,Sano C,Nakajima R,Suzuki T,Yamadera R,Takehara Y,Okano HJ,Sasaki E,Okano H
100-18B was used in Cell Culture to provide an important platform for primate reproductive biology, including possible applications to humans.
Tue May 01 00:00:00 UTC 2012
Satellite cell heterogeneity revealed by G-Tool, an open algorithm to quantify myogenesis through colony-forming assays.
Skeletal muscle
Ippolito J,Arpke RW,Haider KT,Zhang J,Kyba M
Fri Jun 15 00:00:00 UTC 2012
Gene expression profile of adult human olfactory bulb and embryonic neural stem cell suggests distinct signaling pathways and epigenetic control.
PloS one
Marei HE,Ahmed AE,Michetti F,Pescatori M,Pallini R,Casalbore P,Cenciarelli C,Elhadidy M
Fri Jul 27 00:00:00 UTC 2012
Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling.
PloS one
Torres J,Prieto J,Durupt FC,Broad S,Watt FM
Tue Sep 04 00:00:00 UTC 2012
Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering.
International journal of nanomedicine
Ziv-Polat O,Skaat H,Shahar A,Margel S
Tue Jun 19 00:00:00 UTC 2012
A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma.
The Journal of biological chemistry
Hayashi H,Eguchi Y,Fukuchi-Nakaishi Y,Takeya M,Nakagata N,Tanaka K,Vance JE,Tanihara H
Fri Jul 20 00:00:00 UTC 2012
Concentration- and time-dependent response of human gingival fibroblasts to fibroblast growth factor 2 immobilized on titanium dental implants.
International journal of nanomedicine
Ma Q,Wang W,Chu PK,Mei S,Ji K,Jin L,Zhang Y
Wed Sep 26 00:00:00 UTC 2012
Concentration- and time-dependent response of human gingival fibroblasts to fibroblast growth factor 2 immobilized on titanium dental implants.
International journal of nanomedicine
Ma Q,Wang W,Chu PK,Mei S,Ji K,Jin L,Zhang Y
Wed Sep 26 00:00:00 UTC 2012
miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma.
BMC cancer
Põlajeva J,Swartling FJ,Jiang Y,Singh U,Pietras K,Uhrbom L,Westermark B,Roswall P
Wed Aug 29 00:00:00 UTC 2012
Differential gene expression profile associated with the abnormality of bone marrow mesenchymal stem cells in aplastic anemia.
PloS one
Li J,Yang S,Lu S,Zhao H,Feng J,Li W,Ma F,Ren Q,Liu B,Zhang L,Zheng Y,Han ZC
Thu Apr 25 00:00:00 UTC 2013
Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics.
PloS one
Ferro F,Spelat R,D'Aurizio F,Puppato E,Pandolfi M,Beltrami AP,Cesselli D,Falini G,Beltrami CA,Curcio F
Wed Nov 28 00:00:00 UTC 2012
Characterization of liposarcoma cell lines for preclinical and biological studies.
Sarcoma
Stratford EW,Castro R,Daffinrud J,Skårn M,Lauvrak S,Munthe E,Myklebost O
Thu Aug 23 00:00:00 UTC 2012
Cryopreservation of human vascular umbilical cord cells under good manufacturing practice conditions for future cell banks.
Journal of translational medicine
Polchow B,Kebbel K,Schmiedeknecht G,Reichardt A,Henrich W,Hetzer R,Lueders C
Wed May 16 00:00:00 UTC 2012
Identification and characterisation of the early differentiating cells in neural differentiation of human embryonic stem cells.
PloS one
Noisa P,Ramasamy TS,Lamont FR,Yu JS,Sheldon MJ,Russell A,Jin X,Cui W
Tue Jan 08 00:00:00 UTC 2013
Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations.
BMC neuroscience
Hicks SD,Lewis L,Ritchie J,Burke P,Abdul-Malak Y,Adackapara N,Canfield K,Shwarts E,Gentile K,Meszaros ZS,Middleton FA
Thu Oct 25 00:00:00 UTC 2012
Stem cell therapy: social recognition recovery in a FASD model.
Translational psychiatry
Shirasaka T,Hashimoto E,Ukai W,Yoshinaga T,Ishii T,Tateno M,Saito T
Tue Nov 13 00:00:00 UTC 2012
Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation.
The Journal of biological chemistry
Spelat R,Ferro F,Curcio F
Fri Nov 02 00:00:00 UTC 2012
Immunotherapy against the radial glia marker GLAST effectively triggers specific antitumor effectors without autoimmunity.
Oncoimmunology
Cantini G,Pisati F,Pessina S,Finocchiaro G,Pellegatta S
Sat Sep 01 00:00:00 UTC 2012
Generation of virus-free induced pluripotent stem cell clones on a synthetic matrix via a single cell subcloning in the naïve state.
PloS one
Nishishita N,Shikamura M,Takenaka C,Takada N,Fusaki N,Kawamata S
Thu Dec 13 00:00:00 UTC 2012
S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.
PloS one
Lacar B,Herman P,Hartman NW,Hyder F,Bordey A
Fri Aug 03 00:00:00 UTC 2012
Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks.
Nature protocols
Shi Y,Kirwan P,Livesey FJ
100-18B was used in Cell Culture to outline a protocol for directing the differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) to all classes of cortical projection neurons.
Mon Oct 01 00:00:00 UTC 2012
Targeted genomic integration of a selectable floxed dual fluorescence reporter in human embryonic stem cells.
PloS one
Gantz JA,Palpant NJ,Welikson RE,Hauschka SD,Murry CE,Laflamme MA
Thu Apr 11 00:00:00 UTC 2013
Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma.
PloS one
Lou E,Fujisawa S,Morozov A,Barlas A,Romin Y,Dogan Y,Gholami S,Moreira AL,Manova-Todorova K,Moore MA
Mon Aug 20 00:00:00 UTC 2012
Differential association of microRNAs with polysomes reflects distinct strengths of interactions with their mRNA targets.
RNA (New York, N.Y.)
Molotski N,Soen Y
100-18B was used in Cell Culture to introduce a high-throughput method for quantifying polysome occupancies of hundreds of microRNAs and use it to investigate factors affecting these occupancies.
Sat Sep 01 00:00:00 UTC 2012
Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line.
BMC cancer
Martins-Neves SR,Lopes ÁO,do Carmo A,Paiva AA,Simões PC,Abrunhosa AJ,Gomes CM
Wed Apr 04 00:00:00 UTC 2012
Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease.
BMC neuroscience
El-Akabawy G,Rattray I,Johansson SM,Gale R,Bates G,Modo M
Thu Aug 09 00:00:00 UTC 2012
Interaction of inflammation and hyperoxia in a rat model of neonatal white matter damage.
PloS one
Brehmer F,Bendix I,Prager S,van de Looij Y,Reinboth BS,Zimmermanns J,Schlager GW,Brait D,Sifringer M,Endesfelder S,Sizonenko S,Mallard C,Bührer C,Felderhoff-Mueser U,Gerstner B
Thu May 09 00:00:00 UTC 2013
Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
PloS one
Lin SP,Lee YT,Wang JY,Miller SA,Chiou SH,Hung MC,Hung SC
Wed May 22 00:00:00 UTC 2013
RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways.
PloS one
Muto J,Imai T,Ogawa D,Nishimoto Y,Okada Y,Mabuchi Y,Kawase T,Iwanami A,Mischel PS,Saya H,Yoshida K,Matsuzaki Y,Okano H
Mon Aug 20 00:00:00 UTC 2012
Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming.
PloS one
Chen M,Huang J,Yang X,Liu B,Zhang W,Huang L,Deng F,Ma J,Bai Y,Lu R,Huang B,Gao Q,Zhuo Y,Ge J
Mon Nov 19 00:00:00 UTC 2012
Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming.
PloS one
Chen M,Huang J,Yang X,Liu B,Zhang W,Huang L,Deng F,Ma J,Bai Y,Lu R,Huang B,Gao Q,Zhuo Y,Ge J
Mon Nov 19 00:00:00 UTC 2012
Phosphorylation of doublecortin by protein kinase A orchestrates microtubule and actin dynamics to promote neuronal progenitor cell migration.
The Journal of biological chemistry
Toriyama M,Mizuno N,Fukami T,Iguchi T,Toriyama M,Tago K,Itoh H
Fri Apr 13 00:00:00 UTC 2012
Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy.
PloS one
Joshi AD,Loilome W,Siu IM,Tyler B,Gallia GL,Riggins GJ
Tue Apr 02 00:00:00 UTC 2013
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
PloS one
Pelosi E,Castelli G,Martin-Padura I,Bordoni V,Santoro S,Conigliaro A,Cerio AM,De Santis Puzzonia M,Marighetti P,Biffoni M,Alonzi T,Amicone L,Alcalay M,Bertolini F,Testa U,Tripodi M
Tue May 21 00:00:00 UTC 2013
Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors.
Nature communications
Blauwkamp TA,Nigam S,Ardehali R,Weissman IL,Nusse R
Fri Feb 01 00:00:00 UTC 2013
Transcriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexes.
PloS one
Banning A,Ockenga W,Finger F,Siebrasse P,Tikkanen R
Wed Mar 06 00:00:00 UTC 2013
E-cadherin promotes incorporation of mouse epiblast stem cells into normal development.
PloS one
Ohtsuka S,Nishikawa-Torikai S,Niwa H
Thu Feb 28 00:00:00 UTC 2013
Gekko-sulfated glycopeptide inhibits tumor angiogenesis by targeting basic fibroblast growth factor.
The Journal of biological chemistry
Zhang SX,Zhu C,Ba Y,Chen D,Zhou XL,Cao R,Wang LP,Ren Y,Wu XZ
Fri Apr 13 00:00:00 UTC 2012
Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy.
PloS one
Hensel N,Ratzka A,Brinkmann H,Klimaschewski L,Grothe C,Claus P
Tue Jul 31 00:00:00 UTC 2012
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
PloS one
Ring H,Mendu SK,Shirazi-Fard S,Birnir B,Hallböök F
Wed Sep 19 00:00:00 UTC 2012
Perivascular-like cells contribute to the stability of the vascular network of osteogenic tissue formed from cell sheet-based constructs.
PloS one
Mendes LF,Pirraco RP,Szymczyk W,Frias AM,Santos TC,Reis RL,Marques AP
Fri Dec 07 00:00:00 UTC 2012
Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells.
BMC cancer
Monticone M,Daga A,Candiani S,Romeo F,Mirisola V,Viaggi S,Melloni I,Pedemonte S,Zona G,Giaretti W,Pfeffer U,Castagnola P
Fri Aug 17 00:00:00 UTC 2012
Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes.
PloS one
Kim DS,Lee DR,Kim HS,Yoo JE,Jung SJ,Lim BY,Jang J,Kang HC,You S,Hwang DY,Leem JW,Nam TS,Cho SR,Kim DW
Fri Apr 19 00:00:00 UTC 2013
Targeting JNK for therapeutic depletion of stem-like glioblastoma cells.
Scientific reports
Matsuda K,Sato A,Okada M,Shibuya K,Seino S,Suzuki K,Watanabe E,Narita Y,Shibui S,Kayama T,Kitanaka C
Sun Mar 17 00:00:00 UTC 2013
Activin A promotes neuronal differentiation of cerebrocortical neural progenitor cells.
PloS one
Rodríguez-Martínez G,Molina-Hernández A,Velasco I
Tue Jan 29 00:00:00 UTC 2013
Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid.
The Journal of biological chemistry
Ono S,Hane M,Kitajima K,Sato C
Fri Feb 03 00:00:00 UTC 2012
miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis.
PloS one
Silber J,Jacobsen A,Ozawa T,Harinath G,Pedraza A,Sander C,Holland EC,Huse JT
Mon Nov 19 00:00:00 UTC 2012
Loss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells.
The Journal of biological chemistry
Wang PS,Wang J,Zheng Y,Pallen CJ
Fri Apr 06 00:00:00 UTC 2012
Efficient derivation of multipotent neural stem/progenitor cells from non-human primate embryonic stem cells.
PloS one
Shimada H,Okada Y,Ibata K,Ebise H,Ota S,Tomioka I,Nomura T,Maeda T,Kohda K,Yuzaki M,Sasaki E,Nakamura M,Okano H
Mon May 06 00:00:00 UTC 2013
Radiation-Triggered NF-κB Activation is Responsible for the Angiogenic Signaling Pathway and Neovascularization for Breast Cancer Cell Proliferation and Growth.
Breast cancer : basic and clinical research
Yu H,Mohan S,Natarajan M
Thu Aug 23 00:00:00 UTC 2012
Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions.
PloS one
Frank S,Zhang M,Schöler HR,Greber B
100-18B was used in Sample Preparation to imply that using supportive factors at minimal concentrations may still promote robust self-renewal and preserve pluripotency of hPSCs.
Mon Jan 14 00:00:00 UTC 2013
Small molecule-assisted, line-independent maintenance of human pluripotent stem cells in defined conditions.
PloS one
Frank S,Zhang M,Schöler HR,Greber B
100-18B was used in Sample Preparation to imply that using supportive factors at minimal concentrations may still promote robust self-renewal and preserve pluripotency of hPSCs.
Mon Jan 14 00:00:00 UTC 2013
Functional neuronal cells generated by human parthenogenetic stem cells.
PloS one
Ahmad R,Wolber W,Eckardt S,Koch P,Schmitt J,Semechkin R,Geis C,Heckmann M,Brüstle O,McLaughlin JK,Sirén AL,Müller AM
Thu Jan 10 00:00:00 UTC 2013
A unique chromatin signature uncovers early developmental enhancers in humans.
Nature
Rada-Iglesias A,Bajpai R,Swigut T,Brugmann SA,Flynn RA,Wysocka J
Thu Feb 10 00:00:00 UTC 2011
Mosaic analysis with double markers reveals tumor cell of origin in glioma.
Cell
Liu C,Sage JC,Miller MR,Verhaak RG,Hippenmeyer S,Vogel H,Foreman O,Bronson RT,Nishiyama A,Luo L,Zong H
Fri Jul 22 00:00:00 UTC 2011
NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.
Nature methods
Elliott DA,Braam SR,Koutsis K,Ng ES,Jenny R,Lagerqvist EL,Biben C,Hatzistavrou T,Hirst CE,Yu QC,Skelton RJ,Ward-van Oostwaard D,Lim SM,Khammy O,Li X,Hawes SM,Davis RP,Goulburn AL,Passier R,Prall OW,Haynes JM,Pouton CW,Kaye DM,Mummery CL,Elefanty AG,Stanley EG
Sun Oct 23 00:00:00 UTC 2011
Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice.
Cell research
Lu SJ,Li F,Yin H,Feng Q,Kimbrel EA,Hahm E,Thon JN,Wang W,Italiano JE,Cho J,Lanza R
Tue Mar 01 00:00:00 UTC 2011
Mesenchymal stem cells express serine protease inhibitor to evade the host immune response.
Blood
El Haddad N,Heathcote D,Moore R,Yang S,Azzi J,Mfarrej B,Atkinson M,Sayegh MH,Lee JS,Ashton-Rickardt PG,Abdi R
Thu Jan 27 00:00:00 UTC 2011
Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells.
Blood
Huang X,Gschweng E,Van Handel B,Cheng D,Mikkola HK,Witte ON
Thu Feb 17 00:00:00 UTC 2011
MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.
The Journal of clinical investigation
Wu X,Simpson J,Hong JH,Kim KH,Thavarajah NK,Backx PH,Neel BG,Araki T
Tue Mar 01 00:00:00 UTC 2011
Hepatic differentiation of amniotic epithelial cells.
Hepatology (Baltimore, Md.)
Marongiu F,Gramignoli R,Dorko K,Miki T,Ranade AR,Paola Serra M,Doratiotto S,Sini M,Sharma S,Mitamura K,Sellaro TL,Tahan V,Skvorak KJ,Ellis EC,Badylak SF,Davila JC,Hines R,Laconi E,Strom SC
Sun May 01 00:00:00 UTC 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
Tue Mar 01 00:00:00 UTC 2011
Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sciuscio D,Diserens AC,van Dommelen K,Martinet D,Jones G,Janzer RC,Pollo C,Hamou MF,Kaina B,Stupp R,Levivier M,Hegi ME
100-18B was used in Cell Culture to conclude that even a low percentage of MGMT methylation measured in a glioblastoma sample may be relevant and predict benefit from an alkylating agent therapy.
Sat Jan 15 00:00:00 UTC 2011
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor.
Molecular psychiatry
Anacker C,Zunszain PA,Cattaneo A,Carvalho LA,Garabedian MJ,Thuret S,Price J,Pariante CM
Fri Jul 01 00:00:00 UTC 2011
E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models.
Cancer research
Bello E,Colella G,Scarlato V,Oliva P,Berndt A,Valbusa G,Serra SC,D'Incalci M,Cavalletti E,Giavazzi R,Damia G,Camboni G
Tue Feb 15 00:00:00 UTC 2011
E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models.
Cancer research
Bello E,Colella G,Scarlato V,Oliva P,Berndt A,Valbusa G,Serra SC,D'Incalci M,Cavalletti E,Giavazzi R,Damia G,Camboni G
Tue Feb 15 00:00:00 UTC 2011
Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.
Proceedings of the National Academy of Sciences of the United States of America
Watanabe A,Ogiwara H,Ehata S,Mukasa A,Ishikawa S,Maeda D,Ueki K,Ino Y,Todo T,Yamada Y,Fukayama M,Saito N,Miyazono K,Aburatani H
Tue Jul 26 00:00:00 UTC 2011
Transdifferentiation of glioblastoma cells into vascular endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America
Soda Y,Marumoto T,Friedmann-Morvinski D,Soda M,Liu F,Michiue H,Pastorino S,Yang M,Hoffman RM,Kesari S,Verma IM
Tue Mar 15 00:00:00 UTC 2011
Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Papadeas ST,Kraig SE,O'Banion C,Lepore AC,Maragakis NJ
Tue Oct 25 00:00:00 UTC 2011
Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Chu H,Gao J,Chen CW,Huard J,Wang Y
Tue Aug 16 00:00:00 UTC 2011
Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America
Agemy L,Friedmann-Morvinski D,Kotamraju VR,Roth L,Sugahara KN,Girard OM,Mattrey RF,Verma IM,Ruoslahti E
Tue Oct 18 00:00:00 UTC 2011
The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro.
Aging cell
Liu S,Liu S,Wang X,Zhou J,Cao Y,Wang F,Duan E
Mon Aug 01 00:00:00 UTC 2011
Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib.
Oncogene
Welti JC,Gourlaouen M,Powles T,Kudahetti SC,Wilson P,Berney DM,Reynolds AR
Thu Mar 10 00:00:00 UTC 2011
MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis.
Stem cells (Dayton, Ohio)
Sato A,Sunayama J,Matsuda K,Seino S,Suzuki K,Watanabe E,Tachibana K,Tomiyama A,Kayama T,Kitanaka C
Thu Dec 01 00:00:00 UTC 2011
CD24: a novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Jiang W,Sui X,Zhang D,Liu M,Ding M,Shi Y,Deng H
Fri Apr 01 00:00:00 UTC 2011
Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells.
Stem cells (Dayton, Ohio)
Iacovino M,Bosnakovski D,Fey H,Rux D,Bajwa G,Mahen E,Mitanoska A,Xu Z,Kyba M
Sat Oct 01 00:00:00 UTC 2011
Debrided skin as a source of autologous stem cells for wound repair.
Stem cells (Dayton, Ohio)
Natesan S,Wrice NL,Baer DG,Christy RJ
Mon Aug 01 00:00:00 UTC 2011
Human embryonic stem cells suffer from centrosomal amplification.
Stem cells (Dayton, Ohio)
Holubcová Z,Matula P,Sedláčková M,Vinarský V,Doležalová D,Bárta T,Dvořák P,Hampl A
Sat Jan 01 00:00:00 UTC 2011
Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment.
Stem cells (Dayton, Ohio)
Meyer JS,Howden SE,Wallace KA,Verhoeven AD,Wright LS,Capowski EE,Pinilla I,Martin JM,Tian S,Stewart R,Pattnaik B,Thomson JA,Gamm DM
Mon Aug 01 00:00:00 UTC 2011
PBX1: a novel stage-specific regulator of adipocyte development.
Stem cells (Dayton, Ohio)
Monteiro MC,Sanyal M,Cleary ML,Sengenès C,Bouloumié A,Dani C,Billon N
Tue Nov 01 00:00:00 UTC 2011
Neural stem cells maintain their stemness through protein kinase C ζ-mediated inhibition of TRIM32.
Stem cells (Dayton, Ohio)
Hillje AL,Worlitzer MM,Palm T,Schwamborn JC
Thu Sep 01 00:00:00 UTC 2011
Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Alva JA,Lee GE,Escobar EE,Pyle AD
Thu Dec 01 00:00:00 UTC 2011
ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.
Stem cells (Dayton, Ohio)
Romero-Grimaldi C,Murillo-Carretero M,López-Toledano MA,Carrasco M,Castro C,Estrada C
Sat Oct 01 00:00:00 UTC 2011
Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells.
Stem cells (Dayton, Ohio)
Nefzger CM,Haynes JM,Pouton CW
Wed Jun 01 00:00:00 UTC 2011
Neural stem cell gene therapy ameliorates pathology and function in a mouse model of globoid cell leukodystrophy.
Stem cells (Dayton, Ohio)
Neri M,Ricca A,di Girolamo I,Alcala'-Franco B,Cavazzin C,Orlacchio A,Martino S,Naldini L,Gritti A
Sat Oct 01 00:00:00 UTC 2011
Neural stem cell gene therapy ameliorates pathology and function in a mouse model of globoid cell leukodystrophy.
Stem cells (Dayton, Ohio)
Neri M,Ricca A,di Girolamo I,Alcala'-Franco B,Cavazzin C,Orlacchio A,Martino S,Naldini L,Gritti A
Sat Oct 01 00:00:00 UTC 2011
The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells.
Journal of immunology (Baltimore, Md. : 1950)
El Haddad N,Moore R,Heathcote D,Mounayar M,Azzi J,Mfarrej B,Batal I,Ting C,Atkinson M,Sayegh MH,Ashton-Rickardt PG,Abdi R
Thu Sep 01 00:00:00 UTC 2011
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.
Journal of cell science
Bone HK,Nelson AS,Goldring CE,Tosh D,Welham MJ
Wed Jun 15 00:00:00 UTC 2011
Interplay between FGF2 and BMP controls the self-renewal, dormancy and differentiation of rat neural stem cells.
Journal of cell science
Sun Y,Hu J,Zhou L,Pollard SM,Smith A
Wed Jun 01 00:00:00 UTC 2011
Fibroblast Growth Factor-2 Enhances Expansion of Human Bone Marrow-Derived Mesenchymal Stromal Cells without Diminishing Their Immunosuppressive Potential.
Stem cells international
Auletta JJ,Zale EA,Welter JF,Solchaga LA
Thu Mar 03 00:00:00 UTC 2011
Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells.
Bioscience reports
Gaviraghi M,Tunici P,Valensin S,Rossi M,Giordano C,Magnoni L,Dandrea M,Montagna L,Ritelli R,Scarpa A,Bakker A
Tue Feb 01 00:00:00 UTC 2011
Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury.
PloS one
Davies SJ,Shih CH,Noble M,Mayer-Proschel M,Davies JE,Proschel C
Wed Mar 02 00:00:00 UTC 2011
In vivo tracking of human neural stem cells with 19F magnetic resonance imaging.
PloS one
Boehm-Sturm P,Mengler L,Wecker S,Hoehn M,Kallur T
Mon May 21 00:00:00 UTC 2012
Expression profiling of FSHD-1 and FSHD-2 cells during myogenic differentiation evidences common and distinctive gene dysregulation patterns.
PloS one
Cheli S,François S,Bodega B,Ferrari F,Tenedini E,Roncaglia E,Ferrari S,Ginelli E,Meneveri R
Fri Oct 21 00:00:00 UTC 2011
Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells.
ASN neuro
Yanagisawa M,Yoshimura S,Yu RK
Thu Apr 07 00:00:00 UTC 2011
Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.
PloS one
Xu B,Sun Z,Liu Z,Guo H,Liu Q,Jiang H,Zou Y,Gong Y,Tischfield JA,Shao C
Fri Apr 15 00:00:00 UTC 2011
A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40.
The Journal of biological chemistry
Singh SK,Bhardwaj R,Wilczynska KM,Dumur CI,Kordula T
Fri Nov 18 00:00:00 UTC 2011
Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism.
PloS one
Garrido-Urbani S,Jemelin S,Deffert C,Carnesecchi S,Basset O,Szyndralewiez C,Heitz F,Page P,Montet X,Michalik L,Arbiser J,Rüegg C,Krause KH,Imhof BA
Mon Feb 07 00:00:00 UTC 2011
Polybrene inhibits human mesenchymal stem cell proliferation during lentiviral transduction.
PloS one
Lin P,Correa D,Lin Y,Caplan AI
Fri Feb 24 00:00:00 UTC 2012
Cancer stem-like cells enriched in Panc-1 spheres possess increased migration ability and resistance to gemcitabine.
International journal of molecular sciences
Yin T,Wei H,Gou S,Shi P,Yang Z,Zhao G,Wang C
Mon Jan 19 00:00:00 UTC 2015
Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.
PloS one
Shiraki N,Yamazoe T,Qin Z,Ohgomori K,Mochitate K,Kume K,Kume S
Fri Feb 24 00:00:00 UTC 2012
Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.
PloS one
Shiraki N,Yamazoe T,Qin Z,Ohgomori K,Mochitate K,Kume K,Kume S
Fri Feb 24 00:00:00 UTC 2012
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus.
Nature communications
Devine MJ,Ryten M,Vodicka P,Thomson AJ,Burdon T,Houlden H,Cavaleri F,Nagano M,Drummond NJ,Taanman JW,Schapira AH,Gwinn K,Hardy J,Lewis PA,Kunath T
Tue Aug 23 00:00:00 UTC 2011
Differentiation of mesenchymal stem cells derived from pancreatic islets and bone marrow into islet-like cell phenotype.
PloS one
Zanini C,Bruno S,Mandili G,Baci D,Cerutti F,Cenacchi G,Izzi L,Camussi G,Forni M
Mon Aug 27 00:00:00 UTC 2012
CREB is activated by muscle injury and promotes muscle regeneration.
PloS one
Stewart R,Flechner L,Montminy M,Berdeaux R
Tue Feb 28 00:00:00 UTC 2012
A protocol for isolation and enriched monolayer cultivation of neural precursor cells from mouse dentate gyrus.
Frontiers in neuroscience
Babu H,Claasen JH,Kannan S,Rünker AE,Palmer T,Kempermann G
Thu Nov 10 00:00:00 UTC 2011
A new FACS approach isolates hESC derived endoderm using transcription factors.
PloS one
Pan Y,Ouyang Z,Wong WH,Baker JC
Wed Mar 09 00:00:00 UTC 2011
mSEL-1L (Suppressor/enhancer Lin12-like) protein levels influence murine neural stem cell self-renewal and lineage commitment.
The Journal of biological chemistry
Cardano M,Diaferia GR,Cattaneo M,Dessì SS,Long Q,Conti L,Deblasio P,Cattaneo E,Biunno I
Fri May 27 00:00:00 UTC 2011
The unique transcriptional activation domain of nuclear factor-I-X3 is critical to specifically induce marker gene expression in astrocytes.
The Journal of biological chemistry
Singh SK,Wilczynska KM,Grzybowski A,Yester J,Osrah B,Bryan L,Wright S,Griswold-Prenner I,Kordula T
Fri Mar 04 00:00:00 UTC 2011
Dynamic changes in EPCAM expression during spermatogonial stem cell differentiation in the mouse testis.
PloS one
Kanatsu-Shinohara M,Takashima S,Ishii K,Shinohara T
Wed Feb 15 00:00:00 UTC 2012
Widespread expression of BORIS/CTCFL in normal and cancer cells.
PloS one
Jones TA,Ogunkolade BW,Szary J,Aarum J,Mumin MA,Patel S,Pieri CA,Sheer D
Mon Dec 05 00:00:00 UTC 2011
Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord.
BMC neuroscience
Mamaeva D,Ripoll C,Bony C,Teigell M,Perrin FE,Rothhut B,Bieche I,Lidereau R,Privat A,Rigau V,Guillon H,Vachiery-Lahaye F,Noel D,Bauchet L,Hugnot JP
Mon Oct 10 00:00:00 UTC 2011
Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2.
Aging
Bogomazova AN,Lagarkova MA,Tskhovrebova LV,Shutova MV,Kiselev SL
Wed Jun 01 00:00:00 UTC 2011
Microencapsulation technology: a powerful tool for integrating expansion and cryopreservation of human embryonic stem cells.
PloS one
Serra M,Correia C,Malpique R,Brito C,Jensen J,Bjorquist P,Carrondo MJ,Alves PM
Thu Feb 02 00:00:00 UTC 2012
Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.
Stem cell reviews and reports
Funakoshi N,Duret C,Pascussi JM,Blanc P,Maurel P,Daujat-Chavanieu M,Gerbal-Chaloin S
Thu Sep 01 00:00:00 UTC 2011
In vitro model of vascularized bone: synergizing vascular development and osteogenesis.
PloS one
Correia C,Grayson WL,Park M,Hutton D,Zhou B,Guo XE,Niklason L,Sousa RA,Reis RL,Vunjak-Novakovic G
Fri Jul 20 00:00:00 UTC 2012
Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6.
PloS one
Donati C,Marseglia G,Magi A,Serratì S,Cencetti F,Bernacchioni C,Nannetti G,Benelli M,Brunelli S,Torricelli F,Cossu G,Bruni P
Fri Sep 23 00:00:00 UTC 2011
An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells.
PloS one
Gil-Ranedo J,Mendiburu-Eliçabe M,García-Villanueva M,Medina D,del Álamo M,Izquierdo M
Mon Apr 23 00:00:00 UTC 2012
Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes.
Stem cell reviews and reports
Lee YK,Ng KM,Lai WH,Chan YC,Lau YM,Lian Q,Tse HF,Siu CW
Tue Nov 01 00:00:00 UTC 2011
Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice.
PloS one
Meng J,Adkin CF,Xu SW,Muntoni F,Morgan JE
Wed Mar 09 00:00:00 UTC 2011
Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) protein regulates osteoblast differentiation.
The Journal of biological chemistry
Nam HK,Liu J,Li Y,Kragor A,Hatch NE
Fri Nov 11 00:00:00 UTC 2011
Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.
Oncotarget
Weber GL,Parat MO,Binder ZA,Gallia GL,Riggins GJ
Tue Nov 01 00:00:00 UTC 2011
Synaptically-competent neurons derived from canine embryonic stem cells by lineage selection with EGF and Noggin.
PloS one
Wilcox JT,Lai JK,Semple E,Brisson BA,Gartley C,Armstrong JN,Betts DH
Mon Sep 12 00:00:00 UTC 2011
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells.
Molecular cancer
Tabuse M,Ohta S,Ohashi Y,Fukaya R,Misawa A,Yoshida K,Kawase T,Saya H,Thirant C,Chneiweiss H,Matsuzaki Y,Okano H,Kawakami Y,Toda M
Sun May 22 00:00:00 UTC 2011
Induced pluripotent stem cell lines derived from equine fibroblasts.
Stem cell reviews and reports
Nagy K,Sung HK,Zhang P,Laflamme S,Vincent P,Agha-Mohammadi S,Woltjen K,Monetti C,Michael IP,Smith LC,Nagy A
Thu Sep 01 00:00:00 UTC 2011
Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
PloS one
Oliver L,Hue E,Rossignol J,Bougras G,Hulin P,Naveilhan P,Heymann D,Lescaudron L,Vallette FM
Thu May 12 00:00:00 UTC 2011
Efficient co-expression of bicistronic proteins in mesenchymal stem cells by development and optimization of a multifunctional plasmid.
Stem cell research & therapy
Krause CD,Izotova LS,Ren G,Yuan ZR,Shi Y,Chen CC,Ron Y,Pestka S
Mon Mar 14 00:00:00 UTC 2011
Human cardiac-derived adherent proliferating cells reduce murine acute Coxsackievirus B3-induced myocarditis.
PloS one
Miteva K,Haag M,Peng J,Savvatis K,Becher PM,Seifert M,Warstat K,Westermann D,Ringe J,Sittinger M,Schultheiss HP,Tschöpe C,Van Linthout S
Mon Apr 23 00:00:00 UTC 2012
Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein.
The Journal of biological chemistry
Ikushima H,Todo T,Ino Y,Takahashi M,Saito N,Miyazawa K,Miyazono K
Fri Dec 02 00:00:00 UTC 2011
Human cardiac stem cells isolated from atrial appendages stably express c-kit.
PloS one
He JQ,Vu DM,Hunt G,Chugh A,Bhatnagar A,Bolli R
Mon Apr 09 00:00:00 UTC 2012
A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells.
Cell communication and signaling : CCS
Edel MJ,Menchon C,Vaquero JM,Izpisua Belmonte JC
Mon Apr 11 00:00:00 UTC 2011
Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS.
PloS one
Lepore AC,O'Donnell J,Kim AS,Williams T,Tuteja A,Rao MS,Kelley LL,Campanelli JT,Maragakis NJ
Mon Feb 13 00:00:00 UTC 2012
Differential adhesion molecule expression during murine embryonic stem cell commitment to the hematopoietic and endothelial lineages.
PloS one
Stankovich BL,Aguayo E,Barragan F,Sharma A,Pallavicini MG
Thu Jan 05 00:00:00 UTC 2012
An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.
BMC developmental biology
Ogaki S,Harada S,Shiraki N,Kume K,Kume S
Tue Mar 01 00:00:00 UTC 2011
Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model.
Stem cell research & therapy
Watts AE,Yeager AE,Kopyov OV,Nixon AJ
Thu Jan 27 00:00:00 UTC 2011
EGFL6 promotes endothelial cell migration and angiogenesis through the activation of extracellular signal-regulated kinase.
The Journal of biological chemistry
Chim SM,Qin A,Tickner J,Pavlos N,Davey T,Wang H,Guo Y,Zheng MH,Xu J
Fri Jun 24 00:00:00 UTC 2011
Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR.
PloS one
Ruiz-Ferrer M,Torroglosa A,Núñez-Torres R,de Agustín JC,Antiñolo G,Borrego S
Wed Feb 15 00:00:00 UTC 2012
Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin.
The Journal of biological chemistry
Zhang J,Fukuhara S,Sako K,Takenouchi T,Kitani H,Kume T,Koh GY,Mochizuki N
Fri Mar 11 00:00:00 UTC 2011
Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia.
The Journal of biological chemistry
Chavali PL,Saini RK,Matsumoto Y,Ågren H,Funa K
Fri Mar 18 00:00:00 UTC 2011
The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation.
Aging
Brett JO,Renault VM,Rafalski VA,Webb AE,Brunet A
Tue Feb 01 00:00:00 UTC 2011
Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells.
PloS one
Harness JV,Turovets NA,Seiler MJ,Nistor G,Altun G,Agapova LS,Ferguson D,Laurent LC,Loring JF,Keirstead HS
Fri Jan 07 00:00:00 UTC 2011
Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension.
Nature biotechnology
Steiner D,Khaner H,Cohen M,Even-Ram S,Gil Y,Itsykson P,Turetsky T,Idelson M,Aizenman E,Ram R,Berman-Zaken Y,Reubinoff B
Thu Apr 01 00:00:00 UTC 2010
TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma.
Cancer cell
Anido J,Sáez-Borderías A,Gonzàlez-Juncà A,Rodón L,Folch G,Carmona MA,Prieto-Sánchez RM,Barba I,Martínez-Sáez E,Prudkin L,Cuartas I,Raventós C,Martínez-Ricarte F,Poca MA,García-Dorado D,Lahn MM,Yingling JM,Rodón J,Sahuquillo J,Baselga J,Seoane J
Tue Dec 14 00:00:00 UTC 2010
Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels.
Blood
Taylor SM,Nevis KR,Park HL,Rogers GC,Rogers SL,Cook JG,Bautch VL
Thu Oct 21 00:00:00 UTC 2010
Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases.
Blood
Kovarova M,Latour AM,Chason KD,Tilley SL,Koller BH
Thu May 06 00:00:00 UTC 2010
Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.
Blood
Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H
Thu Dec 02 00:00:00 UTC 2010
Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury.
The Journal of clinical investigation
Abematsu M,Tsujimura K,Yamano M,Saito M,Kohno K,Kohyama J,Namihira M,Komiya S,Nakashima K
Wed Sep 01 00:00:00 UTC 2010
CD13 is a therapeutic target in human liver cancer stem cells.
The Journal of clinical investigation
Haraguchi N,Ishii H,Mimori K,Tanaka F,Ohkuma M,Kim HM,Akita H,Takiuchi D,Hatano H,Nagano H,Barnard GF,Doki Y,Mori M
Wed Sep 01 00:00:00 UTC 2010
Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells.
Proceedings of the National Academy of Sciences of the United States of America
Kujuro Y,Suzuki N,Kondo T
Tue May 04 00:00:00 UTC 2010
Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior.
Proceedings of the National Academy of Sciences of the United States of America
Koo JW,Russo SJ,Ferguson D,Nestler EJ,Duman RS
Tue Feb 09 00:00:00 UTC 2010
Sirtuin 1 regulation of developmental genes during differentiation of stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Calvanese V,Lara E,Suárez-Alvarez B,Abu Dawud R,Vázquez-Chantada M,Martínez-Chantar ML,Embade N,López-Nieva P,Horrillo A,Hmadcha A,Soria B,Piazzolla D,Herranz D,Serrano M,Mato JM,Andrews PW,López-Larrea C,Esteller M,Fraga MF
Tue Aug 03 00:00:00 UTC 2010
Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America
Otsuki S,Hanson SR,Miyaki S,Grogan SP,Kinoshita M,Asahara H,Wong CH,Lotz MK
Tue Jun 01 00:00:00 UTC 2010
Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture.
Angiogenesis
Trapp V,Parmakhtiar B,Papazian V,Willmott L,Fruehauf JP
Wed Dec 01 00:00:00 UTC 2010
Chitosan/polyester-based scaffolds for cartilage tissue engineering: assessment of extracellular matrix formation.
Acta biomaterialia
Alves da Silva ML,Crawford A,Mundy JM,Correlo VM,Sol P,Bhattacharya M,Hatton PV,Reis RL,Neves NM
100-18B was used in Cell Culture to investigate the use of chitosan-poly(butylene succinate) scaffolds for cartilage tissue engineering.
Mon Mar 01 00:00:00 UTC 2010
Could recombinant insulin compounds contribute to adenocarcinoma progression by stimulating local angiogenesis?
Diabetologia
Rensing KL,Houttuijn Bloemendaal FM,Weijers EM,Richel DJ,Büller HR,Koolwijk P,van der Loos CM,Twickler TB,von der Thüsen JH
Sat May 01 00:00:00 UTC 2010
Memory in induced pluripotent stem cells: reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation.
Stem cells (Dayton, Ohio)
Hu Q,Friedrich AM,Johnson LV,Clegg DO
Mon Nov 01 00:00:00 UTC 2010
Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo.
Stem cells (Dayton, Ohio)
deCarvalho AC,Nelson K,Lemke N,Lehman NL,Arbab AS,Kalkanis S,Mikkelsen T
Mon Feb 01 00:00:00 UTC 2010
Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming.
Stem cells (Dayton, Ohio)
Ron-Bigger S,Bar-Nur O,Isaac S,Bocker M,Lyko F,Eden A
Sun Aug 01 00:00:00 UTC 2010
Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function.
Stem cells (Dayton, Ohio)
Sordi V,Melzi R,Mercalli A,Formicola R,Doglioni C,Tiboni F,Ferrari G,Nano R,Chwalek K,Lammert E,Bonifacio E,Borg D,Piemonti L
Fri Jan 01 00:00:00 UTC 2010
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.
Stem cells (Dayton, Ohio)
Sunayama J,Matsuda K,Sato A,Tachibana K,Suzuki K,Narita Y,Shibui S,Sakurada K,Kayama T,Tomiyama A,Kitanaka C
Mon Nov 01 00:00:00 UTC 2010
Fibroblast growth factor type 2 signaling is critical for DNA repair in human keratinocyte stem cells.
Stem cells (Dayton, Ohio)
Harfouche G,Vaigot P,Rachidi W,Rigaud O,Moratille S,Marie M,Lemaitre G,Fortunel NO,Martin MT
Wed Sep 01 00:00:00 UTC 2010
The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.
Stem cells (Dayton, Ohio)
Prigione A,Fauler B,Lurz R,Lehrach H,Adjaye J
Thu Apr 01 00:00:00 UTC 2010
Reprogramming of human fibroblasts to induced pluripotent stem cells under xeno-free conditions.
Stem cells (Dayton, Ohio)
Rodríguez-Pizà I,Richaud-Patin Y,Vassena R,González F,Barrero MJ,Veiga A,Raya A,Izpisúa Belmonte JC
Fri Jan 01 00:00:00 UTC 2010
Neural induction intermediates exhibit distinct roles of Fgf signaling.
Stem cells (Dayton, Ohio)
Sterneckert J,Stehling M,Bernemann C,Araúzo-Bravo MJ,Greber B,Gentile L,Ortmeier C,Sinn M,Wu G,Ruau D,Zenke M,Brintrup R,Klein DC,Ko K,Schöler HR
Fri Oct 01 00:00:00 UTC 2010
Using a neodymium magnet to target delivery of ferumoxide-labeled human neural stem cells in a rat model of focal cerebral ischemia.
Human gene therapy
Song M,Kim YJ,Kim YH,Roh J,Kim SU,Yoon BW
Sat May 01 00:00:00 UTC 2010
Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development.
Tissue engineering. Part A
Hellingman CA,Koevoet W,Kops N,Farrell E,Jahr H,Liu W,Baatenburg de Jong RJ,Frenz DA,van Osch GJ
Mon Feb 01 00:00:00 UTC 2010
Short-time survival and engraftment of bone marrow stromal cells in an ectopic model of bone regeneration.
Tissue engineering. Part A
Giannoni P,Scaglione S,Daga A,Ilengo C,Cilli M,Quarto R
Mon Feb 01 00:00:00 UTC 2010
Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions.
Reproduction (Cambridge, England)
Forristal CE,Wright KL,Hanley NA,Oreffo RO,Houghton FD
Fri Jan 01 00:00:00 UTC 2010
Generation of human-induced pluripotent stem cells from gut mesentery-derived cells by ectopic expression of OCT4/SOX2/NANOG.
Cellular reprogramming
Li Y,Zhao H,Lan F,Lee A,Chen L,Lin C,Yao Y,Li L
Tue Jun 01 00:00:00 UTC 2010
Human fetal liver stromal cells that overexpress bFGF support growth and maintenance of human embryonic stem cells.
PloS one
Xi J,Wang Y,Zhang P,He L,Nan X,Yue W,Pei X
Thu Dec 30 00:00:00 UTC 2010
Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells.
Nature protocols
Aasen T,Izpisúa Belmonte JC
100-18B was used in Cell Culture to outline protocols using both feeder-dependent and defined serum- and feeder-free conditions for culturing human keratinocytes from foreskin samples and punch biopsies, as well as how to isolate keratinocytes from plucked hair.
Mon Feb 01 00:00:00 UTC 2010
Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.
BMC cancer
Cohen JR,Resnick DZ,Niewiadomski P,Dong H,Liau LM,Waschek JA
Thu Dec 09 00:00:00 UTC 2010
The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells.
PloS one
Wolfrum K,Wang Y,Prigione A,Sperling K,Lehrach H,Adjaye J
Fri Oct 29 00:00:00 UTC 2010
An ES-like pluripotent state in FGF-dependent murine iPS cells.
PloS one
Di Stefano B,Buecker C,Ungaro F,Prigione A,Chen HH,Welling M,Eijpe M,Mostoslavsky G,Tesar P,Adjaye J,Geijsen N,Broccoli V
Thu Dec 30 00:00:00 UTC 2010
Generation of induced pluripotent stem cells from human cord blood cells with only two factors: Oct4 and Sox2.
Nature protocols
Giorgetti A,Montserrat N,Rodriguez-Piza I,Azqueta C,Veiga A,Izpisúa Belmonte JC
Thu Apr 01 00:00:00 UTC 2010
Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts.
The Journal of biological chemistry
Vora SR,Palamakumbura AH,Mitsi M,Guo Y,Pischon N,Nugent MA,Trackman PC
Fri Mar 05 00:00:00 UTC 2010
Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage.
PloS one
Williams R,Khan IM,Richardson K,Nelson L,McCarthy HE,Analbelsi T,Singhrao SK,Dowthwaite GP,Jones RE,Baird DM,Lewis H,Roberts S,Shaw HM,Dudhia J,Fairclough J,Briggs T,Archer CW
Thu Oct 14 00:00:00 UTC 2010
Effect of all-trans retinoic acid on the proliferation and differentiation of brain tumor stem cells.
Journal of experimental & clinical cancer research : CR
Niu CS,Li MW,Ni YF,Chen JM,Mei JM,Li J,Fu XM
Tue Aug 17 00:00:00 UTC 2010
Apotransferrin-induced recovery after hypoxic/ischaemic injury on myelination.
ASN neuro
Guardia Clausi M,Pasquini LA,Soto EF,Pasquini JM
Fri Nov 19 00:00:00 UTC 2010
Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting.
PloS one
Imaizumi N,Monnier Y,Hegi M,Mirimanoff RO,Rüegg C
Fri Jun 11 00:00:00 UTC 2010
A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells.
Nature protocols
Raya A,Rodríguez-Pizà I,Navarro S,Richaud-Patin Y,Guenechea G,Sánchez-Danés A,Consiglio A,Bueren J,Izpisúa Belmonte JC
100-18B was used in Cell Culture to produce a protocol for the reproducible generation of genetically corrected induced pluripotent stem cells (iPSCs) starting from the skin biopsies of Fanconi anemia patients using retroviral transduction with OCT4, SOX2 and KLF4 which could be applied to other diseases which are susceptible to gene therapy correction.
Thu Apr 01 00:00:00 UTC 2010
Polysialic acid neural cell adhesion molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines.
BMC cancer
Amoureux MC,Coulibaly B,Chinot O,Loundou A,Metellus P,Rougon G,Figarella-Branger D
Wed Mar 10 00:00:00 UTC 2010
Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions.
PloS one
Hayashi Y,Chan T,Warashina M,Fukuda M,Ariizumi T,Okabayashi K,Takayama N,Otsu M,Eto K,Furue MK,Michiue T,Ohnuma K,Nakauchi H,Asashima M
Tue Nov 23 00:00:00 UTC 2010
Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs.
PloS one
Andersson T,Rahman S,Sansom SN,Alsiö JM,Kaneda M,Smith J,O'Carroll D,Tarakhovsky A,Livesey FJ
Mon Oct 18 00:00:00 UTC 2010
Heparan sulfate domain organization and sulfation modulate FGF-induced cell signaling.
The Journal of biological chemistry
Jastrebova N,Vanwildemeersch M,Lindahl U,Spillmann D
Fri Aug 27 00:00:00 UTC 2010
Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells.
PLoS currents
Zhang N,An MC,Montoro D,Ellerby LM
Thu Oct 28 00:00:00 UTC 2010
Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells.
PLoS currents
Zhang N,An MC,Montoro D,Ellerby LM
Thu Oct 28 00:00:00 UTC 2010
Mild hypoxia enhances proliferation and multipotency of human neural stem cells.
PloS one
Santilli G,Lamorte G,Carlessi L,Ferrari D,Rota Nodari L,Binda E,Delia D,Vescovi AL,De Filippis L
Tue Jan 05 00:00:00 UTC 2010
In vitro and in vivo characterization of highly purified human mesothelioma derived cells.
BMC cancer
Melotti A,Daga A,Marubbi D,Zunino A,Mutti L,Corte G
Mon Feb 22 00:00:00 UTC 2010
Subcellular localization of Mayven following expression of wild type and mutant EGFP tagged cDNAs.
BMC neuroscience
Montague P,Kennedy PG,Barnett SC
Wed May 26 00:00:00 UTC 2010
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity.
The Journal of biological chemistry
Levy-Adam F,Feld S,Cohen-Kaplan V,Shteingauz A,Gross M,Arvatz G,Naroditsky I,Ilan N,Doweck I,Vlodavsky I
Fri Sep 03 00:00:00 UTC 2010
Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells.
Journal of molecular cell biology
Cai J,Yu C,Liu Y,Chen S,Guo Y,Yong J,Lu W,Ding M,Deng H
Mon Feb 01 00:00:00 UTC 2010
Generation of homogeneous PDX1(+) pancreatic progenitors from human ES cell-derived endoderm cells.
Journal of molecular cell biology
Cai J,Yu C,Liu Y,Chen S,Guo Y,Yong J,Lu W,Ding M,Deng H
Mon Feb 01 00:00:00 UTC 2010
Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/β-catenin signaling pathway.
Molecular cancer
Yoshihara T,Takahashi-Yanaga F,Shiraishi F,Morimoto S,Watanabe Y,Hirata M,Hoka S,Sasaguri T
Thu Sep 16 00:00:00 UTC 2010
Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.
PloS one
Ware KE,Marshall ME,Heasley LR,Marek L,Hinz TK,Hercule P,Helfrich BA,Doebele RC,Heasley LE
Mon Nov 29 00:00:00 UTC 2010
Direct reprogramming of human neural stem cells by OCT4.
Nature
Kim JB,Greber B,Araúzo-Bravo MJ,Meyer J,Park KI,Zaehres H,Schöler HR
Thu Oct 01 00:00:00 UTC 2009
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.
Nature
Raya A,Rodríguez-Pizà I,Guenechea G,Vassena R,Navarro S,Barrero MJ,Consiglio A,Castellà M,Río P,Sleep E,González F,Tiscornia G,Garreta E,Aasen T,Veiga A,Verma IM,Surrallés J,Bueren J,Izpisúa Belmonte JC
Thu Jul 02 00:00:00 UTC 2009
ErythRED, a hESC line enabling identification of erythroid cells.
Nature methods
Hatzistavrou T,Micallef SJ,Ng ES,Vadolas J,Stanley EG,Elefanty AG
Tue Sep 01 00:00:00 UTC 2009
Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency.
Nature methods
Hotta A,Cheung AY,Farra N,Vijayaragavan K,Séguin CA,Draper JS,Pasceri P,Maksakova IA,Mager DL,Rossant J,Bhatia M,Ellis J
Fri May 01 00:00:00 UTC 2009
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.
Cell research
Song Z,Cai J,Liu Y,Zhao D,Yong J,Duo S,Song X,Guo Y,Zhao Y,Qin H,Yin X,Wu C,Che J,Lu S,Ding M,Deng H
Sun Nov 01 00:00:00 UTC 2009
Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells.
Cell research
Zhang D,Jiang W,Liu M,Sui X,Yin X,Chen S,Shi Y,Deng H
Wed Apr 01 00:00:00 UTC 2009
Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors.
Cancer cell
Li M,Lee KF,Lu Y,Clarke I,Shih D,Eberhart C,Collins VP,Van Meter T,Picard D,Zhou L,Boutros PC,Modena P,Liang ML,Scherer SW,Bouffet E,Rutka JT,Pomeroy SL,Lau CC,Taylor MD,Gajjar A,Dirks PB,Hawkins CE,Huang A
Tue Dec 08 00:00:00 UTC 2009
TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.
Cancer cell
Peñuelas S,Anido J,Prieto-Sánchez RM,Folch G,Barba I,Cuartas I,García-Dorado D,Poca MA,Sahuquillo J,Baselga J,Seoane J
Tue Apr 07 00:00:00 UTC 2009
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.
Blood
Carmona G,Göttig S,Orlandi A,Scheele J,Bäuerle T,Jugold M,Kiessling F,Henschler R,Zeiher AM,Dimmeler S,Chavakis E
Thu Jan 08 00:00:00 UTC 2009
A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis.
Blood
Klimchenko O,Mori M,Distefano A,Langlois T,Larbret F,Lecluse Y,Feraud O,Vainchenker W,Norol F,Debili N
Thu Aug 20 00:00:00 UTC 2009
Epicardium and myocardium separate from a common precursor pool by crosstalk between bone morphogenetic protein- and fibroblast growth factor-signaling pathways.
Circulation research
van Wijk B,van den Berg G,Abu-Issa R,Barnett P,van der Velden S,Schmidt M,Ruijter JM,Kirby ML,Moorman AF,van den Hoff MJ
Fri Aug 28 00:00:00 UTC 2009
Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+ progenitors.
The Journal of clinical investigation
Choi KD,Vodyanik MA,Slukvin II
Tue Sep 01 00:00:00 UTC 2009
The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization.
Biomaterials
Freeman I,Cohen S
Wed Apr 01 00:00:00 UTC 2009
Induction of cartilage integration by a chondrocyte/collagen-scaffold implant.
Biomaterials
Pabbruwe MB,Esfandiari E,Kafienah W,Tarlton JF,Hollander AP
Tue Sep 01 00:00:00 UTC 2009
Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis.
Cancer research
Yang X,Qiao D,Meyer K,Friedl A
Sun Feb 15 00:00:00 UTC 2009
Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis.
Cancer research
Yang X,Qiao D,Meyer K,Friedl A
Sun Feb 15 00:00:00 UTC 2009
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy.
Proceedings of the National Academy of Sciences of the United States of America
Sasportas LS,Kasmieh R,Wakimoto H,Hingtgen S,van de Water JA,Mohapatra G,Figueiredo JL,Martuza RL,Weissleder R,Shah K
Tue Mar 24 00:00:00 UTC 2009
Derivation of induced pluripotent stem cells from pig somatic cells.
Proceedings of the National Academy of Sciences of the United States of America
Ezashi T,Telugu BP,Alexenko AP,Sachdev S,Sinha S,Roberts RM
Tue Jul 07 00:00:00 UTC 2009
HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells.
Proceedings of the National Academy of Sciences of the United States of America
Pietras A,Hansford LM,Johnsson AS,Bridges E,Sjölund J,Gisselsson D,Rehn M,Beckman S,Noguera R,Navarro S,Cammenga J,Fredlund E,Kaplan DR,Påhlman S
Tue Sep 29 00:00:00 UTC 2009
Shifted Transversal Design smart-pooling for high coverage interactome mapping.
Genome research
Xin X,Rual JF,Hirozane-Kishikawa T,Hill DE,Vidal M,Boone C,Thierry-Mieg N
Wed Jul 01 00:00:00 UTC 2009
Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines.
Oncogene
Swartling FJ,Ferletta M,Kastemar M,Weiss WA,Westermark B
Thu Sep 03 00:00:00 UTC 2009
The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking.
The Journal of cell biology
Francavilla C,Cattaneo P,Berezin V,Bock E,Ami D,de Marco A,Christofori G,Cavallaro U
Mon Dec 28 00:00:00 UTC 2009
Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3).
European journal of cell biology
Chioni AM,Grose R
Wed Jul 01 00:00:00 UTC 2009
Endogenous Wnt signaling maintains neural progenitor cell potency.
Stem cells (Dayton, Ohio)
Wexler EM,Paucer A,Kornblum HI,Palmer TD,Geschwind DH
Fri May 01 00:00:00 UTC 2009
Neurogenesis in the dentate gyrus depends on ciliary neurotrophic factor and signal transducer and activator of transcription 3 signaling.
Stem cells (Dayton, Ohio)
Müller S,Chakrapani BP,Schwegler H,Hofmann HD,Kirsch M
Sun Feb 01 00:00:00 UTC 2009
Blood-brain barrier promotes differentiation of human fetal neural precursor cells.
Stem cells (Dayton, Ohio)
Chintawar S,Cayrol R,Antel J,Pandolfo M,Prat A
Wed Apr 01 00:00:00 UTC 2009
Identification of nonepithelial multipotent cells in the embryonic olfactory mucosa.
Stem cells (Dayton, Ohio)
Tomé M,Lindsay SL,Riddell JS,Barnett SC
Tue Sep 01 00:00:00 UTC 2009
Neurosphere formation is an independent predictor of clinical outcome in malignant glioma.
Stem cells (Dayton, Ohio)
Laks DR,Masterman-Smith M,Visnyei K,Angenieux B,Orozco NM,Foran I,Yong WH,Vinters HV,Liau LM,Lazareff JA,Mischel PS,Cloughesy TF,Horvath S,Kornblum HI
Wed Apr 01 00:00:00 UTC 2009
Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens.
Stem cells (Dayton, Ohio)
Xu Q,Liu G,Yuan X,Xu M,Wang H,Ji J,Konda B,Black KL,Yu JS
Sat Aug 01 00:00:00 UTC 2009
Nuclear factor I isoforms regulate gene expression during the differentiation of human neural progenitors to astrocytes.
Stem cells (Dayton, Ohio)
Wilczynska KM,Singh SK,Adams B,Bryan L,Rao RR,Valerie K,Wright S,Griswold-Prenner I,Kordula T
Fri May 01 00:00:00 UTC 2009
SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity.
Stem cells (Dayton, Ohio)
Gangemi RM,Griffero F,Marubbi D,Perera M,Capra MC,Malatesta P,Ravetti GL,Zona GL,Daga A,Corte G
Thu Jan 01 00:00:00 UTC 2009
Hematopoietic and endothelial differentiation of human induced pluripotent stem cells.
Stem cells (Dayton, Ohio)
Choi KD,Yu J,Smuga-Otto K,Salvagiotto G,Rehrauer W,Vodyanik M,Thomson J,Slukvin I
Sun Mar 01 00:00:00 UTC 2009
A novel approach for the derivation of putative primordial germ cells and sertoli cells from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Bucay N,Yebra M,Cirulli V,Afrikanova I,Kaido T,Hayek A,Montgomery AM
Thu Jan 01 00:00:00 UTC 2009
Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells.
Stem cells (Dayton, Ohio)
Takanaga H,Tsuchida-Straeten N,Nishide K,Watanabe A,Aburatani H,Kondo T
Thu Jan 01 00:00:00 UTC 2009
A feeder-free and efficient production of functional neutrophils from human embryonic stem cells.
Stem cells (Dayton, Ohio)
Saeki K,Saeki K,Nakahara M,Matsuyama S,Nakamura N,Yogiashi Y,Yoneda A,Koyanagi M,Kondo Y,Yuo A
Thu Jan 01 00:00:00 UTC 2009
NK cells recognize and kill human glioblastoma cells with stem cell-like properties.
Journal of immunology (Baltimore, Md. : 1950)
Castriconi R,Daga A,Dondero A,Zona G,Poliani PL,Melotti A,Griffero F,Marubbi D,Spaziante R,Bellora F,Moretta L,Moretta A,Corte G,Bottino C
Sun Mar 15 00:00:00 UTC 2009
High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
American journal of physiology. Cell physiology
Mohan S,Konopinski R,Yan B,Centonze VE,Natarajan M
Thu Jan 01 00:00:00 UTC 2009
Human neural stem cells overexpressing glial cell line-derived neurotrophic factor in experimental cerebral hemorrhage.
Gene therapy
Lee HJ,Park IH,Kim HJ,Kim SU
Tue Sep 01 00:00:00 UTC 2009
Evaluation of extracellular matrix formation in polycaprolactone and starch-compounded polycaprolactone nanofiber meshes when seeded with bovine articular chondrocytes.
Tissue engineering. Part A
da Silva MA,Crawford A,Mundy J,Martins A,Araújo JV,Hatton PV,Reis RL,Neves NM
Sun Feb 01 00:00:00 UTC 2009
Evidence for in vivo growth potential and vascular remodeling of tissue-engineered artery.
Tissue engineering. Part A
Cho SW,Kim IK,Kang JM,Song KW,Kim HS,Park CH,Yoo KJ,Kim BS
Wed Apr 01 00:00:00 UTC 2009
Angiogenic capacity of human adipose-derived stromal cells during adipogenic differentiation: an in vitro study.
Tissue engineering. Part A
Verseijden F,Jahr H,Posthumus-van Sluijs SJ,Ten Hagen TL,Hovius SE,Seynhaeve AL,van Neck JW,van Osch GJ,Hofer SO
Sun Feb 01 00:00:00 UTC 2009
Practical induction system for dopamine-producing cells from bone marrow stromal cells using spermine-pullulan-mediated reverse transfection method.
Tissue engineering. Part A
Nagane K,Kitada M,Wakao S,Dezawa M,Tabata Y
Wed Jul 01 00:00:00 UTC 2009
Contribution of rat endothelial progenitor cells on three-dimensional network formation in vitro.
Tissue engineering. Part A
Koga M,Sudo R,Abe Y,Yamamoto K,Ando J,Ikeda M,Tanishita K
Tue Sep 01 00:00:00 UTC 2009
Three-dimensional engineered bone from bone marrow stromal cells and their autogenous extracellular matrix.
Tissue engineering. Part A
Syed-Picard FN,Larkin LM,Shaw CM,Arruda EM
Thu Jan 01 00:00:00 UTC 2009
Visualization of intracellular ice formation using high-speed video cryomicroscopy.
Cryobiology
Stott SL,Karlsson JOM
Sun Feb 01 00:00:00 UTC 2009
Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue.
PloS one
Davis DR,Zhang Y,Smith RR,Cheng K,Terrovitis J,Malliaras K,Li TS,White A,Makkar R,Marbán E
Fri Sep 25 00:00:00 UTC 2009
Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination.
The Journal of biological chemistry
Wang PS,Wang J,Xiao ZC,Pallen CJ
Fri Nov 27 00:00:00 UTC 2009
Antiangiogenic targeting liposomes increase therapeutic efficacy for solid tumors.
The Journal of biological chemistry
Chang DK,Chiu CY,Kuo SY,Lin WC,Lo A,Wang YP,Li PC,Wu HC
Fri May 08 00:00:00 UTC 2009
A continuum of cell states spans pluripotency and lineage commitment in human embryonic stem cells.
PloS one
Hough SR,Laslett AL,Grimmond SB,Kolle G,Pera MF
Thu Nov 05 00:00:00 UTC 2009
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.
The Journal of biological chemistry
Ardi VC,Van den Steen PE,Opdenakker G,Schweighofer B,Deryugina EI,Quigley JP
Fri Sep 18 00:00:00 UTC 2009
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway.
The Journal of biological chemistry
Ardi VC,Van den Steen PE,Opdenakker G,Schweighofer B,Deryugina EI,Quigley JP
Fri Sep 18 00:00:00 UTC 2009
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors.
The Journal of biological chemistry
Essaghir A,Dif N,Marbehant CY,Coffer PJ,Demoulin JB
Fri Apr 17 00:00:00 UTC 2009
Convergence of cells from the progenitor fraction of adult olfactory bulb tissue to remyelinating glia in demyelinating spinal cord lesions.
PloS one
Markakis EA,Sasaki M,Lankford KL,Kocsis JD
Tue Sep 29 00:00:00 UTC 2009
Isolation and cultivation of stem cells from adult mouse testes.
Nature protocols
Guan K,Wolf F,Becker A,Engel W,Nayernia K,Hasenfuss G
Wed Apr 01 00:00:00 UTC 2009
Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors.
The Journal of biological chemistry
Griffero F,Daga A,Marubbi D,Capra MC,Melotti A,Pattarozzi A,Gatti M,Bajetto A,Porcile C,Barbieri F,Favoni RE,Lo Casto M,Zona G,Spaziante R,Florio T,Corte G
Fri Mar 13 00:00:00 UTC 2009
Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1.
PloS one
Casalbore P,Budoni M,Ricci-Vitiani L,Cenciarelli C,Petrucci G,Milazzo L,Montano N,Tabolacci E,Maira G,Larocca LM,Pallini R
Wed Apr 01 00:00:00 UTC 2009
Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus.
BMC neuroscience
Borgs L,Beukelaers P,Vandenbosch R,Nguyen L,Moonen G,Maquet P,Albrecht U,Belachew S,Malgrange B
Fri Mar 27 00:00:00 UTC 2009
Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells.
Cell stem cell
Idelson M,Alper R,Obolensky A,Ben-Shushan E,Hemo I,Yachimovich-Cohen N,Khaner H,Smith Y,Wiser O,Gropp M,Cohen MA,Even-Ram S,Berman-Zaken Y,Matzrafi L,Rechavi G,Banin E,Reubinoff B
Fri Oct 02 00:00:00 UTC 2009
Local ATP generation by brain-type creatine kinase (CK-B) facilitates cell motility.
PloS one
Kuiper JW,van Horssen R,Oerlemans F,Peters W,van Dommelen MM,te Lindert MM,ten Hagen TL,Janssen E,Fransen JA,Wieringa B
Thu May 28 00:00:00 UTC 2009
Functional whole-genome analysis identifies Polo-like kinase 2 and poliovirus receptor as essential for neuronal differentiation upstream of the negative regulator alphaB-crystallin.
The Journal of biological chemistry
Draghetti C,Salvat C,Zanoguera F,Curchod ML,Vignaud C,Peixoto H,Di Cara A,Fischer D,Dhanabal M,Andreas G,Abderrahim H,Rommel C,Camps M
Fri Nov 13 00:00:00 UTC 2009
Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas.
The Journal of biological chemistry
Sim H,Hu B,Viapiano MS
Fri Sep 25 00:00:00 UTC 2009
FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression.
The Journal of biological chemistry
Chen PY,Simons M,Friesel R
Fri Jun 05 00:00:00 UTC 2009
Molecular structure of heparan sulfate from Spalax. Implications of heparanase and hypoxia.
The Journal of biological chemistry
Sandwall E,Bodevin S,Nasser NJ,Nevo E,Avivi A,Vlodavsky I,Li JP
Fri Feb 06 00:00:00 UTC 2009
Two factor reprogramming of human neural stem cells into pluripotency.
PloS one
Hester ME,Song S,Miranda CJ,Eagle A,Schwartz PH,Kaspar BK
Fri Sep 18 00:00:00 UTC 2009
Clinical transplantation of a tissue-engineered airway.
Lancet (London, England)
Macchiarini P,Jungebluth P,Go T,Asnaghi MA,Rees LE,Cogan TA,Dodson A,Martorell J,Bellini S,Parnigotto PP,Dickinson SC,Hollander AP,Mantero S,Conconi MT,Birchall MA
Sat Dec 13 00:00:00 UTC 2008
Generation of pluripotent stem cells from adult human testis.
Nature
Conrad S,Renninger M,Hennenlotter J,Wiesner T,Just L,Bonin M,Aicher W,Bühring HJ,Mattheus U,Mack A,Wagner HJ,Minger S,Matzkies M,Reppel M,Hescheler J,Sievert KD,Stenzl A,Skutella T
Thu Nov 20 00:00:00 UTC 2008
Synergistic antitumor activity of ixabepilone (BMS-247550) plus bevacizumab in multiple in vivo tumor models.
Clinical cancer research : an official journal of the American Association for Cancer Research
Lee FY,Covello KL,Castaneda S,Hawken DR,Kan D,Lewin A,Wen ML,Ryseck RP,Fairchild CR,Fargnoli J,Kramer R
Mon Dec 15 00:00:00 UTC 2008
Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain.
Proceedings of the National Academy of Sciences of the United States of America
Kohyama J,Kojima T,Takatsuka E,Yamashita T,Namiki J,Hsieh J,Gage FH,Namihira M,Okano H,Sawamoto K,Nakashima K
Tue Nov 18 00:00:00 UTC 2008
Setting the conditions for efficient, robust and reproducible generation of functionally active neurons from adult subventricular zone-derived neural stem cells.
Cell death and differentiation
Goffredo D,Conti L,Di Febo F,Biella G,Tosoni A,Vago G,Biunno I,Moiana A,Bolognini D,Toselli M,Cattaneo E
Mon Dec 01 00:00:00 UTC 2008
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1.
The Journal of cell biology
Blagoveshchenskaya A,Cheong FY,Rohde HM,Glover G,Knödler A,Nicolson T,Boehmelt G,Mayinger P
Mon Feb 25 00:00:00 UTC 2008
Hyperoxia causes maturation-dependent cell death in the developing white matter.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gerstner B,DeSilva TM,Genz K,Armstrong A,Brehmer F,Neve RL,Felderhoff-Mueser U,Volpe JJ,Rosenberg PA
100-18B was used in Tissue/organ culture to investigate the pathway of hyperoxia-induced oligodendrocyte death in rats.
Wed Jan 30 00:00:00 UTC 2008
Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells.
Stem cells (Dayton, Ohio)
Johansson S,Price J,Modo M
Mon Sep 01 00:00:00 UTC 2008
Microenvironments engineered by inkjet bioprinting spatially direct adult stem cells toward muscle- and bone-like subpopulations.
Stem cells (Dayton, Ohio)
Phillippi JA,Miller E,Weiss L,Huard J,Waggoner A,Campbell P
Tue Jan 01 00:00:00 UTC 2008
Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal.
Stem cells (Dayton, Ohio)
Mayshar Y,Rom E,Chumakov I,Kronman A,Yayon A,Benvenisty N
Sat Mar 01 00:00:00 UTC 2008
Secreted proteoglycans directly mediate human embryonic stem cell-basic fibroblast growth factor 2 interactions critical for proliferation.
Stem cells (Dayton, Ohio)
Levenstein ME,Berggren WT,Lee JE,Conard KR,Llanas RA,Wagner RJ,Smith LM,Thomson JA
Mon Dec 01 00:00:00 UTC 2008
Similar behaviour and primate-like properties of adult canine Schwann cells and olfactory ensheathing cells in long-term culture.
Brain research
Techangamsuwan S,Imbschweiler I,Kreutzer R,Kreutzer M,Baumgärtner W,Wewetzer K
Thu Nov 13 00:00:00 UTC 2008
FGF signals from the nasal pit are necessary for normal facial morphogenesis.
Developmental biology
Szabo-Rogers HL,Geetha-Loganathan P,Nimmagadda S,Fu KK,Richman JM
Sun Jun 15 00:00:00 UTC 2008
Generation of insulin-secreting islet-like clusters from human skin fibroblasts.
The Journal of biological chemistry
Tateishi K,He J,Taranova O,Liang G,D'Alessio AC,Zhang Y
Fri Nov 14 00:00:00 UTC 2008
MUC1* mediates the growth of human pluripotent stem cells.
PloS one
Hikita ST,Kosik KS,Clegg DO,Bamdad C
Fri Oct 03 00:00:00 UTC 2008
Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.
Arthritis and rheumatism
Sawaji Y,Hynes J,Vincent T,Saklatvala J
Sat Nov 01 00:00:00 UTC 2008
Electroporation strategies for genetic manipulation and cell labeling.
Methods in molecular biology (Clifton, N.J.)
Van Raay TJ,Lassiter RT,Stark MR
100-18B was used in Cell Culture to provide protocols for the application of in ovo chick electroporation and in vitro targeting of neuroepithelial precursor cells.
Thu Apr 17 00:00:00 UTC 2008
Isolation of neural stem and precursor cells from rodent tissue.
Methods in molecular biology (Clifton, N.J.)
Wu Y,Liu Y,Chesnut JD,Rao MS
100-18B was used in Cell Culture to provide a protocol for dissection of rodent embryonic spinal cords by enzymatic separation, and isolation and enrichment (or purification) of neuronal and glial precursors at different developing stages by fluorescence-activated cell sorting.
Thu Apr 17 00:00:00 UTC 2008
FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc.
Blood
Nakayama T,Mutsuga N,Tosato G
Thu Feb 15 00:00:00 UTC 2007
FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc.
Blood
Nakayama T,Mutsuga N,Tosato G
Thu Feb 15 00:00:00 UTC 2007
Conditional activation of FGFR1 in the prostate epithelium induces angiogenesis with concomitant differential regulation of Ang-1 and Ang-2.
Oncogene
Winter SF,Acevedo VD,Gangula RD,Freeman KW,Spencer DM,Greenberg NM
Thu Jul 26 00:00:00 UTC 2007
The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.
Stem cells (Dayton, Ohio)
Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J
Sun Jul 01 00:00:00 UTC 2007
Potentiation of fibroblast growth factor activity by synthetic heparin oligosaccharide glycodendrimers.
Chemistry & biology
de Paz JL,Noti C,Böhm F,Werner S,Seeberger PH
Wed Aug 01 00:00:00 UTC 2007
Potentiation of fibroblast growth factor activity by synthetic heparin oligosaccharide glycodendrimers.
Chemistry & biology
de Paz JL,Noti C,Böhm F,Werner S,Seeberger PH
Wed Aug 01 00:00:00 UTC 2007
Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine.
Annals of the New York Academy of Sciences
Cass WA,Peters LE,Harned ME,Seroogy KB
Tue Aug 01 00:00:00 UTC 2006
BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage.
Developmental biology
Kruithof BP,van Wijk B,Somi S,Kruithof-de Julio M,Pérez Pomares JM,Weesie F,Wessels A,Moorman AF,van den Hoff MJ
Sat Jul 15 00:00:00 UTC 2006
Skin-derived micro-organs induce angiogenesis in rabbits.
Journal of vascular research
Hasson E,Gallula J,Shimoni Y,Grad-Itach E,Marikovsky M,Mitrani E
Thu Mar 16 00:00:00 UTC 2006
Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy.
Journal of translational medicine
Khaitan D,Chandna S,Arya MB,Dwarakanath BS
Thu Mar 02 00:00:00 UTC 2006
Generation and characterization of oligodendrocytes from lineage-selectable embryonic stem cells in vitro.
Methods in molecular biology (Clifton, N.J.)
Billon N,Jolicoeur C,Raff M
100-18B was used in Cell Culture to culture and efficently transform modified mouse ES cells to neural precursor cells, OPCs or oligodendrocytes.
Tue Aug 22 00:00:00 UTC 2006
Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments.
Molecular systems biology
Soen Y,Mori A,Palmer TD,Brown PO
Fri Sep 29 00:00:00 UTC 2006
Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans.
The Journal of biological chemistry
McDowell LM,Frazier BA,Studelska DR,Giljum K,Chen J,Liu J,Yu K,Ornitz DM,Zhang L
Fri Mar 17 00:00:00 UTC 2006
Isolation and differentiation of medaka embryonic stem cells.
Methods in molecular biology (Clifton, N.J.)
Hong Y,Schartl M
100-18B was used in Cell Culture to evaluate the use of midblastula embryos to generate embryonic stem cells from medaka.
Fri Aug 25 00:00:00 UTC 2006
ERM is required for transcriptional control of the spermatogonial stem cell niche.
Nature
Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM
Thu Aug 18 00:00:00 UTC 2005
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.
Developmental cell
Lavine KJ,Yu K,White AC,Zhang X,Smith C,Partanen J,Ornitz DM
Sat Jan 01 00:00:00 UTC 2005
FGF-18 is upregulated in the postnatal rat lung and enhances elastogenesis in myofibroblasts.
American journal of physiology. Lung cellular and molecular physiology
Chailley-Heu B,Boucherat O,Barlier-Mur AM,Bourbon JR
Sat Jan 01 00:00:00 UTC 2005
Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol.
Journal of immunology (Baltimore, Md. : 1950)
Øynebråten I,Barois N,Hagelsteen K,Johansen FE,Bakke O,Haraldsen G
Sat Oct 15 00:00:00 UTC 2005
Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype.
Genes & development
Murakami S,Balmes G,McKinney S,Zhang Z,Givol D,de Crombrugghe B
Sun Feb 01 00:00:00 UTC 2004
Bombesin antagonists inhibit proangiogenic factors in human experimental breast cancers.
British journal of cancer
Bajo AM,Schally AV,Groot K,Szepeshazi K
Mon Jan 12 00:00:00 UTC 2004
Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts.
Arthritis and rheumatism
Nakano K,Okada Y,Saito K,Tanaka Y
Sun Aug 01 00:00:00 UTC 2004
Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded.
Arthritis and rheumatism
Vincent TL,Hermansson MA,Hansen UN,Amis AA,Saklatvala J
Sun Feb 01 00:00:00 UTC 2004
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.
Cancer research
Matsuyama S,Iwadate M,Kondo M,Saitoh M,Hanyu A,Shimizu K,Aburatani H,Mishima HK,Imamura T,Miyazono K,Miyazawa K
Sat Nov 15 00:00:00 UTC 2003
A role for thrombopoietin in hemangioblast development.
Stem cells (Dayton, Ohio)
Perlingeiro RC,Kyba M,Bodie S,Daley GQ
Fri Feb 27 00:00:00 UTC 2004
Heparin/Heparan sulfate domains in binding and signaling of fibroblast growth factor 8b.
The Journal of biological chemistry
Loo BM,Salmivirta M
Fri Sep 06 00:00:00 UTC 2002
FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling.
Development (Cambridge, England)
Lovicu FJ,McAvoy JW
Sat Dec 01 00:00:00 UTC 2001
Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.
Laboratory investigation; a journal of technical methods and pathology
Feraud O,Cao Y,Vittet D
Sat Dec 01 00:00:00 UTC 2001
Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.
Laboratory investigation; a journal of technical methods and pathology
Feraud O,Cao Y,Vittet D
Sat Dec 01 00:00:00 UTC 2001
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hanson MG,Shen S,Wiemelt AP,McMorris FA,Barres BA
Tue Sep 15 00:00:00 UTC 1998
Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures.
The Journal of physiology
Liou JC,Yang RS,Fu WM
Fri Aug 15 00:00:00 UTC 1997
