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Invitrogen
Human FGFR1OP2 (aa 10-95) Control Fragment Recombinant Protein
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Product Details
RP-97727
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
ADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQS
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (99%), Rat (99%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58500. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
FGFR1OP2, also known as FGFR1 oncogene partner 2, is a gene that plays a crucial role in oncogenesis, particularly in myeloproliferative neoplasms. It is known to interact with the FGFR1 (Fibroblast Growth Factor Receptor 1) through chromosomal translocations that can lead to malignancies, such as the formation of the fusion protein FGFR1OP2-FGFR1 in KG-1a leukemic cells. FGFR1OP2 itself is a gene encoding a protein whose function is not entirely understood, but its association with FGFR1 highlights its potential role in oncogenic pathways. The FGFR1 component of the fusion is a receptor tyrosine kinase involved in various cellular processes like cell proliferation, migration, and differentiation. The disruption of these processes through abnormal expression or structural changes such as fusions can lead to uncontrolled cell growth and malignancies. FGFR1 is also frequently studied as a therapeutic target in cancer, given its importance in cellular signaling and cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGFR1 oncogene partner 2; fibroblast growth factor receptor 1 oncogene partner 2; wound inducible transcript 3.0
Gene Aliases: FGFR1OP2; HSPC123; HSPC123-like; WIT3.0
UniProt ID: (Human) Q9NVK5
Entrez Gene ID: (Human) 26127
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