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Invitrogen
Human GTPBP2 (aa 65-165) Control Fragment Recombinant Protein
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Product Details
RP-94951
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
DGNIEYKLKLVNPSQYRFEHLVTQMKWRLQEGRGEAVYQIGVEDNGLLVGLAEEEMRASLKTLHRMAEKVGADITVLREREVDYDSDMPRKITEVLVRKVP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (99%), Rat (99%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56738. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Small G proteins act as molecular switches for regulation of variety of cellular processes, such as nuclear transport, signal transduction, membrane trafficking and protein synthesis. GTPBP2 (GTP-binding protein 2) is a 602 amino acid G protein that is expressed in kidney, skeletal muscle, testis, brain and thymus, though it is not detected in liver. Expression of GTPBP2 is enhanced by ©-interferon stimulation in HeLa cells, THP-1 cells and thioglycollate-elicited mouse peritoneal macrophages. There are four isoforms of GTPBP2 that are expressed as a result of alternative splicing events. Since mutation of the gene encoding GTPBP1 does not lead to any phenotypic abnormalities, it is thought that there may be a genetic redundancy to make up for GTPBP1 lack-of-function. GTPBP2 shares 44% sequence similarity with GTPBP1 and also overlaps in expression pattern, suggesting that the GTPBP2 gene may compensate for GTPBP1 genetic abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein 2; GTPBP2
Gene Aliases: GTPBP2
UniProt ID: (Human) Q9BX10
Entrez Gene ID: (Human) 54676
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