Product References
Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization.
Cellular oncology (Dordrecht, Netherlands)
McAloney CA,Makkawi R,Budhathoki Y,Cannon MV,Franz EM,Gross AC,Cam M,Vetter TA,Duhen R,Davies AE,Roberts RD
100-47 was used in In vitro experiments to develop therapeutic strategies that prevent and treat metastasis by identifying mechanisms that facilitate survival of disseminated tumour cells.
Thu Feb 01 00:00:00 UTC 2024
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.
Nature immunology
Linnerbauer M,Lößlein L,Vandrey O,Peter A,Han Y,Tsaktanis T,Wogram E,Needhamsen M,Kular L,Nagel L,Zissler J,Andert M,Meszaros L,Hanspach J,Zuber F,Naumann UJ,Diebold M,Wheeler MA,Beyer T,Nirschl L,Cirac A,Laun FB,Günther C,Winkler J,Bäuerle T,Jagodic M,Hemmer B,Prinz M,Quintana FJ,Rothhammer V
100-47 was used in Cell Culture to identify astrocyte-derived HB-EGF and its epigenetic regulation as a modulator of autoimmune CNS inflammation and potential therapeutic target in MS.
Fri Mar 01 00:00:00 UTC 2024
Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration.
iScience
Liu F,Lin Q,Shen S,Li Z,Xie X,Cheng Q,Wang L,Long Y,Wang J,Liu L
100-47 was used in In vitro experiments to design an extracellular matrix (ECM)-adhesion mimic hydrogel for intrauterine administration, which was more effective than direct injection in treating intrauterine adhesions.
Fri Jun 21 00:00:00 UTC 2024
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Nature communications
Zhang Y,Fan Y,Hu H,Zhang X,Wang Z,Wu Z,Wang L,Yu X,Song X,Xiang P,Zhang X,Wang T,Tan S,Li C,Gao L,Liang X,Li S,Li N,Yue X,Ma C
100-47 was used in Tissue/organ culture to clarify Zinc Fingers And Homeoboxes 2 as a negative regulator of mitochondrial oxidative phosphorylation and a potential target for developing strategies for improving liver recovery after acute injuries.
Sat Nov 18 00:00:00 UTC 2023
Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study.
International endodontic journal
Guo R,Gu T,Xiao Y,Xiao T,Liu Q,Li Z,Yu J
100-47 was used in In vitro experiments to determine the role of miR-27b-5p in regulating osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth (SHEDs) and further examined the regulatory mechanism of bone morphogenetic protein receptor type-1A (BMPR1A).
Sun Oct 01 00:00:00 UTC 2023
Integrated Multi-Omics Profiling of Young Breast Cancer Patients Reveals a Correlation between Galactose Metabolism Pathway and Poor Disease-Free Survival.
Cancers
Han X,Han B,Luo H,Ling H,Hu X
100-47 was used in Cell Culture to perform an integrative analysis of bulk transcriptional and genomic data from extensive clinical cohorts to identify the prognostic factors.
Tue Sep 19 00:00:00 UTC 2023
Enhanced hippocampal neurogenesis mediated by PGC-1α-activated OXPHOS after neonatal low-dose Propofol exposure.
Frontiers in aging neuroscience
Chen K,Lu D,Yang X,Zhou R,Lan L,Wu Y,Wang C,Xu X,Jiang MH,Wei M,Feng X
100-47 was used in Cell Culture to investigate effects of Propofol anaesthetic on developing brains, modeled in mice.
Tue Aug 16 00:00:00 UTC 2022
Association of glioma CD44 expression with glial dynamics in the tumour microenvironment and patient prognosis.
Computational and structural biotechnology journal
Du Z,Wang Y,Liang J,Gao S,Cai X,Yu Y,Qi Z,Li J,Xie Y,Wang Z
100-47 was used in Cell Culture to find that astrocytes could elevate the CD44 expression level of glioma cells, enhancing the recruitment of M1 macrophages that may promote glioma stemness via osteopontin-CD44 signalling.
Tue Oct 04 00:00:00 UTC 2022
High-throughput formation and image-based analysis of basal-in mammary organoids in 384-well plates.
Scientific reports
Lee S,Chang J,Kang SM,Parigoris E,Lee JH,Huh YS,Takayama S
100-47 was used in Cell Culture to profile early changes in size and circularity.
Mon Jan 10 00:00:00 UTC 2022
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Cancer cell
Hara T,Chanoch-Myers R,Mathewson ND,Myskiw C,Atta L,Bussema L,Eichhorn SW,Greenwald AC,Kinker GS,Rodman C,Gonzalez Castro LN,Wakimoto H,Rozenblatt-Rosen O,Zhuang X,Fan J,Hunter T,Verma IM,Wucherpfennig KW,Regev A,Suvà ML,Tirosh I
Mon Jun 14 00:00:00 UTC 2021
Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time.
Chemical science
Prakash P,Jethava KP,Korte N,Izquierdo P,Favuzzi E,Rose IVL,Guttenplan KA,Manchanda P,Dutta S,Rochet JC,Fishell G,Liddelow SA,Attwell D,Chopra G
100-47 was used in Cell Culture to find that microglia phagocytose more AβpH than astrocytes in culture, in brain slices and in vivo.
Wed Aug 18 00:00:00 UTC 2021
Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53.
Oncogene
Lindzen M,Ghosh S,Noronha A,Drago D,Nataraj NB,Leitner O,Carvalho S,Zmora E,Sapoznik S,Shany KB,Levanon K,Aderka D,Ramírez BS,Dahlhoff M,McNeish I,Yarden Y
Sat May 01 00:00:00 UTC 2021
Neonatal cortical astrocytes possess intrinsic potential in neuronal conversion in defined media.
Acta pharmacologica Sinica
Zeng P,Hua QH,Gong JY,Shi CJ,Pi XP,Xie X,Zhang R
100-47 was used in Cell Culture to suggest that neonatal astrocytes from certain brain regions possess intrinsic potential to differentiate/transdifferentiate into neurons which may have clinical relevance in the future.
Mon Nov 01 00:00:00 UTC 2021
Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models.
Cells
Verma DK,Seo BA,Ghosh A,Ma SX,Hernandez-Quijada K,Andersen JK,Ko HS,Kim YH
100-47 was used in Cell Culture to indicate that PFF-induced pathology could lead to astrocyte and/or microglia senescence in PD brains, which may contribute to neuropathology in this model.
Mon Jul 05 00:00:00 UTC 2021
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex.
Nature communications
Wang P,Ye Y
Mon Jan 04 00:00:00 UTC 2021
Novel factor in olfactory ensheathing cell-astrocyte crosstalk: Anti-inflammatory protein α-crystallin B.
Glia
Saglam A,Calof AL,Wray S
100-47 was used in Cell Culture to indicate CryAB, as well as other factors secreted by OECs, are potential agents that can ameliorate, or even reverse, the growth-inhibitory environment created by neurotoxic reactive astrocytes following CNS injuries.
Thu Apr 01 00:00:00 UTC 2021
A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Yu S,Lu Y,Su A,Chen J,Li J,Zhou B,Liu X,Xia Q,Li Y,Li J,Huang M,Ye Y,Zhao Q,Jiang S,Yan X,Wang X,Di C,Pan J,Su S
Fri Oct 01 00:00:00 UTC 2021
Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening.
Cell reports
Ebisudani T,Sugimoto S,Haga K,Mitsuishi A,Takai-Todaka R,Fujii M,Toshimitsu K,Hamamoto J,Sugihara K,Hishida T,Asamura H,Fukunaga K,Yasuda H,Katayama K,Sato T
Tue Jun 08 00:00:00 UTC 2021
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
Cell
Huang W,Bhaduri A,Velmeshev D,Wang S,Wang L,Rottkamp CA,Alvarez-Buylla A,Rowitch DH,Kriegstein AR
100-47 was used in Cell Culture to indicate properties of OPC derivation, proliferation, and dispersion important for human white matter expansion and myelination.
Thu Aug 06 00:00:00 UTC 2020
A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Smith BA,Balanis NG,Tsai BL,Nguyen K,Cheng MW,Obusan MB,Esedebe FN,Patel SJ,Zhang H,Clark PM,Sisk AE,Said JW,Huang J,Graeber TG,Witte ON,Chin AI,Park JW
100-47 was used in Cell Culture to reveal distinct molecular features of small cell carcinoma of the bladder and provide a transcriptional dataset and a preclinical model for further investigating SCCB biology.
Tue Jan 07 00:00:00 UTC 2020
Regulation of the EGFR/ErbB signalling by clathrin in response to various ligands in hepatocellular carcinoma cell lines.
Journal of cellular and molecular medicine
Liu Y,Calmel C,Desbois-Mouthon C,Sobczak-Thépot J,Karaiskou A,Praz F
Wed Jul 01 00:00:00 UTC 2020
Combined targeting of EGFR and HER2 against prostate cancer stem cells.
Cancer biology & therapy
Rossini A,Giussani M,Ripamonti F,Aiello P,Regondi V,Balsari A,Triulzi T,Tagliabue E
100-47 was used in Cell Culture to provide the preclinical evidence that the dual inhibition of EGFR and HER2 by targeting tumor-initiating cells may improve the efficacy of the current chemotherapy regimen, bringing benefits especially to castration-resistant patients with activated STAT3, and preventing disease progression.
Sun May 03 00:00:00 UTC 2020
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment.
Cell
Gibson EM,Nagaraja S,Ocampo A,Tam LT,Wood LS,Pallegar PN,Greene JJ,Geraghty AC,Goldstein AK,Ni L,Woo PJ,Barres BA,Liddelow S,Vogel H,Monje M
Thu Jan 10 00:00:00 UTC 2019
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis.
Cell
Smillie CS,Biton M,Ordovas-Montanes J,Sullivan KM,Burgin G,Graham DB,Herbst RH,Rogel N,Slyper M,Waldman J,Sud M,Andrews E,Velonias G,Haber AL,Jagadeesh K,Vickovic S,Yao J,Stevens C,Dionne D,Nguyen LT,Villani AC,Hofree M,Creasey EA,Huang H,Rozenblatt-Rosen O,Garber JJ,Khalili H,Desch AN,Daly MJ,Ananthakrishnan AN,Shalek AK,Xavier RJ,Regev A
Thu Jul 25 00:00:00 UTC 2019
Perlecan domain I gradients establish stable biomimetic heparin binding growth factor gradients for cell migration in hydrogels.
Acta biomaterialia
Hubka KM,Carson DD,Harrington DA,Farach-Carson MC
100-47 was used in Cell Culture to demonstrate the ability of a variety of cells, including primary salivary stem/progenitor cells, pre-osteoblastic cells and an invasive breast cancer cell line, to be co-encapsulated in gradient hydrogels by flowing them together through the MGMD.
Tue Oct 01 00:00:00 UTC 2019
Syndecan-4 regulates extravillous trophoblast migration by coordinating protein kinase C activation.
Scientific reports
Jeyarajah MJ,Jaju Bhattad G,Kops BF,Renaud SJ
Mon Jul 15 00:00:00 UTC 2019
TSA restores hair follicle-inductive capacity of skin-derived precursors.
Scientific reports
Guo L,Wang X,Yuan J,Zhu M,Fu X,Xu RH,Wu C,Wu Y
Wed Feb 27 00:00:00 UTC 2019
Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain.
JCI insight
Ruegsegger GN,Vanderboom PM,Dasari S,Klaus KA,Kabiraj P,McCarthy CB,Lucchinetti CF,Nair KS
100-47 was used in Cell Culture to support that insulin sensitising by exercise and metformin restores brain mitochondrial function in insulin-resistant states.
Thu Sep 19 00:00:00 UTC 2019
Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes.
Translational psychiatry
Patel AM,Wierda K,Thorrez L,van Putten M,De Smedt J,Ribeiro L,Tricot T,Gajjar M,Duelen R,Van Damme P,De Waele L,Goemans N,Tanganyika-de Winter C,Costamagna D,Aartsma-Rus A,van Duyvenvoorde H,Sampaolesi M,Buyse GM,Verfaillie CM
Wed Aug 21 00:00:00 UTC 2019
CCL5 secreted by senescent theca-interstitial cells inhibits preantral follicular development via granulosa cellular apoptosis.
Journal of cellular physiology
Shen L,Chen Y,Cheng J,Yuan S,Zhou S,Yan W,Liu J,Luo A,Wang S
100-47 was used in In vitro experiments to suggest that SASP-associated CCL5 produced by senescent theca-interstitial cells may impair follicle development and maturation during ovarian aging by promoting granulosa cell apoptosis.
Sun Dec 01 00:00:00 UTC 2019
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors.
Cell
Konermann S,Lotfy P,Brideau NJ,Oki J,Shokhirev MN,Hsu PD
Thu Apr 19 00:00:00 UTC 2018
Circuit Design Features of a Stable Two-Cell System.
Cell
Zhou X,Franklin RA,Adler M,Jacox JB,Bailis W,Shyer JA,Flavell RA,Mayo A,Alon U,Medzhitov R
Thu Feb 08 00:00:00 UTC 2018
Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling.
Science signaling
Bian G,Yu C,Liu L,Fang C,Chen K,Ren P,Zhang Q,Liu F,Zhang K,Xue Q,Xiang J,Guo H,Song J,Zhao Y,Wu W,Chung SK,Sun R,Ju G,Wang J
Tue Oct 23 00:00:00 UTC 2018
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.
Cell stem cell
Fujii M,Matano M,Toshimitsu K,Takano A,Mikami Y,Nishikori S,Sugimoto S,Sato T
100-47 was used in In vitro experiments to investigate maintenance of intestinal organoid culture with reflective cellular diversity.
Thu Dec 06 00:00:00 UTC 2018
Mesenchymal Stromal Cells-Derived β2-Microglobulin Promotes Epithelial-Mesenchymal Transition of Esophageal Squamous Cell Carcinoma Cells.
Scientific reports
Wang J,Yang W,Wang T,Chen X,Wang J,Zhang X,Cai C,Zhong B,Wu J,Chen Z,Xiang AP,Huang W
Tue Apr 03 00:00:00 UTC 2018
3D-cultured human placenta-derived mesenchymal stem cell spheroids enhance ovary function by inducing folliculogenesis.
Scientific reports
Kim TH,Choi JH,Jun Y,Lim SM,Park S,Paek JY,Lee SH,Hwang JY,Kim GJ
Wed Oct 17 00:00:00 UTC 2018
ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration.
Cell death & disease
Zhang H,Shi JH,Jiang H,Wang K,Lu JY,Jiang X,Ma X,Chen YX,Ren AJ,Zheng J,Xie Z,Guo S,Xu X,Zhang WJ
Tue May 01 00:00:00 UTC 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 UTC 2018
Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.
Nature communications
Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA
Mon Jun 04 00:00:00 UTC 2018
Modulation of endoplasmic reticulum stress and the unfolded protein response in cancerous and noncancerous cells.
SAGE open medicine
Purnell MC,Butawan MB,Bingol K,Tolley EA,Whitt MA
100-47 was used in Cell Culture to study the potential to initiate apoptosis in cancerous cells while relieving cell stress in noncancerous cells in vitro.
Tue Sep 26 00:00:00 UTC 2023
Novel 3-D cell culture system for in vitro evaluation of anticancer drugs under anchorage-independent conditions.
Cancer science
Aihara A,Abe N,Saruhashi K,Kanaki T,Nishino T
Thu Dec 01 00:00:00 UTC 2016
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.
Scientific reports
Miller MA,Moss ML,Powell G,Petrovich R,Edwards L,Meyer AS,Griffith LG,Lauffenburger DA
Mon Oct 19 00:00:00 UTC 2015
Computer-assisted quantification of motile and invasive capabilities of cancer cells.
Scientific reports
Kumar KS,Pillong M,Kunze J,Burghardt I,Weller M,Grotzer MA,Schneider G,Baumgartner M
Wed Oct 21 00:00:00 UTC 2015
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 UTC 2013
2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen.
The Journal of cell biology
Meyer AS,Hughes-Alford SK,Kay JE,Castillo A,Wells A,Gertler FB,Lauffenburger DA
Mon Jun 11 00:00:00 UTC 2012
Tailored cancer immunotherapy using combinations of chemotherapy and a mixture of antibodies against EGF-receptor ligands.
Proceedings of the National Academy of Sciences of the United States of America
Lindzen M,Lavi S,Leitner O,Yarden Y
Tue Jul 13 00:00:00 UTC 2010
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.
Proceedings of the National Academy of Sciences of the United States of America
Wehrman TS,Raab WJ,Casipit CL,Doyonnas R,Pomerantz JH,Blau HM
Tue Dec 12 00:00:00 UTC 2006
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.
Proceedings of the National Academy of Sciences of the United States of America
Wehrman TS,Raab WJ,Casipit CL,Doyonnas R,Pomerantz JH,Blau HM
Tue Dec 12 00:00:00 UTC 2006
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.
Cancer research
Matsuyama S,Iwadate M,Kondo M,Saitoh M,Hanyu A,Shimizu K,Aburatani H,Mishima HK,Imamura T,Miyazono K,Miyazawa K
Sat Nov 15 00:00:00 UTC 2003
