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Gibco
Human IL-31 Recombinant Protein
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Product Details
PHC0314
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
Molecular weight
15.8 kDa
Class
Recombinant
Type
Protein
Purity
>98% by SDS-PAGE
Endotoxin concentration
<0.1 ng/µg
Activity
Determined by its ability to induce STAT3 activation in U87 cells.
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
10mM sodium phosphate, pH 7.5
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Carrier-Free
Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile distilled water to a concentration of 0.1-1.0 mg/mL. Do not vortex. For extended storage, dilute the constituted protein in buffered solution containing carrier protein, such as PBS with 0.1% BSA. Apportion the diluted protein into working aliquots, and store at ≤-20°C to -80°C.
Storage: The lyophilized protein is stable at room temperature for 1 month, but should be kept at -20°C to -80°C for long-term storage, preferably desiccated. The reconstituted protein is stable at 2-8°C for up to 1 week. Working aliquots stored with a carrier protein are stable for at least 3 months at ≤-20°C to ≤-80°C. Avoid repeated freeze-thaw cycles.
Target Information
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IL-31; ILN; Interleukin; Interleukin-31
Gene Aliases: IL-31; IL31
UniProt ID: (Human) Q6EBC2
Entrez Gene ID: (Human) 386653
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