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Invitrogen
Human Kallikrein 4 His-tag Recombinant Protein
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Product Details
RP-88090
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human KLK4, amino acids Met1-Ser254 (Accession # NP_004908.3) with a C-terminal His-tag
Tag
His-tag
Molecular weight
30-35 kDa
Class
Recombinant
Type
Protein
Purity
>94% as determined by SDS-PAGE.
Endotoxin concentration
<1.0 EU/µg
Activity
Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is >250 pmoles/min/ µg. (Activation description: The proenzyme needs to be activated by Thermolysin for an activated form)
Conjugate
Form
Lyophilized
Purification
purified
Storage buffer
PBS, pH 7.4, with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (200 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
Target Information
Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. A novel Kallikrein gene Prostase/KLK-L1 (also known as KLK4) is expressed and is up-regulated by androgens and progestins. KLK-L1 may be involved in the pathogenesis and/or progression of prostate, breast, and possibly other malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: androgen-regulated message 1; enamel matrix serine protease 1; Enamel matrix serine proteinase 1; Kallikrein-4; Kallikrein-like protein 1; kallikrein-related peptidase 4; KLK-4; KLK-L1; KLKL1; Prostase; Serine protease 17
Gene Aliases: AI2A1; ARM1; EMSP; EMSP1; kallikrein; KLK-L1; KLK4; PRSS17; PSTS
UniProt ID: (Human) Q9Y5K2
Entrez Gene ID: (Human) 9622
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