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Invitrogen
Human LRGUK (aa 742-819) Control Fragment Recombinant Protein
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Product Details
RP-92766
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
KCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEETRKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (54%), Rat (54%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56176. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The LRGUK (Leucine-Rich Repeat and Guanylate Kinase-Like Domain Containing 1) gene encodes a protein that plays a critical role in male fertility. It is particularly important for the proper function of the manchette, a microtubule-based structure involved in sperm head shaping and tail formation during spermiogenesis. Research has shown that LRGUK1 is part of a multiprotein complex essential for the initiation of sperm tail growth from the centriole/basal body. Mutations or disruptions in the LRGUK1 gene can lead to defective manchette function, resulting in abnormal sperm morphology and infertility. This gene's role in spermatogenesis underscores its importance in reproductive health, with ongoing studies aimed at elucidating its specific interactions and mechanisms within the manchette complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine-rich repeat and guanylate kinase domain-containing protein; leucine-rich repeats and guanylate kinase domain containing
Gene Aliases: CFAP246; LRGUK
UniProt ID: (Human) Q96M69
Entrez Gene ID: (Human) 136332
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