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Invitrogen
Human LRRC23 (aa 209-289) Control Fragment Recombinant Protein
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Product Details
RP-97633
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
QNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYR
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (85%), Rat (85%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58095. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The LRRC23 (Leucine-Rich Repeat Containing 23) gene encodes a protein that is an evolutionarily conserved component of the radial spoke complex in sperm flagella. It is located on human chromosome 12. The LRRC23 protein interacts with radial spoke head proteins such as RSPH3A and RSPH3B, crucial for the structural integrity and proper function of the radial spokes, which are essential for flagellar motility. Mutations or deficiencies in LRRC23 have been linked to male infertility, specifically causing asthenozoospermia, characterized by reduced sperm motility. Studies have identified various mutations in LRRC23 that result in disorganized radial spokes and impaired sperm motility, leading to infertility
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leucine-rich protein B7; Leucine-rich repeat-containing protein 23
Gene Aliases: LRPB7; LRRC23
UniProt ID: (Human) Q53EV4
Entrez Gene ID: (Human) 10233
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