Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Human MAN2B2 (aa 695-790) Control Fragment Recombinant Protein
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
RP-96590
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
LLCHRIEQEYQAGPLELNREAVLRTSTNLNSQQVIYSDNNGYQMQRRPYVSYVNNSIARNYYPMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVE
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (78%), Rat (78%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57911. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The MAN2B2 (Mannosidase Alpha Class 2B Member 2) gene encodes an enzyme that is involved in the processing and modification of glycoproteins by hydrolyzing alpha-mannosidic linkages. Located on chromosome 4, the MAN2B2 protein is crucial for proper lysosomal function and is part of the glycosyl hydrolase family. Pathogenic variants in the MAN2B2 gene have been linked to a rare congenital disorder of glycosylation (CDG), known as MAN2B2-CDG, characterized by immune deficiency, developmental delay, stroke, and dysmorphic facial features. These mutations lead to an altered mannosylation profile, impacting glycoprotein processing and cellular functions. Studies have shown that reintroducing wild-type MAN2B2 can restore the normal mannosylation profile in patient cells, highlighting its therapeutic potential. Furthermore, recent research has identified circular RNA from this gene (circMAN2B2) that is implicated in the proliferation of hepatocellular carcinoma cells, suggesting a role in cancer biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Alpha-1,6-mannosidase; core-specific lysosomal alpha-1,6-Mannosidase; Epididymis-specific alpha-mannosidase; HMG17L3; Mannosidase alpha class 2B member 2; mannosidase, alpha, class 2B, member 2; NHC
Gene Aliases: KIAA0935; MAN2B2
UniProt ID: (Human) Q9Y2E5
Entrez Gene ID: (Human) 23324
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support