Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
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Highest antigen sequence indentity to the following orthologs: Mouse (41%), Rat (41%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-53212. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Exophilin-3; leaden; Melanophilin; MGC2771; MGC59733; OTTMUSP00000025451; SlaC2-a; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a
Gene Aliases: MLPH; SLAC2-A; SLAC2A
UniProt ID: (Human) Q9BV36
Entrez Gene ID: (Human) 79083
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