Gibco

Human NT-3 Recombinant Protein, PeproTech®

Product Details

450-03-10UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

View 2 publications 2 publications

Functional Assay (Functional)

Assay-dependent

View 2 publications 2 publications

In vitro Assay (IV)

View 186 publications 186 publications

Miscellaneous PubMed (MISC)

View 32 publications 32 publications

Product Specifications

Species

Human

Published species

Amphibian, Bovine, Chicken, Dog, Human, Mouse, Pig, Rat, Virus

Expression System

E. coli

Amino acid sequence

MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

Molecular weight

27.2 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues).

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias.

Cell reports. Medicine

Fan Y,Huang S,Li S,Wu B,Zhao Q,Huang L,Zheng Z,Xie X,Liu J,Huang W,Sun J,Zhu X,Zhu J,Xiang AP,Li W

450-03 was used in In vitro experiments to show that adipocyte-derived leptin activates sympathetic neurons and increases the release of neuropeptide Y (NPY), which in turn triggers arrhythmia in cardiomyocytes by interacting with the Y1 receptor (Y1R) and subsequently enhancing the activity of the Na+/Ca2+ exchanger (NCX) and calcium/calmodulin-dependent protein kinase II (CaMKII).

Tue May 21 00:00:00 UTC 2024

Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression.

Nature protocols

Liu Y,Wang J,Südhof TC,Wernig M

450-03 was used in Cell Culture to provide a detailed approach for the efficient and reproducible generation of functional iN cells from mouse ESC cultures by the genetically induced expression of neurogenin-2.

Sun Oct 01 00:00:00 UTC 2023

Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity.

Biomaterials science

Dutta D,Pirolli NH,Levy D,Tsao J,Seecharan N,Wang Z,Xu X,Jia X,Jay SM

450-03 was used in In vitro experiments to assess whether oligodendrocyte precursor cells and immature oligodendrocytes, which are further differentiated than neural progenitor/stem cells (NPSCs) and which both give rise to mature myelinating oligodendrocytes, could yield extracellular vesicles with neurotherapeutic properties comparable or superior to those from NPSCs.

Tue Aug 08 00:00:00 UTC 2023

Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2.

iScience

Flamier A,Bisht P,Richards A,Tomasello DL,Jaenisch R

450-03 was used in Cell Culture to indicate that sensory neurons can be infected by the original WA1/2020 strain of SARS-CoV-2 as well as the delta and omicron variants, yet infectability differs between the original strain and the variants.

Fri Sep 15 00:00:00 UTC 2023

Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice.

JCI insight

Sleigh JN,Villarroel-Campos D,Surana S,Wickenden T,Tong Y,Simkin RL,Vargas JNS,Rhymes ER,Tosolini AP,West SJ,Zhang Q,Yang XL,Schiavo G

450-03 was used in In vivo experiments to suggest that selectively targeting muscles with BDNF-boosting therapies could represent a viable therapeutic strategy for CMT2D.

Mon May 08 00:00:00 UTC 2023

An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming.

Science advances

Weng M,Hu H,Graus MS,Tan DS,Gao Y,Ren S,Ho DHH,Langer J,Holzner M,Huang Y,Ling GS,Lai CSW,Francois M,Jauch R

450-03 was used in In vitro experiments to report iNSC reprogramming from embryonic and aged mouse fibroblasts as well as from human blood using an engineered Sox17 (eSox17FNV).

Fri Aug 25 00:00:00 UTC 2023

Glioma synapses recruit mechanisms of adaptive plasticity.

Nature

Taylor KR,Barron T,Hui A,Spitzer A,Yalçin B,Ivec AE,Geraghty AC,Hartmann GG,Arzt M,Gillespie SM,Kim YS,Maleki Jahan S,Zhang H,Shamardani K,Su M,Ni L,Du PP,Woo PJ,Silva-Torres A,Venkatesh HS,Mancusi R,Ponnuswami A,Mulinyawe S,Keough MB,Chau I,Aziz-Bose R,Tirosh I,Suvà ML,Monje M

450-03 was used in Cell Culture to indicate that brain-derived neurotrophic factor1-3-TrkB signalling promotes malignant synaptic plasticity and augments tumour progression.

Wed Nov 01 00:00:00 UTC 2023

Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte-derived lipid transport.

Journal of neurochemistry

Mok KK,Yeung SH,Cheng GW,Ma IW,Lee RH,Herrup K,Tse KH

450-03 was used in In vitro experiments to propose that high myelin turnover and OL exhaustion found in APOE4 carriers is a likely explanation for the APOE-dependent myelin phenotypes of the AD brain.

Sat Apr 01 00:00:00 UTC 2023

Protocol Optimization for Direct Reprogramming of Primary Human Fibroblast into Induced Striatal Neurons.

International journal of molecular sciences

Kraskovskaya N,Bolshakova A,Khotin M,Bezprozvanny I,Mikhailova N

450-03 was used in Cell Culture to demonstrate that iSNs are functionally active and able to form synaptic connections in co-cultures with mouse cortical neurons.

Wed Apr 05 00:00:00 UTC 2023

Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination.

STAR protocols

von der Bey M,De Cicco S,Zach S,Hengerer B,Ercan-Herbst E

450-03 was used in In vitro experiments to describe steps to differentiate hiPSCs into cortical neurons and oligodendrocyte lineage cells on 3D nanofibers.

Fri Mar 17 00:00:00 UTC 2023

Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity.

Nature communications

Pagliaro A,Finger R,Zoutendijk I,Bunschuh S,Clevers H,Hendriks D,Artegiani B

450-03 was used in Cell Culture to find that a prolonged, decreasing gradient of TGF-β signaling is a determining factor in expanded neuroepithelium organoid formation and allows for an extended phase of neuroepithelium expansion.

Tue Nov 28 00:00:00 UTC 2023

Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome.

International journal of molecular sciences

Campbell NB,Patel Y,Moore TL,Medalla M,Zeldich E

450-03 was used in Cell Culture to show the efficacy of EVs in mitigating DS and AD-related cellular phenotypes and pathological depositions in human CS.

Thu Feb 09 00:00:00 UTC 2023

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis.

eLife

Harrington EP,Catenacci RB,Smith MD,Heo D,Miller CE,Meyers KR,Glatzer J,Bergles DE,Calabresi PA

450-03 was used in Cell Culture to define oligodendrocytes and their progenitors in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury, and disease.

Fri Apr 14 00:00:00 UTC 2023

Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons.

Cell genomics

Zhang S,Zhang H,Forrest MP,Zhou Y,Sun X,Bagchi VA,Kozlova A,Santos MD,Piguel NH,Dionisio LE,Sanders AR,Pang ZP,He X,Penzes P,Duan J

450-03 was used in Cell Culture to reveal that multiple genes at a single GWAS risk locus mediate a compound effect on neural function, providing a mechanistic link between a non-coding risk variant and disease-related cellular phenotypes.

Wed Sep 13 00:00:00 UTC 2023

Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment.

Nature

Meng X,Yao D,Imaizumi K,Chen X,Kelley KW,Reis N,Thete MV,Arjun McKinney A,Kulkarni S,Panagiotakos G,Bassik MC,Pașca SP

450-03 was used in In vitro experiments to highlight the power of this CRISPR-assembloid platform to systematically map NDD genes onto human development and reveal disease mechanisms.

Sun Oct 01 00:00:00 UTC 2023

Accelerated differentiation of human induced pluripotent stem cells into regionally specific dorsal and ventral spinal neural progenitor cells for application in spinal cord therapeutics.

Frontiers in neuroscience

Huntemer-Silveira A,Malone D,Frie A,Walsh P,Parr AM

450-03 was used in In vitro experiments to describe here the production of a diverse population of both ventral spinal and dorsal horn progenitor cells.

Sat Feb 10 00:00:00 UTC 2024

C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress.

iScience

Cicardi ME,Hallgren JH,Mawrie D,Krishnamurthy K,Markandaiah SS,Nelson AT,Kankate V,Anderson EN,Pasinelli P,Pandey UB,Eischen CM,Trotti D

450-03 was used in Cell Culture to find evidence for the induction of programmed cell death via caspase-3 activation.

Fri Sep 15 00:00:00 UTC 2023

Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation.

Nature communications

Li Z,Lui KN,Lau ST,Lai FP,Li P,Chung PH,Wong KK,Tam PK,Garica-Barcelo MM,Hui CC,Sham PC,Ngan ES

450-03 was used in In vitro experiments to define various factors associated with Hirschsprung pathogenesis and demonstrate the implications of oxidative phosphorylation in enteric neural crest development.

Sat Apr 15 00:00:00 UTC 2023

Differential response of C9orf72 transcripts following neuronal depolarization.

iScience

Ghaffari LT,Trotti D,Haeusler AR

450-03 was used in Cell Culture to reveal the impact of depolarization on C9orf72 transcripts, and how this response diverges in C9-NRE-carriers, which may have important implications in the underlying unique clinical associations of C9-NRE transcripts and disease pathogenesis.

Fri Jun 16 00:00:00 UTC 2023

Higher throughput workflow with sensitive, reliable and automatic quantification of myelination in vitro suitable for drug screening.

Scientific reports

Seiler S,Wälti CM,de Barros V,Barbash S,Foo LC

450-03 was used in Cell Culture to develop a method allowing systematic and reliable testing of remyelinating compound efficacy.

Sat Feb 18 00:00:00 UTC 2023

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.

Nature neuroscience

Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M

450-03 was used in Cell Culture to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.

Thu Sep 01 00:00:00 UTC 2022

Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.

The Journal of clinical investigation

Li Z,Duan H,Jia Y,Zhao C,Li W,Wang X,Gong Y,Dong C,Ma B,Dou S,Zhang B,Li D,Cao Y,Xie L,Zhou Q,Shi W

Tue Jan 04 00:00:00 UTC 2022

Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.

Cellular and molecular life sciences : CMLS

Solomon S,Sampathkumar NK,Carre I,Mondal M,Chennell G,Vernon AC,Ruepp MD,Mitchell JC

450-03 was used in Sample Preparation to investigate P522R in Alzheimer’s disease.

Wed Jul 27 00:00:00 UTC 2022

Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.

Cell stem cell

Capano LS,Sato C,Ficulle E,Yu A,Horie K,Kwon JS,Burbach KF,Barthélemy NR,Fox SG,Karch CM,Bateman RJ,Houlden H,Morimoto RI,Holtzman DM,Duff KE,Yoo AS

450-03 was used in Cell Culture to demonstrate the utility of miRNA-induced neuronal reprogramming to recapitulate endogenous tau regulation comparable with the adult brain in health and disease.

Thu Jun 02 00:00:00 UTC 2022

Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

He ZQ,Li YH,Feng GH,Yuan XW,Lu ZB,Dai M,Hu YP,Zhang Y,Zhou Q,Li W

450-03 was used in Cell Culture to report a robust method to convert fibroblasts to neurons through targeting the cytoskeleton followed by exposure to lineage-specification surroundings.

Sun May 01 00:00:00 UTC 2022

OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease.

NPJ Regenerative medicine

Yun W,Choi KA,Hwang I,Zheng J,Park M,Hong W,Jang AY,Kim JH,Choi W,Kim DS,Kim IY,Kim YJ,Liu Y,Yoon BS,Park G,Song G,Hong S,You S

Thu Jan 13 00:00:00 UTC 2022

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics.

Journal of visualized experiments : JoVE

Frankenfield A,Ni J,Hao L

450-03 was used in Cell Culture to demonstrate a detailed protocol for endogenous (knock-in) lysosome proximity labeling proteomic method in human induced pluripotent stem cell (hiPSC)-derived neurons.

Thu Jun 23 00:00:00 UTC 2022

Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.

Neuron

Goldsmith J,Ordureau A,Harper JW,Holzbaur ELF

450-03 was used in Cell Culture to propose that localized Drp1-dependent fission of nucleoid-enriched fragments in proximity to the sites of autophagosome biogenesis enhances their capture.

Wed Mar 16 00:00:00 UTC 2022

Culturing and Neuronal Differentiation of Human Dental Pulp Stem Cells.

Current protocols

Goorha S,Victor AK,Reiter LT

450-03 was used in In vitro experiments to provide our protocol for the differentiation of early passage DPSC cultures into neurons for molecular and cellular studies.

Tue Nov 01 00:00:00 UTC 2022

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.

Nature

Iram T,Kern F,Kaur A,Myneni S,Morningstar AR,Shin H,Garcia MA,Yerra L,Palovics R,Yang AC,Hahn O,Lu N,Shuken SR,Haney MS,Lehallier B,Iyer M,Luo J,Zetterberg H,Keller A,Zuchero JB,Wyss-Coray T

450-03 was used in Cell Culture to demonstrate the rejuvenating power of young CSF and identify Fgf17 as a key target to restore oligodendrocyte function in the ageing brain.

Sun May 01 00:00:00 UTC 2022

Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation.

Nature genetics

Kaluscha S,Domcke S,Wirbelauer C,Stadler MB,Durdu S,Burger L,Schübeler D

450-03 was used in Cell Culture to reveal methylation-sensitive TFs in vivo and argues that direct inhibition, rather than indirect repression by the tested MBD proteins, is the prevailing mechanism of methylation-mediated repression at regulatory regions and repeats.

Thu Dec 01 00:00:00 UTC 2022

A transgenic mouse embryonic stem cell line for puromycin selection of V0_V interneurons from heterogenous induced cultures.

Stem cell research & therapy

Pardieck J,Harb M,Sakiyama-Elbert SE

450-03 was used in Cell Culture to generate a transgenic mESC line to enrich V0V INs from induced cultures to allow for a scalable, enriched population for future in vitro and in vivo studies.

Mon Mar 28 00:00:00 UTC 2022

The m⁶A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

eLife

Niu F,Han P,Zhang J,She Y,Yang L,Yu J,Zhuang M,Tang K,Shi Y,Yang B,Liu C,Peng B,Ji SJ

450-03 was used in Cell Culture to show that the N6-methyladenosine (m6A) reader YTHDF2 is highly expressed in mouse retinal ganglion cells.

Fri Feb 18 00:00:00 UTC 2022

The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model.

Cells

Bauch J,Faissner A

450-03 was used in Cell Culture to study how tenascins interfere with remyelination in vivo.

Sat May 28 00:00:00 UTC 2022

Alzheimer's disease like neuropathology in Down syndrome cortical organoids.

Frontiers in cellular neuroscience

Zhao HH,Haddad GG

450-03 was used in Cell Culture to use induced pluripotent stem cell (iPSC) and iPSC-derived 3D cortical organoids to model Alzheimer's disease in Down syndrome and explore the earliest cellular and molecular changes during DS fetal brain development.

Tue Jan 03 00:00:00 UTC 2023

Coactivator-associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development.

Developmental neurobiology

Ishino Y,Shimizu S,Tohyama M,Miyata S

450-03 was used in Cell Culture to propose that Carm1 is an essential molecule for the development of OPCs and OLs during brain development.

Fri Apr 01 00:00:00 UTC 2022

S1-END-seq reveals DNA secondary structures in human cells.

Molecular cell

Matos-Rodrigues G,van Wietmarschen N,Wu W,Tripathi V,Koussa NC,Pavani R,Nathan WJ,Callen E,Belinky F,Mohammed A,Napierala M,Usdin K,Ansari AZ,Mirkin SM,Nussenzweig A

450-03 was used in Cell Culture to identify dynamic DNA secondary structures in vivo that contribute to elevated genome instability.

Thu Oct 06 00:00:00 UTC 2022

Veteran-derived cerebral organoids display multifaceted pathological defects in studies on Gulf War Illness.

Frontiers in cellular neuroscience

Yates PL,Case K,Sun X,Sullivan K,Baas PW,Qiang L

450-03 was used in Cell Culture to suggest that veteran-derived human cerebral organoids not only can be used as an innovative human model to uncover the cellular responses to GW toxicants but can also serve as a platform for developing personalized medicine approaches for the veterans.

Wed Jan 11 00:00:00 UTC 2023

Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models.

American journal of human genetics

Tai DJC,Razaz P,Erdin S,Gao D,Wang J,Nuttle X,de Esch CE,Collins RL,Currall BB,O'Keefe K,Burt ND,Yadav R,Wang L,Mohajeri K,Aneichyk T,Ragavendran A,Stortchevoi A,Morini E,Ma W,Lucente D,Hastie A,Kelleher RJ,Perlis RH,Talkowski ME,Gusella JF

450-03 was used in In vitro experiments to indicate the genomic disorder involves disruption of multiple contributing biological processes and that this disruption has relative impacts that are context specific.

Thu Oct 06 00:00:00 UTC 2022

CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes.

Nature communications

Lam M,Takeo K,Almeida RG,Cooper MH,Wu K,Iyer M,Kantarci H,Zuchero JB

450-03 was used in Cell Culture to study how CNS myelin membrane addition requires exocytosis mediated by the vesicular SNARE proteins VAMP2/3.

Fri Sep 23 00:00:00 UTC 2022

CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes.

Nature communications

Lam M,Takeo K,Almeida RG,Cooper MH,Wu K,Iyer M,Kantarci H,Zuchero JB

450-03 was used in Cell Culture to study how CNS myelin membrane addition requires exocytosis mediated by the vesicular SNARE proteins VAMP2/3.

Fri Sep 23 00:00:00 UTC 2022

Neurotoxic reactive astrocytes induce cell death via saturated lipids.

Nature

Guttenplan KA,Weigel MK,Prakash P,Wijewardhane PR,Hasel P,Rufen-Blanchette U,Münch AE,Blum JA,Fine J,Neal MC,Bruce KD,Gitler AD,Chopra G,Liddelow SA,Barres BA

Mon Nov 01 00:00:00 UTC 2021

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.

Cell

Nuñez JK,Chen J,Pommier GC,Cogan JZ,Replogle JM,Adriaens C,Ramadoss GN,Shi Q,Hung KL,Samelson AJ,Pogson AN,Kim JYS,Chung A,Leonetti MD,Chang HY,Kampmann M,Bernstein BE,Hovestadt V,Gilbert LA,Weissman JS

Thu Apr 29 00:00:00 UTC 2021

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.

Cell

Bowles KR,Silva MC,Whitney K,Bertucci T,Berlind JE,Lai JD,Garza JC,Boles NC,Mahali S,Strang KH,Marsh JA,Chen C,Pugh DA,Liu Y,Gordon RE,Goderie SK,Chowdhury R,Lotz S,Lane K,Crary JF,Haggarty SJ,Karch CM,Ichida JK,Goate AM,Temple S

Thu Aug 19 00:00:00 UTC 2021

H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.

Cancer cell

Haag D,Mack N,Benites Goncalves da Silva P,Statz B,Clark J,Tanabe K,Sharma T,Jäger N,Jones DTW,Kawauchi D,Wernig M,Pfister SM

Mon Mar 08 00:00:00 UTC 2021

Long-term maturation of human cortical organoids matches key early postnatal transitions.

Nature neuroscience

Gordon A,Yoon SJ,Tran SS,Makinson CD,Park JY,Andersen J,Valencia AM,Horvath S,Xiao X,Huguenard JR,Pașca SP,Geschwind DH

450-03 was used in Cell Culture to suggest that important components of an intrinsic in vivo developmental program persist in vitro.

Mon Mar 01 00:00:00 UTC 2021

Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs.

Cell stem cell

Cates K,McCoy MJ,Kwon JS,Liu Y,Abernathy DG,Zhang B,Liu S,Gontarz P,Kim WK,Chen S,Kong W,Ho JN,Burbach KF,Gabel HW,Morris SA,Yoo AS

Thu Jan 07 00:00:00 UTC 2021

Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs.

Cell stem cell

Cates K,McCoy MJ,Kwon JS,Liu Y,Abernathy DG,Zhang B,Liu S,Gontarz P,Kim WK,Chen S,Kong W,Ho JN,Burbach KF,Gabel HW,Morris SA,Yoo AS

Thu Jan 07 00:00:00 UTC 2021

Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy.

Molecular cell

Ordureau A,Kraus F,Zhang J,An H,Park S,Ahfeldt T,Paulo JA,Harper JW

Thu Dec 16 00:00:00 UTC 2021

Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction.

Brain : a journal of neurology

Van Lent J,Verstraelen P,Asselbergh B,Adriaenssens E,Mateiu L,Verbist C,De Winter V,Eggermont K,Van Den Bosch L,De Vos WH,Timmerman V

450-03 was used in Cell Culture to reveal shared cellular phenotypes across different CMT2 subtypes and suggests that targeting such common pathomechanisms could allow the development of a uniform treatment for CMT2.

Sat Sep 04 00:00:00 UTC 2021

Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids.

EMBO molecular medicine

Trujillo CA,Adams JW,Negraes PD,Carromeu C,Tejwani L,Acab A,Tsuda B,Thomas CA,Sodhi N,Fichter KM,Romero S,Zanella F,Sejnowski TJ,Ulrich H,Muotri AR

Mon Jan 11 00:00:00 UTC 2021

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.

EMBO molecular medicine

Emmenegger M,De Cecco E,Hruska-Plochan M,Eninger T,Schneider MM,Barth M,Tantardini E,de Rossi P,Bacioglu M,Langston RG,Kaganovich A,Bengoa-Vergniory N,Gonzalez-Guerra A,Avar M,Heinzer D,Reimann R,Häsler LM,Herling TW,Matharu NS,Landeck N,Luk K,Melki R,Kahle PJ,Hornemann S,Knowles TPJ,Cookson MR,Polymenidou M,Jucker M,Aguzzi A

Tue Sep 07 00:00:00 UTC 2021

BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.

Autophagy

Yazdankhah M,Ghosh S,Shang P,Stepicheva N,Hose S,Liu H,Chamling X,Tian S,Sullivan MLG,Calderon MJ,Fitting CS,Weiss J,Jayagopal A,Handa JT,Sahel JA,Zigler JS,Kinchington PR,Zack DJ,Sinha D

450-03 was used in Sample Preparation (FC/FACS) to investigate mechanisms of oligodendrocyte progenitor cell differentiation to identify treatment options.

Fri Oct 01 00:00:00 UTC 2021

Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes.

Current biology : CB

Boecker CA,Goldsmith J,Dou D,Cajka GG,Holzbaur ELF

Mon May 24 00:00:00 UTC 2021

Human cell transformation by combined lineage conversion and oncogene expression.

Oncogene

Sahu B,Pihlajamaa P,Zhang K,Palin K,Ahonen S,Cervera A,Ristimäki A,Aaltonen LA,Hautaniemi S,Taipale J

Wed Sep 01 00:00:00 UTC 2021

Premigratory neural crest stem cells generate enteric neurons populating the mouse colon and regulating peristalsis in tissue-engineered intestine.

Stem cells translational medicine

Yuan H,Hu H,Chen R,Mu W,Wang L,Li Y,Chen Y,Ding X,Xi Y,Mao S,Jiang M,Chen J,He Y,Wang L,Dong Y,Tou J,Chen W

Tue Jun 01 00:00:00 UTC 2021

The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury.

Neurobiology of disease

Triplet EM,Kim HN,Yoon H,Radulovic M,Kleppe L,Simon WL,Choi CI,Walsh PJ,Dutton JR,Scarisbrick IA

450-03 was used in In vitro experiments to identify the thrombin receptor (Protease Activated Receptor 1 (PAR1)) as an integral facet of this machine with roles in regulating neurite growth through a growth factor- and cholesterol-dependent mechanism.

Sat May 01 00:00:00 UTC 2021

Extracellular Vesicles in Serum and Central Nervous System Tissues Contain microRNA Signatures in Sporadic Amyotrophic Lateral Sclerosis.

Frontiers in molecular neuroscience

Lo TW,Figueroa-Romero C,Hur J,Pacut C,Stoll E,Spring C,Lewis R,Nair A,Goutman SA,Sakowski SA,Nagrath S,Feldman EL

450-03 was used in In vitro experiments to study the role of circulating extracellular vesicles in the pathogenesis of amyotrophic lateral sclerosis.

Wed May 08 00:00:00 UTC 2024

Allele-Specific Gene Editing Rescues Pathology in a Human Model of Charcot-Marie-Tooth Disease Type 2E.

Frontiers in cell and developmental biology

Feliciano CM,Wu K,Watry HL,Marley CBE,Ramadoss GN,Ghanim HY,Liu AZ,Zholudeva LV,McDevitt TC,Saporta MA,Conklin BR,Judge LM

450-03 was used in Cell Culture to study how allele-specific CRISPR gene editing in a human model of axonal Charcot-Marie-Tooth (CMT) disease rescues pathology caused by a dominant missense mutation in the neurofilament light chain gene (NEFL, CMT type 2E).

Tue May 07 00:00:00 UTC 2024

Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel.

Clinical and translational science

Xiong C,Chua KC,Stage TB,Priotti J,Kim J,Altman-Merino A,Chan D,Saraf K,Canato Ferracini A,Fattahi F,Kroetz DL

Mon Mar 01 00:00:00 UTC 2021

Induction of Ventral Spinal V0 Interneurons from Mouse Embryonic Stem Cells.

Stem cells and development

Pardieck J,Harb M,Sakiyama-Elbert S

450-03 was used in Cell Culture to investigate V0 interneuron isolation to improve understanding of spinal central pattern generators.

Sun Aug 15 00:00:00 UTC 2021

Deep learning-based predictive identification of neural stem cell differentiation.

Nature communications

Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R

Mon May 10 00:00:00 UTC 2021

Deep learning-based predictive identification of neural stem cell differentiation.

Nature communications

Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R

Mon May 10 00:00:00 UTC 2021

5-HT3 Signaling Alters Development of Sacral Neural Crest Derivatives That Innervate the Lower Urinary Tract.

International journal of molecular sciences

Ritter KE,Buehler DP,Asher SB,Deal KK,Zhao S,Guo Y,Southard-Smith EM

450-03 was used in Cell Culture to study the development of pelvic ganglia neuronal diversity.

Fri Jun 25 00:00:00 UTC 2021

Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.

Communications biology

Sanchez CG,Acker CM,Gray A,Varadarajan M,Song C,Cochran NR,Paula S,Lindeman A,An S,McAllister G,Alford J,Reece-Hoyes J,Russ C,Craig L,Capre K,Doherty C,Hoffman GR,Luchansky SJ,Polydoro M,Dolmetsch R,Elwood F

Mon Jun 14 00:00:00 UTC 2021

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.

Scientific reports

Cheng C,Reis SA,Adams ET,Fass DM,Angus SP,Stuhlmiller TJ,Richardson J,Olafson H,Wang ET,Patnaik D,Beauchamp RL,Feldman DA,Silva MC,Sur M,Johnson GL,Ramesh V,Miller BL,Temple S,Kosik KS,Dickerson BC,Haggarty SJ

Mon Aug 23 00:00:00 UTC 2021

STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.

iScience

Morozzi G,Rothen J,Toussaint G,De Lange K,Westritschnig K,Doelemeyer A,Ueberschlag VP,Kahle P,Lambert C,Obrecht M,Beckmann N,Ritter V,Panesar M,Stauffer D,Garnier I,Mueller M,Guerini D,Keller CG,Knehr J,Roma G,Bidinosti M,Brachat S,Morvan F,Fornaro M

450-03 was used in In vitro experiments to investigate relationship between peripheral nerve injury and inflammation.

Fri Dec 17 00:00:00 UTC 2021

Identification of Novel Positive Allosteric Modulators of Neurotrophin Receptors for the Treatment of Cognitive Dysfunction.

Cells

Dahlström M,Madjid N,Nordvall G,Halldin MM,Vazquez-Juarez E,Lindskog M,Sandin J,Winblad B,Eriksdotter M,Forsell P

450-03 was used in In vitro experiments to identify small molecules with stimulatory effects on the signaling of two neurotrophins, the nerve growth factor (NGF) and the brain derived neurotrophic factor (BDNF).

Fri Jul 23 00:00:00 UTC 2021

SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells.

Cell death & disease

Lai X,Liu J,Zou Z,Wang Y,Wang Y,Liu X,Huang W,Ma Y,Chen Q,Li F,Wu G,Li W,Wang W,Yuan Y,Jiang B

Fri Aug 27 00:00:00 UTC 2021

MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling.

Cell reports

Nakashima H,Tsujimura K,Irie K,Imamura T,Trujillo CA,Ishizu M,Uesaka M,Pan M,Noguchi H,Okada K,Aoyagi K,Andoh-Noda T,Okano H,Muotri AR,Nakashima K

Tue May 18 00:00:00 UTC 2021

SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome.

Nature communications

Banfi F,Rubio A,Zaghi M,Massimino L,Fagnocchi G,Bellini E,Luoni M,Cancellieri C,Bagliani A,Di Resta C,Maffezzini C,Ianielli A,Ferrari M,Piazza R,Mologni L,Broccoli V,Sessa A

Wed Jun 30 00:00:00 UTC 2021

BASP1 labels neural stem cells in the neurogenic niches of mammalian brain.

Scientific reports

Manganas LN,Durá I,Osenberg S,Semerci F,Tosun M,Mishra R,Parkitny L,Encinas JM,Maletic-Savatic M

Wed Mar 10 00:00:00 UTC 2021

Select neurotrophins promote oligodendrocyte progenitor cell process outgrowth in the presence of chondroitin sulfate proteoglycans.

Journal of neuroscience research

Siebert JR,Osterhout DJ

Thu Apr 01 00:00:00 UTC 2021

Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination.

Nature communications

Saraswat D,Shayya HJ,Polanco JJ,Tripathi A,Welliver RR,Pol SU,Seidman RA,Broome JE,O'Bara MA,van Kuppervelt TH,Phillips JJ,Dutta R,Sim FJ

Fri Mar 26 00:00:00 UTC 2021

An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions.

Cell reports. Medicine

Clark AJ,Kugathasan U,Baskozos G,Priestman DA,Fugger N,Lone MA,Othman A,Chu KH,Blesneac I,Wilson ER,Laurà M,Kalmar B,Greensmith L,Hornemann T,Platt FM,Reilly MM,Bennett DL

Tue Jul 20 00:00:00 UTC 2021

Development of a specific live-cell assay for native autophagic flux.

The Journal of biological chemistry

Safren N,Tank EM,Malik AM,Chua JP,Santoro N,Barmada SJ

Wed Sep 01 00:00:00 UTC 2021

One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2.

Stem cell reports

Chanoumidou K,Hernández-Rodríguez B,Windener F,Thomas C,Stehling M,Mozafari S,Albrecht S,Ottoboni L,Antel J,Kim KP,Velychko S,Cui QL,Xu YKT,Martino G,Winkler J,Schöler HR,Baron-Van Evercooren A,Boespflug-Tanguy O,Vaquerizas JM,Ehrlich M,Kuhlmann T

Tue Apr 13 00:00:00 UTC 2021

Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.

Cell reports

Kempf J,Knelles K,Hersbach BA,Petrik D,Riedemann T,Bednarova V,Janjic A,Simon-Ebert T,Enard W,Smialowski P,Götz M,Masserdotti G

Tue Jul 20 00:00:00 UTC 2021

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome.

Nature medicine

Khan TA,Revah O,Gordon A,Yoon SJ,Krawisz AK,Goold C,Sun Y,Kim CH,Tian Y,Li MY,Schaepe JM,Ikeda K,Amin ND,Sakai N,Yazawa M,Kushan L,Nishino S,Porteus MH,Rapoport JL,Bernstein JA,O'Hara R,Bearden CE,Hallmayer JF,Huguenard JR,Geschwind DH,Dolmetsch RE,Paşca SP

450-03 was used in Cell Culture to illustrate how stem cell derived models can be used to uncover and rescue cellular phenotypes associated with genetic forms of neuropsychiatric disease.

Tue Dec 01 00:00:00 UTC 2020

Functionally Distinct Neuronal Ensembles within the Memory Engram.

Cell

Sun X,Bernstein MJ,Meng M,Rao S,Sørensen AT,Yao L,Zhang X,Anikeeva PO,Lin Y

Thu Apr 16 00:00:00 UTC 2020

Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.

Cell

Huang W,Bhaduri A,Velmeshev D,Wang S,Wang L,Rottkamp CA,Alvarez-Buylla A,Rowitch DH,Kriegstein AR

450-03 was used in Cell Culture to indicate properties of OPC derivation, proliferation, and dispersion important for human white matter expansion and myelination.

Thu Aug 06 00:00:00 UTC 2020

SARS-CoV-2 infects human neural progenitor cells and brain organoids.

Cell research

Zhang BZ,Chu H,Han S,Shuai H,Deng J,Hu YF,Gong HR,Lee AC,Zou Z,Yau T,Wu W,Hung IF,Chan JF,Yuen KY,Huang JD

Thu Oct 01 00:00:00 UTC 2020

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.

Molecular cell

Sarraf SA,Shah HV,Kanfer G,Pickrell AM,Holtzclaw LA,Ward ME,Youle RJ

450-03 was used in Cell Culture to show that TAX1BP1 mediates clearance of a broad range of cytotoxic proteins indicating therapeutic potential in neurodegenerative diseases.

Thu Dec 03 00:00:00 UTC 2020

Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.

Molecular cell

Young-Baird SK,Lourenço MB,Elder MK,Klann E,Liebau S,Dever TE

450-03 was used in In vitro experiments to show that a mutation at the C terminus of eIF2γ impairs CDC123 promotion of eIF2 complex formation and decreases the level of eIF2-GTP-Met-tRNAiMet ternary complexes, using patient-derived induced pluripotent stem cells.

Thu Feb 20 00:00:00 UTC 2020

Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy.

Neuron

Fox LM,Kim K,Johnson CW,Chen S,Croce KR,Victor MB,Eenjes E,Bosco JR,Randolph LK,Dragatsis I,Dragich JM,Yoo AS,Yamamoto A

Wed Mar 04 00:00:00 UTC 2020

m⁶A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination.

Neuron

Xu H,Dzhashiashvili Y,Shah A,Kunjamma RB,Weng YL,Elbaz B,Fei Q,Jones JS,Li YI,Zhuang X,Ming GL,He C,Popko B

Wed Jan 22 00:00:00 UTC 2020

USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway.

Proceedings of the National Academy of Sciences of the United States of America

Zhang T,Periz G,Lu YN,Wang J

Tue Nov 10 00:00:00 UTC 2020

The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2.

Glia

Jarjour AA,Velichkova AN,Boyd A,Lord KM,Torsney C,Henderson DJ,Ffrench-Constant C

Tue Sep 01 00:00:00 UTC 2020

Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors.

American journal of physiology. Cell physiology

Sepehrimanesh M,Ding B

Thu Oct 01 00:00:00 UTC 2020

Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction.

Scientific reports

Nzou G,Wicks RT,VanOstrand NR,Mekky GA,Seale SA,El-Taibany A,Wicks EE,Nechtman CM,Marrotte EJ,Makani VS,Murphy SV,Seeds MC,Jackson JD,Atala AJ

Wed Jun 17 00:00:00 UTC 2020

Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection.

Stem cell reports

Ryan SK,Gonzalez MV,Garifallou JP,Bennett FC,Williams KS,Sotuyo NP,Mironets E,Cook K,Hakonarson H,Anderson SA,Jordan-Sciutto KL

Tue Apr 14 00:00:00 UTC 2020

Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens.

Cell reports

Black JB,McCutcheon SR,Dube S,Barrera A,Klann TS,Rice GA,Adkar SS,Soderling SH,Reddy TE,Gersbach CA

Tue Dec 01 00:00:00 UTC 2020

Varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency.

Nature communications

Ouwendijk WJD,Depledge DP,Rajbhandari L,Lenac Rovis T,Jonjic S,Breuer J,Venkatesan A,Verjans GMGM,Sadaoka T

Thu Dec 10 00:00:00 UTC 2020

Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice.

Nature communications

Sun J,Huang Y,Gong J,Wang J,Fan Y,Cai J,Wang Y,Qiu Y,Wei Y,Xiong C,Chen J,Wang B,Ma Y,Huang L,Chen X,Zheng S,Huang W,Ke Q,Wang T,Li X,Zhang W,Xiang AP,Li W

Thu Oct 15 00:00:00 UTC 2020

Cofilin dysregulation alters actin turnover in frataxin-deficient neurons.

Scientific reports

Muñoz-Lasso DC,Mollá B,Calap-Quintana P,García-Giménez JL,Pallardo FV,Palau F,Gonzalez-Cabo P

Mon Mar 23 00:00:00 UTC 2020

Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia.

STAR protocols

Ryan SK,Jordan-Sciutto KL,Anderson SA

Fri Dec 18 00:00:00 UTC 2020

Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells.

Nature protocols

García-León JA,García-Díaz B,Eggermont K,Cáceres-Palomo L,Neyrinck K,Madeiro da Costa R,Dávila JC,Baron-Van Evercooren A,Gutiérrez A,Verfaillie CM

Sun Nov 01 00:00:00 UTC 2020

Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model.

eLife

Lee H,Lee HY,Lee BE,Gerovska D,Park SY,Zaehres H,Araúzo-Bravo MJ,Kim JI,Ha Y,Schöler HR,Kim JB

450-03 was used in Cell Culture to investigate the use of induced motor neurons to treat spinal cord injury.

Tue Jun 23 00:00:00 UTC 2020

Photoactivatable Cre recombinase 3.0 for in vivo mouse applications.

Nature communications

Morikawa K,Furuhashi K,de Sena-Tomas C,Garcia-Garcia AL,Bekdash R,Klein AD,Gallerani N,Yamamoto HE,Park SE,Collins GS,Kawano F,Sato M,Lin CS,Targoff KL,Au E,Salling MC,Yazawa M

Fri May 01 00:00:00 UTC 2020

Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons.

Nature communications

Mazzara PG,Muggeo S,Luoni M,Massimino L,Zaghi M,Valverde PT,Brusco S,Marzi MJ,Palma C,Colasante G,Iannielli A,Paulis M,Cordiglieri C,Giannelli SG,Podini P,Gellera C,Taroni F,Nicassio F,Rasponi M,Broccoli V

Fri Aug 21 00:00:00 UTC 2020

Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing.

Scientific reports

Moses C,Hodgetts SI,Nugent F,Ben-Ary G,Park KK,Blancafort P,Harvey AR

Thu Jul 09 00:00:00 UTC 2020

Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder.

Translational psychiatry

Truvé K,Parris TZ,Vizlin-Hodzic D,Salmela S,Berger E,Ågren H,Funa K

Mon Nov 09 00:00:00 UTC 2020

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.

Nature medicine

Swarup V,Hinz FI,Rexach JE,Noguchi KI,Toyoshiba H,Oda A,Hirai K,Sarkar A,Seyfried NT,Cheng C,Haggarty SJ,Grossman M,Van Deerlin VM,Trojanowski JQ,Lah JJ,Levey AI,Kondou S,Geschwind DH

450-03 was used in Cell Culture to identify small molecules that can normalize the disease-associated modules.

Tue Jan 01 00:00:00 UTC 2019

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment.

Cell

Gibson EM,Nagaraja S,Ocampo A,Tam LT,Wood LS,Pallegar PN,Greene JJ,Geraghty AC,Goldstein AK,Ni L,Woo PJ,Barres BA,Liddelow S,Vogel H,Monje M

Thu Jan 10 00:00:00 UTC 2019

Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.

Cell

Patzke C,Brockmann MM,Dai J,Gan KJ,Grauel MK,Fenske P,Liu Y,Acuna C,Rosenmund C,Südhof TC

Thu Oct 03 00:00:00 UTC 2019

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.

Cell

Liao YC,Fernandopulle MS,Wang G,Choi H,Hao L,Drerup CM,Patel R,Qamar S,Nixon-Abell J,Shen Y,Meadows W,Vendruscolo M,Knowles TPJ,Nelson M,Czekalska MA,Musteikyte G,Gachechiladze MA,Stephens CA,Pasolli HA,Forrest LR,St George-Hyslop P,Lippincott-Schwartz J,Ward ME

Thu Sep 19 00:00:00 UTC 2019

Reliability of human cortical organoid generation.

Nature methods

Yoon SJ,Elahi LS,Pașca AM,Marton RM,Gordon A,Revah O,Miura Y,Walczak EM,Holdgate GM,Fan HC,Huguenard JR,Geschwind DH,Pașca SP

450-03 was used in Cell Culture to find that spheroid generation was highly reliable and consistent.

Tue Jan 01 00:00:00 UTC 2019

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.

Nature neuroscience

Sellgren CM,Gracias J,Watmuff B,Biag JD,Thanos JM,Whittredge PB,Fu T,Worringer K,Brown HE,Wang J,Kaykas A,Karmacharya R,Goold CP,Sheridan SD,Perlis RH

450-03 was used in Cell Culture to demonstrate increased synapse elimination in patient-derived neural cultures and isolated synaptosomes.

Fri Mar 01 00:00:00 UTC 2019

Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.

Cell stem cell

Nobuta H,Yang N,Ng YH,Marro SG,Sabeur K,Chavali M,Stockley JH,Killilea DW,Walter PB,Zhao C,Huie P,Goldman SA,Kriegstein AR,Franklin RJM,Rowitch DH,Wernig M

450-03 was used in Cell Culture to demonstrate that patient-derived oligodendrocytes can develop to the pre-myelinating stage, but subsequently undergo cell death using induced pluripotent stem cell (iPSC) and gene-correction.

Thu Oct 03 00:00:00 UTC 2019

Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination.

Neuron

Liu Z,Yan M,Liang Y,Liu M,Zhang K,Shao D,Jiang R,Li L,Wang C,Nussenzveig DR,Zhang K,Chen S,Zhong C,Mo W,Fontoura BMA,Zhang L

Wed May 08 00:00:00 UTC 2019

Defining the Functional Role of Na_V1.7 in Human Nociception.

Neuron

McDermott LA,Weir GA,Themistocleous AC,Segerdahl AR,Blesneac I,Baskozos G,Clark AJ,Millar V,Peck LJ,Ebner D,Tracey I,Serra J,Bennett DL

Wed Mar 06 00:00:00 UTC 2019

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.

Neuron

Sohn PD,Huang CT,Yan R,Fan L,Tracy TE,Camargo CM,Montgomery KM,Arhar T,Mok SA,Freilich R,Baik J,He M,Gong S,Roberson ED,Karch CM,Gestwicki JE,Xu K,Kosik KS,Gan L

Wed Nov 06 00:00:00 UTC 2019

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.

Neuron

Geraghty AC,Gibson EM,Ghanem RA,Greene JJ,Ocampo A,Goldstein AK,Ni L,Yang T,Marton RM,Paşca SP,Greenberg ME,Longo FM,Monje M

Wed Jul 17 00:00:00 UTC 2019

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.

Neuron

Geraghty AC,Gibson EM,Ghanem RA,Greene JJ,Ocampo A,Goldstein AK,Ni L,Yang T,Marton RM,Paşca SP,Greenberg ME,Longo FM,Monje M

Wed Jul 17 00:00:00 UTC 2019

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.

Neuron

Tian R,Gachechiladze MA,Ludwig CH,Laurie MT,Hong JY,Nathaniel D,Prabhu AV,Fernandopulle MS,Patel R,Abshari M,Ward ME,Kampmann M

Wed Oct 23 00:00:00 UTC 2019

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion.

Neuron

Matsuda T,Irie T,Katsurabayashi S,Hayashi Y,Nagai T,Hamazaki N,Adefuin AMD,Miura F,Ito T,Kimura H,Shirahige K,Takeda T,Iwasaki K,Imamura T,Nakashima K

Wed Feb 06 00:00:00 UTC 2019

A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan.

EMBO reports

Kim J,Lana B,Torelli S,Ryan D,Catapano F,Ala P,Luft C,Stevens E,Konstantinidis E,Louzada S,Fu B,Paredes-Redondo A,Chan AE,Yang F,Stemple DL,Liu P,Ketteler R,Selwood DL,Muntoni F,Lin YY

Tue Nov 05 00:00:00 UTC 2019

Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation.

Glia

Li J,Khankan RR,Caneda C,Godoy MI,Haney MS,Krawczyk MC,Bassik MC,Sloan SA,Zhang Y

Thu Aug 01 00:00:00 UTC 2019

Perfluorocarbon Labeling of Human Glial-Restricted Progenitors for ¹⁹ F Magnetic Resonance Imaging.

Stem cells translational medicine

Richard JP,Hussain U,Gross S,Taga A,Kouser M,Almad A,Campanelli JT,Bulte JWM,Maragakis NJ

Mon Apr 01 00:00:00 UTC 2019

Harnessing neurovascular interaction to guide axon growth.

Scientific reports

Partyka PP,Jin Y,Bouyer J,DaSilva A,Godsey GA,Nagele RG,Fischer I,Galie PA

Mon Feb 18 00:00:00 UTC 2019

Harnessing neurovascular interaction to guide axon growth.

Scientific reports

Partyka PP,Jin Y,Bouyer J,DaSilva A,Godsey GA,Nagele RG,Fischer I,Galie PA

Mon Feb 18 00:00:00 UTC 2019

Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging.

Stem cell reports

Cozzi A,Orellana DI,Santambrogio P,Rubio A,Cancellieri C,Giannelli S,Ripamonti M,Taverna S,Di Lullo G,Rovida E,Ferrari M,Forni GL,Fiorillo C,Broccoli V,Levi S

Tue Nov 12 00:00:00 UTC 2019

Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology.

Scientific reports

Fenske P,Grauel MK,Brockmann MM,Dorrn AL,Trimbuch T,Rosenmund C

Wed Mar 20 00:00:00 UTC 2019

Postinjury Inhibition of miR-181a Promotes Restoration of Hippocampal CA1 Neurons after Transient Forebrain Ischemia in Rats.

eNeuro

Griffiths BB,Ouyang YB,Xu L,Sun X,Giffard RG,Stary CM

450-03 was used in In vitro experiments to evaluate the use of anti-miR-181a for postinjury treatment of CA1 neuron recovery.

Thu Mar 05 00:00:00 UTC 2020

A cell fitness selection model for neuronal survival during development.

Nature communications

Wang Y,Wu H,Fontanet P,Codeluppi S,Akkuratova N,Petitpré C,Xue-Franzén Y,Niederreither K,Sharma A,Da Silva F,Comai G,Agirman G,Palumberi D,Linnarsson S,Adameyko I,Moqrich A,Schedl A,La Manno G,Hadjab S,Lallemend F

Thu Sep 12 00:00:00 UTC 2019

Chromatin Decondensation by FOXP2 Promotes Human Neuron Maturation and Expression of Neurodevelopmental Disease Genes.

Cell reports

Hickey SL,Berto S,Konopka G

450-03 was used in Cell Culture to study the mechanisms by which FOXP2 exerts regulatory control over targets during neuronal maturation.

Tue May 07 00:00:00 UTC 2019

GAIN domain-mediated cleavage is required for activation of G protein-coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist.

The Journal of biological chemistry

Zhu B,Luo R,Jin P,Li T,Oak HC,Giera S,Monk KR,Lak P,Shoichet BK,Piao X

Fri Dec 13 00:00:00 UTC 2019

Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes.

Acta neuropathologica

Reyes JF,Sackmann C,Hoffmann A,Svenningsson P,Winkler J,Ingelsson M,Hallbeck M

450-03 was used in Cell Culture to study how the gap junction protein connexin-32 (Cx32) is centrally involved in the preferential uptake of α-syn oligomeric assemblies (oα-syn) in neurons and oligodendrocytes to provide compelling evidence for Cx32 as a novel target for therapeutic intervention in Parkinson's disease (PD) and related α-synucleinopathies.

Mon Jul 01 00:00:00 UTC 2019

Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang N,Milbreta U,Chin JS,Pinese C,Lin J,Shirahama H,Jiang W,Liu H,Mi R,Hoke A,Wu W,Chew SY

Fri May 03 00:00:00 UTC 2019

V2a interneuron differentiation from mouse and human pluripotent stem cells.

Nature protocols

Butts JC,Iyer N,White N,Thompson R,Sakiyama-Elbert S,McDevitt TC

450-03 was used in Cell Culture to describe how to produce V2a interneurons from mouse and human pluripotent stem cells (PSCs), as well as strategies to characterize and mature the cells for further analysis.

Fri Nov 01 00:00:00 UTC 2019

V2a interneuron differentiation from mouse and human pluripotent stem cells.

Nature protocols

Butts JC,Iyer N,White N,Thompson R,Sakiyama-Elbert S,McDevitt TC

Fri Nov 01 00:00:00 UTC 2019

Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination.

Cell reports

Tripathi A,Volsko C,Garcia JP,Agirre E,Allan KC,Tesar PJ,Trapp BD,Castelo-Branco G,Sim FJ,Dutta R

450-03 was used in Cell Culture to provide evidence supporting a critical role for a steady-state level of OL-specific miR-27a in supporting multiple steps in the complex process of OPC maturation and remyelination.

Tue Oct 22 00:00:00 UTC 2019

Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination.

Cell reports

Tripathi A,Volsko C,Garcia JP,Agirre E,Allan KC,Tesar PJ,Trapp BD,Castelo-Branco G,Sim FJ,Dutta R

Tue Oct 22 00:00:00 UTC 2019

Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer's disease using patient iPSC-derived neurons.

Scientific reports

Wu PC,Fann MJ,Tran TT,Chen SC,Devina T,Cheng IH,Lien CC,Kao LS,Wang SJ,Fuh JL,Tzeng TT,Huang CY,Shiao YJ,Wong YH

Tue Dec 17 00:00:00 UTC 2019

A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons.

Scientific reports

Sridharan B,Hubbs C,Llamosas N,Kilinc M,Singhera FU,Willems E,Piper DR,Scampavia L,Rumbaugh G,Spicer TP

Fri Jun 21 00:00:00 UTC 2019

Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome.

Nature communications

Zhu W,Zhang B,Li M,Mo F,Mi T,Wu Y,Teng Z,Zhou Q,Li W,Hu B

Mon Feb 25 00:00:00 UTC 2019

Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility.

Nature communications

Won H,Huang J,Opland CK,Hartl CL,Geschwind DH

Mon Jun 03 00:00:00 UTC 2019

The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis.

Cell

de la Torre-Ubieta L,Stein JL,Won H,Opland CK,Liang D,Lu D,Geschwind DH

Thu Jan 11 00:00:00 UTC 2018

3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds.

Advanced functional materials

Joung D,Truong V,Neitzke CC,Guo SZ,Walsh PJ,Monat JR,Meng F,Park SH,Dutton JR,Parr AM,McAlpine MC

450-03 was used in Cell Culture to introduce a living platform to model spinal cord cytoarchitecture which could ultimately be used as a therapeutic for chronic spinal cord injury to regenerate axons across the lesion site.

Wed Sep 26 00:00:00 UTC 2018

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

Neuron

Lin YT,Seo J,Gao F,Feldman HM,Wen HL,Penney J,Cam HP,Gjoneska E,Raja WK,Cheng J,Rueda R,Kritskiy O,Abdurrob F,Peng Z,Milo B,Yu CJ,Elmsaouri S,Dey D,Ko T,Yankner BA,Tsai LH

Wed Jun 27 00:00:00 UTC 2018

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.

The Journal of experimental medicine

Ackerman SD,Luo R,Poitelon Y,Mogha A,Harty BL,D'Rozario M,Sanchez NE,Lakkaraju AKK,Gamble P,Li J,Qu J,MacEwan MR,Ray WZ,Aguzzi A,Feltri ML,Piao X,Monk KR

Mon Mar 05 00:00:00 UTC 2018

Generation and assembly of human brain region-specific three-dimensional cultures.

Nature protocols

Sloan SA,Andersen J,Pașca AM,Birey F,Pașca SP

450-03 was used in In vitro experiments to propose a method to generate and assemble subdomain-specific forebrain spheroids, also known as brain region-specific organoids, from human pluripotent stem cells (hPSCs).

Sat Sep 01 00:00:00 UTC 2018

MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts.

Developmental cell

Lee SW,Oh YM,Lu YL,Kim WK,Yoo AS

450-03 was used in In vitro experiments to study how miR-9/9∗-124 breaks the cell fate barrier to activate the neuronal program.

Mon Jul 02 00:00:00 UTC 2018

Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors.

Stem cell reports

Hwang I,Cao D,Na Y,Kim DY,Zhang T,Yao J,Oh H,Hu J,Zheng H,Yao Y,Paik J

Tue Apr 10 00:00:00 UTC 2018

Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.

Nature communications

Weider M,Starost LJ,Groll K,Küspert M,Sock E,Wedel M,Fröb F,Schmitt C,Baroti T,Hartwig AC,Hillgärtner S,Piefke S,Fadler T,Ehrlich M,Ehlert C,Stehling M,Albrecht S,Jabali A,Schöler HR,Winkler J,Kuhlmann T,Wegner M

Fri Mar 02 00:00:00 UTC 2018

Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.

Nature communications

Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA

Mon Jun 04 00:00:00 UTC 2018

Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.

Nature communications

Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA

Mon Jun 04 00:00:00 UTC 2018

Chemical conversion of human lung fibroblasts into neuronal cells.

International journal of molecular medicine

Wan XY,Xu LY,Li B,Sun QH,Ji QL,Huang DD,Zhao L,Xiao YT

450-03 was used in Cell Culture to investigate whether a cocktail of small molecules can convert human lung fibroblast cells into neurons.

Thu Mar 01 00:00:00 UTC 2018

Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids.

Cell death & disease

Zhang B,He Y,Xu Y,Mo F,Mi T,Shen QS,Li C,Li Y,Liu J,Wu Y,Chen G,Zhu W,Qin C,Hu B,Zhou G

Mon Jun 18 00:00:00 UTC 2018

The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis.

The Journal of biological chemistry

Shen C,Liu Y,Yu H,Gulbranson DR,Kogut I,Bilousova G,Zhang C,Stowell MHB,Shen J

Fri Nov 23 00:00:00 UTC 2018

Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo.

Scientific reports

Russell OM,Fruh I,Rai PK,Marcellin D,Doll T,Reeve A,Germain M,Bastien J,Rygiel KA,Cerino R,Sailer AW,Lako M,Taylor RW,Mueller M,Lightowlers RN,Turnbull DM,Helliwell SB

Mon Jan 29 00:00:00 UTC 2018

Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.

Scientific reports

Bayó-Puxan N,Terrasso AP,Creyssels S,Simão D,Begon-Pescia C,Lavigne M,Salinas S,Bernex F,Bosch A,Kalatzis V,Levade T,Cuervo AM,Lory P,Consiglio A,Brito C,Kremer EJ

Fri Nov 09 00:00:00 UTC 2018

Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis.

Nature communications

Daynac M,Chouchane M,Collins HY,Murphy NE,Andor N,Niu J,Fancy SPJ,Stallcup WB,Petritsch CK

Tue Aug 21 00:00:00 UTC 2018

Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling.

Scientific reports

Nzou G,Wicks RT,Wicks EE,Seale SA,Sane CH,Chen A,Murphy SV,Jackson JD,Atala AJ

Wed May 09 00:00:00 UTC 2018

Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells.

Scientific reports

Alshawaf AJ,Viventi S,Qiu W,D'Abaco G,Nayagam B,Erlichster M,Chana G,Everall I,Ivanusic J,Skafidas E,Dottori M

Fri Jan 12 00:00:00 UTC 2018

Oxaliplatin induces pH acidification in dorsal root ganglia neurons.

Scientific reports

Riva B,Dionisi M,Potenzieri A,Chiorazzi A,Cordero-Sanchez C,Rigolio R,Carozzi VA,Lim D,Cavaletti G,Marmiroli P,Distasi C,Genazzani AA

Wed Oct 10 00:00:00 UTC 2018

SiO₂ nanoparticles modulate the electrical activity of neuroendocrine cells without exerting genomic effects.

Scientific reports

Distasi C,Ruffinatti FA,Dionisi M,Antoniotti S,Gilardino A,Croci G,Riva B,Bassino E,Alberto G,Castroflorio E,Incarnato D,Morandi E,Martra G,Oliviero S,Munaron L,Lovisolo D

Fri Feb 09 00:00:00 UTC 2018

Assembly of functionally integrated human forebrain spheroids.

Nature

Birey F,Andersen J,Makinson CD,Islam S,Wei W,Huber N,Fan HC,Metzler KRC,Panagiotakos G,Thom N,O'Rourke NA,Steinmetz LM,Bernstein JA,Hallmayer J,Huguenard JR,Paşca SP

Thu May 04 00:00:00 UTC 2017

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

Neuron

Petersen MA,Ryu JK,Chang KJ,Etxeberria A,Bardehle S,Mendiola AS,Kamau-Devers W,Fancy SPJ,Thor A,Bushong EA,Baeza-Raja B,Syme CA,Wu MD,Rios Coronado PE,Meyer-Franke A,Yahn S,Pous L,Lee JK,Schachtrup C,Lassmann H,Huang EJ,Han MH,Absinta M,Reich DS,Ellisman MH,Rowitch DH,Chan JR,Akassoglou K

Wed Dec 06 00:00:00 UTC 2017

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.

Neuron

Sloan SA,Darmanis S,Huber N,Khan TA,Birey F,Caneda C,Reimer R,Quake SR,Barres BA,Paşca SP

Wed Aug 16 00:00:00 UTC 2017

Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.

Stem cell reports

Rodrigues GMC,Gaj T,Adil MM,Wahba J,Rao AT,Lorbeer FK,Kulkarni RU,Diogo MM,Cabral JMS,Miller EW,Hockemeyer D,Schaffer DV

Tue Jun 06 00:00:00 UTC 2017

LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair.

eLife

Lin JP,Mironova YA,Shrager P,Giger RJ

450-03 was used in Cell Culture to reveal a novel role for low-density lipoprotein receptor-related protein-1 in peroxisome biogenesis, lipid homeostasis, and oligodendrocyte progenitor cell differentiation during white matter development and repair.

Mon Dec 18 00:00:00 UTC 2017

Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment.

Scientific reports

Nguyen LH,Gao M,Lin J,Wu W,Wang J,Chew SY

Tue Feb 07 00:00:00 UTC 2017

Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening.

Cell reports

He ZQ,Xia BL,Wang YK,Li J,Feng GH,Zhang LL,Li YH,Wan HF,Li TD,Xu K,Yuan XW,Li YF,Zhang XX,Zhang Y,Wang L,Li W,Zhou Q

450-03 was used in Cell Culture to demonstrate that the spontaneous diploidisation of haploid embryonic stem cells happens in metaphase due to mitotic slippage.

Tue Aug 29 00:00:00 UTC 2017

Generation of Otic Sensory Neurons from Mouse Embryonic Stem Cells in 3D Culture.

Frontiers in cellular neuroscience

Perny M,Ting CC,Kleinlogel S,Senn P,Roccio M

Wed Sep 30 00:00:00 UTC 2020

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.

Stem cell reports

Wang C,Ward ME,Chen R,Liu K,Tracy TE,Chen X,Xie M,Sohn PD,Ludwig C,Meyer-Franke A,Karch CM,Ding S,Gan L

Tue Oct 10 00:00:00 UTC 2017

Discovery of long-range inhibitory signaling to ensure single axon formation.

Nature communications

Takano T,Wu M,Nakamuta S,Naoki H,Ishizawa N,Namba T,Watanabe T,Xu C,Hamaguchi T,Yura Y,Amano M,Hahn KM,Kaibuchi K

Mon Jun 26 00:00:00 UTC 2017

Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.

The Journal of experimental medicine

Patzke C,Acuna C,Giam LR,Wernig M,Südhof TC

Mon Apr 04 00:00:00 UTC 2016

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos.

Proceedings of the National Academy of Sciences of the United States of America

Cohen MA,Wert KJ,Goldmann J,Markoulaki S,Buganim Y,Fu D,Jaenisch R

Tue Feb 09 00:00:00 UTC 2016

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

Proceedings of the National Academy of Sciences of the United States of America

He J,Zhou R,Wu Z,Carrasco MA,Kurshan PT,Farley JE,Simon DJ,Wang G,Han B,Hao J,Heller E,Freeman MR,Shen K,Maniatis T,Tessier-Lavigne M,Zhuang X

Tue May 24 00:00:00 UTC 2016

Generation of highly enriched V2a interneurons from mouse embryonic stem cells.

Experimental neurology

Iyer NR,Huettner JE,Butts JC,Brown CR,Sakiyama-Elbert SE

450-03 was used in Cell Culture to provide a unique tool to begin studying V2a INs in isolation or for use in in vitro models of spinal microcircuits.

Tue Mar 01 00:00:00 UTC 2016

Sustained release of neurotrophin-3 via calcium phosphate-coated sutures promotes axonal regeneration after spinal cord injury.

Journal of neuroscience research

Hanna A,Thompson DL,Hellenbrand DJ,Lee JS,Madura CJ,Wesley MG,Dillon NJ,Sharma T,Enright CJ,Murphy WL

450-03 was used in In vivo experiments to demonstrate that PNGs serve as scaffolds for axonal growth after SCI and that CaP-coated sutures can efficiently release NT-3 to increase axonal regeneration.

Fri Jul 01 00:00:00 UTC 2016

Organ of Corti explants direct tonotopically graded morphology of spiral ganglion neurons in vitro.

The Journal of comparative neurology

Smith FL,Davis RL

450-03 was used in Cell Culture to study the interplay between different regulators of neuronal morphology using cocultured neuron explants with peripheral target tissues removed from distinct cochlear locations.

Mon Aug 01 00:00:00 UTC 2016

Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure.

Scientific reports

Suzuki J,Corfas G,Liberman MC

Mon Apr 25 00:00:00 UTC 2016

BMS-708163 and Nilotinib restore synaptic dysfunction in human embryonic stem cell-derived Alzheimer's disease models.

Scientific reports

Nishioka H,Tooi N,Isobe T,Nakatsuji N,Aiba K

Mon Sep 19 00:00:00 UTC 2016

Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds.

Nature communications

Carlson AL,Bennett NK,Francis NL,Halikere A,Clarke S,Moore JC,Hart RP,Paradiso K,Wernig M,Kohn J,Pang ZP,Moghe PV

Thu Mar 17 00:00:00 UTC 2016

Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds.

Nature communications

Carlson AL,Bennett NK,Francis NL,Halikere A,Clarke S,Moore JC,Hart RP,Paradiso K,Wernig M,Kohn J,Pang ZP,Moghe PV

Thu Mar 17 00:00:00 UTC 2016

Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan.

PloS one

Albrecht S,Hagemeier K,Ehrlich M,Kemming C,Trotter J,Kuhlmann T

450-03 was used in Cell Culture to influence the expression of genes, such as prostaglandin D2 synthase which has neuromodulatory properties.

Fri Nov 17 00:00:00 UTC 2017

Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3.

Scientific reports

Wright T,Gillespie LN,O'Leary SJ,Needham K

Thu Jun 23 00:00:00 UTC 2016

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.

The Journal of clinical investigation

Walsh JT,Hendrix S,Boato F,Smirnov I,Zheng J,Lukens JR,Gadani S,Hechler D,Gölz G,Rosenberger K,Kammertöns T,Vogt J,Vogelaar C,Siffrin V,Radjavi A,Fernandez-Castaneda A,Gaultier A,Gold R,Kanneganti TD,Nitsch R,Zipp F,Kipnis J

Sun Feb 01 00:00:00 UTC 2015

Analysis of conditional heterozygous STXBP1 mutations in human neurons.

The Journal of clinical investigation

Patzke C,Han Y,Covy J,Yi F,Maxeiner S,Wernig M,Südhof TC

Tue Sep 01 00:00:00 UTC 2015

Analysis of conditional heterozygous STXBP1 mutations in human neurons.

The Journal of clinical investigation

Patzke C,Han Y,Covy J,Yi F,Maxeiner S,Wernig M,Südhof TC

Tue Sep 01 00:00:00 UTC 2015

Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia.

Molecular therapy : the journal of the American Society of Gene Therapy

Li Y,Polak U,Bhalla AD,Rozwadowska N,Butler JS,Lynch DR,Dent SYR,Napierala M

450-03 was used in Cell Culture to investigate GAA repeats in Friedrich’s ataxia.

Mon Jun 01 00:00:00 UTC 2015

Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.

Cell research

Jiang MH,Cai B,Tuo Y,Wang J,Zang ZJ,Tu X,Gao Y,Su Z,Li W,Li G,Zhang M,Jiao J,Wan Z,Deng C,Lahn BT,Xiang AP

Mon Dec 01 00:00:00 UTC 2014

Human glial chimeric mice reveal astrocytic dependence of JC virus infection.

The Journal of clinical investigation

Kondo Y,Windrem MS,Zou L,Chandler-Militello D,Schanz SJ,Auvergne RM,Betstadt SJ,Harrington AR,Johnson M,Kazarov A,Gorelik L,Goldman SA

Mon Dec 01 00:00:00 UTC 2014

Endothelial NT-3 delivered by vasculature and CSF promotes quiescence of subependymal neural stem cells through nitric oxide induction.

Neuron

Delgado AC,Ferrón SR,Vicente D,Porlan E,Perez-Villalba A,Trujillo CM,D'Ocón P,Fariñas I

Wed Aug 06 00:00:00 UTC 2014

Endothelial NT-3 delivered by vasculature and CSF promotes quiescence of subependymal neural stem cells through nitric oxide induction.

Neuron

Delgado AC,Ferrón SR,Vicente D,Porlan E,Perez-Villalba A,Trujillo CM,D'Ocón P,Fariñas I

Wed Aug 06 00:00:00 UTC 2014

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.

Proceedings of the National Academy of Sciences of the United States of America

Wang Y,Chakravarty P,Ranes M,Kelly G,Brooks PJ,Neilan E,Stewart A,Schiavo G,Svejstrup JQ

Tue Oct 07 00:00:00 UTC 2014

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Pathak MM,Nourse JL,Tran T,Hwe J,Arulmoli J,Le DT,Bernardis E,Flanagan LA,Tombola F

Tue Nov 11 00:00:00 UTC 2014

The evolutionary young miR-1290 favors mitotic exit and differentiation of human neural progenitors through altering the cell cycle proteins.

Cell death & disease

Yelamanchili SV,Morsey B,Harrison EB,Rennard DA,Emanuel K,Thapa I,Bastola DR,Fox HS

Thu Jan 09 00:00:00 UTC 2014

Purification of dorsal root ganglion neurons from rat by immunopanning.

Cold Spring Harbor protocols

Zuchero JB

450-03 was used in Sample Preparation to propose a method to study the role of glia in the biology of dorsal root ganglion neurons (DRGs).

Fri Aug 01 00:00:00 UTC 2014

Direct conversion of human fibroblasts into neuronal restricted progenitors.

The Journal of biological chemistry

Zou Q,Yan Q,Zhong J,Wang K,Sun H,Yi X,Lai L

Fri Feb 21 00:00:00 UTC 2014

Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.

Cell

Xue Y,Ouyang K,Huang J,Zhou Y,Ouyang H,Li H,Wang G,Wu Q,Wei C,Bi Y,Jiang L,Cai Z,Sun H,Zhang K,Zhang Y,Chen J,Fu XD

Thu Jan 17 00:00:00 UTC 2013

Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits.

Cell

Xue Y,Ouyang K,Huang J,Zhou Y,Ouyang H,Li H,Wang G,Wu Q,Wei C,Bi Y,Jiang L,Cai Z,Sun H,Zhang K,Zhang Y,Chen J,Fu XD

Thu Jan 17 00:00:00 UTC 2013

Rapid single-step induction of functional neurons from human pluripotent stem cells.

Neuron

Zhang Y,Pak C,Han Y,Ahlenius H,Zhang Z,Chanda S,Marro S,Patzke C,Acuna C,Covy J,Xu W,Yang N,Danko T,Chen L,Wernig M,Südhof TC

Wed Jun 05 00:00:00 UTC 2013

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.

Proceedings of the National Academy of Sciences of the United States of America

Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA

Tue Mar 19 00:00:00 UTC 2013

Purification of oligodendrocyte precursor cells from rat cortices by immunopanning.

Cold Spring Harbor protocols

Dugas JC,Emery B

450-03 was used in Cell Culture to demonstrate how to purify oligodendrocyte precursor cells (OPCs) from postnatal rodent brains.

Thu Aug 01 00:00:00 UTC 2013

Long-distance growth and connectivity of neural stem cells after severe spinal cord injury.

Cell

Lu P,Wang Y,Graham L,McHale K,Gao M,Wu D,Brock J,Blesch A,Rosenzweig ES,Havton LA,Zheng B,Conner JM,Marsala M,Tuszynski MH

Fri Sep 14 00:00:00 UTC 2012

miR-200c targets a NF-κB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer.

PloS one

Howe EN,Cochrane DR,Cittelly DM,Richer JK

Thu May 30 00:00:00 UTC 2013

3D multicolor super-resolution imaging offers improved accuracy in neuron tracing.

PloS one

Lakadamyali M,Babcock H,Bates M,Zhuang X,Lichtman J

Mon Jun 04 00:00:00 UTC 2012

Oligodendrocyte differentiation from adult multipotent stem cells is modulated by glutamate.

Cell death & disease

Cavaliere F,Urra O,Alberdi E,Matute C

Thu Feb 02 00:00:00 UTC 2012

Coseeded Schwann cells myelinate neurites from differentiated neural stem cells in neurotrophin-3-loaded PLGA carriers.

International journal of nanomedicine

Xiong Y,Zhu JX,Fang ZY,Zeng CG,Zhang C,Qi GL,Li MH,Zhang W,Quan DP,Wan J

Wed Sep 26 00:00:00 UTC 2012

Coseeded Schwann cells myelinate neurites from differentiated neural stem cells in neurotrophin-3-loaded PLGA carriers.

International journal of nanomedicine

Xiong Y,Zhu JX,Fang ZY,Zeng CG,Zhang C,Qi GL,Li MH,Zhang W,Quan DP,Wan J

Wed Sep 26 00:00:00 UTC 2012

MicroRNA-mediated conversion of human fibroblasts to neurons.

Nature

Yoo AS,Sun AX,Li L,Shcheglovitov A,Portmann T,Li Y,Lee-Messer C,Dolmetsch RE,Tsien RW,Crabtree GR

Wed Jul 13 00:00:00 UTC 2011

Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons.

Cell

Qiang L,Fujita R,Yamashita T,Angulo S,Rhinn H,Rhee D,Doege C,Chau L,Aubry L,Vanti WB,Moreno H,Abeliovich A

Fri Aug 05 00:00:00 UTC 2011

Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice.

The Journal of clinical investigation

Cazorla M,Prémont J,Mann A,Girard N,Kellendonk C,Rognan D

Sun May 01 00:00:00 UTC 2011

Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Papadeas ST,Kraig SE,O'Banion C,Lepore AC,Maragakis NJ

Tue Oct 25 00:00:00 UTC 2011

The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro.

Aging cell

Liu S,Liu S,Wang X,Zhou J,Cao Y,Wang F,Duan E

Mon Aug 01 00:00:00 UTC 2011

Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelination.

PloS one

Binder MD,Xiao J,Kemper D,Ma GZ,Murray SS,Kilpatrick TJ

Thu Mar 10 00:00:00 UTC 2011

Biophysical characteristics reveal neural stem cell differentiation potential.

PloS one

Labeed FH,Lu J,Mulhall HJ,Marchenko SA,Hoettges KF,Estrada LC,Lee AP,Hughes MP,Flanagan LA

Thu Jan 26 00:00:00 UTC 2012

Efficient derivation of human neuronal progenitors and neurons from pluripotent human embryonic stem cells with small molecule induction.

Journal of visualized experiments : JoVE

Parsons XH,Teng YD,Parsons JF,Snyder EY,Smotrich DB,Moore DA

Fri Oct 28 00:00:00 UTC 2011

Canonical Wnt signalling requires the BMP pathway to inhibit oligodendrocyte maturation.

ASN neuro

Feigenson K,Reid M,See J,Crenshaw III EB,Grinspan JB

Thu Jun 16 00:00:00 UTC 2011

Canonical Wnt signalling requires the BMP pathway to inhibit oligodendrocyte maturation.

ASN neuro

Feigenson K,Reid M,See J,Crenshaw III EB,Grinspan JB

Thu Jun 16 00:00:00 UTC 2011

Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension.

Nature biotechnology

Steiner D,Khaner H,Cohen M,Even-Ram S,Gil Y,Itsykson P,Turetsky T,Idelson M,Aizenman E,Ram R,Berman-Zaken Y,Reubinoff B

Thu Apr 01 00:00:00 UTC 2010

The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.

Cell

Greer PL,Hanayama R,Bloodgood BL,Mardinly AR,Lipton DM,Flavell SW,Kim TK,Griffith EC,Waldon Z,Maehr R,Ploegh HL,Chowdhury S,Worley PF,Steen J,Greenberg ME

Fri Mar 05 00:00:00 UTC 2010

Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons.

BMC biology

Li Wq,Shi L,You Yg,Gong Yh,Yin B,Yuan Jg,Peng Xz

Fri Jun 18 00:00:00 UTC 2010

Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons.

BMC biology

Li Wq,Shi L,You Yg,Gong Yh,Yin B,Yuan Jg,Peng Xz

Fri Jun 18 00:00:00 UTC 2010

Kinetic analysis of neurotrophin-3-mediated differentiation of embryonic stem cells into neurons.

Tissue engineering. Part A

Willerth SM,Sakiyama-Elbert SE

Sun Feb 01 00:00:00 UTC 2009

Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice.

PloS one

Katayama K,Zine A,Ota M,Matsumoto Y,Inoue T,Fritzsch B,Aruga J

Wed Nov 11 00:00:00 UTC 2009

Dendritic branching of olfactory bulb mitral and tufted cells: regulation by TrkB.

PloS one

Imamura F,Greer CA

Tue Aug 25 00:00:00 UTC 2009

Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect.

Proceedings of the National Academy of Sciences of the United States of America

Jeanneteau F,Garabedian MJ,Chao MV

Tue Mar 25 00:00:00 UTC 2008

Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice.

BMC developmental biology

Stewart AL,Anderson RB,Kobayashi K,Young HM

Fri Jul 25 00:00:00 UTC 2008

Isolation of neural stem and precursor cells from rodent tissue.

Methods in molecular biology (Clifton, N.J.)

Wu Y,Liu Y,Chesnut JD,Rao MS

450-03 was used in Cell Culture to provide a protocol for dissection of rodent embryonic spinal cords by enzymatic separation, and isolation and enrichment (or purification) of neuronal and glial precursors at different developing stages by fluorescence-activated cell sorting.