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Invitrogen
Human RBM41 (aa 10-154) Control Fragment Recombinant Protein
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Product Details
RP-92118
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
SDEHVLEELETEGERQLKSLLQHQLDTSVSIEECMSKKESFAPGTMYKPFGKEAAGTMTLSQFQTLHEKDQETASLRELGLNETEILIWKSHVSGEKKTKLRATPEAIQNRLQDIEERISERQRILCLPQRFAKSKQLTRREMEI
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-60155. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
RBM41, known as RNA Binding Motif Protein 41, is identified as a novel component of the minor spliceosome, particularly interacting with its paralog, U11/U12-65K. Both RBM41 and U11/U12-65K share similar C-terminal RNA recognition motifs (RRMs), which are crucial for their role in spliceosomal activity. Distinctly, RBM41 has been associated with spliceosomal functions, although its precise cellular functions remain largely unexplored. Understanding the structural and functional parallels between RBM41 and U11/U12-65K aids in elucidating the mechanisms underlying minor spliceosome activity. The minor spliceosome itself is involved in the splicing of U12-type introns, thus playing a significant role in the regulation of gene expression. Additionally, RBM41's functional characterization in protein complexes and its involvement with RNA-binding activities enrich our understanding of gene regulation and cellular processes where the spliceosome plays a pivotal role. Research on RBM41 contributes to broader insights into RNA splicing and molecular genetics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RNA-binding motif protein 41; RNA-binding protein 41
Gene Aliases: RBM41
UniProt ID: (Human) Q96IZ5
Entrez Gene ID: (Human) 55285
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