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Invitrogen
Human RGL4 Control Fragment Recombinant Protein
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Product Details
RP-91551
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
KLLTNLPAAAVLSAQVYSAVLRGLWEENVCGTPGRTRVCTALLYGQVCPFQDSTDGLRTITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGLGLEDHQEIVLGQLVLPEPNEAKPDDPAPRPGQHAL
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (20%), Rat (20%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57492. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Ral Guanine Nucleotide Dissociation Stimulator-Like 4 (RGL4) is a gene that encodes a member of the RalGDS family, which is involved in the regulation of the Ras signaling pathway. This gene is located on chromosome 22 and is highly expressed in various tissues, including the brain and reproductive organs. RGL4 is known to interact with RalA and RalB, small GTPases that play crucial roles in cellular processes such as vesicular trafficking, cytoskeleton dynamics, and cell proliferation. Studies have shown that the expression of RGL4 has significant implications in various cancers. For instance, low expression of RGL4 is associated with poor prognosis and increased immune infiltration in lung adenocarcinoma (LUAD). Conversely, overexpression of RGL4 has been correlated with resistance to Midostaurin in FLT3-ITD mutant acute myeloid leukemia (AML) samples. These findings highlight the gene's potential as a biomarker for prognosis and therapy response in certain cancers, making it a valuable target for further research and clinical applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hRGR; Ral guanine nucleotide dissociation stimulator-like 4; Ral-GDS related protein Rgr; Ral-GDS-related protein; RalGDS related oncogene; RalGDS-like 4
Gene Aliases: RGL4; RGR
UniProt ID: (Human) Q8IZJ4
Entrez Gene ID: (Human) 266747
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