Invitrogen

Human ROR1 Recombinant Protein, Biotin

Human ROR1 Protein in SDS-PAGE (SDS-PAGE)

FIGURE: 1 / 1

Human ROR1 Protein (RP-88153) in SDS-PAGE

SDS-PAGE analysis of Human ROR1 (Product # RP-88153) shows purity to be: ≥ 95 % (SDS-PAGE), ≥ 90 % (SEC-HPLC).

Product Image Gallery

Product Details

RP-88153

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

Product Specifications

Species

Human

Expression System

HEK293 cells

Amino acid sequence

Met1-Glu403|LEVLFQ

Molecular weight

42.8 kDa

Class

Recombinant

Type

Protein

Purity

>95% as determined by SDS-PAGE.

Conjugate

Biotin Biotin Biotin

Form

Lyophilized

Purification

purified

Storage buffer

PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

It is recommended that the protein be aliquoted for optimal storage.

It is recommended that sterile water (400 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.

Concentration is measured by UV.

Target Information

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an "orphan" receptor due to the fact its related ligand remained elusive. Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?

Let us know so we can reference it here.

Cite this product

Bioinformatics

Protein Aliases: Inactive tyrosine-protein kinase transmembrane receptor ROR1; MGC99659; Neurotrophic tyrosine kinase, receptor-related 1; receptor tyrosine kinase-like orphan receptor 1; T-ROR1