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Invitrogen
Human RhoV (aa 195-236) Control Fragment Recombinant Protein
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Product Details
RP-104211
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
KEVFDSAILSAIEHKARLEKKLNAKGVRTLSRCRWKKFFCFV
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62781. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. Rho V (ras homolog gene family, member V), also known as Rho GTPase-like protein ARHV, CHP or WRCH2 (Wnt-1 responsive Cdc42 homolog 2), is a 236 amino acid protein that controls the actin cytoskeleton through activation of the JNK pathway. A member of the Rho family and small GTPase superfamily, Rho V functions as a lipid anchor at the cytoplasmic side of the cell membrane and is expressed in placenta, pancreas and fetal brain. Rho V is implicated in cell transformation and is encoded by a gene located on human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC42-like GTPase 2; GTP-binding protein-like 2; ras homolog gene family, member V; Rho GTPase-like protein ARHV; Rho-related GTP-binding protein RhoV; RHOV; Wnt-1 regulated Cdc42 homolog 2; Wnt-1 responsive Cdc42 homolog 2; WRCH-2; WRCH1-related GTPase
Gene Aliases: ARHV; CHP; RHOV; WRCH2
UniProt ID: (Human) Q96L33
Entrez Gene ID: (Human) 171177
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