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Invitrogen
Human SCIN (aa 517-622) Control Fragment Recombinant Protein
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Product Details
RP-92602
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
RNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNK
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (89%), Rat (89%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-55034. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The SCIN gene, also known as scinderin, encodes for a calcium-dependent actin filament-severing protein that is involved in the regulation of the cytoskeleton. It plays a significant role in actin filament dynamics, influencing cellular processes such as cell shape, motility, secretion, and division. SCIN has been identified as a novel oncogene, with its abnormal expression strongly correlated to various cancers, including glioma and uterine corpus endometrial carcinoma. Specific mutations like S673F and S381Y in SCIN are linked with poor prognosis and are potential targets for cancer diagnosis, prognosis, and treatment strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adseverin; Scinderin
Gene Aliases: KIAA1905; SCIN
UniProt ID: (Human) Q9Y6U3
Entrez Gene ID: (Human) 85477
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