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Invitrogen
Human SCLY (aa 279-347) Control Fragment Recombinant Protein
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Product Details
RP-103918
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
LYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQKRIHLNS
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (90%), Rat (90%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-63172. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The SCLY gene encodes selenocysteine lyase, an enzyme involved in selenium metabolism, which plays a critical role in the recycling of selenocysteine from selenoproteins. SCLY catalyzes the conversion of selenocysteine into alanine, releasing selenium for reuse in the biosynthesis of new selenoproteins. It is chiefly active in the liver and kidneys, contributing to maintaining selenium homeostasis, which is vital for numerous biological functions due to selenium's role in antioxidant defense and thyroid hormone metabolism. Alterations in SCLY function or expression can affect selenium levels in the body and are associated with disorders related to oxidative stress and metabolic imbalances. Given the importance of selenium in cellular protection and immune function, SCLY is also of interest in studies focusing on dietary supplementation and disease prevention strategies, particularly in conditions like cancer and cardiovascular diseases where oxidative damage is prevalent.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSCL; Selenocysteine lyase
Gene Aliases: hSCL; SCL; SCLY
UniProt ID: (Human) Q96I15
Entrez Gene ID: (Human) 51540
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