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Invitrogen
Human SERTAD1 (aa 179-231) Control Fragment Recombinant Protein
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Product Details
RP-107226
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
TSMYDNELWAPASEGLKPGPEDGPGKEEAPELDEAELDYLMDVLVGTQALERP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (91%), Rat (91%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66571. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals provided by transcription factors. Acting at E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, thereby transmitting their signals to the promoter and stimulating transcriptional activity. SEI-1 exists as a multiprotein complex with E2F-1 and DP-1 and is expressed at different levels throughout the cell cycle, allowing it to regulate cell cycle progression via promoter control during the G1 and S phases. Additionally, SEI-1 can render the activity of the cyclin D-Cdk4 complex, an important catalyst of the cell cycle, resistant to the inhibitory effects of p16. Overexpression of SEI-1 is implicated in the development of squamous cell carcinomas of the head and neck.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDK4-binding protein p34SEI; CDK4-binding protein p34SEI1; SEI-1; SERTA domain-containing protein 1; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIP-Br1
Gene Aliases: SEI1; SERTAD1; TRIP-Br1; TRIPBR1
UniProt ID: (Human) Q9UHV2
Entrez Gene ID: (Human) 29950
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