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Invitrogen
Human SH3YL1 (aa 150-218) Control Fragment Recombinant Protein
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Product Details
RP-95959
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
FTYCKSRGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILDSFTEKYENEG
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (93%), Rat (93%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56593. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The SH3YL1 gene encodes a protein that contains an SH3 domain and is involved in various signaling pathways. It is particularly significant in the context of androgen receptor (AR) signaling, where it acts as a coregulator for AR target genes. Studies have shown that SH3YL1 is essential for the transcriptional activation of genes modulated by the AR, and its dysregulation is associated with aggressive prostate cancer. Additionally, elevated plasma levels of SH3YL1 have been identified as a biomarker for diabetic nephropathy, indicating its broader role in human health and disease. SH3YL1 protein expression is particularly noted in the kidneys of diabetic patients, suggesting its involvement in the development of diabetic complications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SH3 domain containing, Ysc84-like 1; SH3 domain-containing YSC84-like protein 1
Gene Aliases: RAY; SH3YL1
UniProt ID: (Human) Q96HL8
Entrez Gene ID: (Human) 26751
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