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Invitrogen
Human SIPA1L1 Synthetic Peptide
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Product Details
PEP-0961
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human SIPA1L1.
PEP-0961 can be used as a blocking peptide with polyclonal antibody PA5-20847.
Target Information
Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E6-targeted protein 1; H_DJ1140G11.1; High-risk human papilloma viruses E6 oncoproteins targeted protein 1; signal-induced proliferation-associated 1 like 1; Signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; WUGSC:H_DJ1140G11.1
Gene Aliases: E6TP1; KIAA0440; SIPA1L1
UniProt ID: (Human) O43166
Entrez Gene ID: (Human) 26037
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