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Search Thermo Fisher Scientific
Invitrogen
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Highest antigen sequence indentity to the following orthologs: Mouse (97%), Rat (97%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-65229. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IMP-4; Intramembrane protease 4; MGC111084; Presenilin homologous protein 4; Presenilin-like protein 1; PSH4; Signal peptide peptidase-like 2B; SPP-like 2B
Gene Aliases: IMP-4; IMP4; KIAA1532; PSH4; PSL1; SPPL2B
UniProt ID: (Human) Q8TCT7
Entrez Gene ID: (Human) 56928
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