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Invitrogen
Human TC2N (aa 6-144) Control Fragment Recombinant Protein
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Product Details
RP-88889
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
IKSCCGGCFYGETEKHNFSVERDFKAAVPNSQNATISVPPLTSVSVKPQLGCTEDYLLSKLPSDGKEVPFVVPKFKLSYIQPRTQETPSHLEELEGSARASFGDRKVELSSSSQHGPSYDVYNPFYMYQHISPDLSRRF
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (80%), Rat (80%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-55651. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The TC2N gene encodes the Tandem C2 domains nuclear protein, which is characterized by the presence of two C2 domains, C2A and C2B, at the C-terminus. These domains are structured as an eight-stranded antiparallel beta-sandwich, initially recognized as a Ca2+ binding module. TC2N's role varies significantly across different types of cancer. It has been identified as an oncogene in lung, gastric, and hepatocellular carcinomas, where its overexpression promotes cell proliferation, migration, and metastasis. Conversely, in breast cancer, TC2N functions as a tumor suppressor, inhibiting distant metastasis and stemness via the PI3K-Akt signaling pathway. These dual roles highlight its complex involvement in tumorigenesis, with its impact being highly context-dependent on the cancer type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C2 calcium-dependent domain containing 1; membrane targeting (tandem) C2 domain containing 1; Membrane targeting tandem C2 domain-containing protein 1; Tac2-N; Tandem C2 domains nuclear protein; Tandem C2 protein in nucleus
Gene Aliases: C14orf47; C2CD1; MTAC2D1; Tac2-N; TC2N
UniProt ID: (Human) Q8N9U0
Entrez Gene ID: (Human) 123036
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