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Invitrogen
Human TFB2M (aa 322-395) Control Fragment Recombinant Protein
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Product Details
RP-107043
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
HLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLED
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (54%), Rat (54%).
This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dimethyladenosine transferase 2, mitochondrial; FLJ22661; FLJ23182; h-mtTFB; h-mtTFB2; HCV NS5A-transactivated protein 5; Hepatitis C virus NS5A-transactivated protein 5; hTFB2M; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
Gene Aliases: Hkp1; mtTFB2; NS5ATP5; TFB2M
UniProt ID: (Human) Q9H5Q4
Entrez Gene ID: (Human) 64216
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