Gibco

Human TL-1A Recombinant Protein, PeproTech®

Product Details

310-23-20UG

Applications

Tested Dilution

Publications

In vitro Assay (IV)

View 5 publications 5 publications

Product Specifications

Published species

Human

Expression System

E. coli

Class

Recombinant

Type

Protein

Conjugate

Unconjugated Unconjugated Unconjugated

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

310-23-1MG will be provided as 2 x 500 µg (310-23-500UG).

Recombinant Human TL-1A is a 22.0 kDa polypeptide of 194 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

BEST1 Positive Monocytes in Circulation: Visualize Intratumoral Crosstalk between Cancer Cells and Monocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang L,Wang Y,Yuan W,An C,Tan Q,Ma J

310-23 was used in In vitro experiments to report that Bestrophin1 (BEST1), a component protein of Ca2+ -activated Cl- channels, is highly expressed on classical monocytes in the peripheral blood of Head and neck squamous cell carcinomas patients.

Thu Jun 01 00:00:00 UTC 2023

Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi.

Nature communications

Hong SP,Yang MJ,Cho H,Park I,Bae H,Choe K,Suh SH,Adams RH,Alitalo K,Lim D,Koh GY

Fri Aug 14 00:00:00 UTC 2020

Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation.

Nature communications

Li J,Shi W,Sun H,Ji Y,Chen Y,Guo X,Sheng H,Shu J,Zhou L,Cai T,Qiu J

Mon Jul 29 00:00:00 UTC 2019

A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.

Proceedings of the National Academy of Sciences of the United States of America

Hedl M,Abraham C

Tue Sep 16 00:00:00 UTC 2014

The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.

Journal of immunology (Baltimore, Md. : 1950)

McLaren JE,Calder CJ,McSharry BP,Sexton K,Salter RC,Singh NN,Wilkinson GW,Wang EC,Ramji DP

Sat May 15 00:00:00 UTC 2010