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Invitrogen
Human TMED5 (aa 122-177) Control Fragment Recombinant Protein
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Product Details
RP-101218
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
FELILDNMGEQAQEQEDWKKYITGTDILDMKLEDILESINSIKSRLSKSGHIQTLL
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (89%), Rat (89%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62164. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The TMED5 gene encodes the transmembrane emp24 domain-containing protein 5, a member of the TMED family, which is involved in intracellular protein trafficking. This family is essential for the transport of proteins between the endoplasmic reticulum and the Golgi apparatus. TMED5 is a member of the γ subfamily and has been shown to regulate vital cellular processes, including protein secretion and signal transduction. Dysregulation of TMED5 has been implicated in various diseases, including hepatocellular carcinoma (HCC). Increased expression of TMED5 mRNA in HCC tissues is associated with poorer overall survival rates compared to normal tissues, suggesting its role in tumor progression and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p24 family protein gamma-2; p24gamma2; p28; Transmembrane emp24 domain-containing protein 5; transmembrane emp24 protein transport domain containing 5
Gene Aliases: CGI-100; p24g2; p28; TMED5; UNQ397/PRO733
UniProt ID: (Human) Q9Y3A6
Entrez Gene ID: (Human) 50999
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