Product References
Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood.
Stem cell research & therapy
Xiong M,Xiu Y,Long J,Zhao X,Wang Q,Yang H,Yu H,Bian L,Ju Y,Yin H,Hou Q,Liang F,Liu N,Chen F,Fan R,Sun Y,Zeng Y
AF-300-18 was used in Cell Culture to investigate whether perturbing glutathione metabolism affects reactive oxygen species (ROS) production, the metabolic state, and the expansion of human Hematopoietic stem progenitor cells.
Sun Sep 15 00:00:00 UTC 2024
A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.
RNA (New York, N.Y.)
Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF
AF-300-18 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.
Thu Sep 01 00:00:00 UTC 2022
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells.
Blood cancer discovery
Mian SA,Abarrategi A,Kong KL,Rouault-Pierre K,Wood H,Oedekoven CA,Smith AE,Batsivari A,Ariza-McNaughton L,Johnson P,Snoeks T,Mufti GJ,Bonnet D
AF-300-18 was used in Cell Culture to show that human microenvironment but not mouse is essential to MDS-SCs homing and engraftment.
Mon Mar 01 00:00:00 UTC 2021
Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals.
Scientific reports
Eernstman J,Veldhuisen B,Ligthart P,von Lindern M,van der Schoot CE,van den Akker E
Fri Sep 17 00:00:00 UTC 2021
Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.
Blood
Alvarado LJ,Huntsman HD,Cheng H,Townsley DM,Winkler T,Feng X,Dunbar CE,Young NS,Larochelle A
Thu May 09 00:00:00 UTC 2019
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.
Cell stem cell
Ho YH,Del Toro R,Rivera-Torres J,Rak J,Korn C,García-García A,Macías D,González-Gómez C,Del Monte A,Wittner M,Waller AK,Foster HR,López-Otín C,Johnson RS,Nerlov C,Ghevaert C,Vainchenker W,Louache F,Andrés V,Méndez-Ferrer S
AF-300-18 was used in Cell Culture to show that the bone marrow microenvironment promotes myelopoiesis in premature/physiological aging.
Thu Sep 05 00:00:00 UTC 2019
Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.
Stem cells translational medicine
Trump LR,Nayak RC,Singh AK,Emberesh S,Wellendorf AM,Lutzko CM,Cancelas JA
Sat Jun 01 00:00:00 UTC 2019
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.
Cell stem cell
Vannini N,Campos V,Girotra M,Trachsel V,Rojas-Sutterlin S,Tratwal J,Ragusa S,Stefanidis E,Ryu D,Rainer PY,Nikitin G,Giger S,Li TY,Semilietof A,Oggier A,Yersin Y,Tauzin L,Pirinen E,Cheng WC,Ratajczak J,Canto C,Ehrbar M,Sizzano F,Petrova TV,Vanhecke D,Zhang L,Romero P,Nahimana A,Cherix S,Duchosal MA,Ho PC,Deplancke B,Coukos G,Auwerx J,Lutolf MP,Naveiras O
AF-300-18 was used in Cell Culture to demonstrate a positive effect of NAD+-boosting strategies on the most primitive blood stem cells, establishing a link between HSC mitochondrial stress, mitophagy, and stem-cell fate decision.
Thu Mar 07 00:00:00 UTC 2019
Gene correction for SCID-X1 in long-term hematopoietic stem cells.
Nature communications
Pavel-Dinu M,Wiebking V,Dejene BT,Srifa W,Mantri S,Nicolas CE,Lee C,Bao G,Kildebeck EJ,Punjya N,Sindhu C,Inlay MA,Saxena N,DeRavin SS,Malech H,Roncarolo MG,Weinberg KI,Porteus MH
AF-300-18 was used in In vitro experiments to evaluate the use of SCID-X1 in targeting the cDNA in human long-term hematopoietic stem cells.
Tue Apr 09 00:00:00 UTC 2019
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Nature communications
Minuesa G,Albanese SK,Xie W,Kazansky Y,Worroll D,Chow A,Schurer A,Park SM,Rotsides CZ,Taggart J,Rizzi A,Naden LN,Chou T,Gourkanti S,Cappel D,Passarelli MC,Fairchild L,Adura C,Glickman JF,Schulman J,Famulare C,Patel M,Eibl JK,Ross GM,Bhattacharya S,Tan DS,Leslie CS,Beuming T,Patel DJ,Goldgur Y,Chodera JD,Kharas MG
Wed Jun 19 00:00:00 UTC 2019
Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing.
Nature communications
McGrath E,Shin H,Zhang L,Phue JN,Wu WW,Shen RF,Jang YY,Revollo J,Ye Z
Mon Nov 25 00:00:00 UTC 2019
Quantifying single-cell secretion in real time using resonant hyperspectral imaging.
Proceedings of the National Academy of Sciences of the United States of America
Juan-Colás J,Hitchcock IS,Coles M,Johnson S,Krauss TF
Wed Dec 26 00:00:00 UTC 2018
Ex Vivo Expansion of CD34+ CD90+ CD49f+ Hematopoietic Stem and Progenitor Cells from Non-Enriched Umbilical Cord Blood with Azole Compounds.
Stem cells translational medicine
Bari S,Zhong Q,Fan X,Poon Z,Lim AST,Lim TH,Dighe N,Li S,Chiu GNC,Chai CLL,Hwang WYK
Tue May 01 00:00:00 UTC 2018
Engraftment and in vivo proliferation advantage of gene-corrected mobilized CD34+ cells from Fanconi anemia patients.
Blood
Río P,Navarro S,Guenechea G,Sánchez-Domínguez R,Lamana ML,Yañez R,Casado JA,Mehta PA,Pujol MR,Surrallés J,Charrier S,Galy A,Segovia JC,Díaz de Heredia C,Sevilla J,Bueren JA
Thu Sep 28 00:00:00 UTC 2017
Gene therapy for Wiskott-Aldrich syndrome in a severely affected adult.
Blood
Morris EC,Fox T,Chakraverty R,Tendeiro R,Snell K,Rivat C,Grace S,Gilmour K,Workman S,Buckland K,Butler K,Chee R,Salama AD,Ibrahim H,Hara H,Duret C,Mavilio F,Male F,Bushman FD,Galy A,Burns SO,Gaspar HB,Thrasher AJ
Thu Sep 14 00:00:00 UTC 2017
Identification of novel genes and networks governing hematopoietic stem cell development.
EMBO reports
Han T,Yang CS,Chang KY,Zhang D,Imam FB,Rana TM
Thu Dec 01 00:00:00 UTC 2016
Generation and Characterization of Patient-Specific Induced Pluripotent Stem Cell for Disease Modeling.
Methods in molecular biology (Clifton, N.J.)
Sivapatham R,Zeng X
AF-300-18 was used in Cell Culture to describe the generation and characterization of iPSC from blood or fibroblast on a routine base and focus on the integration-free methodologies.
Thu Aug 18 00:00:00 UTC 2016
USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.
Stem cell reports
Higuchi M,Kawamura H,Matsuki H,Hara T,Takahashi M,Saito S,Saito K,Jiang S,Naito M,Kiyonari H,Fujii M
Tue Dec 13 00:00:00 UTC 2016
Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.
The Journal of clinical investigation
Nayak RC,Trump LR,Aronow BJ,Myers K,Mehta P,Kalfa T,Wellendorf AM,Valencia CA,Paddison PJ,Horwitz MS,Grimes HL,Lutzko C,Cancelas JA
Mon Aug 03 00:00:00 UTC 2015
CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.
The Journal of experimental medicine
Mende N,Kuchen EE,Lesche M,Grinenko T,Kokkaliaris KD,Hanenberg H,Lindemann D,Dahl A,Platz A,Höfer T,Calegari F,Waskow C
Mon Jul 27 00:00:00 UTC 2015
Genomic impact of transient low-dose decitabine treatment on primary AML cells.
Blood
Klco JM,Spencer DH,Lamprecht TL,Sarkaria SM,Wylie T,Magrini V,Hundal J,Walker J,Varghese N,Erdmann-Gilmore P,Lichti CF,Meyer MR,Townsend RR,Wilson RK,Mardis ER,Ley TJ
Thu Feb 28 00:00:00 UTC 2013
Role of SOX17 in hematopoietic development from human embryonic stem cells.
Blood
Nakajima-Takagi Y,Osawa M,Oshima M,Takagi H,Miyagi S,Endoh M,Endo TA,Takayama N,Eto K,Toyoda T,Koseki H,Nakauchi H,Iwama A
Thu Jan 17 00:00:00 UTC 2013
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.
Molecular therapy : the journal of the American Society of Gene Therapy
Scaramuzza S,Biasco L,Ripamonti A,Castiello MC,Loperfido M,Draghici E,Hernandez RJ,Benedicenti F,Radrizzani M,Salomoni M,Ranzani M,Bartholomae CC,Vicenzi E,Finocchi A,Bredius R,Bosticardo M,Schmidt M,von Kalle C,Montini E,Biffi A,Roncarolo MG,Naldini L,Villa A,Aiuti A
Tue Jan 01 00:00:00 UTC 2013
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
Nature methods
Certo MT,Gwiazda KS,Kuhar R,Sather B,Curinga G,Mandt T,Brault M,Lambert AR,Baxter SK,Jacoby K,Ryu BY,Kiem HP,Gouble A,Paques F,Rawlings DJ,Scharenberg AM
Mon Oct 01 00:00:00 UTC 2012
RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.
Blood
Baudet A,Karlsson C,Safaee Talkhoncheh M,Galeev R,Magnusson M,Larsson J
Thu Jun 28 00:00:00 UTC 2012
Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells.
Blood
Gori JL,Chandrasekaran D,Kowalski JP,Adair JE,Beard BC,D'Souza SL,Kiem HP
Thu Sep 27 00:00:00 UTC 2012
Impaired ribosomal subunit association in Shwachman-Diamond syndrome.
Blood
Burwick N,Coats SA,Nakamura T,Shimamura A
Thu Dec 20 00:00:00 UTC 2012
PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.
Blood
van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM
Thu Dec 13 00:00:00 UTC 2012
PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.
Blood
van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM
Thu Dec 13 00:00:00 UTC 2012
FANCL ubiquitinates β-catenin and enhances its nuclear function.
Blood
Dao KH,Rotelli MD,Petersen CL,Kaech S,Nelson WD,Yates JE,Hanlon Newell AE,Olson SB,Druker BJ,Bagby GC
Thu Jul 12 00:00:00 UTC 2012
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models.
The Journal of experimental medicine
Thiollier C,Lopez CK,Gerby B,Ignacimouttou C,Poglio S,Duffourd Y,Guégan J,Rivera-Munoz P,Bluteau O,Mabialah V,Diop M,Wen Q,Petit A,Bauchet AL,Reinhardt D,Bornhauser B,Gautheret D,Lecluse Y,Landman-Parker J,Radford I,Vainchenker W,Dastugue N,de Botton S,Dessen P,Bourquin JP,Crispino JD,Ballerini P,Bernard OA,Pflumio F,Mercher T
Mon Oct 22 00:00:00 UTC 2012
A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.
The Journal of experimental medicine
Kaufmann KB,Gründer A,Hadlich T,Wehrle J,Gothwal M,Bogeska R,Seeger TS,Kayser S,Pham KB,Jutzi JS,Ganzenmüller L,Steinemann D,Schlegelberger B,Wagner JM,Jung M,Will B,Steidl U,Aumann K,Werner M,Günther T,Schüle R,Rambaldi A,Pahl HL
Mon Jan 16 00:00:00 UTC 2012
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.
The Journal of experimental medicine
Oguro H,Yuan J,Tanaka S,Miyagi S,Mochizuki-Kashio M,Ichikawa H,Yamazaki S,Koseki H,Nakauchi H,Iwama A
Mon Mar 12 00:00:00 UTC 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 UTC 2012
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21.
Proceedings of the National Academy of Sciences of the United States of America
Roy A,Cowan G,Mead AJ,Filippi S,Bohn G,Chaidos A,Tunstall O,Chan JK,Choolani M,Bennett P,Kumar S,Atkinson D,Wyatt-Ashmead J,Hu M,Stumpf MP,Goudevenou K,O'Connor D,Chou ST,Weiss MJ,Karadimitris A,Jacobsen SE,Vyas P,Roberts I
Tue Oct 23 00:00:00 UTC 2012
Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion.
Cytotherapy
Chu PP,Bari S,Fan X,Gay FP,Ang JM,Chiu GN,Lim SK,Hwang WY
Mon Oct 01 00:00:00 UTC 2012
Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice.
Stem cells (Dayton, Ohio)
Reimann C,Six E,Dal-Cortivo L,Schiavo A,Appourchaux K,Lagresle-Peyrou C,de Chappedelaine C,Ternaux B,Coulombel L,Beldjord K,Cavazzana-Calvo M,Andre-Schmutz I
Wed Aug 01 00:00:00 UTC 2012
GITR ligand provided by thrombopoietic cells inhibits NK cell antitumor activity.
Journal of immunology (Baltimore, Md. : 1950)
Placke T,Salih HR,Kopp HG
Sun Jul 01 00:00:00 UTC 2012
Pharmacological inhibition of caspase and calpain proteases: a novel strategy to enhance the homing responses of cord blood HSPCs during expansion.
PloS one
Sangeetha VM,Kadekar D,Kale VP,Limaye LS
Mon May 14 00:00:00 UTC 2012
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics.
PloS one
Danova-Alt R,Heider A,Egger D,Cross M,Alt R
Tue Aug 07 00:00:00 UTC 2012
Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities.
PloS one
Aggarwal R,Lu J,Kanji S,Joseph M,Das M,Noble GJ,McMichael BK,Agarwal S,Hart RT,Sun Z,Lee BS,Rosol TJ,Jackson R,Mao HQ,Pompili VJ,Das H
Wed Dec 12 00:00:00 UTC 2012
Suppression of homeobox transcription factor VentX promotes expansion of human hematopoietic stem/multipotent progenitor cells.
The Journal of biological chemistry
Gao H,Wu X,Sun Y,Zhou S,Silberstein LE,Zhu Z
Fri Aug 24 00:00:00 UTC 2012
Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation.
PloS one
Dumon S,Walton DS,Volpe G,Wilson N,Dassé E,Del Pozzo W,Landry JR,Turner B,O'Neill LP,Göttgens B,Frampton J
Tue Feb 19 00:00:00 UTC 2013
Generation of virus-free induced pluripotent stem cell clones on a synthetic matrix via a single cell subcloning in the naïve state.
PloS one
Nishishita N,Shikamura M,Takenaka C,Takada N,Fusaki N,Kawamata S
Thu Dec 13 00:00:00 UTC 2012
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
PloS one
Pelosi E,Castelli G,Martin-Padura I,Bordoni V,Santoro S,Conigliaro A,Cerio AM,De Santis Puzzonia M,Marighetti P,Biffoni M,Alonzi T,Amicone L,Alcalay M,Bertolini F,Testa U,Tripodi M
Tue May 21 00:00:00 UTC 2013
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
PloS one
Nakamura S,Oshima M,Yuan J,Saraya A,Miyagi S,Konuma T,Yamazaki S,Osawa M,Nakauchi H,Koseki H,Iwama A
Tue Oct 16 00:00:00 UTC 2012
Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.
PloS one
Yamagata Y,Parietti V,Stockholm D,Corre G,Poinsignon C,Touleimat N,Delafoy D,Besse C,Tost J,Galy A,Paldi A
Wed Jul 24 00:00:00 UTC 2013
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 UTC 2011
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
Blood
Jaako P,Flygare J,Olsson K,Quere R,Ehinger M,Henson A,Ellis S,Schambach A,Baum C,Richter J,Larsson J,Bryder D,Karlsson S
Thu Dec 01 00:00:00 UTC 2011
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
Blood
Bouma G,Mendoza-Naranjo A,Blundell MP,de Falco E,Parsley KL,Burns SO,Thrasher AJ
Thu Sep 01 00:00:00 UTC 2011
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow.
Blood
Matthes T,Dunand-Sauthier I,Santiago-Raber ML,Krause KH,Donze O,Passweg J,McKee T,Huard B
Thu Aug 18 00:00:00 UTC 2011
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Blood
Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE
Thu Sep 29 00:00:00 UTC 2011
Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site.
PloS one
Okada Y,Nobori H,Shimizu M,Watanabe M,Yonekura M,Nakai T,Kamikawa Y,Wakimura A,Funahashi N,Naruse H,Watanabe A,Yamasaki D,Fukada S,Yasui K,Matsumoto K,Sato T,Kitajima K,Nakano T,Aird WC,Doi T
Tue Feb 28 00:00:00 UTC 2012
Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase.
PloS one
Nishino T,Wang C,Mochizuki-Kashio M,Osawa M,Nakauchi H,Iwama A
Mon Jan 30 00:00:00 UTC 2012
Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
The Journal of biological chemistry
Sarma NJ,Yaseen NR
Fri Nov 11 00:00:00 UTC 2011
Magnetic resonance imaging of bone marrow cell-mediated interleukin-10 gene therapy of atherosclerosis.
PloS one
Sun J,Li X,Feng H,Gu H,Blair T,Li J,Soriano S,Meng Y,Zhang F,Feng Q,Yang X
Tue Feb 14 00:00:00 UTC 2012
