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Invitrogen
Human TRANK1 (aa 905-990) Control Fragment Recombinant Protein
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Product Details
RP-96430
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
CKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFST
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (90%), Rat (90%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57300. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The TRANK1 gene encodes the tetratricopeptide repeat and ankyrin repeat containing 1 protein, which has been associated with neurodevelopmental and psychiatric conditions, particularly bipolar disorder and schizophrenia. Located on chromosome 9, this gene contains both tetratricopeptide repeats and ankyrin repeats, which contribute to protein-protein interactions and structural stability. TRANK1 is thought to possibly participate in cellular functions related to brain development and synaptic transmission, impacting neuronal signaling and cognitive processes. Genetic studies have identified variations in the TRANK1 gene that may alter its expression, influencing susceptibility to bipolar disorder by modulating pathways related to neurotransmitter regulation and neuroplasticity. The specific mechanisms by which TRANK1 influences psychiatric disorders remain under investigation, but it is hypothesized that TRANK1's interaction with other proteins involved in signal transduction could be pivotal. Given its potential linkage to complex neurological disorders, TRANK1 serves as a significant focal point for studies aiming to understand the genetic basis of these conditions and develop targeted interventions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lupus brain antigen 1 homolog; TPR and ankyrin repeat-containing protein 1
Gene Aliases: KIAA0342; LBA1; TRANK1
UniProt ID: (Human) O15050
Entrez Gene ID: (Human) 9881
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