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Invitrogen
Human TTC40 (aa 519-591) Control Fragment Recombinant Protein
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Product Details
RP-97213
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
LAPDAFQIVLDSENEAKVSTGKNRGRFTYLCAKAWHHTVSVDKAAGHLRRLGNENDKERIQIWAELAKVARKQ
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (82%), Rat (82%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58104. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The TTC40 gene, which stands for Tetratricopeptide repeat domain 40, is a member of the TPR protein family characterized by highly conserved motifs that facilitate protein-protein interactions. This gene plays a significant role in various cellular processes, including signal transduction and protein assembly. TTC40 has been identified as a novel methylated gene in nasopharyngeal carcinoma, where its expression is significantly reduced in tumor tissues due to hypermethylation. This epigenetic alteration suggests a potential role of TTC40 in tumorigenesis, possibly acting as a tumor suppressor. The decreased expression of TTC40 in cancerous tissues highlights its importance in maintaining cellular homeostasis and integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cilia- and flagella-associated protein 46; protein CFAP46; tetratricopeptide repeat domain 40; Tetratricopeptide repeat protein 40; TPR repeat-containing protein C10orf93
Gene Aliases: bA288G11.4; bA288G11.5; bB137A17.2; bB137A17.3; C10orf123; C10orf124; C10orf92; C10orf93; CFAP46; TTC40
UniProt ID: (Human) Q8IYW2
Entrez Gene ID: (Human) 54777
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