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Invitrogen
Human UTRN (aa 1354-1496) Control Fragment Recombinant Protein
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Product Details
RP-101029
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVI
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (92%), Rat (92%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-53873. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The UTRN gene encodes the utrophin protein, which is closely related to dystrophin in structure and function, playing a crucial role in maintaining the integrity of muscle fiber membranes. Located on chromosome 6, utrophin is expressed widely in fetal tissues but is replaced by dystrophin in mature muscle fibers; however, it remains present in adult tissues such as the neuromuscular junction and blood vessels. Utrophin's primary role is to stabilize the cytoskeleton and membrane linkages, forming part of the protein complex responsible for structural support in muscle cells. This protein has garnered significant attention in the context of muscular dystrophies, particularly Duchenne Muscular Dystrophy (DMD), where utrophin upregulation is considered a potential therapeutic strategy to compensate for the lack of functional dystrophin. It helps to ameliorate muscle pathology by mimicking the stabilizing effects of dystrophin, thus preserving muscle function and reducing damage. Research on enhancing utrophin expression is ongoing, aiming to provide an effective treatment modality for DMD and other dystrophin-associated disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DRP-1; Dystrophin-related protein 1; Utrophin
Gene Aliases: DMDL; DRP; DRP1; UTRN
UniProt ID: (Human) P46939
Entrez Gene ID: (Human) 7402
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